Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 14

Gene

ZNF14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri103 – 125C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri141 – 163C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 191C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 217C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST21
Zinc fingeri223 – 245C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri251 – 273C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 14
Alternative name(s):
Gonadotropin-inducible ovary transcription repressor 4
Short name:
GIOT-4
Zinc finger protein KOX6
Gene namesi
Name:ZNF14
Synonyms:GIOT4, KOX6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105708.8
HGNCiHGNC:12924 ZNF14
MIMi194556 gene
neXtProtiNX_P17017

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7561
OpenTargetsiENSG00000105708
PharmGKBiPA37511

Polymorphism and mutation databases

BioMutaiZNF14
DMDMi313104250

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473371 – 642Zinc finger protein 14Add BLAST642

Proteomic databases

EPDiP17017
MaxQBiP17017
PaxDbiP17017
PeptideAtlasiP17017
PRIDEiP17017

PTM databases

iPTMnetiP17017
PhosphoSitePlusiP17017

Expressioni

Gene expression databases

BgeeiENSG00000105708
CleanExiHS_ZNF14
GenevisibleiP17017 HS

Organism-specific databases

HPAiHPA049863

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000340514

Structurei

3D structure databases

ProteinModelPortaliP17017
SMRiP17017
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 76KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri103 – 125C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri141 – 163C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 191C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 217C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST21
Zinc fingeri223 – 245C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri251 – 273C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119089
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP17017
KOiK09228
OMAiKFRMHER
OrthoDBiEOG091G02KC
PhylomeDBiP17017
TreeFamiTF343410

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 18 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

Sequencei

Sequence statusi: Complete.

P17017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVSFEDVA VNFTLEEWAL LDSSQKKLYE DVMQETFKNL VCLGKKWEDQ
60 70 80 90 100
DIEDDHRNQG KNRRCHMVER LCESRRGSKC GETTSQMPNV NINKETFTGA
110 120 130 140 150
KPHECSFCGR DFIHHSSLNR HMRSHTGQKP NEYQEYEKQP CKCKAVGKTF
160 170 180 190 200
SYHHCFRKHE RTHTGVKPYE CKQCGKAFIY YQPFQRHERT HAGQKPYECK
210 220 230 240 250
QCGKTFIYYQ SFQKHAHTGK KPYECKQCGK AFICYQSFQR HKRTHTGEKP
260 270 280 290 300
YECKQCGKAF SCPTYFRTHE RTHTGEKPYK CKECGKAFSF LSSFRRHKRT
310 320 330 340 350
HSGEKPYECK ECGKAFFYSA SFRAHVIIHT GARPYKCKEC GKAFNSSNSC
360 370 380 390 400
RVHERTHIGE KPYECKRCGK SFSWSISLRL HERTHTGEKP YECKQCHKTF
410 420 430 440 450
SFSSSLREHE TTHTGEKPYE CKQCGKTFSF SSSLQRHERT HNAEKPYECK
460 470 480 490 500
QCGKAFRCSS YFRIHERSHT GEKPYECKQC GKVFIRSSSF RLHERTHTGE
510 520 530 540 550
KPYECKLCGK TFSFSSSLRE HEKIHTGNKP FECKQCGKAF LRSSQIRLHE
560 570 580 590 600
RTHTGEKPYQ CKQCGKAFIS SSKFRMHERT HTGEKPYRCK QCGKAFRFSS
610 620 630 640
SVRIHERSHT GEKPYECKQC GKAFISSSHF RLHERTHMGE KV
Length:642
Mass (Da):75,353
Last modified:November 30, 2010 - v3
Checksum:i806374FBDC480CE3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054791274T → S1 PublicationCorresponds to variant dbSNP:rs12973901Ensembl.1
Natural variantiVAR_057381379R → Q. Corresponds to variant dbSNP:rs3752153Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021644 mRNA Translation: BAA86990.1
AC011458 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84858.1
BC136323 mRNA Translation: AAI36324.1
X52337 mRNA Translation: CAA36563.1
CCDSiCCDS12409.1
PIRiI37974
RefSeqiNP_066358.2, NM_021030.2
UniGeneiHs.659932

Genome annotation databases

EnsembliENST00000344099; ENSP00000340514; ENSG00000105708
GeneIDi7561
KEGGihsa:7561
UCSCiuc002nnk.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZNF14_HUMAN
AccessioniPrimary (citable) accession number: P17017
Secondary accession number(s): B9EGA4, Q9ULZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 30, 2010
Last modified: May 23, 2018
This is version 170 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health