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P16993 (NCAP_BUNGE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name=Protein N
Gene names
Name:N
OrganismBunyavirus germiston
Taxonomic identifier11574 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostCulex [TaxID: 53527]

Protein attributes

Sequence length233 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Encapsidates the genome protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication. Seems to participate in the nuclear relocalization of host PABP1, thereby inhibiting host cellular translation By similarity.

Subunit structure

Homomultimerizes to form the nucleocapsid By similarity. Binds to viral genomic RNA By similarity. Interacts with host PABP1 By similarity.

Subcellular location

Virion. Note: Internal protein of virus particle.

Sequence similarities

Belongs to the orthobunyavirus nucleocapsid protein family.

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]
Isoform N (identifier: P16993-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform NSS (identifier: P16992-1)

The sequence of this isoform can be found in the external entry P16992.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by alternative initiation in the N gene, but encoded on another frame.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 233233Nucleoprotein
PRO_0000221989

Sequences

Sequence LengthMass (Da)Tools
Isoform N [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 56456B22F30E2185

FASTA23326,703
        10         20         30         40         50         60 
MLELEFEDVP NNIGSTFDPE SGYTNFQRNY LPGVTLDQIR IFYIKGREIK NSLSKRSEWE 

        70         80         90        100        110        120 
VTLNLGGWKV PVLNTNFPGN RNNAVPDYGL TFHRISGYLA RYLLGKYLAE TEPEKLIMRT 

       130        140        150        160        170        180 
KIVNPLAEKN GITWESGPEV YLSFFPGAEM FLGTFRFYPL AIGIYKVQRK EMDPKFLEKT 

       190        200        210        220        230 
MRQRYLGIDA QTWTTTKLGE VEAALKVVSG LGWKKTNVSS AAREFLSKFG IRM 

« Hide

Isoform NSS [UniParc].

See P16992.

References

[1]"The S segment of the Germiston virus RNA genome can code for three proteins."
Gerbaud S., Vialat P., Pardigon N., Wychowski C., Girard M., Bouloy M.
Virus Res. 8:1-13(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M19420 Genomic RNA. Translation: AAA87603.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001784. Bunya_nucleocap.
[Graphical view]
PfamPF00952. Bunya_nucleocap. 1 hit.
[Graphical view]
PIRSFPIRSF003947. N_OrthobunV. 1 hit.
ProDomPD001909. Bunya_nucleocap. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameNCAP_BUNGE
AccessionPrimary (citable) accession number: P16993
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 9, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families