Reviewed, UniProtKB/Swiss-Prot P16928 (ACSA_EMENI)

Names and origin

Protein names

Recommended name:
    Acetyl-coenzyme A synthetase
    EC=6.2.1.1
Alternative name(s):
    Acetate--CoA ligase
    Acyl-activating enzyme

Gene names

Name:	facA
Synonyms:	acuA
ORF Names:	AN5626

Organism

Emericella nidulans (Aspergillus nidulans) [Complete proteome]

Taxonomic identifier

162425 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella

Protein attributes

Sequence length	670 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
Induction	By acetate.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 670	670	Acetyl-coenzyme A synthetase		PRO_0000208413
Experimental info
	Sequence conflict	343	1	C → V in CAA34858. Ref.1
	Sequence conflict	509	1	N → Q in CAA34858. Ref.1
	Sequence conflict	647	1	D → S in CAA34858. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P16928-1 [UniParc]. Last modified May 1, 2007. Version 2. Checksum: 69CB00F68E5ED15A	FASTA	670	74,280
	10 20 30 40 50 60 MSDGPIAPPK PAVVAEAHEV DTFHVPKAFF DKHPSGPHLK NLDEYKKLYE ESIRSPDVFW 70 80 90 100 110 120 ARKARELLTF DKDFQTTRIG SLENGDVAWF PEGRLNASFN CVDRHAIKNP NKVAIIYEAD 130 140 150 160 170 180 EPNEGRTITY GELLREVSRV AWVLKQRGVK KGDTVAIYLP MIPEAIIAFL ACSRIGAVHS 190 200 210 220 230 240 VVFAGFSSDS LRDRVLDAGS KVVITTDEGK RGGKVIGTKR IVDEGLKQCP DVSTVLVYKR 250 260 270 280 290 300 TGAEVPWTEG RDIWWHEEVE KYPAYIAPDS VNSEDPLFLL YTSGSTGKPK GVMHTTAGYL 310 320 330 340 350 360 LGAAMTGKYV FDIHDDDRYF CGGDVGWITG HTYVVYAPLL LGCSTVVFES TPAYPDFSRY 370 380 390 400 410 420 WDVIEKHKVT QFYVAPTALR LLKRAGDHHI HHKMEHLRVL GSVGEPIAAE VWKWYFEKVG 430 440 450 460 470 480 KEEAHICDTY WQTETGSNVI TPLAGVTPTK PGSASLPFFG IEPAIIDPVS GEEISGNDVE 490 500 510 520 530 540 GVLAFKQPWP SMARTVWGAH KRYMDTYLNV YKGYYFTGDG AGRDHEGYYW IRGRVDDVVN 550 560 570 580 590 600 VSGHRLSTAE IEAALIEHPM VAEAAVVGIA DELTGQAVNA FVSLKEGNET NDQVRKDLIL 610 620 630 640 650 660 QVRKSIGPFA APKAVFVVDD LPKTRSGKIM RRILRKILSG EEDSLGDIST LSDPSVVERI 670 IATVHASRGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparison and cross-species expression of the acetyl-CoA synthetase genes of the Ascomycete fungi, Aspergillus nidulans and Neurospora crassa." Connerton I.F., Fincham J.R.S., Sandeman R.A., Hynes M.J. Mol. Microbiol. 4:451-460(1990) [PubMed: 1972535] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: D1.
[2]	"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae." Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W. Nature 438:1105-1115(2005) [PubMed: 16372000] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC 4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X16990 Genomic DNA. Translation: CAA34858.1. AACD01000098 Genomic DNA. Translation: EAA62719.1.
PIR	SYASAA. S09245.
RefSeq	XP_663230.1.
3D structure databases
HSSP	HSSP built from PDB template 1PG4 based on UniProtKB Q8ZKF6.
ModBase	Search...
Genome annotation databases
GeneID	2871910.
KEGG	ani:AN5626.2.
Enzyme and pathway databases
BRENDA	6.2.1.1. 3859.
Family and domain databases
InterPro	IPR011904. Ac_CoA_lig_AcsA. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACSA_EMENI

Accession

Primary (citable) accession number: P16928
Secondary accession number(s): Q5B1F4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	May 1, 2007
Last modified:	September 22, 2009
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)