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P16970 (ABCD3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-binding cassette sub-family D member 3
Alternative name(s):
70 kDa peroxisomal membrane protein
Short name=PMP70
Gene names
Name:Abcd3
Synonyms:Pmp70, Pxmp1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length659 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Homodimer or heterodimer Potential. Interacts with PEX19 By similarity.

Subcellular location

Peroxisome membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. [View classification]

Contains 1 ABC transmembrane type-1 domain.

Contains 1 ABC transporter domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 659658ATP-binding cassette sub-family D member 3
PRO_0000093311

Regions

Transmembrane84 – 10421Helical; Potential
Transmembrane126 – 14621Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane313 – 33321Helical; Potential
Domain85 – 372288ABC transmembrane type-1
Domain434 – 659226ABC transporter
Nucleotide binding473 – 4808ATP Potential
Region2 – 199198Interaction with PEX19 By similarity
Region2 – 124123Targeting to peroxisomes By similarity

Amino acid modifications

Modified residue611N6-acetyllysine By similarity
Modified residue2601N6-acetyllysine By similarity
Modified residue3991N6-acetyllysine By similarity
Modified residue5331N6-acetyllysine By similarity
Modified residue6591Phosphoserine By similarity
Glycosylation121N-linked (GlcNAc...) Potential
Glycosylation1061N-linked (GlcNAc...) Potential
Glycosylation2061N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P16970 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: CA567F3DBE80B169

FASTA65975,316
        10         20         30         40         50         60 
MAAFSKYLTA RNSSLAGAAF LLFCLLHKRR RALGLHGKKS GKPPLQNNEK EGKKERAVVD 

        70         80         90        100        110        120 
KVFLSRLSQI LKIMVPRTFC KETGYLILIA VMLVSRTYCD VWMIQNGTLI ESGIIGRSSK 

       130        140        150        160        170        180 
DFKRYLFNFI AAMPLISLVN NFLKYGLNEL KLCFRVRLTR YLYEEYLQAF TYYKMGNLDN 

       190        200        210        220        230        240 
RIANPDQLLT QDVEKFCNSV VDLYSNLSKP FLDIVLYIFK LTSAIGAQGP ASMMAYLLVS 

       250        260        270        280        290        300 
GLFLTRLRRP IGKMTIMEQK YEGEYRFVNS RLITNSEEIA FYNGNKREKQ TIHSVFRKLV 

       310        320        330        340        350        360 
EHLHNFIFFR FSMGFIDSII AKYIATVVGY LVVSRPFLDL AHPRHLHSTH SELLEDYYQS 

       370        380        390        400        410        420 
GRMLLRMSQA LGRIVLAGRE MTRLAGFTAR ITELMQVLKD LNHGKYERTM VSQQDKGIEG 

       430        440        450        460        470        480 
AQASPLIPGA GEIINADNII KFDHVPLATP NGDILIQDLS FEVRSGANVL ICGPNGCGKS 

       490        500        510        520        530        540 
SLFRVLGELW PLFGGHLTKP ERGKLFYVPQ RPYMTLGTLR DQVIYPDGKE DQKKKGISDQ 

       550        560        570        580        590        600 
VLKGYLDNVQ LGHILEREGG WDSVQDWMDV LSGGEKQRMA MARLFYHKPQ FAILDECTSA 

       610        620        630        640        650 
VSVDVEDYIY SHCRKVGITL FTVSHRKSLW KHHEYYLHMD GRGNYEFKKI TEDTVEFGS 

« Hide

References

[1]"The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glycoprotein)-related ATP-binding protein superfamily."
Kamijo K., Taketani S., Yokota S., Osumi T., Hashimoto T.
J. Biol. Chem. 265:4534-4540(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Strain: Wistar.
Tissue: Liver.
[2]"Alkaline density gradient floatation of membranes: polypeptide composition of the mammalian peroxisomal membrane."
Gouveia A.M.M., Reguenga C., Oliveira M.E.M., Eckerskorn C., Sa-Miranda C., Azevedo J.E.
Anal. Biochem. 274:270-277(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-15 AND 283-296.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D90038 mRNA. Translation: BAA14086.1.
PIRA35723.
RefSeqNP_036936.1. NM_012804.1.
UniGeneRn.7024.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid247310. 2 interactions.
STRING10116.ENSRNOP00000016739.

PTM databases

PhosphoSiteP16970.

Proteomic databases

PaxDbP16970.
PRIDEP16970.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID25270.
KEGGrno:25270.
UCSCRGD:2007. rat.

Organism-specific databases

CTD5825.
RGD2007. Abcd3.

Phylogenomic databases

eggNOGCOG4178.
HOGENOMHOG000206081.
HOVERGENHBG050438.
InParanoidP16970.
KOK05677.
PhylomeDBP16970.

Gene expression databases

GenevestigatorP16970.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR010509. ABC_Peroxi_TM.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR005283. FA_transporter.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF06472. ABC_membrane_2. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsTIGR00954. 3a01203. 1 hit.
PROSITEPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio605953.
PROP16970.

Entry information

Entry nameABCD3_RAT
AccessionPrimary (citable) accession number: P16970
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families