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Protein

Zinc finger protein 18

Gene

ZNF18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri408 – 430C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 18
Alternative name(s):
Heart development-specific gene 1 protein
Zinc finger protein 535
Zinc finger protein KOX11
Zinc finger protein with KRAB and SCAN domains 6
Gene namesi
Name:ZNF18
Synonyms:HDSG1, KOX11, ZKSCAN6, ZNF535
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000154957.13
HGNCiHGNC:12969 ZNF18
MIMi194524 gene
neXtProtiNX_P17022

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000154957
PharmGKBiPA37551

Polymorphism and mutation databases

BioMutaiZNF18
DMDMi85681864

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473401 – 549Zinc finger protein 18Add BLAST549

Proteomic databases

EPDiP17022
PaxDbiP17022
PeptideAtlasiP17022
PRIDEiP17022

PTM databases

iPTMnetiP17022
PhosphoSitePlusiP17022

Expressioni

Gene expression databases

BgeeiENSG00000154957
CleanExiHS_ZNF18
ExpressionAtlasiP17022 baseline and differential
GenevisibleiP17022 HS

Organism-specific databases

HPAiHPA006144

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113397, 9 interactors
IntActiP17022, 4 interactors
MINTiP17022
STRINGi9606.ENSP00000315664

Structurei

3D structure databases

ProteinModelPortaliP17022
SMRiP17022
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 123SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini211 – 283KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri408 – 430C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144000
HOGENOMiHOG000234619
HOVERGENiHBG102043
InParanoidiP17022
KOiK09229
OMAiVMSGPHE
OrthoDBiEOG091G04IJ
PhylomeDBiP17022
TreeFamiTF337489

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR027764 Zfp18/Zfp446
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR45403 PTHR45403, 1 hit
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17022-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVDLGQALG LLPSLAKAED SQFSESDAAL QEELSSPETA RQLFRQFRYQ
60 70 80 90 100
VMSGPHETLK QLRKLCFQWL QPEVHTKEQI LEILMLEQFL TILPGEIQMW
110 120 130 140 150
VRKQCPGSGE EAVTLVESLK GDPQRLWQWI SIQVLGQDIL SEKMESPSCQ
160 170 180 190 200
VGEVEPHLEV VPQELGLENS SSGPGELLSH IVKEESDTEA ELALAASQPA
210 220 230 240 250
RLEERLIRDQ DLGASLLPAA PQEQWRQLDS TQKEQYWDLM LETYGKMVSG
260 270 280 290 300
AGISHPKSDL TNSIEFGEEL AGIYLHVNEK IPRPTCIGDR QENDKENLNL
310 320 330 340 350
ENHRDQELLH ASCQASGEVP SQASLRGFFT EDEPGCFGEG ENLPEALQNI
360 370 380 390 400
QDEGTGEQLS PQERISEKQL GQHLPNPHSG EMSTMWLEEK RETSQKGQPR
410 420 430 440 450
APMAQKLPTC RECGKTFYRN SQLIFHQRTH TGETYFQCTI CKKAFLRSSD
460 470 480 490 500
FVKHQRTHTG EKPCKCDYCG KGFSDFSGLR HHEKIHTGEK PYKCPICEKS
510 520 530 540
FIQRSNFNRH QRVHTGEKPY KCSHCGKSFS WSSSLDKHQR SHLGKKPFQ
Length:549
Mass (Da):62,288
Last modified:January 10, 2006 - v2
Checksum:i5468BA67A459174D
GO
Isoform 2 (identifier: P17022-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     251-251: Missing.

Show »
Length:548
Mass (Da):62,217
Checksum:i16D51E59E7C7EEA2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024835210Q → R1 PublicationCorresponds to variant dbSNP:rs17857095Ensembl.1
Natural variantiVAR_024836240M → I1 PublicationCorresponds to variant dbSNP:rs17853545Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016947251Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY491053 mRNA Translation: AAS67595.1
AK092656 mRNA Translation: BAC03939.1
BC036096 mRNA Translation: AAH36096.1
X52342 mRNA Translation: CAA36568.1
CCDSiCCDS32568.1 [P17022-1]
CCDS76957.1 [P17022-2]
PIRiI37950 S10399
RefSeqiNP_001290210.1, NM_001303281.1 [P17022-1]
NP_001290211.1, NM_001303282.1 [P17022-2]
NP_653281.2, NM_144680.3 [P17022-1]
XP_011522304.1, XM_011524002.2 [P17022-1]
XP_016880495.1, XM_017025006.1 [P17022-1]
XP_016880496.1, XM_017025007.1 [P17022-1]
XP_016880497.1, XM_017025008.1 [P17022-2]
XP_016880498.1, XM_017025009.1 [P17022-2]
XP_016880499.1, XM_017025010.1 [P17022-2]
XP_016880500.1, XM_017025011.1 [P17022-2]
UniGeneiHs.370473

Genome annotation databases

EnsembliENST00000322748; ENSP00000315664; ENSG00000154957 [P17022-1]
ENST00000454073; ENSP00000391376; ENSG00000154957 [P17022-2]
ENST00000580306; ENSP00000463471; ENSG00000154957 [P17022-1]
ENST00000580613; ENSP00000462296; ENSG00000154957 [P17022-1]
GeneIDi7566
KEGGihsa:7566
UCSCiuc002gng.1 human [P17022-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZNF18_HUMAN
AccessioniPrimary (citable) accession number: P17022
Secondary accession number(s): Q5QHQ3, Q8IYC4, Q8NAH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 10, 2006
Last modified: March 28, 2018
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health