Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 708

Gene

ZNF708

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri76 – 98C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri104 – 126C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri132 – 154C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri160 – 182C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri188 – 210C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 266C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri300 – 322C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri328 – 350C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 490C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 708
Alternative name(s):
Zinc finger protein 15
Zinc finger protein 15-like 1
Zinc finger protein KOX8
Gene namesi
Name:ZNF708
Synonyms:KOX8, ZNF15, ZNF15L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000182141.9
HGNCiHGNC:12945 ZNF708
neXtProtiNX_P17019

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi527504092

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477061 – 499Zinc finger protein 708Add BLAST499

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei480PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP17019
MaxQBiP17019
PaxDbiP17019
PeptideAtlasiP17019
PRIDEiP17019

PTM databases

iPTMnetiP17019
PhosphoSitePlusiP17019

Expressioni

Gene expression databases

BgeeiENSG00000182141
CleanExiHS_ZNF708
ExpressionAtlasiP17019 baseline and differential
GenevisibleiP17019 HS

Interactioni

Protein-protein interaction databases

BioGridi113394, 3 interactors
STRINGi9606.ENSP00000349401

Structurei

3D structure databases

ProteinModelPortaliP17019
SMRiP17019
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri76 – 98C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri104 – 126C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri132 – 154C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri160 – 182C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri188 – 210C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 266C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri300 – 322C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri328 – 350C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 490C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP17019
KOiK09228
OrthoDBiEOG091G02KC
TreeFamiTF342117

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

Sequencei

Sequence statusi: Complete.

P17019-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRHEMAAKP PAMCSHFAKD LRPEQYIKNS FQQVILRRYG KCGYQKGCKS
60 70 80 90 100
VDEHKLHKGG HKGLNRCVTT TQSKIVQCDK YVKVFHKYSN AKRHKIRHTG
110 120 130 140 150
KNPFKCKECG KSFCMLSQLT QHEIIHTGEK PYKCEECGKA FKKSSNLTNH
160 170 180 190 200
KIIHTGEKPY KCEECGKAFN QSSTLTRHKI IHTGEKLYKC EECGKAFNRS
210 220 230 240 250
SNLTKHKIVH TGEKPYKCEE CGKAFKQSSN LTNHKKIHTG EKPYKCGECG
260 270 280 290 300
KAFTLSSHLT THKRIHTGEK PYKCEECGKA FSVFSTLTKH KIIHTEEKPY
310 320 330 340 350
KCEECGKAFN RSSHLTNHKV IHTGEKPYKC EECGKAFTKS STLTYHKVIH
360 370 380 390 400
TGKKPYKCEE CGKAFSIFSI LTKHKVIHTE DKPYKCEECG KTFNYSSNFT
410 420 430 440 450
NHKKIHTGEK PYKCEECGKS FILSSHLTTH KIIHTGEKPY KCKECGKAFN
460 470 480 490
QSSTLMKHKI IHTGEKPYKC EECGKAFNQS PNLTKHKRIH TKEKPYKCK
Length:499
Mass (Da):57,357
Last modified:July 24, 2013 - v5
Checksum:iED1ECC35F4CBA3F1
GO

Sequence cautioni

The sequence BAD18665 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0547957A → V1 PublicationCorresponds to variant dbSNP:rs547516Ensembl.1
Natural variantiVAR_05479649K → E1 PublicationCorresponds to variant dbSNP:rs1781873Ensembl.1
Natural variantiVAR_05479758K → T. Corresponds to variant dbSNP:rs1781872Ensembl.1
Natural variantiVAR_05479866R → Q1 PublicationCorresponds to variant dbSNP:rs504280Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131527 mRNA Translation: BAD18665.1 Different initiation.
AK095062 mRNA No translation available.
AC022432 Genomic DNA No translation available.
X52339 mRNA Translation: CAA36565.1
PIRiI37976
RefSeqiNP_001284489.1, NM_001297560.1
NP_001284490.1, NM_001297561.1
UniGeneiHs.466296

Genome annotation databases

EnsembliENST00000356929; ENSP00000349401; ENSG00000182141
GeneIDi7562
KEGGihsa:7562
UCSCiuc002npq.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN708_HUMAN
AccessioniPrimary (citable) accession number: P17019
Secondary accession number(s): Q6ZMR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 24, 2013
Last modified: March 28, 2018
This is version 163 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health