ID ZNF19_HUMAN Reviewed; 458 AA. AC P17023; A8K895; Q86Y66; Q8NDE2; Q96M79; Q96NE5; DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot. DT 24-MAR-2009, sequence version 4. DT 27-MAR-2024, entry version 212. DE RecName: Full=Zinc finger protein 19; DE AltName: Full=Zinc finger protein KOX12; GN Name=ZNF19; Synonyms=KOX12; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS RP HIS-218 AND GLN-224. RC TISSUE=Lung, and Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15616553; DOI=10.1038/nature03187; RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M., RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., RA Myers R.M., Rubin E.M., Pennacchio L.A.; RT "The sequence and analysis of duplication-rich human chromosome 16."; RL Nature 432:988-994(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT HIS-218. RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 120-458 (ISOFORMS 1/2), AND RP VARIANT HIS-218. RC TISSUE=Brain; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 270-334 (ISOFORMS 1/2). RC TISSUE=Placenta; RX PubMed=1946370; DOI=10.1073/pnas.88.21.9563; RA Bray P.L., Lichter P., Thiesen H.-J., Ward D.C., Dawid I.B.; RT "Characterization and mapping of human genes encoding zinc finger RT proteins."; RL Proc. Natl. Acad. Sci. U.S.A. 88:9563-9567(1991). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] OF 273-328 (ISOFORMS 1/2). RC TISSUE=Lymphoid tissue; RX PubMed=2288909; RA Thiesen H.-J.; RT "Multiple genes encoding zinc finger domains are expressed in human T RT cells."; RL New Biol. 2:363-374(1990). CC -!- FUNCTION: May be involved in transcriptional regulation. CC -!- INTERACTION: CC P17023; Q9BXS5: AP1M1; NbExp=3; IntAct=EBI-12884200, EBI-541426; CC P17023; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-12884200, EBI-1166928; CC P17023; Q9P287: BCCIP; NbExp=3; IntAct=EBI-12884200, EBI-711154; CC P17023; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-12884200, EBI-745073; CC P17023; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-12884200, EBI-11530605; CC P17023; Q86X02: CDR2L; NbExp=3; IntAct=EBI-12884200, EBI-11063830; CC P17023; Q96Q77: CIB3; NbExp=3; IntAct=EBI-12884200, EBI-10292696; CC P17023; Q9BW66: CINP; NbExp=3; IntAct=EBI-12884200, EBI-739784; CC P17023; P67870: CSNK2B; NbExp=3; IntAct=EBI-12884200, EBI-348169; CC P17023; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-12884200, EBI-11962928; CC P17023; Q6L9T8: FAM72D; NbExp=3; IntAct=EBI-12884200, EBI-18397873; CC P17023; P14136: GFAP; NbExp=3; IntAct=EBI-12884200, EBI-744302; CC P17023; Q9NSC5: HOMER3; NbExp=3; IntAct=EBI-12884200, EBI-748420; CC P17023; P42858: HTT; NbExp=3; IntAct=EBI-12884200, EBI-466029; CC P17023; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-12884200, EBI-1055254; CC P17023; P25800: LMO1; NbExp=3; IntAct=EBI-12884200, EBI-8639312; CC P17023; P25791-3: LMO2; NbExp=3; IntAct=EBI-12884200, EBI-11959475; CC P17023; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-12884200, EBI-746778; CC P17023; O14561: NDUFAB1; NbExp=3; IntAct=EBI-12884200, EBI-1246261; CC P17023; P19404: NDUFV2; NbExp=3; IntAct=EBI-12884200, EBI-713665; CC P17023; Q9BRQ3: NUDT22; NbExp=3; IntAct=EBI-12884200, EBI-10297093; CC P17023; P40937: RFC5; NbExp=5; IntAct=EBI-12884200, EBI-712376; CC P17023; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-12884200, EBI-748391; CC P17023; Q5MJ10: SPANXN2; NbExp=3; IntAct=EBI-12884200, EBI-12023934; CC P17023; O75558: STX11; NbExp=3; IntAct=EBI-12884200, EBI-714135; CC P17023; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-12884200, EBI-740727; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=P17023-1; Sequence=Displayed; CC Name=2; CC IsoId=P17023-2; Sequence=VSP_036733; CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein CC family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAA36814.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK055567; BAB70957.1; -; mRNA. DR EMBL; AK057330; BAB71430.1; -; mRNA. DR EMBL; AK292260; BAF84949.1; -; mRNA. DR EMBL; AC010547; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC047091; AAH47091.1; -; mRNA. DR EMBL; AL834237; CAD38915.1; -; mRNA. DR EMBL; M77171; AAA36814.1; ALT_INIT; Genomic_DNA. DR EMBL; X52343; CAA36569.1; -; mRNA. DR CCDS; CCDS10901.1; -. [P17023-1] DR PIR; B56409; B56409. DR RefSeq; NP_008892.2; NM_006961.3. [P17023-1] DR AlphaFoldDB; P17023; -. DR SMR; P17023; -. DR BioGRID; 113398; 30. DR IntAct; P17023; 29. DR STRING; 9606.ENSP00000288177; -. DR GlyGen; P17023; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; P17023; -. DR PhosphoSitePlus; P17023; -. DR BioMuta; ZNF19; -. DR DMDM; 229485313; -. DR jPOST; P17023; -. DR MassIVE; P17023; -. DR MaxQB; P17023; -. DR PaxDb; 9606-ENSP00000288177; -. DR PeptideAtlas; P17023; -. DR ProteomicsDB; 53422; -. [P17023-1] DR ProteomicsDB; 53423; -. [P17023-2] DR Antibodypedia; 16592; 197 antibodies from 21 providers. DR DNASU; 7567; -. DR Ensembl; ENST00000288177.10; ENSP00000288177.5; ENSG00000157429.16. [P17023-1] DR Ensembl; ENST00000564230.5; ENSP00000458105.1; ENSG00000157429.16. [P17023-1] DR GeneID; 7567; -. DR KEGG; hsa:7567; -. DR MANE-Select; ENST00000288177.10; ENSP00000288177.5; NM_006961.4; NP_008892.2. DR UCSC; uc002fam.2; human. [P17023-1] DR AGR; HGNC:12981; -. DR CTD; 7567; -. DR DisGeNET; 7567; -. DR GeneCards; ZNF19; -. DR HGNC; HGNC:12981; ZNF19. DR HPA; ENSG00000157429; Low tissue specificity. DR MIM; 194525; gene. DR neXtProt; NX_P17023; -. DR OpenTargets; ENSG00000157429; -. DR PharmGKB; PA37562; -. DR VEuPathDB; HostDB:ENSG00000157429; -. DR eggNOG; KOG1721; Eukaryota. DR GeneTree; ENSGT00940000163278; -. DR HOGENOM; CLU_002678_44_0_1; -. DR InParanoid; P17023; -. DR OMA; CEYVKYE; -. DR OrthoDB; 3120634at2759; -. DR PhylomeDB; P17023; -. DR TreeFam; TF350808; -. DR PathwayCommons; P17023; -. DR Reactome; R-HSA-212436; Generic Transcription Pathway. DR SignaLink; P17023; -. DR BioGRID-ORCS; 7567; 9 hits in 1160 CRISPR screens. DR ChiTaRS; ZNF19; human. DR GeneWiki; ZNF19; -. DR GenomeRNAi; 7567; -. DR Pharos; P17023; Tdark. DR PRO; PR:P17023; -. DR Proteomes; UP000005640; Chromosome 16. DR RNAct; P17023; Protein. DR Bgee; ENSG00000157429; Expressed in right uterine tube and 125 other cell types or tissues. DR ExpressionAtlas; P17023; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central. DR CDD; cd07765; KRAB_A-box; 1. DR Gene3D; 6.10.140.140; -; 1. DR Gene3D; 3.30.160.60; Classic Zinc Finger; 10. DR InterPro; IPR001909; KRAB. DR InterPro; IPR036051; KRAB_dom_sf. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR47772:SF4; REDUCED EXPRESSION 2-RELATED; 1. DR PANTHER; PTHR47772; ZINC FINGER PROTEIN 200; 1. DR Pfam; PF01352; KRAB; 1. DR Pfam; PF00096; zf-C2H2; 9. DR SMART; SM00349; KRAB; 1. DR SMART; SM00355; ZnF_C2H2; 9. DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5. DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1. DR PROSITE; PS50805; KRAB; 1. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10. DR Genevisible; P17023; HS. PE 1: Evidence at protein level; KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; KW Zinc-finger. FT CHAIN 1..458 FT /note="Zinc finger protein 19" FT /id="PRO_0000047343" FT DOMAIN 14..85 FT /note="KRAB" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119" FT ZN_FING 161..183 FT /note="C2H2-type 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 189..211 FT /note="C2H2-type 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 217..239 FT /note="C2H2-type 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 245..267 FT /note="C2H2-type 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 273..295 FT /note="C2H2-type 5" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 301..323 FT /note="C2H2-type 6" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 329..351 FT /note="C2H2-type 7" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 357..379 FT /note="C2H2-type 8" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 385..407 FT /note="C2H2-type 9" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 413..433 FT /note="C2H2-type 10; atypical" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT VAR_SEQ 1..12 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_036733" FT VARIANT 218 FT /note="Q -> H (in dbSNP:rs8050871)" FT /evidence="ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005" FT /id="VAR_054792" FT VARIANT 224 FT /note="R -> Q (in dbSNP:rs10500557)" FT /evidence="ECO:0000269|PubMed:14702039" FT /id="VAR_054793" FT CONFLICT 34 FT /note="A -> V (in Ref. 3; AAH47091)" FT /evidence="ECO:0000305" FT CONFLICT 120 FT /note="L -> V (in Ref. 4; CAD38915)" FT /evidence="ECO:0000305" SQ SEQUENCE 458 AA; 52449 MW; C53350D55D969A0C CRC64; MAAMPLKAQY QEMVTFEDVA VHFTKTEWTG LSPAQRALYR SVMLENFGNL TALGYPVPKP ALISLLERGD MAWGLEAQDD PPAERTKNVC KDVETNIDSE STLIQGISEE RDGMMSHGQL KSVPQRTDFP ETRNVEKHQD IPTVKNIQGK VPRIPCARKP FICEECGKSF SYFSYYARHQ RIHTGEKPFE CSECGKAFNG NSSLIRHQRI HTGERPYQCE ECGRAFNDNA NLIRHQRIHS GDRPYYCTEC GNSFTSSSEF VIHQRIHTGE KPYECNECGK AFVGNSPLLR HQKIHTGEKP YECNECGKSF GRTSHLSQHQ RIHTGEKPYS CKVCGQAFNF HTKLTRHQRI HSEEKPFDCV DCGKAFSAQE QLKRHLRIHT QESSYVCDEC GKALTSKRNL HQHQRIHTGE KPYECSKYEK AFGTSSQLGH LEHVYSGEKP VLDICRFGLP EFFTPFYW //