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Protein

Zinc finger protein 12

Gene

ZNF12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri269 – 291C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 319C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164631-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 12
Alternative name(s):
Gonadotropin-inducible ovary transcription repressor 3
Short name:
GIOT-3
Zinc finger protein 325
Zinc finger protein KOX3
Gene namesi
Name:ZNF12
Synonyms:GIOT3, KOX3, ZNF325
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:12902. ZNF12.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164631.
PharmGKBiPA134931984.
PA37491.

Polymorphism and mutation databases

BioMutaiZNF12.
DMDMi317373491.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473351 – 697Zinc finger protein 12Add BLAST697

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki98Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki544Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP17014.
MaxQBiP17014.
PaxDbiP17014.
PeptideAtlasiP17014.
PRIDEiP17014.

PTM databases

iPTMnetiP17014.
PhosphoSitePlusiP17014.

Expressioni

Tissue specificityi

Widely expressed in various adult tissues and embryonic developmental stages (isoform 3).1 Publication

Developmental stagei

Shows a relatively higher expression level in the fetal brain and a lower level in adult. The expression level in liver is highest at 16 weeks of development and declines from 16 to 24 weeks and is lower in adult. Expressed strongly in fetal heart on 18 and 24 weeks, but relatively weakly on the other development stage of embryo, and then reaches a higher level in adult (isoform 3).1 Publication

Gene expression databases

BgeeiENSG00000164631.
CleanExiHS_ZNF12.
ExpressionAtlasiP17014. baseline and differential.
GenevisibleiP17014. HS.

Organism-specific databases

HPAiHPA054014.
HPA063402.

Interactioni

Protein-protein interaction databases

BioGridi113391. 2 interactors.
IntActiP17014. 7 interactors.
STRINGi9606.ENSP00000385939.

Structurei

3D structure databases

ProteinModelPortaliP17014.
SMRiP17014.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri269 – 291C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 319C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133681.
HOVERGENiHBG067759.
InParanoidiP17014.
KOiK09228.
OMAiTFYLNSA.
OrthoDBiEOG091G02KC.
PhylomeDBiP17014.
TreeFamiTF350803.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17014-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKSLGPVSF KDVAVDFTQE EWQQLDPEQK ITYRDVMLEN YSNLVSVGYH
60 70 80 90 100
IIKPDVISKL EQGEEPWIVE GEFLLQSYPD EVWQTDDLIE RIQEEENKPS
110 120 130 140 150
RQTVFIETLI EERGNVPGKT FDVETNPVPS RKIAYKNSLC DSCEKCLTSV
160 170 180 190 200
SEYISSDGSY ARMKADECSG CGKSLLHIKL EKTHPGDQAY EFNQNGEPYT
210 220 230 240 250
LNEESLYQKI RILEKPFEYI ECQKAFQKDT VFVNHMEEKP YKWNGSEIAF
260 270 280 290 300
LQMSDLTVHQ TSHMEMKPYE CSECGKSFCK KSKFIIHQRT HTGEKPYECN
310 320 330 340 350
QCGKSFCQKG TLTVHQRTHT GEKPYECNEC GKNFYQKLHL IQHQRTHSGE
360 370 380 390 400
KPYECSYCGK SFCQKTHLTQ HQRTHSGERP YVCHDCGKTF SQKSALNDHQ
410 420 430 440 450
KIHTGVKLYK CSECGKCFCR KSTLTTHLRT HTGEKPYECN ECGKFFSRLS
460 470 480 490 500
YLTVHYRTHS GEKPYECNEC GKTFYLNSAL MRHQRVHTGE KPYECNECGK
510 520 530 540 550
LFSQLSYLTI HHRTHSGVKP YECSECGKTF YQNSALCRHR RIHKGEKPYE
560 570 580 590 600
CYICGKFFSQ MSYLTIHHRI HSGEKPYECS ECGKTFCQNS ALNRHQRTHT
610 620 630 640 650
GEKAYECYEC GKCFSQMSYL TIHHRIHSGE KPFECNECGK AFSRMSYLTV
660 670 680 690
HYRTHSGEKP YECTECGKKF YHKSAFNSHQ RIHRRGNMNV IDVGRLL
Length:697
Mass (Da):81,202
Last modified:January 11, 2011 - v3
Checksum:i3D12F61C265D6BE3
GO
Isoform 2 (identifier: P17014-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-653: Missing.

Show »
Length:501
Mass (Da):58,223
Checksum:iADF25EBC8378EA8C
GO
Isoform 3 (identifier: P17014-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-235: Missing.

Show »
Length:462
Mass (Da):54,051
Checksum:iED006CB45373F75A
GO
Isoform 4 (identifier: P17014-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.
     114-151: Missing.

Show »
Length:623
Mass (Da):72,906
Checksum:iBDC0B647761EB17F
GO
Isoform 5 (identifier: P17014-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-151: Missing.

Show »
Length:659
Mass (Da):77,131
Checksum:i4EF63A8987DA48D0
GO

Sequence cautioni

The sequence BAB14183 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG57306 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86D → E in AAI54415 (PubMed:15489334).Curated1
Sequence conflicti508L → P in CAE45857 (PubMed:17974005).Curated1
Sequence conflicti525E → G in BAB14183 (PubMed:14702039).Curated1
Sequence conflicti551C → Y in CAE45857 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0403341 – 235Missing in isoform 3. 1 PublicationAdd BLAST235
Alternative sequenceiVSP_0407381 – 36Missing in isoform 4. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_040739114 – 151Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST38
Alternative sequenceiVSP_040335458 – 653Missing in isoform 2. 1 PublicationAdd BLAST196

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF505656 mRNA. Translation: AAM28195.1.
AB021643 mRNA. Translation: BAA86989.1.
AK022691 mRNA. Translation: BAB14183.1. Different initiation.
AK293925 mRNA. Translation: BAG57306.1. Different initiation.
BX640749 mRNA. Translation: CAE45857.1.
AC073343 Genomic DNA. No translation available.
CH878731 Genomic DNA. Translation: EAW55016.1.
BC051892 mRNA. No translation available.
BC137068 mRNA. Translation: AAI37069.1.
BC137069 mRNA. Translation: AAI37070.1.
BC154414 mRNA. Translation: AAI54415.1.
X52334 mRNA. Translation: CAA36560.1.
CCDSiCCDS47538.1. [P17014-1]
CCDS47539.1. [P17014-5]
PIRiI37970.
RefSeqiNP_008887.2. NM_006956.2. [P17014-5]
NP_057349.2. NM_016265.3. [P17014-1]
UniGeneiHs.431471.

Genome annotation databases

EnsembliENST00000342651; ENSP00000344745; ENSG00000164631. [P17014-5]
ENST00000404360; ENSP00000384405; ENSG00000164631. [P17014-4]
ENST00000405858; ENSP00000385939; ENSG00000164631. [P17014-1]
GeneIDi7559.
KEGGihsa:7559.
UCSCiuc003sqs.3. human. [P17014-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF505656 mRNA. Translation: AAM28195.1.
AB021643 mRNA. Translation: BAA86989.1.
AK022691 mRNA. Translation: BAB14183.1. Different initiation.
AK293925 mRNA. Translation: BAG57306.1. Different initiation.
BX640749 mRNA. Translation: CAE45857.1.
AC073343 Genomic DNA. No translation available.
CH878731 Genomic DNA. Translation: EAW55016.1.
BC051892 mRNA. No translation available.
BC137068 mRNA. Translation: AAI37069.1.
BC137069 mRNA. Translation: AAI37070.1.
BC154414 mRNA. Translation: AAI54415.1.
X52334 mRNA. Translation: CAA36560.1.
CCDSiCCDS47538.1. [P17014-1]
CCDS47539.1. [P17014-5]
PIRiI37970.
RefSeqiNP_008887.2. NM_006956.2. [P17014-5]
NP_057349.2. NM_016265.3. [P17014-1]
UniGeneiHs.431471.

3D structure databases

ProteinModelPortaliP17014.
SMRiP17014.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113391. 2 interactors.
IntActiP17014. 7 interactors.
STRINGi9606.ENSP00000385939.

PTM databases

iPTMnetiP17014.
PhosphoSitePlusiP17014.

Polymorphism and mutation databases

BioMutaiZNF12.
DMDMi317373491.

Proteomic databases

EPDiP17014.
MaxQBiP17014.
PaxDbiP17014.
PeptideAtlasiP17014.
PRIDEiP17014.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342651; ENSP00000344745; ENSG00000164631. [P17014-5]
ENST00000404360; ENSP00000384405; ENSG00000164631. [P17014-4]
ENST00000405858; ENSP00000385939; ENSG00000164631. [P17014-1]
GeneIDi7559.
KEGGihsa:7559.
UCSCiuc003sqs.3. human. [P17014-1]

Organism-specific databases

CTDi7559.
GeneCardsiZNF12.
HGNCiHGNC:12902. ZNF12.
HPAiHPA054014.
HPA063402.
MIMi194536. gene.
neXtProtiNX_P17014.
OpenTargetsiENSG00000164631.
PharmGKBiPA134931984.
PA37491.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133681.
HOVERGENiHBG067759.
InParanoidiP17014.
KOiK09228.
OMAiTFYLNSA.
OrthoDBiEOG091G02KC.
PhylomeDBiP17014.
TreeFamiTF350803.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164631-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF12. human.
GenomeRNAii7559.
PROiP17014.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164631.
CleanExiHS_ZNF12.
ExpressionAtlasiP17014. baseline and differential.
GenevisibleiP17014. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF12_HUMAN
AccessioniPrimary (citable) accession number: P17014
Secondary accession number(s): A8MYC4
, A8WFQ8, B2RNQ7, B4DF45, Q6N016, Q8NHZ0, Q9H9P0, Q9ULZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 165 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.