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Protein

ATP-binding cassette sub-family D member 3

Gene

Abcd3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi473 – 480ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: RGD
  • ATP binding Source: RGD
  • long-chain fatty acid transporter activity Source: InterPro
  • protein homodimerization activity Source: Ensembl
  • protein self-association Source: RGD

GO - Biological processi

  • fatty acid beta-oxidation Source: Ensembl
  • fatty acid biosynthetic process Source: UniProtKB
  • peroxisomal long-chain fatty acid import Source: RGD
  • peroxisome organization Source: Ensembl
  • response to drug Source: RGD
  • response to organic cyclic compound Source: RGD
  • very long-chain fatty acid catabolic process Source: Ensembl

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-1369062 ABC transporters in lipid homeostasis

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family D member 3
Alternative name(s):
70 kDa peroxisomal membrane protein
Short name:
PMP70
Gene namesi
Name:Abcd3
Synonyms:Pmp70, Pxmp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2007 Abcd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei84 – 104HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei126 – 146HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei224 – 244HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei313 – 333HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000933112 – 659ATP-binding cassette sub-family D member 3Add BLAST658

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei61N6-acetyllysineBy similarity1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei260N6-acetyllysineBy similarity1
Modified residuei399N6-acetyllysineBy similarity1
Modified residuei424PhosphoserineBy similarity1
Modified residuei533N6-acetyllysineBy similarity1
Modified residuei659PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP16970
PRIDEiP16970

PTM databases

iPTMnetiP16970
PhosphoSitePlusiP16970

Expressioni

Gene expression databases

BgeeiENSRNOG00000011929
GenevisibleiP16970 RN

Interactioni

Subunit structurei

Homodimer or heterodimer (Potential). Interacts with PEX19 (By similarity).By similarityCurated

GO - Molecular functioni

  • protein homodimerization activity Source: Ensembl
  • protein self-association Source: RGD

Protein-protein interaction databases

BioGridi247310, 2 interactors
STRINGi10116.ENSRNOP00000016739

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 372ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST288
Domaini434 – 659ABC transporterPROSITE-ProRule annotationAdd BLAST226

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 199Interaction with PEX19By similarityAdd BLAST198
Regioni2 – 124Targeting to peroxisomesBy similarityAdd BLAST123

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0064 Eukaryota
COG4178 LUCA
GeneTreeiENSGT00390000003950
HOGENOMiHOG000206081
HOVERGENiHBG050438
InParanoidiP16970
KOiK05677
OMAiSMMAYLI
OrthoDBiEOG091G04M1
PhylomeDBiP16970

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR031241 ABCD3
IPR005283 FA_transporter
IPR027417 P-loop_NTPase
PANTHERiPTHR11384:SF34 PTHR11384:SF34, 1 hit
PfamiView protein in Pfam
PF06472 ABC_membrane_2, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR00954 3a01203, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAFSKYLTA RNSSLAGAAF LLFCLLHKRR RALGLHGKKS GKPPLQNNEK
60 70 80 90 100
EGKKERAVVD KVFLSRLSQI LKIMVPRTFC KETGYLILIA VMLVSRTYCD
110 120 130 140 150
VWMIQNGTLI ESGIIGRSSK DFKRYLFNFI AAMPLISLVN NFLKYGLNEL
160 170 180 190 200
KLCFRVRLTR YLYEEYLQAF TYYKMGNLDN RIANPDQLLT QDVEKFCNSV
210 220 230 240 250
VDLYSNLSKP FLDIVLYIFK LTSAIGAQGP ASMMAYLLVS GLFLTRLRRP
260 270 280 290 300
IGKMTIMEQK YEGEYRFVNS RLITNSEEIA FYNGNKREKQ TIHSVFRKLV
310 320 330 340 350
EHLHNFIFFR FSMGFIDSII AKYIATVVGY LVVSRPFLDL AHPRHLHSTH
360 370 380 390 400
SELLEDYYQS GRMLLRMSQA LGRIVLAGRE MTRLAGFTAR ITELMQVLKD
410 420 430 440 450
LNHGKYERTM VSQQDKGIEG AQASPLIPGA GEIINADNII KFDHVPLATP
460 470 480 490 500
NGDILIQDLS FEVRSGANVL ICGPNGCGKS SLFRVLGELW PLFGGHLTKP
510 520 530 540 550
ERGKLFYVPQ RPYMTLGTLR DQVIYPDGKE DQKKKGISDQ VLKGYLDNVQ
560 570 580 590 600
LGHILEREGG WDSVQDWMDV LSGGEKQRMA MARLFYHKPQ FAILDECTSA
610 620 630 640 650
VSVDVEDYIY SHCRKVGITL FTVSHRKSLW KHHEYYLHMD GRGNYEFKKI

TEDTVEFGS
Length:659
Mass (Da):75,316
Last modified:January 23, 2007 - v3
Checksum:iCA567F3DBE80B169
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90038 mRNA Translation: BAA14086.1
PIRiA35723
RefSeqiNP_036936.1, NM_012804.1
UniGeneiRn.7024

Genome annotation databases

EnsembliENSRNOT00000016739; ENSRNOP00000016739; ENSRNOG00000011929
GeneIDi25270
KEGGirno:25270
UCSCiRGD:2007 rat

Similar proteinsi

Entry informationi

Entry nameiABCD3_RAT
AccessioniPrimary (citable) accession number: P16970
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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