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Protein

Zinc finger protein 19

Gene

ZNF19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri161 – 183C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri189 – 211C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri217 – 239C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri245 – 267C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri273 – 295C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri301 – 323C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 433C2H2-type 10; atypicalPROSITE-ProRule annotationAdd BLAST21

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 19
Alternative name(s):
Zinc finger protein KOX12
Gene namesi
Name:ZNF19
Synonyms:KOX12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:12981. ZNF19.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000157429.
PharmGKBiPA37562.

Polymorphism and mutation databases

BioMutaiZNF19.
DMDMi229485313.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473431 – 458Zinc finger protein 19Add BLAST458

Proteomic databases

MaxQBiP17023.
PaxDbiP17023.
PeptideAtlasiP17023.
PRIDEiP17023.

PTM databases

iPTMnetiP17023.
PhosphoSitePlusiP17023.

Expressioni

Gene expression databases

BgeeiENSG00000157429.
CleanExiHS_ZNF19.
ExpressionAtlasiP17023. baseline and differential.
GenevisibleiP17023. HS.

Organism-specific databases

HPAiHPA053189.
HPA063685.

Interactioni

Protein-protein interaction databases

BioGridi113398. 2 interactors.
STRINGi9606.ENSP00000288177.

Structurei

3D structure databases

ProteinModelPortaliP17023.
SMRiP17023.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri161 – 183C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri189 – 211C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri217 – 239C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri245 – 267C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri273 – 295C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri301 – 323C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 433C2H2-type 10; atypicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132425.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17023.
KOiK09228.
OMAiLDICRFG.
OrthoDBiEOG091G02KC.
PhylomeDBiP17023.
TreeFamiTF350808.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17023-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAMPLKAQY QEMVTFEDVA VHFTKTEWTG LSPAQRALYR SVMLENFGNL
60 70 80 90 100
TALGYPVPKP ALISLLERGD MAWGLEAQDD PPAERTKNVC KDVETNIDSE
110 120 130 140 150
STLIQGISEE RDGMMSHGQL KSVPQRTDFP ETRNVEKHQD IPTVKNIQGK
160 170 180 190 200
VPRIPCARKP FICEECGKSF SYFSYYARHQ RIHTGEKPFE CSECGKAFNG
210 220 230 240 250
NSSLIRHQRI HTGERPYQCE ECGRAFNDNA NLIRHQRIHS GDRPYYCTEC
260 270 280 290 300
GNSFTSSSEF VIHQRIHTGE KPYECNECGK AFVGNSPLLR HQKIHTGEKP
310 320 330 340 350
YECNECGKSF GRTSHLSQHQ RIHTGEKPYS CKVCGQAFNF HTKLTRHQRI
360 370 380 390 400
HSEEKPFDCV DCGKAFSAQE QLKRHLRIHT QESSYVCDEC GKALTSKRNL
410 420 430 440 450
HQHQRIHTGE KPYECSKYEK AFGTSSQLGH LEHVYSGEKP VLDICRFGLP

EFFTPFYW
Length:458
Mass (Da):52,449
Last modified:March 24, 2009 - v4
Checksum:iC53350D55D969A0C
GO
Isoform 2 (identifier: P17023-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Show »
Length:446
Mass (Da):51,086
Checksum:i048F578E75C53705
GO

Sequence cautioni

The sequence AAA36814 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34A → V in AAH47091 (PubMed:15489334).Curated1
Sequence conflicti120L → V in CAD38915 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054792218Q → H.3 PublicationsCorresponds to variant rs8050871dbSNPEnsembl.1
Natural variantiVAR_054793224R → Q.1 PublicationCorresponds to variant rs10500557dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0367331 – 12Missing in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055567 mRNA. Translation: BAB70957.1.
AK057330 mRNA. Translation: BAB71430.1.
AK292260 mRNA. Translation: BAF84949.1.
AC010547 Genomic DNA. No translation available.
BC047091 mRNA. Translation: AAH47091.1.
AL834237 mRNA. Translation: CAD38915.1.
M77171 Genomic DNA. Translation: AAA36814.1. Different initiation.
X52343 mRNA. Translation: CAA36569.1.
CCDSiCCDS10901.1. [P17023-1]
PIRiB56409.
RefSeqiNP_008892.2. NM_006961.3. [P17023-1]
UniGeneiHs.660076.

Genome annotation databases

EnsembliENST00000288177; ENSP00000288177; ENSG00000157429. [P17023-1]
ENST00000564230; ENSP00000458105; ENSG00000157429. [P17023-1]
GeneIDi7567.
KEGGihsa:7567.
UCSCiuc002fam.2. human. [P17023-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055567 mRNA. Translation: BAB70957.1.
AK057330 mRNA. Translation: BAB71430.1.
AK292260 mRNA. Translation: BAF84949.1.
AC010547 Genomic DNA. No translation available.
BC047091 mRNA. Translation: AAH47091.1.
AL834237 mRNA. Translation: CAD38915.1.
M77171 Genomic DNA. Translation: AAA36814.1. Different initiation.
X52343 mRNA. Translation: CAA36569.1.
CCDSiCCDS10901.1. [P17023-1]
PIRiB56409.
RefSeqiNP_008892.2. NM_006961.3. [P17023-1]
UniGeneiHs.660076.

3D structure databases

ProteinModelPortaliP17023.
SMRiP17023.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113398. 2 interactors.
STRINGi9606.ENSP00000288177.

PTM databases

iPTMnetiP17023.
PhosphoSitePlusiP17023.

Polymorphism and mutation databases

BioMutaiZNF19.
DMDMi229485313.

Proteomic databases

MaxQBiP17023.
PaxDbiP17023.
PeptideAtlasiP17023.
PRIDEiP17023.

Protocols and materials databases

DNASUi7567.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288177; ENSP00000288177; ENSG00000157429. [P17023-1]
ENST00000564230; ENSP00000458105; ENSG00000157429. [P17023-1]
GeneIDi7567.
KEGGihsa:7567.
UCSCiuc002fam.2. human. [P17023-1]

Organism-specific databases

CTDi7567.
GeneCardsiZNF19.
HGNCiHGNC:12981. ZNF19.
HPAiHPA053189.
HPA063685.
MIMi194525. gene.
neXtProtiNX_P17023.
OpenTargetsiENSG00000157429.
PharmGKBiPA37562.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132425.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17023.
KOiK09228.
OMAiLDICRFG.
OrthoDBiEOG091G02KC.
PhylomeDBiP17023.
TreeFamiTF350808.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GeneWikiiZNF19.
GenomeRNAii7567.
PROiP17023.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157429.
CleanExiHS_ZNF19.
ExpressionAtlasiP17023. baseline and differential.
GenevisibleiP17023. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF19_HUMAN
AccessioniPrimary (citable) accession number: P17023
Secondary accession number(s): A8K895
, Q86Y66, Q8NDE2, Q96M79, Q96NE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: March 24, 2009
Last modified: November 30, 2016
This is version 165 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.