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Protein

Protein elav

Gene

elav

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Required for the proper development and maintenance of neurons presumably by affecting RNA metabolism.1 Publication

GO - Molecular functioni

  • mRNA binding Source: FlyBase
  • nucleotide binding Source: InterPro
  • poly(U) RNA binding Source: FlyBase
  • RNA binding Source: FlyBase
  • translation repressor activity, nucleic acid binding Source: UniProtKB

GO - Biological processi

  • central nervous system development Source: FlyBase
  • embryo development Source: UniProtKB
  • germ cell development Source: UniProtKB
  • negative regulation of mRNA 3'-end processing Source: FlyBase
  • negative regulation of oskar mRNA translation Source: UniProtKB
  • nervous system development Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-DME-450520. HuR (ELAVL1) binds and stabilizes mRNA.
R-DME-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein elav
Alternative name(s):
Embryonic lethal abnormal visual protein
Gene namesi
Name:elav
ORF Names:CG4262
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0260400. elav.

Subcellular locationi

GO - Cellular componenti

  • Cajal body Source: FlyBase
  • nucleus Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815751 – 483Protein elavAdd BLAST483

Proteomic databases

PaxDbiP16914.
PRIDEiP16914.

Expressioni

Gene expression databases

BgeeiFBgn0260400.
ExpressionAtlasiP16914. baseline.
GenevisibleiP16914. DM.

Interactioni

Protein-protein interaction databases

BioGridi57569. 4 interactors.
DIPiDIP-23700N.
IntActiP16914. 2 interactors.
MINTiMINT-1597597.
STRINGi7227.FBpp0298002.

Structurei

3D structure databases

ProteinModelPortaliP16914.
SMRiP16914.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 240RRM 1PROSITE-ProRule annotationAdd BLAST92
Domaini248 – 329RRM 2PROSITE-ProRule annotationAdd BLAST82
Domaini402 – 480RRM 3PROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 126Ala/Gln-richAdd BLAST103

Sequence similaritiesi

Belongs to the RRM elav family.Curated
Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0145. Eukaryota.
ENOG410XP7S. LUCA.
GeneTreeiENSGT00760000118913.
InParanoidiP16914.
KOiK13208.
OMAiVYIDPLN.
OrthoDBiEOG091G0G9L.
PhylomeDBiP16914.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 4 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P16914-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFIMANTGA GGGVDTQAQL MQSAAAAAAV AATNAAAAPV QNAAAVAAAA
60 70 80 90 100
QLQQQQVQQA ILQVQQQQTQ QAVAAAAAAV TQQLQQQQQA VVAQQAVVQQ
110 120 130 140 150
QQQQAAAVVQ QAAVQQAVVP QPQQAQPNTN GNAGSGSQNG SNGSTETRTN
160 170 180 190 200
LIVNYLPQTM TEDEIRSLFS SVGEIESVKL IRDKSQVYID PLNPQAPSKG
210 220 230 240 250
QSLGYGFVNY VRPQDAEQAV NVLNGLRLQN KTIKVSFARP SSDAIKGANL
260 270 280 290 300
YVSGLPKTMT QQELEAIFAP FGAIITSRIL QNAGNDTQTK GVGFIRFDKR
310 320 330 340 350
EEATRAIIAL NGTTPSSCTD PIVVKFSNTP GSTSKIIQPQ LPAFLNPQLV
360 370 380 390 400
RRIGGAMHTP VNKGLARFSP MAGDMLDVML PNGLGAAAAA ATTLASGPGG
410 420 430 440 450
AYPIFIYNLA PETEEAALWQ LFGPFGAVQS VKIVKDPTTN QCKGYGFVSM
460 470 480
TNYDEAAMAI RALNGYTMGN RVLQVSFKTN KAK
Length:483
Mass (Da):50,817
Last modified:August 1, 1990 - v1
Checksum:iE57336106310810B
GO
Isoform B (identifier: P16914-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: Missing.

Note: No experimental confirmation available.
Show »
Length:479
Mass (Da):50,311
Checksum:iD5D1554716982662
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0365821 – 4Missing in isoform B. Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21152 mRNA. Translation: AAA28506.1.
AE014298 Genomic DNA. Translation: AAF45517.2.
AE014298 Genomic DNA. Translation: ACL82875.1.
AE014298 Genomic DNA. Translation: AAX52472.1.
AL022139 Genomic DNA. Translation: CAA18091.1.
AL022139 Genomic DNA. Translation: CAB37430.1.
AY051822 mRNA. Translation: AAK93246.1.
PIRiA33130.
RefSeqiNP_001014713.1. NM_001014713.4. [P16914-2]
NP_001138142.1. NM_001144670.2. [P16914-2]
NP_001245447.1. NM_001258518.3. [P16914-1]
NP_525033.1. NM_080294.5. [P16914-1]
UniGeneiDm.4473.

Genome annotation databases

EnsemblMetazoaiFBtr0070091; FBpp0070086; FBgn0260400. [P16914-1]
FBtr0307173; FBpp0298002; FBgn0260400. [P16914-1]
GeneIDi31000.
KEGGidme:Dmel_CG4262.
UCSCiCG4262-RB. d. melanogaster.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21152 mRNA. Translation: AAA28506.1.
AE014298 Genomic DNA. Translation: AAF45517.2.
AE014298 Genomic DNA. Translation: ACL82875.1.
AE014298 Genomic DNA. Translation: AAX52472.1.
AL022139 Genomic DNA. Translation: CAA18091.1.
AL022139 Genomic DNA. Translation: CAB37430.1.
AY051822 mRNA. Translation: AAK93246.1.
PIRiA33130.
RefSeqiNP_001014713.1. NM_001014713.4. [P16914-2]
NP_001138142.1. NM_001144670.2. [P16914-2]
NP_001245447.1. NM_001258518.3. [P16914-1]
NP_525033.1. NM_080294.5. [P16914-1]
UniGeneiDm.4473.

3D structure databases

ProteinModelPortaliP16914.
SMRiP16914.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi57569. 4 interactors.
DIPiDIP-23700N.
IntActiP16914. 2 interactors.
MINTiMINT-1597597.
STRINGi7227.FBpp0298002.

Proteomic databases

PaxDbiP16914.
PRIDEiP16914.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0070091; FBpp0070086; FBgn0260400. [P16914-1]
FBtr0307173; FBpp0298002; FBgn0260400. [P16914-1]
GeneIDi31000.
KEGGidme:Dmel_CG4262.
UCSCiCG4262-RB. d. melanogaster.

Organism-specific databases

CTDi31000.
FlyBaseiFBgn0260400. elav.

Phylogenomic databases

eggNOGiKOG0145. Eukaryota.
ENOG410XP7S. LUCA.
GeneTreeiENSGT00760000118913.
InParanoidiP16914.
KOiK13208.
OMAiVYIDPLN.
OrthoDBiEOG091G0G9L.
PhylomeDBiP16914.

Enzyme and pathway databases

ReactomeiR-DME-450520. HuR (ELAVL1) binds and stabilizes mRNA.
R-DME-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

GenomeRNAii31000.
PROiP16914.

Gene expression databases

BgeeiFBgn0260400.
ExpressionAtlasiP16914. baseline.
GenevisibleiP16914. DM.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 4 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELAV_DROME
AccessioniPrimary (citable) accession number: P16914
Secondary accession number(s): Q7K7L9, Q9V3F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 30, 2016
This is version 162 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.