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P17023

- ZNF19_HUMAN

UniProt

P17023 - ZNF19_HUMAN

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Protein

Zinc finger protein 19

Gene

ZNF19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri161 – 18323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri189 – 21123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri245 – 26723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri273 – 29523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri301 – 32323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri329 – 35123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri357 – 37923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri385 – 40723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri413 – 43321C2H2-type 10; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 19
Alternative name(s):
Zinc finger protein KOX12
Gene namesi
Name:ZNF19
Synonyms:KOX12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:12981. ZNF19.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37562.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458Zinc finger protein 19PRO_0000047343Add
BLAST

Proteomic databases

PaxDbiP17023.
PRIDEiP17023.

PTM databases

PhosphoSiteiP17023.

Expressioni

Gene expression databases

BgeeiP17023.
CleanExiHS_ZNF19.
ExpressionAtlasiP17023. baseline.
GenevestigatoriP17023.

Organism-specific databases

HPAiHPA053189.

Interactioni

Protein-protein interaction databases

BioGridi113398. 2 interactions.
STRINGi9606.ENSP00000288177.

Structurei

3D structure databases

ProteinModelPortaliP17023.
SMRiP17023. Positions 14-55, 129-440.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri161 – 18323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri189 – 21123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri245 – 26723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri273 – 29523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri301 – 32323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri329 – 35123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri357 – 37923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri385 – 40723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri413 – 43321C2H2-type 10; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120563.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17023.
KOiK09228.
OMAiLDICRFG.
PhylomeDBiP17023.
TreeFamiTF350808.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P17023-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAMPLKAQY QEMVTFEDVA VHFTKTEWTG LSPAQRALYR SVMLENFGNL
60 70 80 90 100
TALGYPVPKP ALISLLERGD MAWGLEAQDD PPAERTKNVC KDVETNIDSE
110 120 130 140 150
STLIQGISEE RDGMMSHGQL KSVPQRTDFP ETRNVEKHQD IPTVKNIQGK
160 170 180 190 200
VPRIPCARKP FICEECGKSF SYFSYYARHQ RIHTGEKPFE CSECGKAFNG
210 220 230 240 250
NSSLIRHQRI HTGERPYQCE ECGRAFNDNA NLIRHQRIHS GDRPYYCTEC
260 270 280 290 300
GNSFTSSSEF VIHQRIHTGE KPYECNECGK AFVGNSPLLR HQKIHTGEKP
310 320 330 340 350
YECNECGKSF GRTSHLSQHQ RIHTGEKPYS CKVCGQAFNF HTKLTRHQRI
360 370 380 390 400
HSEEKPFDCV DCGKAFSAQE QLKRHLRIHT QESSYVCDEC GKALTSKRNL
410 420 430 440 450
HQHQRIHTGE KPYECSKYEK AFGTSSQLGH LEHVYSGEKP VLDICRFGLP

EFFTPFYW
Length:458
Mass (Da):52,449
Last modified:March 24, 2009 - v4
Checksum:iC53350D55D969A0C
GO
Isoform 2 (identifier: P17023-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Show »
Length:446
Mass (Da):51,086
Checksum:i048F578E75C53705
GO

Sequence cautioni

The sequence AAA36814.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341A → V in AAH47091. (PubMed:15489334)Curated
Sequence conflicti120 – 1201L → V in CAD38915. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti218 – 2181Q → H.3 Publications
Corresponds to variant rs8050871 [ dbSNP | Ensembl ].
VAR_054792
Natural varianti224 – 2241R → Q.1 Publication
Corresponds to variant rs10500557 [ dbSNP | Ensembl ].
VAR_054793

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1212Missing in isoform 2. 1 PublicationVSP_036733Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055567 mRNA. Translation: BAB70957.1.
AK057330 mRNA. Translation: BAB71430.1.
AK292260 mRNA. Translation: BAF84949.1.
AC010547 Genomic DNA. No translation available.
BC047091 mRNA. Translation: AAH47091.1.
AL834237 mRNA. Translation: CAD38915.1.
M77171 Genomic DNA. Translation: AAA36814.1. Different initiation.
X52343 mRNA. Translation: CAA36569.1.
CCDSiCCDS10901.1. [P17023-1]
PIRiB56409.
RefSeqiNP_008892.2. NM_006961.3. [P17023-1]
UniGeneiHs.660076.

Genome annotation databases

EnsembliENST00000288177; ENSP00000288177; ENSG00000157429. [P17023-1]
ENST00000564230; ENSP00000458105; ENSG00000157429. [P17023-1]
GeneIDi7567.
KEGGihsa:7567.
UCSCiuc002fak.1. human. [P17023-1]

Polymorphism databases

DMDMi229485313.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055567 mRNA. Translation: BAB70957.1 .
AK057330 mRNA. Translation: BAB71430.1 .
AK292260 mRNA. Translation: BAF84949.1 .
AC010547 Genomic DNA. No translation available.
BC047091 mRNA. Translation: AAH47091.1 .
AL834237 mRNA. Translation: CAD38915.1 .
M77171 Genomic DNA. Translation: AAA36814.1 . Different initiation.
X52343 mRNA. Translation: CAA36569.1 .
CCDSi CCDS10901.1. [P17023-1 ]
PIRi B56409.
RefSeqi NP_008892.2. NM_006961.3. [P17023-1 ]
UniGenei Hs.660076.

3D structure databases

ProteinModelPortali P17023.
SMRi P17023. Positions 14-55, 129-440.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113398. 2 interactions.
STRINGi 9606.ENSP00000288177.

PTM databases

PhosphoSitei P17023.

Polymorphism databases

DMDMi 229485313.

Proteomic databases

PaxDbi P17023.
PRIDEi P17023.

Protocols and materials databases

DNASUi 7567.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000288177 ; ENSP00000288177 ; ENSG00000157429 . [P17023-1 ]
ENST00000564230 ; ENSP00000458105 ; ENSG00000157429 . [P17023-1 ]
GeneIDi 7567.
KEGGi hsa:7567.
UCSCi uc002fak.1. human. [P17023-1 ]

Organism-specific databases

CTDi 7567.
GeneCardsi GC16M071507.
HGNCi HGNC:12981. ZNF19.
HPAi HPA053189.
MIMi 194525. gene.
neXtProti NX_P17023.
PharmGKBi PA37562.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00770000120563.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi P17023.
KOi K09228.
OMAi LDICRFG.
PhylomeDBi P17023.
TreeFami TF350808.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GeneWikii ZNF19.
GenomeRNAii 7567.
NextBioi 29595.
PROi P17023.
SOURCEi Search...

Gene expression databases

Bgeei P17023.
CleanExi HS_ZNF19.
ExpressionAtlasi P17023. baseline.
Genevestigatori P17023.

Family and domain databases

Gene3Di 3.30.160.60. 10 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS HIS-218 AND GLN-224.
    Tissue: Lung and Testis.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-218.
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 120-458 (ISOFORMS 1/2), VARIANT HIS-218.
    Tissue: Brain.
  5. "Characterization and mapping of human genes encoding zinc finger proteins."
    Bray P.L., Lichter P., Thiesen H.-J., Ward D.C., Dawid I.B.
    Proc. Natl. Acad. Sci. U.S.A. 88:9563-9567(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 270-334 (ISOFORMS 1/2).
    Tissue: Placenta.
  6. "Multiple genes encoding zinc finger domains are expressed in human T cells."
    Thiesen H.-J.
    New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 273-328 (ISOFORMS 1/2).
    Tissue: Lymphoid tissue.

Entry informationi

Entry nameiZNF19_HUMAN
AccessioniPrimary (citable) accession number: P17023
Secondary accession number(s): A8K895
, Q86Y66, Q8NDE2, Q96M79, Q96NE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: March 24, 2009
Last modified: November 26, 2014
This is version 149 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3