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Protein

Zinc finger X-chromosomal protein

Gene

Zfx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcriptional activator.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri419 – 44426C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri482 – 50423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri513 – 53624C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri542 – 56423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri570 – 59324C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri599 – 62123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri627 – 65024C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri656 – 67823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri684 – 70724C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri713 – 73523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri741 – 76424C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri770 – 79223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • fertilization Source: MGI
  • germ cell development Source: MGI
  • homeostasis of number of cells Source: MGI
  • multicellular organism growth Source: MGI
  • oocyte development Source: MGI
  • ovarian follicle development Source: MGI
  • parental behavior Source: MGI
  • post-embryonic development Source: MGI
  • regulation of transcription, DNA-templated Source: GO_Central
  • spermatogenesis Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger X-chromosomal protein
Gene namesi
Name:Zfx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:99211. Zfx.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 799799Zinc finger X-chromosomal proteinPRO_0000047259Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei269 – 2691PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP17012.
MaxQBiP17012.
PaxDbiP17012.
PRIDEiP17012.

PTM databases

iPTMnetiP17012.
PhosphoSiteiP17012.

Expressioni

Gene expression databases

BgeeiP17012.
CleanExiMM_ZFX.
ExpressionAtlasiP17012. baseline and differential.
GenevisibleiP17012. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085423.

Structurei

3D structure databases

ProteinModelPortaliP17012.
SMRiP17012. Positions 419-798.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri419 – 44426C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri482 – 50423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri513 – 53624C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri542 – 56423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri570 – 59324C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri599 – 62123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri627 – 65024C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri656 – 67823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri684 – 70724C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri713 – 73523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri741 – 76424C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri770 – 79223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063297.
HOGENOMiHOG000231717.
HOVERGENiHBG000337.
InParanoidiP17012.
OMAiGHVGHVE.
OrthoDBiEOG75XGK4.
PhylomeDBiP17012.
TreeFamiTF335557.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR006794. Transcrp_activ_Zfx/Zfy-dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF04704. Zfx_Zfy_act. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17012-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEDGLELQQ QAPNSFFDAT GAGATHMDGN QIVVEVQETV YVSDVVDSDI
60 70 80 90 100
TVHNYVPDDP DSVVIQDVIE DVVIEDVQCT DIMDEADVSE TVIIPEQVLD
110 120 130 140 150
SDVTEEVSLT HCTVPDDVLA SDITSASISM PEHVLTSESI HVSDVGHVEH
160 170 180 190 200
VVHDSVVEAE IVTDPLAADV VSEEVLVADC ASEAVIDANG IPVNQQDEEK
210 220 230 240 250
NNCEDYLMIS LDDAGKIEHD GSSGLTMDNE TEIDPCKVDG TCPEVIKVYI
260 270 280 290 300
FKADPGEDDL GGTVDIVESE PENEHGVELL DPNNSIRVPR EKMVYMAVND
310 320 330 340 350
SQQEEEELNV AEIADEVYME VIVGEEDAAA AAAAAVHEQQ VEDNEMKTFM
360 370 380 390 400
PIAWAAAYGN NSDGIENRNG TASALLHIDE SAGLGRLAKQ KPKKRRRPDS
410 420 430 440 450
RQYQTAIIIG PDGHPLTVYP CMICGKKFKS RGFLKRHMKN HPEHLAKKKY
460 470 480 490 500
RCTDCDYTTN KKISLHNHLE SHKLTSKAEK AIECDECGKH FSHAGALFTH
510 520 530 540 550
KMVHKEKGAN KMHKCKFCEY ETAEQGLLNR HLLAVHSKNF PHICVECGKG
560 570 580 590 600
FRHPSELKKH MRIHTGEKPY ECQYCEYRSA DSSNLKTHVK TKHSKEMPFK
610 620 630 640 650
CDICLLTFSD TKEVQQHALV HQESKTHQCL HCDHKSSNSS DLKRHIISVH
660 670 680 690 700
TKDYPHKCDM CDKGFHRPSE LKKHVAAHKG KKMHQCRHCD FKIADPFVLS
710 720 730 740 750
RHILSVHTKD LPFRCKRCRK GFRQQSELKK HMKTHSGRKV YQCEYCEYST
760 770 780 790
TDASGFKRHV ISIHTKDYPH RCEYCKKGFR RPSEKNQHIM RHHKEVGLP
Length:799
Mass (Da):90,026
Last modified:July 25, 2006 - v2
Checksum:i3FB6B4D2159EADFD
GO

Sequence cautioni

The sequence AAA40585.1 differs from that shown.The sequence differs from that shown due to a duplication of 120 bp after position 480.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32308 mRNA. Translation: AAA40584.1.
M32309 mRNA. Translation: AAA40585.1. Sequence problems.
L19714 mRNA. Translation: AAA75393.1.
CCDSiCCDS30276.1.
PIRiA34729.
RefSeqiNP_001037851.1. NM_001044386.1.
NP_035898.2. NM_011768.2.
XP_006528029.1. XM_006527966.2.
XP_011245879.1. XM_011247577.1.
XP_011245880.1. XM_011247578.1.
UniGeneiMm.919.

Genome annotation databases

EnsembliENSMUST00000088102; ENSMUSP00000085423; ENSMUSG00000079509.
ENSMUST00000113926; ENSMUSP00000109559; ENSMUSG00000079509.
ENSMUST00000113927; ENSMUSP00000109560; ENSMUSG00000079509.
GeneIDi22764.
KEGGimmu:22764.
UCSCiuc009tsz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32308 mRNA. Translation: AAA40584.1.
M32309 mRNA. Translation: AAA40585.1. Sequence problems.
L19714 mRNA. Translation: AAA75393.1.
CCDSiCCDS30276.1.
PIRiA34729.
RefSeqiNP_001037851.1. NM_001044386.1.
NP_035898.2. NM_011768.2.
XP_006528029.1. XM_006527966.2.
XP_011245879.1. XM_011247577.1.
XP_011245880.1. XM_011247578.1.
UniGeneiMm.919.

3D structure databases

ProteinModelPortaliP17012.
SMRiP17012. Positions 419-798.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085423.

PTM databases

iPTMnetiP17012.
PhosphoSiteiP17012.

Proteomic databases

EPDiP17012.
MaxQBiP17012.
PaxDbiP17012.
PRIDEiP17012.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088102; ENSMUSP00000085423; ENSMUSG00000079509.
ENSMUST00000113926; ENSMUSP00000109559; ENSMUSG00000079509.
ENSMUST00000113927; ENSMUSP00000109560; ENSMUSG00000079509.
GeneIDi22764.
KEGGimmu:22764.
UCSCiuc009tsz.1. mouse.

Organism-specific databases

CTDi7543.
MGIiMGI:99211. Zfx.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063297.
HOGENOMiHOG000231717.
HOVERGENiHBG000337.
InParanoidiP17012.
OMAiGHVGHVE.
OrthoDBiEOG75XGK4.
PhylomeDBiP17012.
TreeFamiTF335557.

Miscellaneous databases

PROiP17012.
SOURCEiSearch...

Gene expression databases

BgeeiP17012.
CleanExiMM_ZFX.
ExpressionAtlasiP17012. baseline and differential.
GenevisibleiP17012. MM.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR006794. Transcrp_activ_Zfx/Zfy-dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF04704. Zfx_Zfy_act. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse Zfx protein is similar to Zfy-2: each contains an acidic activating domain and 13 zinc fingers."
    Mardon G., Luoh S.-W., Simpson E.M., Gill G., Brown L.G., Page D.C.
    Mol. Cell. Biol. 10:681-688(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The structure of the Zfx gene on the mouse X chromosome."
    Luoh S.-W., Page D.C.
    Genomics 19:310-319(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-216.
    Strain: FVB/N.
    Tissue: Testis.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-269, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-269, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Lung, Pancreas and Spleen.

Entry informationi

Entry nameiZFX_MOUSE
AccessioniPrimary (citable) accession number: P17012
Secondary accession number(s): P17011
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 25, 2006
Last modified: July 6, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.