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P16992

- NSS_BUNGE

UniProt

P16992 - NSS_BUNGE

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Protein

Non-structural protein NS-S

Gene

N

Organism
Bunyavirus germiston
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Inhibits host transcriptional machinery, by producing modifications to the phosphorylation state of the C-terminal domain (CTD) of RNA polymerase II. Inhibits phosphorylation at serine 2 in the heptapeptide repeat (YSPTSPS) of the CTD of RNA polymerase II, suggesting that the elongation step of transcription and/or 3'-end processing is prevented. Inhibition of host transcription machinery leads to shut off of host cell protein synthesis and inhibition of the host innate immune response. NSs also seems to be involved in the nuclear relocalization of host PABP1 (By similarity).By similarity

GO - Biological processi

  1. suppression by virus of host gene expression Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of eukaryotic host transcription initiation by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein NS-S
Gene namesi
Name:N
OrganismiBunyavirus germiston
Taxonomic identifieri11574 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostiCulex [TaxID: 53527]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 109109Non-structural protein NS-SPRO_0000221972Add
BLAST

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR000797. Bunya_NSs.
[Graphical view]
PfamiPF01104. Bunya_NS-S. 1 hit.
[Graphical view]
PIRSFiPIRSF003954. NS-S_OrthobunV. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform NSS (identifier: P16992-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLITSGVLL TQSQDTLTFS VTTCQGLRLT KFASSTLKDA RLKIVSQKEV
60 70 80 90 100
NGKLRLTLGA GRYLYSIRIS LETGTMQCLT TVLPSTVSVD TLPGTYLEST

LQRQNQKSS

Note: Produced by alternative initiation in the N gene, but encoded on another frame.

Length:109
Mass (Da):11,891
Last modified:August 1, 1990 - v1
Checksum:i1A49188EC6818BC0
GO
Isoform N (identifier: P16993-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry P16993.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:233
Mass (Da):26,703
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19420 Genomic RNA. Translation: AAA87604.1.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19420 Genomic RNA. Translation: AAA87604.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR000797. Bunya_NSs.
[Graphical view ]
Pfami PF01104. Bunya_NS-S. 1 hit.
[Graphical view ]
PIRSFi PIRSF003954. NS-S_OrthobunV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The S segment of the Germiston virus RNA genome can code for three proteins."
    Gerbaud S., Vialat P., Pardigon N., Wychowski C., Girard M., Bouloy M.
    Virus Res. 8:1-13(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNSS_BUNGE
AccessioniPrimary (citable) accession number: P16992
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 1, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3