P16966 (TTR_PSESZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyltransferase
EC=2.3.1.-

Alternative name(s):
Tabtoxin resistance protein

Gene names

Name:

ttr

Organism

Pseudomonas syringae pv. tabaci

Taxonomic identifier

322 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas amygdali

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Renders tabtoxin-producing pathogens tolerant to their own phytotoxins. Ref.2
Miscellaneous	Tabtoxin causes wildfire disease of tobacco.
Sequence similarities	Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Molecular function	Acyltransferase Transferase
Technical term	3D-structure
Gene Ontology (GO)
Molecular function	N-acetyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 177

177

Acetyltransferase

PRO_0000065680

Regions

Domain

4 – 174

171

N-acetyltransferase

Region

96 – 98

3

Acetyl-CoA binding

Region

104 – 109

6

Acetyl-CoA binding

Region

130 – 131

2

Acetyl-CoA binding

Sites

Binding site

27

1

Acetyl-CoA

Binding site

141

1

Acetyl-CoA

Secondary structure

1

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177

Helix Strand Turn

Details...

Beta strand

5 – 8

4

Turn

11 – 13

3

Helix

14 – 30

17

Helix

43 – 51

9

Helix

54 – 59

6

Beta strand

60 – 69

10

Beta strand

72 – 81

10

Beta strand

90 – 98

9

Helix

100 – 102

3

Helix

107 – 121

15

Beta strand

126 – 132

7

Helix

136 – 143

8

Beta strand

147 – 157

11

Beta strand

163 – 172

10

Sequences

	Sequence		Length	Mass (Da)
	P16966 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: 8D278EC9AB27E9DF	FASTA	177	19,235
	10 20 30 40 50 60 MNHAQLRRVT AESFAHYRHG LAQLLFETVH GGASVGFMAD LDMQQAYAWC DGLKADIAAG 70 80 90 100 110 120 SLLLWVVAED DNVLASAQLS LCQKPNGLNR AEVQKLMVLP SARGRGLGRQ LMDEVEQVAV 130 140 150 160 170 KHKRGLLHLD TEAGSVAEAF YSALAYTRVG ELPGYCATPD GRLHPTAIYF KTLGQPT

References

[1]

"The nucleotide sequence of tabtoxin resistance gene (ttr) of Pseudomonas syringae pv. tabaci." Anzai H., Yoneyama K., Yamaguchi I. Nucleic Acids Res. 18:1890-1890(1990) [PubMed: 2336364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: MAFF03-01075.

[2]

"Crystal structure of tabtoxin resistance protein complexed with acetyl coenzyme A reveals the mechanism for beta-lactam acetylation." He H., Ding Y., Bartlam M., Sun F., Le Y., Qin X., Tang H., Zhang R., Joachimiak A., Liu J., Zhao N., Rao Z. J. Mol. Biol. 325:1019-1030(2003) [PubMed: 12527305] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) IN COMPLEX WITH ACETYL-COENZYME A, FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X17150 Genomic DNA. Translation: CAA35037.1.

PIR

S09214.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1GHE	X-ray	1.55	A/B	1-177	[»]
1J4J	X-ray	2.55	A/B	1-177	[»]

ProteinModelPortal

P16966.

SMR

P16966. Positions 3-173.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR000182. AcTrfase_GCN5-related_dom.
IPR016181. Acyl_CoA_acyltransferase.
[Graphical view]

Gene3D

G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.

Pfam

PF00583. Acetyltransf_1. 1 hit.
[Graphical view]

SUPFAM

SSF55729. Acyl_CoA_acyltransferase. 1 hit.

PROSITE

PS51186. GNAT. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

TTR_PSESZ

Accession

Primary (citable) accession number: P16966

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	November 30, 2010
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program