Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 14

Gene

ZNF14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri103 – 12523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri141 – 16323C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri169 – 19123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21721C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri223 – 24523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri251 – 27323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri475 – 49723C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri503 – 52523C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri531 – 55323C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri559 – 58123C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri587 – 60923C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri615 – 63723C2H2-type 19PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 14
Alternative name(s):
Gonadotropin-inducible ovary transcription repressor 4
Short name:
GIOT-4
Zinc finger protein KOX6
Gene namesi
Name:ZNF14
Synonyms:GIOT4, KOX6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12924. ZNF14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37511.

Polymorphism and mutation databases

BioMutaiZNF14.
DMDMi313104250.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642Zinc finger protein 14PRO_0000047337Add
BLAST

Proteomic databases

EPDiP17017.
MaxQBiP17017.
PaxDbiP17017.
PeptideAtlasiP17017.
PRIDEiP17017.

PTM databases

iPTMnetiP17017.
PhosphoSiteiP17017.

Expressioni

Gene expression databases

BgeeiENSG00000105708.
CleanExiHS_ZNF14.
GenevisibleiP17017. HS.

Organism-specific databases

HPAiHPA049863.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000340514.

Structurei

3D structure databases

ProteinModelPortaliP17017.
SMRiP17017. Positions 4-641.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7673KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri103 – 12523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri141 – 16323C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri169 – 19123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21721C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri223 – 24523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri251 – 27323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri475 – 49723C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri503 – 52523C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri531 – 55323C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri559 – 58123C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri587 – 60923C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri615 – 63723C2H2-type 19PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17017.
KOiK09228.
OMAiKFRMHER.
OrthoDBiEOG091G02KC.
PhylomeDBiP17017.
TreeFamiTF343410.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 8 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVSFEDVA VNFTLEEWAL LDSSQKKLYE DVMQETFKNL VCLGKKWEDQ
60 70 80 90 100
DIEDDHRNQG KNRRCHMVER LCESRRGSKC GETTSQMPNV NINKETFTGA
110 120 130 140 150
KPHECSFCGR DFIHHSSLNR HMRSHTGQKP NEYQEYEKQP CKCKAVGKTF
160 170 180 190 200
SYHHCFRKHE RTHTGVKPYE CKQCGKAFIY YQPFQRHERT HAGQKPYECK
210 220 230 240 250
QCGKTFIYYQ SFQKHAHTGK KPYECKQCGK AFICYQSFQR HKRTHTGEKP
260 270 280 290 300
YECKQCGKAF SCPTYFRTHE RTHTGEKPYK CKECGKAFSF LSSFRRHKRT
310 320 330 340 350
HSGEKPYECK ECGKAFFYSA SFRAHVIIHT GARPYKCKEC GKAFNSSNSC
360 370 380 390 400
RVHERTHIGE KPYECKRCGK SFSWSISLRL HERTHTGEKP YECKQCHKTF
410 420 430 440 450
SFSSSLREHE TTHTGEKPYE CKQCGKTFSF SSSLQRHERT HNAEKPYECK
460 470 480 490 500
QCGKAFRCSS YFRIHERSHT GEKPYECKQC GKVFIRSSSF RLHERTHTGE
510 520 530 540 550
KPYECKLCGK TFSFSSSLRE HEKIHTGNKP FECKQCGKAF LRSSQIRLHE
560 570 580 590 600
RTHTGEKPYQ CKQCGKAFIS SSKFRMHERT HTGEKPYRCK QCGKAFRFSS
610 620 630 640
SVRIHERSHT GEKPYECKQC GKAFISSSHF RLHERTHMGE KV
Length:642
Mass (Da):75,353
Last modified:November 30, 2010 - v3
Checksum:i806374FBDC480CE3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti274 – 2741T → S.1 Publication
Corresponds to variant rs12973901 [ dbSNP | Ensembl ].
VAR_054791
Natural varianti379 – 3791R → Q.
Corresponds to variant rs3752153 [ dbSNP | Ensembl ].
VAR_057381

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021644 mRNA. Translation: BAA86990.1.
AC011458 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84858.1.
BC136323 mRNA. Translation: AAI36324.1.
X52337 mRNA. Translation: CAA36563.1.
CCDSiCCDS12409.1.
PIRiI37974.
RefSeqiNP_066358.2. NM_021030.2.
UniGeneiHs.659932.

Genome annotation databases

EnsembliENST00000344099; ENSP00000340514; ENSG00000105708.
GeneIDi7561.
KEGGihsa:7561.
UCSCiuc002nnk.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021644 mRNA. Translation: BAA86990.1.
AC011458 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84858.1.
BC136323 mRNA. Translation: AAI36324.1.
X52337 mRNA. Translation: CAA36563.1.
CCDSiCCDS12409.1.
PIRiI37974.
RefSeqiNP_066358.2. NM_021030.2.
UniGeneiHs.659932.

3D structure databases

ProteinModelPortaliP17017.
SMRiP17017. Positions 4-641.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000340514.

PTM databases

iPTMnetiP17017.
PhosphoSiteiP17017.

Polymorphism and mutation databases

BioMutaiZNF14.
DMDMi313104250.

Proteomic databases

EPDiP17017.
MaxQBiP17017.
PaxDbiP17017.
PeptideAtlasiP17017.
PRIDEiP17017.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344099; ENSP00000340514; ENSG00000105708.
GeneIDi7561.
KEGGihsa:7561.
UCSCiuc002nnk.2. human.

Organism-specific databases

CTDi7561.
GeneCardsiZNF14.
HGNCiHGNC:12924. ZNF14.
HPAiHPA049863.
MIMi194556. gene.
neXtProtiNX_P17017.
PharmGKBiPA37511.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17017.
KOiK09228.
OMAiKFRMHER.
OrthoDBiEOG091G02KC.
PhylomeDBiP17017.
TreeFamiTF343410.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF14. human.
GenomeRNAii7561.
PROiP17017.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105708.
CleanExiHS_ZNF14.
GenevisibleiP17017. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 8 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF14_HUMAN
AccessioniPrimary (citable) accession number: P17017
Secondary accession number(s): B9EGA4, Q9ULZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 30, 2010
Last modified: September 7, 2016
This is version 159 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.