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P17023 (ZNF19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 142. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 19
Alternative name(s):
Zinc finger protein KOX12
Gene names
Name:ZNF19
Synonyms:KOX12
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length458 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 10 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence AAA36814.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P17023-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P17023-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 458458Zinc finger protein 19
PRO_0000047343

Regions

Domain14 – 8572KRAB
Zinc finger161 – 18323C2H2-type 1
Zinc finger189 – 21123C2H2-type 2
Zinc finger217 – 23923C2H2-type 3
Zinc finger245 – 26723C2H2-type 4
Zinc finger273 – 29523C2H2-type 5
Zinc finger301 – 32323C2H2-type 6
Zinc finger329 – 35123C2H2-type 7
Zinc finger357 – 37923C2H2-type 8
Zinc finger385 – 40723C2H2-type 9
Zinc finger413 – 43321C2H2-type 10; atypical

Natural variations

Alternative sequence1 – 1212Missing in isoform 2.
VSP_036733
Natural variant2181Q → H. Ref.1 Ref.3 Ref.4
Corresponds to variant rs8050871 [ dbSNP | Ensembl ].
VAR_054792
Natural variant2241R → Q. Ref.1
Corresponds to variant rs10500557 [ dbSNP | Ensembl ].
VAR_054793

Experimental info

Sequence conflict341A → V in AAH47091. Ref.3
Sequence conflict1201L → V in CAD38915. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 24, 2009. Version 4.
Checksum: C53350D55D969A0C

FASTA45852,449
        10         20         30         40         50         60 
MAAMPLKAQY QEMVTFEDVA VHFTKTEWTG LSPAQRALYR SVMLENFGNL TALGYPVPKP 

        70         80         90        100        110        120 
ALISLLERGD MAWGLEAQDD PPAERTKNVC KDVETNIDSE STLIQGISEE RDGMMSHGQL 

       130        140        150        160        170        180 
KSVPQRTDFP ETRNVEKHQD IPTVKNIQGK VPRIPCARKP FICEECGKSF SYFSYYARHQ 

       190        200        210        220        230        240 
RIHTGEKPFE CSECGKAFNG NSSLIRHQRI HTGERPYQCE ECGRAFNDNA NLIRHQRIHS 

       250        260        270        280        290        300 
GDRPYYCTEC GNSFTSSSEF VIHQRIHTGE KPYECNECGK AFVGNSPLLR HQKIHTGEKP 

       310        320        330        340        350        360 
YECNECGKSF GRTSHLSQHQ RIHTGEKPYS CKVCGQAFNF HTKLTRHQRI HSEEKPFDCV 

       370        380        390        400        410        420 
DCGKAFSAQE QLKRHLRIHT QESSYVCDEC GKALTSKRNL HQHQRIHTGE KPYECSKYEK 

       430        440        450 
AFGTSSQLGH LEHVYSGEKP VLDICRFGLP EFFTPFYW 

« Hide

Isoform 2 [UniParc].

Checksum: 048F578E75C53705
Show »

FASTA44651,086

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS HIS-218 AND GLN-224.
Tissue: Lung and Testis.
[2]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-218.
Tissue: Testis.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 120-458 (ISOFORMS 1/2), VARIANT HIS-218.
Tissue: Brain.
[5]"Characterization and mapping of human genes encoding zinc finger proteins."
Bray P.L., Lichter P., Thiesen H.-J., Ward D.C., Dawid I.B.
Proc. Natl. Acad. Sci. U.S.A. 88:9563-9567(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 270-334 (ISOFORMS 1/2).
Tissue: Placenta.
[6]"Multiple genes encoding zinc finger domains are expressed in human T cells."
Thiesen H.-J.
New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 273-328 (ISOFORMS 1/2).
Tissue: Lymphoid tissue.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK055567 mRNA. Translation: BAB70957.1.
AK057330 mRNA. Translation: BAB71430.1.
AK292260 mRNA. Translation: BAF84949.1.
AC010547 Genomic DNA. No translation available.
BC047091 mRNA. Translation: AAH47091.1.
AL834237 mRNA. Translation: CAD38915.1.
M77171 Genomic DNA. Translation: AAA36814.1. Different initiation.
X52343 mRNA. Translation: CAA36569.1.
PIRB56409.
RefSeqNP_008892.2. NM_006961.3.
UniGeneHs.660076.

3D structure databases

ProteinModelPortalP17023.
SMRP17023. Positions 14-55, 87-441.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000288177.

PTM databases

PhosphoSiteP17023.

Polymorphism databases

DMDM229485313.

Proteomic databases

PaxDbP17023.
PRIDEP17023.

Protocols and materials databases

DNASU7567.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000288177; ENSP00000288177; ENSG00000157429. [P17023-1]
ENST00000564230; ENSP00000458105; ENSG00000157429. [P17023-1]
GeneID7567.
KEGGhsa:7567.
UCSCuc002fak.1. human. [P17023-1]

Organism-specific databases

CTD7567.
GeneCardsGC16M071507.
HGNCHGNC:12981. ZNF19.
HPAHPA053189.
MIM194525. gene.
neXtProtNX_P17023.
PharmGKBPA37562.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidP17023.
KOK09228.
OMALDICRFG.
PhylomeDBP17023.
TreeFamTF350808.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressP17023.
BgeeP17023.
CleanExHS_ZNF19.
GenevestigatorP17023.

Family and domain databases

Gene3D3.30.160.60. 10 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiZNF19.
GenomeRNAi7567.
NextBio29595.
PROP17023.
SOURCESearch...

Entry information

Entry nameZNF19_HUMAN
AccessionPrimary (citable) accession number: P17023
Secondary accession number(s): A8K895 expand/collapse secondary AC list , Q86Y66, Q8NDE2, Q96M79, Q96NE5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: March 24, 2009
Last modified: April 16, 2014
This is version 142 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM