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Protein

Thrombospondin-related anonymous protein

Gene

TRAP

Organism
Plasmodium falciparum
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding
Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombospondin-related anonymous protein
Gene namesi
Name:TRAP
OrganismiPlasmodium falciparum
Taxonomic identifieri5833 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 496ExtracellularSequence analysisAdd BLAST471
Transmembranei497 – 515HelicalSequence analysisAdd BLAST19
Topological domaini516 – 559CytoplasmicSequence analysisAdd BLAST44

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Keywords - Diseasei

Malaria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000002462926 – 559Thrombospondin-related anonymous proteinAdd BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki77Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in Factor 3(A))Sequence analysis
Cross-linki78Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in Factor 3(A))Sequence analysis
Glycosylationi132N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi244 ↔ 273PROSITE-ProRule annotation1 Publication
Disulfide bondi253 ↔ 281PROSITE-ProRule annotation1 Publication
Disulfide bondi257 ↔ 286PROSITE-ProRule annotation1 Publication
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi460N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi468N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond

Proteomic databases

PRIDEiP16893.

Expressioni

Developmental stagei

Expressed during erythrocytic stage of life cycle.

Structurei

Secondary structure

1559
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi254 – 265Combined sources12
Beta strandi276 – 280Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BBXNMR-A242-288[»]
ProteinModelPortaliP16893.
SMRiP16893.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16893.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 234VWFAPROSITE-ProRule annotationAdd BLAST187
Domaini241 – 287TSP type-1PROSITE-ProRule annotationAdd BLAST47

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi307 – 309Cell attachment site3

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.20.100.10. 1 hit.
3.40.50.410. 1 hit.
InterProiView protein in InterPro
IPR000884. TSP1_rpt.
IPR002035. VWF_A.
PfamiView protein in Pfam
PF00090. TSP_1. 1 hit.
PF00092. VWA. 1 hit.
SMARTiView protein in SMART
SM00209. TSP1. 1 hit.
SM00327. VWA. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiView protein in PROSITE
PS50092. TSP1. 1 hit.
PS50234. VWFA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHLGNVKYL VIVFLIFFDL FLVNGRDVQN NIVDEIKYSE EVCNDQVDLY
60 70 80 90 100
LLMDCSGSIR RHNWVNHAVP LAMKLIQQLN LNDNAIHLYV NVFSNNAKEI
110 120 130 140 150
IRLHSDASKN KEKALIIIRS LLSTNLPYGR TNLTDALLQV RKHLNDRINR
160 170 180 190 200
ENANQLVVIL TDGIPDSIQD SLKESRKLSD RGVKIAVFGI GQGINVAFNR
210 220 230 240 250
FLVGCHPSDG KCNLYADSAW ENVKNVIGPF MKAVCVEVEK TASCGVWDEW
260 270 280 290 300
SPCSVTCGKG TRSRKREILH EGCTSEIQEQ CEEERCPPKW EPLDVPDEPE
310 320 330 340 350
DDQPRPRGDN SSVQKPEENI IDNNPQEPSP NPEEGKDENP NGFDLDENPE
360 370 380 390 400
NPPNPDIPEQ KPNIPEDSEK EVPSDVPKNP EDDREENFDI PKKPENKHDN
410 420 430 440 450
QNNLPNDKSD RNIPYSPLPP KVLDNERKQS DPQSQDNNGN RHVPNSEDRE
460 470 480 490 500
TRPHGRNNEN RSYNRKYNDT PKHPEREEHE KPDNNKKKGE SDNKYKIAGG
510 520 530 540 550
IAGGLALLAC AGLAYKFVVP GAATPYAGEP APFDETLGEE DKDLDEPEQF

RLPEENEWN
Length:559
Mass (Da):63,300
Last modified:August 1, 1990 - v1
Checksum:i02A20164D198C37A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13022 Genomic DNA. Translation: CAA31440.1.
PIRiS04531.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTRAP_PLAFA
AccessioniPrimary (citable) accession number: P16893
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 10, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references