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Protein

Zinc finger protein 20

Gene

ZNF20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri103 – 13028C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri143 – 16523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri171 – 19323C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri199 – 22123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri227 – 24923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri255 – 27723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri283 – 30523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri311 – 33323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri339 – 36123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri367 – 38923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri395 – 41723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri423 – 44523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri451 – 47323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri479 – 50022C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 20
Alternative name(s):
Zinc finger protein KOX13
Gene namesi
Name:ZNF20
Synonyms:KOX13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12992. ZNF20.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37572.

Polymorphism and mutation databases

BioMutaiZNF20.
DMDMi12643268.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Zinc finger protein 20PRO_0000047344Add
BLAST

Proteomic databases

EPDiP17024.
MaxQBiP17024.
PaxDbiP17024.
PeptideAtlasiP17024.
PRIDEiP17024.

PTM databases

iPTMnetiP17024.
PhosphoSiteiP17024.

Expressioni

Gene expression databases

BgeeiP17024.
CleanExiHS_ZNF20.
ExpressionAtlasiP17024. baseline and differential.
GenevisibleiP17024. HS.

Organism-specific databases

HPAiHPA020887.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC102BA1A4H13EBI-717634,EBI-10171570
CCDC136Q96JN2-23EBI-717634,EBI-10171416
CCNDBP1O952733EBI-717634,EBI-748961
FSD2A1L4K13EBI-717634,EBI-5661036
KIFC3Q9BVG83EBI-717634,EBI-2125614
KRT31Q153233EBI-717634,EBI-948001
KRT38O760153EBI-717634,EBI-1047263
KRT40Q6A1623EBI-717634,EBI-10171697
KRTAP10-5P603703EBI-717634,EBI-10172150
KRTAP10-7P604093EBI-717634,EBI-10172290
KRTAP10-8P604103EBI-717634,EBI-10171774
KRTAP10-9P604113EBI-717634,EBI-10172052
KRTAP4-12Q9BQ663EBI-717634,EBI-739863
KRTAP4-2Q9BYR53EBI-717634,EBI-10172511
LZTS2Q9BRK43EBI-717634,EBI-741037
MTUS2Q5JR593EBI-717634,EBI-742948
TRAF1Q130773EBI-717634,EBI-359224

Protein-protein interaction databases

BioGridi113399. 20 interactions.
IntActiP17024. 19 interactions.
MINTiMINT-8373458.
STRINGi9606.ENSP00000335437.

Structurei

3D structure databases

ProteinModelPortaliP17024.
SMRiP17024. Positions 7-57, 104-529.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 7872KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri103 – 13028C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri143 – 16523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri171 – 19323C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri199 – 22123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri227 – 24923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri255 – 27723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri283 – 30523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri311 – 33323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri339 – 36123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri367 – 38923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri395 – 41723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri423 – 44523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri451 – 47323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri479 – 50022C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17024.
KOiK09228.
OMAiIRYHERT.
PhylomeDBiP17024.
TreeFamiTF338854.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFQDSVAFE DVAVSFTQEE WALLDPSQKN LYRDVMQETF KNLTSVGKTW
60 70 80 90 100
KVQNIEDEYK NPRRNLSLMR EKLCESKESH HCGESFNQIA DDMLNRKTLP
110 120 130 140 150
GITPCESSVC GEVGTGHSSL NTHIRADTGH KSSEYQEYGE NPYRNKECKK
160 170 180 190 200
AFSYLDSFQS HDKACTKEKP YDGKECTETF ISHSCIQRHR VMHSGDGPYK
210 220 230 240 250
CKFCGKAFYF LNLCLIHERI HTGVKPYKCK QCGKAFTRST TLPVHERTHT
260 270 280 290 300
GVNADECKEC GNAFSFPSEI RRHKRSHTGE KPYECKQCGK VFISFSSIQY
310 320 330 340 350
HKMTHTGEKP YECKQCGKAF RCGSHLQKHG RTHTGEKPYE CRQCGKAFRC
360 370 380 390 400
TSDLQRHEKT HTEDKPYGCK QCGKGFRCAS QLQIHERTHS GEKPHECKEC
410 420 430 440 450
GKVFKYFSSL RIHERTHTGE KPHECKQCGK AFRYFSSLHI HERTHTGDKP
460 470 480 490 500
YECKVCGKAF TCSSSIRYHE RTHTGEKPYE CKHCGKAFIS NYIRYHERTH
510 520 530
TGEKPYQCKQ CGKAFIRASS CREHERTHTI NR
Length:532
Mass (Da):61,567
Last modified:December 1, 2000 - v2
Checksum:iC92473E875FCAA42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080125 mRNA. Translation: CAB45723.2.
CH471106 Genomic DNA. Translation: EAW84260.1.
BC036714 mRNA. Translation: AAH36714.3.
X52344 mRNA. Translation: CAA36570.1.
CCDSiCCDS45986.1.
PIRiT12489.
RefSeqiNP_066966.2. NM_021143.3.
UniGeneiHs.512823.

Genome annotation databases

EnsembliENST00000334213; ENSP00000335437; ENSG00000132010.
GeneIDi7568.
KEGGihsa:7568.
UCSCiuc002mtf.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080125 mRNA. Translation: CAB45723.2.
CH471106 Genomic DNA. Translation: EAW84260.1.
BC036714 mRNA. Translation: AAH36714.3.
X52344 mRNA. Translation: CAA36570.1.
CCDSiCCDS45986.1.
PIRiT12489.
RefSeqiNP_066966.2. NM_021143.3.
UniGeneiHs.512823.

3D structure databases

ProteinModelPortaliP17024.
SMRiP17024. Positions 7-57, 104-529.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113399. 20 interactions.
IntActiP17024. 19 interactions.
MINTiMINT-8373458.
STRINGi9606.ENSP00000335437.

PTM databases

iPTMnetiP17024.
PhosphoSiteiP17024.

Polymorphism and mutation databases

BioMutaiZNF20.
DMDMi12643268.

Proteomic databases

EPDiP17024.
MaxQBiP17024.
PaxDbiP17024.
PeptideAtlasiP17024.
PRIDEiP17024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334213; ENSP00000335437; ENSG00000132010.
GeneIDi7568.
KEGGihsa:7568.
UCSCiuc002mtf.3. human.

Organism-specific databases

CTDi7568.
GeneCardsiZNF20.
HGNCiHGNC:12992. ZNF20.
HPAiHPA020887.
MIMi194557. gene.
neXtProtiNX_P17024.
PharmGKBiPA37572.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17024.
KOiK09228.
OMAiIRYHERT.
PhylomeDBiP17024.
TreeFamiTF338854.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF20. human.
GenomeRNAii7568.
PROiP17024.
SOURCEiSearch...

Gene expression databases

BgeeiP17024.
CleanExiHS_ZNF20.
ExpressionAtlasiP17024. baseline and differential.
GenevisibleiP17024. HS.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: B-cell.
  4. "Multiple genes encoding zinc finger domains are expressed in human T cells."
    Thiesen H.-J.
    New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 227-282.

Entry informationi

Entry nameiZNF20_HUMAN
AccessioniPrimary (citable) accession number: P17024
Secondary accession number(s): Q8N457, Q9UG41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: December 1, 2000
Last modified: July 6, 2016
This is version 158 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.