ATP-binding cassette sub-family D member 3

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P16970 (ABCD3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 122. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
ATP-binding cassette sub-family D member 3

Alternative name(s):
70 kDa peroxisomal membrane protein
Short name=PMP70

Gene names

Name:	Abcd3
Synonyms:	Pmp70, Pxmp1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	659 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure

Homodimer or heterodimer Potential. Interacts with PEX19 By similarity.

Subcellular location

Peroxisome membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. [View classification]

Contains 1 ABC transmembrane type-1 domain.

Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Peroxisome
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
PTM	Acetylation Glycoprotein Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	peroxisomal long-chain fatty acid import Traceable author statement PubMed 11883951. Source: RGD response to drug Inferred from expression pattern PubMed 9108325. Source: RGD
Cellular_component	integral to membrane Non-traceable author statement Ref.1. Source: RGD mitochondrion Inferred from direct assay PubMed 19010322. Source: UniProtKB peroxisomal membrane Inferred from direct assay PubMed 14561759. Source: HGNC
Molecular_function	ATP binding Inferred from direct assay PubMed 12176987. Source: RGD ATPase activity, coupled to transmembrane movement of substances Traceable author statement PubMed 11883951. Source: RGD protein self-association Inferred from direct assay PubMed 11883951. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed Ref.2

Chain

2 – 659

658

ATP-binding cassette sub-family D member 3

PRO_0000093311

Regions

Transmembrane

84 – 104

Helical; Potential

Transmembrane

126 – 146

Helical; Potential

Transmembrane

224 – 244

Helical; Potential

Transmembrane

313 – 333

Helical; Potential

Domain

85 – 372

288

ABC transmembrane type-1

Domain

434 – 659

226

ABC transporter

Nucleotide binding

473 – 480

ATP Potential

Region

2 – 199

198

Interaction with PEX19 By similarity

Region

2 – 124

123

Targeting to peroxisomes By similarity

Amino acid modifications

Modified residue

260

N6-acetyllysine By similarity

Modified residue

399

N6-acetyllysine By similarity

Modified residue

424

Phosphoserine By similarity

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

106

N-linked (GlcNAc...) Potential

Glycosylation

206

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

P16970 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: CA567F3DBE80B169
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FASTA

659

75,316

        10         20         30         40         50         60 
MAAFSKYLTA RNSSLAGAAF LLFCLLHKRR RALGLHGKKS GKPPLQNNEK EGKKERAVVD 

        70         80         90        100        110        120 
KVFLSRLSQI LKIMVPRTFC KETGYLILIA VMLVSRTYCD VWMIQNGTLI ESGIIGRSSK 

       130        140        150        160        170        180 
DFKRYLFNFI AAMPLISLVN NFLKYGLNEL KLCFRVRLTR YLYEEYLQAF TYYKMGNLDN 

       190        200        210        220        230        240 
RIANPDQLLT QDVEKFCNSV VDLYSNLSKP FLDIVLYIFK LTSAIGAQGP ASMMAYLLVS 

       250        260        270        280        290        300 
GLFLTRLRRP IGKMTIMEQK YEGEYRFVNS RLITNSEEIA FYNGNKREKQ TIHSVFRKLV 

       310        320        330        340        350        360 
EHLHNFIFFR FSMGFIDSII AKYIATVVGY LVVSRPFLDL AHPRHLHSTH SELLEDYYQS 

       370        380        390        400        410        420 
GRMLLRMSQA LGRIVLAGRE MTRLAGFTAR ITELMQVLKD LNHGKYERTM VSQQDKGIEG 

       430        440        450        460        470        480 
AQASPLIPGA GEIINADNII KFDHVPLATP NGDILIQDLS FEVRSGANVL ICGPNGCGKS 

       490        500        510        520        530        540 
SLFRVLGELW PLFGGHLTKP ERGKLFYVPQ RPYMTLGTLR DQVIYPDGKE DQKKKGISDQ 

       550        560        570        580        590        600 
VLKGYLDNVQ LGHILEREGG WDSVQDWMDV LSGGEKQRMA MARLFYHKPQ FAILDECTSA 

       610        620        630        640        650 
VSVDVEDYIY SHCRKVGITL FTVSHRKSLW KHHEYYLHMD GRGNYEFKKI TEDTVEFGS

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References

[1]	"The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glycoprotein)-related ATP-binding protein superfamily." Kamijo K., Taketani S., Yokota S., Osumi T., Hashimoto T. J. Biol. Chem. 265:4534-4540(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Strain: Wistar. Tissue: Liver.
[2]	"Alkaline density gradient floatation of membranes: polypeptide composition of the mammalian peroxisomal membrane." Gouveia A.M.M., Reguenga C., Oliveira M.E.M., Eckerskorn C., Sa-Miranda C., Azevedo J.E. Anal. Biochem. 274:270-277(1999) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-15 AND 283-296. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D90038 mRNA. Translation: BAA14086.1.
IPI	IPI00231860.
PIR	A35723.
RefSeq	NP_036936.1. NM_012804.1.
UniGene	Rn.7024.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000016739.
PTM databases
PhosphoSite	P16970.
Proteomic databases
PaxDb	P16970.
PRIDE	P16970.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	25270.
KEGG	rno:25270.
UCSC	RGD:2007. rat.
Organism-specific databases
CTD	5825.
RGD	2007. Abcd3.
Phylogenomic databases
eggNOG	COG4178.
HOGENOM	HOG000206081.
HOVERGEN	HBG050438.
InParanoid	P16970.
KO	K05677.
OrthoDB	EOG4ZPDTZ.
Gene expression databases
ArrayExpress	P16970.
Genevestigator	P16970.
GermOnline	ENSRNOG00000011929. Rattus norvegicus.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR010509. ABC_Ald_N. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR011527. ABC_transptrTM_dom_typ1. IPR005283. FA_transporter. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF06472. ABC_membrane_2. 1 hit. PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 1 hit. SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR00954. 3a01203. 1 hit.
PROSITE	PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	605953.

Entry information

Entry name

ABCD3_RAT

Accession

Primary (citable) accession number: P16970

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	January 23, 2007
Last modified:	May 29, 2013
This is version 122 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents