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P16970

- ABCD3_RAT

UniProt

P16970 - ABCD3_RAT

Protein

ATP-binding cassette sub-family D member 3

Gene

Abcd3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi473 – 4808ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: RGD
    2. ATP binding Source: RGD
    3. protein binding Source: RGD
    4. protein self-association Source: RGD

    GO - Biological processi

    1. peroxisomal long-chain fatty acid import Source: RGD
    2. response to drug Source: RGD
    3. response to organic cyclic compound Source: RGD

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-binding cassette sub-family D member 3
    Alternative name(s):
    70 kDa peroxisomal membrane protein
    Short name:
    PMP70
    Gene namesi
    Name:Abcd3
    Synonyms:Pmp70, Pxmp1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2007. Abcd3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: RGD
    2. mitochondrion Source: UniProtKB
    3. peroxisomal membrane Source: HGNC
    4. peroxisome Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 659658ATP-binding cassette sub-family D member 3PRO_0000093311Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
    Modified residuei61 – 611N6-acetyllysineBy similarity
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
    Modified residuei260 – 2601N6-acetyllysineBy similarity
    Modified residuei399 – 3991N6-acetyllysineBy similarity
    Modified residuei533 – 5331N6-acetyllysineBy similarity
    Modified residuei659 – 6591PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP16970.
    PRIDEiP16970.

    PTM databases

    PhosphoSiteiP16970.

    Expressioni

    Gene expression databases

    GenevestigatoriP16970.

    Interactioni

    Subunit structurei

    Homodimer or heterodimer Potential. Interacts with PEX19 By similarity.By similarityCurated

    Protein-protein interaction databases

    BioGridi247310. 2 interactions.
    STRINGi10116.ENSRNOP00000016739.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei84 – 10421HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei126 – 14621HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei224 – 24421HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei313 – 33321HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini85 – 372288ABC transmembrane type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini434 – 659226ABC transporterPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 199198Interaction with PEX19By similarityAdd
    BLAST
    Regioni2 – 124123Targeting to peroxisomesBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
    Contains 1 ABC transporter domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4178.
    HOGENOMiHOG000206081.
    HOVERGENiHBG050438.
    InParanoidiP16970.
    KOiK05677.
    PhylomeDBiP16970.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR010509. ABC_Peroxi_TM.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR005283. FA_transporter.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF06472. ABC_membrane_2. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF90123. SSF90123. 1 hit.
    TIGRFAMsiTIGR00954. 3a01203. 1 hit.
    PROSITEiPS50929. ABC_TM1F. 1 hit.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P16970-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAFSKYLTA RNSSLAGAAF LLFCLLHKRR RALGLHGKKS GKPPLQNNEK    50
    EGKKERAVVD KVFLSRLSQI LKIMVPRTFC KETGYLILIA VMLVSRTYCD 100
    VWMIQNGTLI ESGIIGRSSK DFKRYLFNFI AAMPLISLVN NFLKYGLNEL 150
    KLCFRVRLTR YLYEEYLQAF TYYKMGNLDN RIANPDQLLT QDVEKFCNSV 200
    VDLYSNLSKP FLDIVLYIFK LTSAIGAQGP ASMMAYLLVS GLFLTRLRRP 250
    IGKMTIMEQK YEGEYRFVNS RLITNSEEIA FYNGNKREKQ TIHSVFRKLV 300
    EHLHNFIFFR FSMGFIDSII AKYIATVVGY LVVSRPFLDL AHPRHLHSTH 350
    SELLEDYYQS GRMLLRMSQA LGRIVLAGRE MTRLAGFTAR ITELMQVLKD 400
    LNHGKYERTM VSQQDKGIEG AQASPLIPGA GEIINADNII KFDHVPLATP 450
    NGDILIQDLS FEVRSGANVL ICGPNGCGKS SLFRVLGELW PLFGGHLTKP 500
    ERGKLFYVPQ RPYMTLGTLR DQVIYPDGKE DQKKKGISDQ VLKGYLDNVQ 550
    LGHILEREGG WDSVQDWMDV LSGGEKQRMA MARLFYHKPQ FAILDECTSA 600
    VSVDVEDYIY SHCRKVGITL FTVSHRKSLW KHHEYYLHMD GRGNYEFKKI 650
    TEDTVEFGS 659
    Length:659
    Mass (Da):75,316
    Last modified:January 23, 2007 - v3
    Checksum:iCA567F3DBE80B169
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90038 mRNA. Translation: BAA14086.1.
    PIRiA35723.
    RefSeqiNP_036936.1. NM_012804.1.
    UniGeneiRn.7024.

    Genome annotation databases

    GeneIDi25270.
    KEGGirno:25270.
    UCSCiRGD:2007. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90038 mRNA. Translation: BAA14086.1 .
    PIRi A35723.
    RefSeqi NP_036936.1. NM_012804.1.
    UniGenei Rn.7024.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 247310. 2 interactions.
    STRINGi 10116.ENSRNOP00000016739.

    PTM databases

    PhosphoSitei P16970.

    Proteomic databases

    PaxDbi P16970.
    PRIDEi P16970.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25270.
    KEGGi rno:25270.
    UCSCi RGD:2007. rat.

    Organism-specific databases

    CTDi 5825.
    RGDi 2007. Abcd3.

    Phylogenomic databases

    eggNOGi COG4178.
    HOGENOMi HOG000206081.
    HOVERGENi HBG050438.
    InParanoidi P16970.
    KOi K05677.
    PhylomeDBi P16970.

    Miscellaneous databases

    NextBioi 605953.
    PROi P16970.

    Gene expression databases

    Genevestigatori P16970.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR010509. ABC_Peroxi_TM.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR005283. FA_transporter.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF06472. ABC_membrane_2. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF90123. SSF90123. 1 hit.
    TIGRFAMsi TIGR00954. 3a01203. 1 hit.
    PROSITEi PS50929. ABC_TM1F. 1 hit.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glycoprotein)-related ATP-binding protein superfamily."
      Kamijo K., Taketani S., Yokota S., Osumi T., Hashimoto T.
      J. Biol. Chem. 265:4534-4540(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Strain: Wistar.
      Tissue: Liver.
    2. "Alkaline density gradient floatation of membranes: polypeptide composition of the mammalian peroxisomal membrane."
      Gouveia A.M.M., Reguenga C., Oliveira M.E.M., Eckerskorn C., Sa-Miranda C., Azevedo J.E.
      Anal. Biochem. 274:270-277(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-15 AND 283-296.
      Tissue: Liver.

    Entry informationi

    Entry nameiABCD3_RAT
    AccessioniPrimary (citable) accession number: P16970
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 131 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3