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P17023

- ZNF19_HUMAN

UniProt

P17023 - ZNF19_HUMAN

Protein

Zinc finger protein 19

Gene

ZNF19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 4 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri161 – 18323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri189 – 21123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri217 – 23923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri245 – 26723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri273 – 29523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri301 – 32323C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri329 – 35123C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri357 – 37923C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri385 – 40723C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri413 – 43321C2H2-type 10; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 19
    Alternative name(s):
    Zinc finger protein KOX12
    Gene namesi
    Name:ZNF19
    Synonyms:KOX12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:12981. ZNF19.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37562.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 458458Zinc finger protein 19PRO_0000047343Add
    BLAST

    Proteomic databases

    PaxDbiP17023.
    PRIDEiP17023.

    PTM databases

    PhosphoSiteiP17023.

    Expressioni

    Gene expression databases

    ArrayExpressiP17023.
    BgeeiP17023.
    CleanExiHS_ZNF19.
    GenevestigatoriP17023.

    Organism-specific databases

    HPAiHPA053189.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000288177.

    Structurei

    3D structure databases

    ProteinModelPortaliP17023.
    SMRiP17023. Positions 14-55, 129-440.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri161 – 18323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri189 – 21123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri217 – 23923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri245 – 26723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri273 – 29523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri301 – 32323C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri329 – 35123C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri357 – 37923C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri385 – 40723C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri413 – 43321C2H2-type 10; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiP17023.
    KOiK09228.
    OMAiLDICRFG.
    PhylomeDBiP17023.
    TreeFamiTF350808.

    Family and domain databases

    Gene3Di3.30.160.60. 10 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 9 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 9 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P17023-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAMPLKAQY QEMVTFEDVA VHFTKTEWTG LSPAQRALYR SVMLENFGNL    50
    TALGYPVPKP ALISLLERGD MAWGLEAQDD PPAERTKNVC KDVETNIDSE 100
    STLIQGISEE RDGMMSHGQL KSVPQRTDFP ETRNVEKHQD IPTVKNIQGK 150
    VPRIPCARKP FICEECGKSF SYFSYYARHQ RIHTGEKPFE CSECGKAFNG 200
    NSSLIRHQRI HTGERPYQCE ECGRAFNDNA NLIRHQRIHS GDRPYYCTEC 250
    GNSFTSSSEF VIHQRIHTGE KPYECNECGK AFVGNSPLLR HQKIHTGEKP 300
    YECNECGKSF GRTSHLSQHQ RIHTGEKPYS CKVCGQAFNF HTKLTRHQRI 350
    HSEEKPFDCV DCGKAFSAQE QLKRHLRIHT QESSYVCDEC GKALTSKRNL 400
    HQHQRIHTGE KPYECSKYEK AFGTSSQLGH LEHVYSGEKP VLDICRFGLP 450
    EFFTPFYW 458
    Length:458
    Mass (Da):52,449
    Last modified:March 24, 2009 - v4
    Checksum:iC53350D55D969A0C
    GO
    Isoform 2 (identifier: P17023-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-12: Missing.

    Show »
    Length:446
    Mass (Da):51,086
    Checksum:i048F578E75C53705
    GO

    Sequence cautioni

    The sequence AAA36814.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti34 – 341A → V in AAH47091. (PubMed:15489334)Curated
    Sequence conflicti120 – 1201L → V in CAD38915. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti218 – 2181Q → H.3 Publications
    Corresponds to variant rs8050871 [ dbSNP | Ensembl ].
    VAR_054792
    Natural varianti224 – 2241R → Q.1 Publication
    Corresponds to variant rs10500557 [ dbSNP | Ensembl ].
    VAR_054793

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1212Missing in isoform 2. 1 PublicationVSP_036733Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055567 mRNA. Translation: BAB70957.1.
    AK057330 mRNA. Translation: BAB71430.1.
    AK292260 mRNA. Translation: BAF84949.1.
    AC010547 Genomic DNA. No translation available.
    BC047091 mRNA. Translation: AAH47091.1.
    AL834237 mRNA. Translation: CAD38915.1.
    M77171 Genomic DNA. Translation: AAA36814.1. Different initiation.
    X52343 mRNA. Translation: CAA36569.1.
    CCDSiCCDS10901.1. [P17023-1]
    PIRiB56409.
    RefSeqiNP_008892.2. NM_006961.3. [P17023-1]
    UniGeneiHs.660076.

    Genome annotation databases

    EnsembliENST00000288177; ENSP00000288177; ENSG00000157429. [P17023-1]
    ENST00000564230; ENSP00000458105; ENSG00000157429. [P17023-1]
    GeneIDi7567.
    KEGGihsa:7567.
    UCSCiuc002fak.1. human. [P17023-1]

    Polymorphism databases

    DMDMi229485313.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055567 mRNA. Translation: BAB70957.1 .
    AK057330 mRNA. Translation: BAB71430.1 .
    AK292260 mRNA. Translation: BAF84949.1 .
    AC010547 Genomic DNA. No translation available.
    BC047091 mRNA. Translation: AAH47091.1 .
    AL834237 mRNA. Translation: CAD38915.1 .
    M77171 Genomic DNA. Translation: AAA36814.1 . Different initiation.
    X52343 mRNA. Translation: CAA36569.1 .
    CCDSi CCDS10901.1. [P17023-1 ]
    PIRi B56409.
    RefSeqi NP_008892.2. NM_006961.3. [P17023-1 ]
    UniGenei Hs.660076.

    3D structure databases

    ProteinModelPortali P17023.
    SMRi P17023. Positions 14-55, 129-440.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000288177.

    PTM databases

    PhosphoSitei P17023.

    Polymorphism databases

    DMDMi 229485313.

    Proteomic databases

    PaxDbi P17023.
    PRIDEi P17023.

    Protocols and materials databases

    DNASUi 7567.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000288177 ; ENSP00000288177 ; ENSG00000157429 . [P17023-1 ]
    ENST00000564230 ; ENSP00000458105 ; ENSG00000157429 . [P17023-1 ]
    GeneIDi 7567.
    KEGGi hsa:7567.
    UCSCi uc002fak.1. human. [P17023-1 ]

    Organism-specific databases

    CTDi 7567.
    GeneCardsi GC16M071507.
    HGNCi HGNC:12981. ZNF19.
    HPAi HPA053189.
    MIMi 194525. gene.
    neXtProti NX_P17023.
    PharmGKBi PA37562.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi P17023.
    KOi K09228.
    OMAi LDICRFG.
    PhylomeDBi P17023.
    TreeFami TF350808.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GeneWikii ZNF19.
    GenomeRNAii 7567.
    NextBioi 29595.
    PROi P17023.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P17023.
    Bgeei P17023.
    CleanExi HS_ZNF19.
    Genevestigatori P17023.

    Family and domain databases

    Gene3Di 3.30.160.60. 10 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 9 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 9 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS HIS-218 AND GLN-224.
      Tissue: Lung and Testis.
    2. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-218.
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 120-458 (ISOFORMS 1/2), VARIANT HIS-218.
      Tissue: Brain.
    5. "Characterization and mapping of human genes encoding zinc finger proteins."
      Bray P.L., Lichter P., Thiesen H.-J., Ward D.C., Dawid I.B.
      Proc. Natl. Acad. Sci. U.S.A. 88:9563-9567(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 270-334 (ISOFORMS 1/2).
      Tissue: Placenta.
    6. "Multiple genes encoding zinc finger domains are expressed in human T cells."
      Thiesen H.-J.
      New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 273-328 (ISOFORMS 1/2).
      Tissue: Lymphoid tissue.

    Entry informationi

    Entry nameiZNF19_HUMAN
    AccessioniPrimary (citable) accession number: P17023
    Secondary accession number(s): A8K895
    , Q86Y66, Q8NDE2, Q96M79, Q96NE5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 147 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3