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Protein

Thrombospondin-related anonymous protein

Gene

TRAP

Organism
Plasmodium falciparum
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombospondin-related anonymous protein
Gene namesi
Name:TRAP
OrganismiPlasmodium falciparum
Taxonomic identifieri5833 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 496471ExtracellularSequence analysisAdd
BLAST
Transmembranei497 – 51519HelicalSequence analysisAdd
BLAST
Topological domaini516 – 55944CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Keywords - Diseasei

Malaria

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 559534Thrombospondin-related anonymous proteinPRO_0000024629Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki77 – 77Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in Factor 3(A))Sequence analysis
Cross-linki78 – 78Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in Factor 3(A))Sequence analysis
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence analysis
Disulfide bondi244 ↔ 273PROSITE-ProRule annotation1 Publication
Disulfide bondi253 ↔ 281PROSITE-ProRule annotation1 Publication
Disulfide bondi257 ↔ 286PROSITE-ProRule annotation1 Publication
Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence analysis
Glycosylationi460 – 4601N-linked (GlcNAc...)Sequence analysis
Glycosylationi468 – 4681N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond

Expressioni

Developmental stagei

Expressed during erythrocytic stage of life cycle.

Structurei

Secondary structure

1
559
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi254 – 26512Combined sources
Beta strandi276 – 2805Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BBXNMR-A242-288[»]
ProteinModelPortaliP16893.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16893.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 234187VWFAPROSITE-ProRule annotationAdd
BLAST
Domaini241 – 28747TSP type-1PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi307 – 3093Cell attachment site

Sequence similaritiesi

Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR000884. TSP1_rpt.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00090. TSP_1. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00209. TSP1. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS50092. TSP1. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHLGNVKYL VIVFLIFFDL FLVNGRDVQN NIVDEIKYSE EVCNDQVDLY
60 70 80 90 100
LLMDCSGSIR RHNWVNHAVP LAMKLIQQLN LNDNAIHLYV NVFSNNAKEI
110 120 130 140 150
IRLHSDASKN KEKALIIIRS LLSTNLPYGR TNLTDALLQV RKHLNDRINR
160 170 180 190 200
ENANQLVVIL TDGIPDSIQD SLKESRKLSD RGVKIAVFGI GQGINVAFNR
210 220 230 240 250
FLVGCHPSDG KCNLYADSAW ENVKNVIGPF MKAVCVEVEK TASCGVWDEW
260 270 280 290 300
SPCSVTCGKG TRSRKREILH EGCTSEIQEQ CEEERCPPKW EPLDVPDEPE
310 320 330 340 350
DDQPRPRGDN SSVQKPEENI IDNNPQEPSP NPEEGKDENP NGFDLDENPE
360 370 380 390 400
NPPNPDIPEQ KPNIPEDSEK EVPSDVPKNP EDDREENFDI PKKPENKHDN
410 420 430 440 450
QNNLPNDKSD RNIPYSPLPP KVLDNERKQS DPQSQDNNGN RHVPNSEDRE
460 470 480 490 500
TRPHGRNNEN RSYNRKYNDT PKHPEREEHE KPDNNKKKGE SDNKYKIAGG
510 520 530 540 550
IAGGLALLAC AGLAYKFVVP GAATPYAGEP APFDETLGEE DKDLDEPEQF

RLPEENEWN
Length:559
Mass (Da):63,300
Last modified:August 1, 1990 - v1
Checksum:i02A20164D198C37A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13022 Genomic DNA. Translation: CAA31440.1.
PIRiS04531.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13022 Genomic DNA. Translation: CAA31440.1.
PIRiS04531.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BBXNMR-A242-288[»]
ProteinModelPortaliP16893.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP16893.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR000884. TSP1_rpt.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00090. TSP_1. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00209. TSP1. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS50092. TSP1. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A highly conserved amino-acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite."
    Robson K.J.H., Hall J.R.S., Jennings M.W., Harris T.J.R., Marsh K., Newbold C.I., Tate V.E., Weatherall D.J.
    Nature 335:79-82(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The layered fold of the TSR domain of P. falciparum TRAP contains a heparin binding site."
    Tossavainen H., Pihlajamaa T., Huttunen T.K., Raulo E., Rauvala H., Permi P., Kilpelainen I.
    Protein Sci. 15:1760-1768(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 241-288, SUBCELLULAR LOCATION, HEPARIN-BINDING, DISULFIDE BONDS.

Entry informationi

Entry nameiTRAP_PLAFA
AccessioniPrimary (citable) accession number: P16893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 11, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.