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Protein

Protein elav

Gene

elav

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for the proper development and maintenance of neurons presumably by affecting RNA metabolism.1 Publication

GO - Molecular functioni

  • mRNA binding Source: FlyBase
  • poly(U) RNA binding Source: FlyBase
  • RNA binding Source: FlyBase
  • translation repressor activity, mRNA regulatory element binding Source: UniProtKB

GO - Biological processi

  • central nervous system development Source: FlyBase
  • embryo development ending in birth or egg hatching Source: UniProtKB
  • germ cell development Source: UniProtKB
  • negative regulation of mRNA 3'-end processing Source: FlyBase
  • negative regulation of oskar mRNA translation Source: UniProtKB
  • nervous system development Source: FlyBase

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

ReactomeiR-DME-450520 HuR (ELAVL1) binds and stabilizes mRNA
R-DME-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein elav
Alternative name(s):
Embryonic lethal abnormal visual protein
Gene namesi
Name:elav
ORF Names:CG4262
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0260400 elav

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815751 – 483Protein elavAdd BLAST483

Proteomic databases

PaxDbiP16914
PRIDEiP16914

Expressioni

Gene expression databases

BgeeiFBgn0260400
ExpressionAtlasiP16914 differential
GenevisibleiP16914 DM

Interactioni

Protein-protein interaction databases

BioGridi57569, 18 interactors
DIPiDIP-23700N
IntActiP16914, 3 interactors
STRINGi7227.FBpp0298002

Structurei

3D structure databases

ProteinModelPortaliP16914
SMRiP16914
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 240RRM 1PROSITE-ProRule annotationAdd BLAST92
Domaini248 – 329RRM 2PROSITE-ProRule annotationAdd BLAST82
Domaini402 – 480RRM 3PROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 126Ala/Gln-richAdd BLAST103

Sequence similaritiesi

Belongs to the RRM elav family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0145 Eukaryota
ENOG410XP7S LUCA
GeneTreeiENSGT00760000118913
InParanoidiP16914
KOiK13208
OrthoDBiEOG091G0G9L
PhylomeDBiP16914

Family and domain databases

CDDicd12650 RRM1_Hu, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR006548 ELAD_HU_SF
IPR034775 ELAV/Hu_RRM1
IPR002343 Hud_Sxl_RNA
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 4 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
TIGRFAMsiTIGR01661 ELAV_HUD_SF, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P16914-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFIMANTGA GGGVDTQAQL MQSAAAAAAV AATNAAAAPV QNAAAVAAAA
60 70 80 90 100
QLQQQQVQQA ILQVQQQQTQ QAVAAAAAAV TQQLQQQQQA VVAQQAVVQQ
110 120 130 140 150
QQQQAAAVVQ QAAVQQAVVP QPQQAQPNTN GNAGSGSQNG SNGSTETRTN
160 170 180 190 200
LIVNYLPQTM TEDEIRSLFS SVGEIESVKL IRDKSQVYID PLNPQAPSKG
210 220 230 240 250
QSLGYGFVNY VRPQDAEQAV NVLNGLRLQN KTIKVSFARP SSDAIKGANL
260 270 280 290 300
YVSGLPKTMT QQELEAIFAP FGAIITSRIL QNAGNDTQTK GVGFIRFDKR
310 320 330 340 350
EEATRAIIAL NGTTPSSCTD PIVVKFSNTP GSTSKIIQPQ LPAFLNPQLV
360 370 380 390 400
RRIGGAMHTP VNKGLARFSP MAGDMLDVML PNGLGAAAAA ATTLASGPGG
410 420 430 440 450
AYPIFIYNLA PETEEAALWQ LFGPFGAVQS VKIVKDPTTN QCKGYGFVSM
460 470 480
TNYDEAAMAI RALNGYTMGN RVLQVSFKTN KAK
Length:483
Mass (Da):50,817
Last modified:August 1, 1990 - v1
Checksum:iE57336106310810B
GO
Isoform B (identifier: P16914-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: Missing.

Note: No experimental confirmation available.
Show »
Length:479
Mass (Da):50,311
Checksum:iD5D1554716982662
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0365821 – 4Missing in isoform B. Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21152 mRNA Translation: AAA28506.1
AE014298 Genomic DNA Translation: AAF45517.2
AE014298 Genomic DNA Translation: ACL82875.1
AE014298 Genomic DNA Translation: AAX52472.1
AL022139 Genomic DNA Translation: CAA18091.1
AL022139 Genomic DNA Translation: CAB37430.1
AY051822 mRNA Translation: AAK93246.1
PIRiA33130
RefSeqiNP_001014713.1, NM_001014713.4 [P16914-2]
NP_001138142.1, NM_001144670.2 [P16914-2]
NP_001245447.1, NM_001258518.3 [P16914-1]
NP_525033.1, NM_080294.5 [P16914-1]
UniGeneiDm.4473

Genome annotation databases

EnsemblMetazoaiFBtr0070091; FBpp0070086; FBgn0260400 [P16914-1]
FBtr0100254; FBpp0099643; FBgn0260400 [P16914-2]
FBtr0114366; FBpp0112915; FBgn0260400 [P16914-2]
FBtr0307173; FBpp0298002; FBgn0260400 [P16914-1]
GeneIDi31000
KEGGidme:Dmel_CG4262
UCSCiCG4262-RB d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiELAV_DROME
AccessioniPrimary (citable) accession number: P16914
Secondary accession number(s): Q7K7L9, Q9V3F6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 25, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health