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Protein

Zinc finger protein 20

Gene

ZNF20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri103 – 130C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST28
Zinc fingeri143 – 165C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri171 – 193C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri479 – 500C2H2-type 14PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri506 – 528C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 20
Alternative name(s):
Zinc finger protein KOX13
Gene namesi
Name:ZNF20
Synonyms:KOX13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12992. ZNF20.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7568.
PharmGKBiPA37572.

Polymorphism and mutation databases

BioMutaiZNF20.
DMDMi12643268.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473441 – 532Zinc finger protein 20Add BLAST532

Proteomic databases

EPDiP17024.
MaxQBiP17024.
PaxDbiP17024.
PeptideAtlasiP17024.
PRIDEiP17024.

PTM databases

iPTMnetiP17024.
PhosphoSitePlusiP17024.

Expressioni

Gene expression databases

BgeeiENSG00000132010.
CleanExiHS_ZNF20.
ExpressionAtlasiP17024. baseline and differential.
GenevisibleiP17024. HS.

Organism-specific databases

HPAiHPA020887.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113399. 20 interactors.
IntActiP17024. 24 interactors.
MINTiMINT-8373458.
STRINGi9606.ENSP00000335437.

Structurei

3D structure databases

ProteinModelPortaliP17024.
SMRiP17024.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 78KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri103 – 130C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST28
Zinc fingeri143 – 165C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri171 – 193C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri479 – 500C2H2-type 14PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri506 – 528C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17024.
KOiK09228.
OMAiIRYHERT.
OrthoDBiEOG091G02KC.
PhylomeDBiP17024.
TreeFamiTF338854.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di2.10.110.10. 1 hit.
2.20.28.10. 3 hits.
3.30.160.60. 14 hits.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR004039. Rubredoxin-type_fold.
IPR013087. Znf_C2H2_type.
IPR001781. Znf_LIM.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 8 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.

Sequencei

Sequence statusi: Complete.

P17024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFQDSVAFE DVAVSFTQEE WALLDPSQKN LYRDVMQETF KNLTSVGKTW
60 70 80 90 100
KVQNIEDEYK NPRRNLSLMR EKLCESKESH HCGESFNQIA DDMLNRKTLP
110 120 130 140 150
GITPCESSVC GEVGTGHSSL NTHIRADTGH KSSEYQEYGE NPYRNKECKK
160 170 180 190 200
AFSYLDSFQS HDKACTKEKP YDGKECTETF ISHSCIQRHR VMHSGDGPYK
210 220 230 240 250
CKFCGKAFYF LNLCLIHERI HTGVKPYKCK QCGKAFTRST TLPVHERTHT
260 270 280 290 300
GVNADECKEC GNAFSFPSEI RRHKRSHTGE KPYECKQCGK VFISFSSIQY
310 320 330 340 350
HKMTHTGEKP YECKQCGKAF RCGSHLQKHG RTHTGEKPYE CRQCGKAFRC
360 370 380 390 400
TSDLQRHEKT HTEDKPYGCK QCGKGFRCAS QLQIHERTHS GEKPHECKEC
410 420 430 440 450
GKVFKYFSSL RIHERTHTGE KPHECKQCGK AFRYFSSLHI HERTHTGDKP
460 470 480 490 500
YECKVCGKAF TCSSSIRYHE RTHTGEKPYE CKHCGKAFIS NYIRYHERTH
510 520 530
TGEKPYQCKQ CGKAFIRASS CREHERTHTI NR
Length:532
Mass (Da):61,567
Last modified:December 1, 2000 - v2
Checksum:iC92473E875FCAA42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080125 mRNA. Translation: CAB45723.2.
CH471106 Genomic DNA. Translation: EAW84260.1.
BC036714 mRNA. Translation: AAH36714.3.
X52344 mRNA. Translation: CAA36570.1.
CCDSiCCDS45986.1.
PIRiT12489.
RefSeqiNP_066966.2. NM_021143.3.
UniGeneiHs.512823.

Genome annotation databases

EnsembliENST00000334213; ENSP00000335437; ENSG00000132010.
GeneIDi7568.
KEGGihsa:7568.
UCSCiuc002mtf.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080125 mRNA. Translation: CAB45723.2.
CH471106 Genomic DNA. Translation: EAW84260.1.
BC036714 mRNA. Translation: AAH36714.3.
X52344 mRNA. Translation: CAA36570.1.
CCDSiCCDS45986.1.
PIRiT12489.
RefSeqiNP_066966.2. NM_021143.3.
UniGeneiHs.512823.

3D structure databases

ProteinModelPortaliP17024.
SMRiP17024.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113399. 20 interactors.
IntActiP17024. 24 interactors.
MINTiMINT-8373458.
STRINGi9606.ENSP00000335437.

PTM databases

iPTMnetiP17024.
PhosphoSitePlusiP17024.

Polymorphism and mutation databases

BioMutaiZNF20.
DMDMi12643268.

Proteomic databases

EPDiP17024.
MaxQBiP17024.
PaxDbiP17024.
PeptideAtlasiP17024.
PRIDEiP17024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334213; ENSP00000335437; ENSG00000132010.
GeneIDi7568.
KEGGihsa:7568.
UCSCiuc002mtf.3. human.

Organism-specific databases

CTDi7568.
DisGeNETi7568.
GeneCardsiZNF20.
HGNCiHGNC:12992. ZNF20.
HPAiHPA020887.
MIMi194557. gene.
neXtProtiNX_P17024.
PharmGKBiPA37572.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17024.
KOiK09228.
OMAiIRYHERT.
OrthoDBiEOG091G02KC.
PhylomeDBiP17024.
TreeFamiTF338854.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF20. human.
GenomeRNAii7568.
PROiPR:P17024.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132010.
CleanExiHS_ZNF20.
ExpressionAtlasiP17024. baseline and differential.
GenevisibleiP17024. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di2.10.110.10. 1 hit.
2.20.28.10. 3 hits.
3.30.160.60. 14 hits.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR004039. Rubredoxin-type_fold.
IPR013087. Znf_C2H2_type.
IPR001781. Znf_LIM.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 8 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiZNF20_HUMAN
AccessioniPrimary (citable) accession number: P17024
Secondary accession number(s): Q8N457, Q9UG41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: December 1, 2000
Last modified: April 12, 2017
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.