P17023 (ZNF19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 19

Alternative name(s):
Zinc finger protein KOX12

Gene names

Name:	ZNF19
Synonyms:	KOX12

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 10 C2H2-type zinc fingers. Contains 1 KRAB domain.
Sequence caution	The sequence AAA36814.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Non-traceable author statement PubMed 7557990. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Non-traceable author statement PubMed 7557990. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P17023-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P17023-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 458	458	Zinc finger protein 19		PRO_0000047343
Regions
	Domain	14 – 85	72	KRAB
	Zinc finger	161 – 183	23	C2H2-type 1
	Zinc finger	189 – 211	23	C2H2-type 2
	Zinc finger	217 – 239	23	C2H2-type 3
	Zinc finger	245 – 267	23	C2H2-type 4
	Zinc finger	273 – 295	23	C2H2-type 5
	Zinc finger	301 – 323	23	C2H2-type 6
	Zinc finger	329 – 351	23	C2H2-type 7
	Zinc finger	357 – 379	23	C2H2-type 8
	Zinc finger	385 – 407	23	C2H2-type 9
	Zinc finger	413 – 433	21	C2H2-type 10; atypical
Natural variations
	Alternative sequence	1 – 12	12	Missing in isoform 2.		VSP_036733
	Natural variant	218	1	Q → H. Ref.1 Ref.3 Ref.4 Corresponds to variant rs8050871 [ dbSNP | Ensembl ].		VAR_054792
	Natural variant	224	1	R → Q. Ref.1 Corresponds to variant rs10500557 [ dbSNP | Ensembl ].		VAR_054793
Experimental info
	Sequence conflict	34	1	A → V in AAH47091. Ref.3
	Sequence conflict	120	1	L → V in CAD38915. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 24, 2009. Version 4. Checksum: C53350D55D969A0C	FASTA	458	52,449
	10 20 30 40 50 60 MAAMPLKAQY QEMVTFEDVA VHFTKTEWTG LSPAQRALYR SVMLENFGNL TALGYPVPKP 70 80 90 100 110 120 ALISLLERGD MAWGLEAQDD PPAERTKNVC KDVETNIDSE STLIQGISEE RDGMMSHGQL 130 140 150 160 170 180 KSVPQRTDFP ETRNVEKHQD IPTVKNIQGK VPRIPCARKP FICEECGKSF SYFSYYARHQ 190 200 210 220 230 240 RIHTGEKPFE CSECGKAFNG NSSLIRHQRI HTGERPYQCE ECGRAFNDNA NLIRHQRIHS 250 260 270 280 290 300 GDRPYYCTEC GNSFTSSSEF VIHQRIHTGE KPYECNECGK AFVGNSPLLR HQKIHTGEKP 310 320 330 340 350 360 YECNECGKSF GRTSHLSQHQ RIHTGEKPYS CKVCGQAFNF HTKLTRHQRI HSEEKPFDCV 370 380 390 400 410 420 DCGKAFSAQE QLKRHLRIHT QESSYVCDEC GKALTSKRNL HQHQRIHTGE KPYECSKYEK 430 440 450 AFGTSSQLGH LEHVYSGEKP VLDICRFGLP EFFTPFYW
	Isoform 2 [UniParc]. Checksum: 048F578E75C53705	FASTA	446	51,086
	10 20 30 40 50 60 MVTFEDVAVH FTKTEWTGLS PAQRALYRSV MLENFGNLTA LGYPVPKPAL ISLLERGDMA 70 80 90 100 110 120 WGLEAQDDPP AERTKNVCKD VETNIDSEST LIQGISEERD GMMSHGQLKS VPQRTDFPET 130 140 150 160 170 180 RNVEKHQDIP TVKNIQGKVP RIPCARKPFI CEECGKSFSY FSYYARHQRI HTGEKPFECS 190 200 210 220 230 240 ECGKAFNGNS SLIRHQRIHT GERPYQCEEC GRAFNDNANL IRHQRIHSGD RPYYCTECGN 250 260 270 280 290 300 SFTSSSEFVI HQRIHTGEKP YECNECGKAF VGNSPLLRHQ KIHTGEKPYE CNECGKSFGR 310 320 330 340 350 360 TSHLSQHQRI HTGEKPYSCK VCGQAFNFHT KLTRHQRIHS EEKPFDCVDC GKAFSAQEQL 370 380 390 400 410 420 KRHLRIHTQE SSYVCDECGK ALTSKRNLHQ HQRIHTGEKP YECSKYEKAF GTSSQLGHLE 430 440 HVYSGEKPVL DICRFGLPEF FTPFYW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS HIS-218 AND GLN-224. Tissue: Lung and Testis.
[2]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-218. Tissue: Testis.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 120-458 (ISOFORMS 1/2), VARIANT HIS-218. Tissue: Brain.
[5]	"Characterization and mapping of human genes encoding zinc finger proteins." Bray P.L., Lichter P., Thiesen H.-J., Ward D.C., Dawid I.B. Proc. Natl. Acad. Sci. U.S.A. 88:9563-9567(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 270-334 (ISOFORMS 1/2). Tissue: Placenta.
[6]	"Multiple genes encoding zinc finger domains are expressed in human T cells." Thiesen H.-J. New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 273-328 (ISOFORMS 1/2). Tissue: Lymphoid tissue.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK055567 mRNA. Translation: BAB70957.1. AK057330 mRNA. Translation: BAB71430.1. AK292260 mRNA. Translation: BAF84949.1. AC010547 Genomic DNA. No translation available. BC047091 mRNA. Translation: AAH47091.1. AL834237 mRNA. Translation: CAD38915.1. M77171 Genomic DNA. Translation: AAA36814.1. Different initiation. X52343 mRNA. Translation: CAA36569.1.
IPI	IPI00012358. IPI00643896.
PIR	B56409.
RefSeq	NP_008892.2. NM_006961.3.
UniGene	Hs.660076.
3D structure databases
ProteinModelPortal	P17023.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000288177.
PTM databases
PhosphoSite	P17023.
Polymorphism databases
DMDM	229485313.
Proteomic databases
PaxDb	P17023.
PRIDE	P17023.
Protocols and materials databases
DNASU	7567.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000288177; ENSP00000288177; ENSG00000157429. ENST00000564230; ENSP00000458105; ENSG00000157429.
GeneID	7567.
KEGG	hsa:7567.
UCSC	uc002fak.1. human.
Organism-specific databases
CTD	7567.
GeneCards	GC16M071507.
HGNC	HGNC:12981. ZNF19.
HPA	HPA053189.
MIM	194525. gene.
neXtProt	NX_P17023.
PharmGKB	PA37562.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	P17023.
KO	K09228.
OMA	CARKPFI.
OrthoDB	EOG48PMK0.
PhylomeDB	P17023.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P17023.
Bgee	P17023.
CleanEx	HS_ZNF19.
Genevestigator	P17023.
GermOnline	ENSG00000157429. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 10 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 9 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 9 hits. PS50157. ZINC_FINGER_C2H2_2. 10 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7567.
NextBio	29595.
SOURCE	Search...

Entry information

Entry name

ZNF19_HUMAN

Accession

Primary (citable) accession number: P17023
Secondary accession number(s): A8K895 , Q86Y66, Q8NDE2, Q96M79, Q96NE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	March 24, 2009
Last modified:	May 1, 2013
This is version 134 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.