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Protein

Zinc finger protein 708

Gene

ZNF708

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri76 – 9823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri104 – 12623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri132 – 15423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri160 – 18223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri188 – 21023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri468 – 49023C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 708
Alternative name(s):
Zinc finger protein 15
Zinc finger protein 15-like 1
Zinc finger protein KOX8
Gene namesi
Name:ZNF708
Synonyms:KOX8, ZNF15, ZNF15L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12945. ZNF708.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi527504092.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Zinc finger protein 708PRO_0000047706Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei480 – 4801PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP17019.
PaxDbiP17019.
PeptideAtlasiP17019.
PRIDEiP17019.

PTM databases

iPTMnetiP17019.
PhosphoSiteiP17019.

Expressioni

Gene expression databases

BgeeiENSG00000182141.
CleanExiHS_ZNF708.
ExpressionAtlasiP17019. baseline and differential.
GenevisibleiP17019. HS.

Interactioni

Protein-protein interaction databases

BioGridi113394. 1 interaction.
STRINGi9606.ENSP00000349401.

Structurei

3D structure databases

ProteinModelPortaliP17019.
SMRiP17019. Positions 78-498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri76 – 9823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri104 – 12623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri132 – 15423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri160 – 18223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri188 – 21023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri468 – 49023C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17019.
KOiK09228.
OrthoDBiEOG091G02KC.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 9 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 14 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17019-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRHEMAAKP PAMCSHFAKD LRPEQYIKNS FQQVILRRYG KCGYQKGCKS
60 70 80 90 100
VDEHKLHKGG HKGLNRCVTT TQSKIVQCDK YVKVFHKYSN AKRHKIRHTG
110 120 130 140 150
KNPFKCKECG KSFCMLSQLT QHEIIHTGEK PYKCEECGKA FKKSSNLTNH
160 170 180 190 200
KIIHTGEKPY KCEECGKAFN QSSTLTRHKI IHTGEKLYKC EECGKAFNRS
210 220 230 240 250
SNLTKHKIVH TGEKPYKCEE CGKAFKQSSN LTNHKKIHTG EKPYKCGECG
260 270 280 290 300
KAFTLSSHLT THKRIHTGEK PYKCEECGKA FSVFSTLTKH KIIHTEEKPY
310 320 330 340 350
KCEECGKAFN RSSHLTNHKV IHTGEKPYKC EECGKAFTKS STLTYHKVIH
360 370 380 390 400
TGKKPYKCEE CGKAFSIFSI LTKHKVIHTE DKPYKCEECG KTFNYSSNFT
410 420 430 440 450
NHKKIHTGEK PYKCEECGKS FILSSHLTTH KIIHTGEKPY KCKECGKAFN
460 470 480 490
QSSTLMKHKI IHTGEKPYKC EECGKAFNQS PNLTKHKRIH TKEKPYKCK
Length:499
Mass (Da):57,357
Last modified:July 24, 2013 - v5
Checksum:iED1ECC35F4CBA3F1
GO

Sequence cautioni

The sequence BAD18665 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71A → V.1 Publication
Corresponds to variant rs547516 [ dbSNP | Ensembl ].
VAR_054795
Natural varianti49 – 491K → E.1 Publication
Corresponds to variant rs1781873 [ dbSNP | Ensembl ].
VAR_054796
Natural varianti58 – 581K → T.
Corresponds to variant rs1781872 [ dbSNP | Ensembl ].
VAR_054797
Natural varianti66 – 661R → Q.1 Publication
Corresponds to variant rs504280 [ dbSNP | Ensembl ].
VAR_054798

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131527 mRNA. Translation: BAD18665.1. Different initiation.
AK095062 mRNA. No translation available.
AC022432 Genomic DNA. No translation available.
X52339 mRNA. Translation: CAA36565.1.
PIRiI37976.
RefSeqiNP_001284489.1. NM_001297560.1.
NP_001284490.1. NM_001297561.1.
UniGeneiHs.466296.

Genome annotation databases

EnsembliENST00000356929; ENSP00000349401; ENSG00000182141.
GeneIDi7562.
KEGGihsa:7562.
UCSCiuc002npq.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131527 mRNA. Translation: BAD18665.1. Different initiation.
AK095062 mRNA. No translation available.
AC022432 Genomic DNA. No translation available.
X52339 mRNA. Translation: CAA36565.1.
PIRiI37976.
RefSeqiNP_001284489.1. NM_001297560.1.
NP_001284490.1. NM_001297561.1.
UniGeneiHs.466296.

3D structure databases

ProteinModelPortaliP17019.
SMRiP17019. Positions 78-498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113394. 1 interaction.
STRINGi9606.ENSP00000349401.

PTM databases

iPTMnetiP17019.
PhosphoSiteiP17019.

Polymorphism and mutation databases

DMDMi527504092.

Proteomic databases

MaxQBiP17019.
PaxDbiP17019.
PeptideAtlasiP17019.
PRIDEiP17019.

Protocols and materials databases

DNASUi7562.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356929; ENSP00000349401; ENSG00000182141.
GeneIDi7562.
KEGGihsa:7562.
UCSCiuc002npq.2. human.

Organism-specific databases

CTDi7562.
GeneCardsiZNF708.
HGNCiHGNC:12945. ZNF708.
neXtProtiNX_P17019.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17019.
KOiK09228.
OrthoDBiEOG091G02KC.
TreeFamiTF342117.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF708. human.
GenomeRNAii7562.
PROiP17019.

Gene expression databases

BgeeiENSG00000182141.
CleanExiHS_ZNF708.
ExpressionAtlasiP17019. baseline and differential.
GenevisibleiP17019. HS.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 9 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 14 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN708_HUMAN
AccessioniPrimary (citable) accession number: P17019
Secondary accession number(s): Q6ZMR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 24, 2013
Last modified: September 7, 2016
This is version 151 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.