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Protein

Zinc finger protein 18

Gene

ZNF18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri408 – 43023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 18
Alternative name(s):
Heart development-specific gene 1 protein
Zinc finger protein 535
Zinc finger protein KOX11
Zinc finger protein with KRAB and SCAN domains 6
Gene namesi
Name:ZNF18
Synonyms:HDSG1, KOX11, ZKSCAN6, ZNF535
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:12969. ZNF18.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37551.

Polymorphism and mutation databases

BioMutaiZNF18.
DMDMi85681864.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Zinc finger protein 18PRO_0000047340Add
BLAST

Proteomic databases

EPDiP17022.
PaxDbiP17022.
PeptideAtlasiP17022.
PRIDEiP17022.

PTM databases

iPTMnetiP17022.
PhosphoSiteiP17022.

Expressioni

Gene expression databases

BgeeiENSG00000154957.
CleanExiHS_ZNF18.
ExpressionAtlasiP17022. baseline and differential.
GenevisibleiP17022. HS.

Organism-specific databases

HPAiHPA006144.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNCP248634EBI-8648067,EBI-395261
TTC32Q5I0X73EBI-8648067,EBI-8636434

Protein-protein interaction databases

BioGridi113397. 9 interactions.
IntActiP17022. 2 interactions.
STRINGi9606.ENSP00000315664.

Structurei

3D structure databases

ProteinModelPortaliP17022.
SMRiP17022. Positions 37-119, 378-549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 12383SCAN boxPROSITE-ProRule annotationAdd
BLAST
Domaini211 – 28373KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri408 – 43023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129746.
HOGENOMiHOG000234619.
HOVERGENiHBG102043.
InParanoidiP17022.
KOiK09229.
OMAiSHIVKEE.
OrthoDBiEOG091G04IJ.
PhylomeDBiP17022.
TreeFamiTF337489.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 5 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR027764. Zfp18.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF11. PTHR10032:SF11. 1 hit.
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17022-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVDLGQALG LLPSLAKAED SQFSESDAAL QEELSSPETA RQLFRQFRYQ
60 70 80 90 100
VMSGPHETLK QLRKLCFQWL QPEVHTKEQI LEILMLEQFL TILPGEIQMW
110 120 130 140 150
VRKQCPGSGE EAVTLVESLK GDPQRLWQWI SIQVLGQDIL SEKMESPSCQ
160 170 180 190 200
VGEVEPHLEV VPQELGLENS SSGPGELLSH IVKEESDTEA ELALAASQPA
210 220 230 240 250
RLEERLIRDQ DLGASLLPAA PQEQWRQLDS TQKEQYWDLM LETYGKMVSG
260 270 280 290 300
AGISHPKSDL TNSIEFGEEL AGIYLHVNEK IPRPTCIGDR QENDKENLNL
310 320 330 340 350
ENHRDQELLH ASCQASGEVP SQASLRGFFT EDEPGCFGEG ENLPEALQNI
360 370 380 390 400
QDEGTGEQLS PQERISEKQL GQHLPNPHSG EMSTMWLEEK RETSQKGQPR
410 420 430 440 450
APMAQKLPTC RECGKTFYRN SQLIFHQRTH TGETYFQCTI CKKAFLRSSD
460 470 480 490 500
FVKHQRTHTG EKPCKCDYCG KGFSDFSGLR HHEKIHTGEK PYKCPICEKS
510 520 530 540
FIQRSNFNRH QRVHTGEKPY KCSHCGKSFS WSSSLDKHQR SHLGKKPFQ
Length:549
Mass (Da):62,288
Last modified:January 10, 2006 - v2
Checksum:i5468BA67A459174D
GO
Isoform 2 (identifier: P17022-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     251-251: Missing.

Show »
Length:548
Mass (Da):62,217
Checksum:i16D51E59E7C7EEA2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti210 – 2101Q → R.1 Publication
Corresponds to variant rs17857095 [ dbSNP | Ensembl ].
VAR_024835
Natural varianti240 – 2401M → I.1 Publication
Corresponds to variant rs17853545 [ dbSNP | Ensembl ].
VAR_024836

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei251 – 2511Missing in isoform 2. 1 PublicationVSP_016947

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY491053 mRNA. Translation: AAS67595.1.
AK092656 mRNA. Translation: BAC03939.1.
BC036096 mRNA. Translation: AAH36096.1.
X52342 mRNA. Translation: CAA36568.1.
CCDSiCCDS32568.1. [P17022-1]
CCDS76957.1. [P17022-2]
PIRiI37950. S10399.
RefSeqiNP_001290210.1. NM_001303281.1. [P17022-1]
NP_001290211.1. NM_001303282.1. [P17022-2]
NP_653281.2. NM_144680.3. [P17022-1]
XP_011522304.1. XM_011524002.2. [P17022-1]
UniGeneiHs.370473.

Genome annotation databases

EnsembliENST00000322748; ENSP00000315664; ENSG00000154957. [P17022-1]
ENST00000454073; ENSP00000391376; ENSG00000154957. [P17022-2]
ENST00000580306; ENSP00000463471; ENSG00000154957. [P17022-1]
ENST00000580613; ENSP00000462296; ENSG00000154957. [P17022-1]
GeneIDi7566.
KEGGihsa:7566.
UCSCiuc002gng.1. human. [P17022-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY491053 mRNA. Translation: AAS67595.1.
AK092656 mRNA. Translation: BAC03939.1.
BC036096 mRNA. Translation: AAH36096.1.
X52342 mRNA. Translation: CAA36568.1.
CCDSiCCDS32568.1. [P17022-1]
CCDS76957.1. [P17022-2]
PIRiI37950. S10399.
RefSeqiNP_001290210.1. NM_001303281.1. [P17022-1]
NP_001290211.1. NM_001303282.1. [P17022-2]
NP_653281.2. NM_144680.3. [P17022-1]
XP_011522304.1. XM_011524002.2. [P17022-1]
UniGeneiHs.370473.

3D structure databases

ProteinModelPortaliP17022.
SMRiP17022. Positions 37-119, 378-549.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113397. 9 interactions.
IntActiP17022. 2 interactions.
STRINGi9606.ENSP00000315664.

PTM databases

iPTMnetiP17022.
PhosphoSiteiP17022.

Polymorphism and mutation databases

BioMutaiZNF18.
DMDMi85681864.

Proteomic databases

EPDiP17022.
PaxDbiP17022.
PeptideAtlasiP17022.
PRIDEiP17022.

Protocols and materials databases

DNASUi7566.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322748; ENSP00000315664; ENSG00000154957. [P17022-1]
ENST00000454073; ENSP00000391376; ENSG00000154957. [P17022-2]
ENST00000580306; ENSP00000463471; ENSG00000154957. [P17022-1]
ENST00000580613; ENSP00000462296; ENSG00000154957. [P17022-1]
GeneIDi7566.
KEGGihsa:7566.
UCSCiuc002gng.1. human. [P17022-1]

Organism-specific databases

CTDi7566.
GeneCardsiZNF18.
HGNCiHGNC:12969. ZNF18.
HPAiHPA006144.
MIMi194524. gene.
neXtProtiNX_P17022.
PharmGKBiPA37551.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129746.
HOGENOMiHOG000234619.
HOVERGENiHBG102043.
InParanoidiP17022.
KOiK09229.
OMAiSHIVKEE.
OrthoDBiEOG091G04IJ.
PhylomeDBiP17022.
TreeFamiTF337489.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii7566.
PROiP17022.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154957.
CleanExiHS_ZNF18.
ExpressionAtlasiP17022. baseline and differential.
GenevisibleiP17022. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 5 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR027764. Zfp18.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF11. PTHR10032:SF11. 1 hit.
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF18_HUMAN
AccessioniPrimary (citable) accession number: P17022
Secondary accession number(s): Q5QHQ3, Q8IYC4, Q8NAH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 10, 2006
Last modified: September 7, 2016
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.