Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P16993

- NCAP_BUNGE

UniProt

P16993 - NCAP_BUNGE

Protein

Nucleoprotein

Gene

N

Organism
Bunyavirus germiston
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Encapsidates the genome protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication. Seems to participate in the nuclear relocalization of host PABP1, thereby inhibiting host cellular translation By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. suppression by virus of host gene expression Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction

    Keywords - Ligandi

    RNA-binding, Viral nucleoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoprotein
    Alternative name(s):
    Nucleocapsid protein
    Short name:
    Protein N
    Gene namesi
    Name:N
    OrganismiBunyavirus germiston
    Taxonomic identifieri11574 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
    Virus hostiCulex [TaxID: 53527]

    Subcellular locationi

    Virion
    Note: Internal protein of virus particle.

    GO - Cellular componenti

    1. helical viral capsid Source: UniProtKB-KW
    2. ribonucleoprotein complex Source: UniProtKB-KW
    3. viral nucleocapsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Helical capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233NucleoproteinPRO_0000221989Add
    BLAST

    Interactioni

    Subunit structurei

    Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with host PABP1.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR001784. Bunya_nucleocap.
    [Graphical view]
    PfamiPF00952. Bunya_nucleocap. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003947. N_OrthobunV. 1 hit.
    ProDomiPD001909. Bunya_nucleocap. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform N (identifier: P16993-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLELEFEDVP NNIGSTFDPE SGYTNFQRNY LPGVTLDQIR IFYIKGREIK    50
    NSLSKRSEWE VTLNLGGWKV PVLNTNFPGN RNNAVPDYGL TFHRISGYLA 100
    RYLLGKYLAE TEPEKLIMRT KIVNPLAEKN GITWESGPEV YLSFFPGAEM 150
    FLGTFRFYPL AIGIYKVQRK EMDPKFLEKT MRQRYLGIDA QTWTTTKLGE 200
    VEAALKVVSG LGWKKTNVSS AAREFLSKFG IRM 233
    Length:233
    Mass (Da):26,703
    Last modified:August 1, 1990 - v1
    Checksum:i56456B22F30E2185
    GO
    Isoform NSS (identifier: P16992-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry P16992.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: Produced by alternative initiation in the N gene, but encoded on another frame.

    Length:109
    Mass (Da):11,891
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M19420 Genomic RNA. Translation: AAA87603.1.

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M19420 Genomic RNA. Translation: AAA87603.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR001784. Bunya_nucleocap.
    [Graphical view ]
    Pfami PF00952. Bunya_nucleocap. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003947. N_OrthobunV. 1 hit.
    ProDomi PD001909. Bunya_nucleocap. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "The S segment of the Germiston virus RNA genome can code for three proteins."
      Gerbaud S., Vialat P., Pardigon N., Wychowski C., Girard M., Bouloy M.
      Virus Res. 8:1-13(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiNCAP_BUNGE
    AccessioniPrimary (citable) accession number: P16993
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3