P16891 (DCUP_SYNE7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	Synpcc7942_1086

Organism

Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP]

Taxonomic identifier

1140 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus › Synechococcus elongatus

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP-Rule MF_00218
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP-Rule MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP-Rule MF_00218
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Uroporphyrinogen decarboxylase HAMAP-Rule MF_00218		PRO_0000187650
Regions
	Region	28 – 32	5	Substrate binding By similarity
Sites
	Binding site	47	1	Substrate By similarity
	Binding site	78	1	Substrate By similarity
	Binding site	155	1	Substrate By similarity
	Binding site	210	1	Substrate By similarity
	Binding site	325	1	Substrate By similarity
	Site	78	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	P16891 [UniParc]. Last modified April 1, 1993. Version 2. Checksum: 3F6846658734C1E9	FASTA	354	39,278
	10 20 30 40 50 60 MVASSSLPRL LRAARGEVLD RPPVWMMRQA GRYMKVYRDL RDKYPGFRER SETPELAIEI 70 80 90 100 110 120 SLQPFRAFKP DGVILFSDIL TPLPGMGIPF DIIESKGPIL EPPIRTAEQV AAVHDLDPEE 130 140 150 160 170 180 ATPFIRPILE TLRQEVGNEA AVLGFAGAPW TLAAYAIEGK SSKTYANIKH LAFSEPTILH 190 200 210 220 230 240 ELLGKLADNI AIYLCHQIDC GAQVVQLFDS WAGQLSPIDY DTFALPYQQR VFQQVKAKHP 250 260 270 280 290 300 EVPLILYISG SAGVLERMGQ SGCDIVSVDW TVDLLDARRR LGPDIGLQGN IDPGVLFGSQ 310 320 330 340 350 DFIRDRILDT VRKAGNQRHI LNLGHGILPG TPEDNARHFF ETAKNLDQLL AASH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the Synechococcus sp. PCC7942 hemE gene encoding the homologue of mammalian uroporphyrinogen decarboxylase." Kiel J.A.K.W., ten Berge A.M., Venema G. DNA Seq. 2:415-418(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7942.
[3]	"Nucleotide sequence of the Synechococcus sp. PCC7942 branching enzyme gene (glgB): expression in Bacillus subtilis." Kiel J.A.K.W., Boels J.M., Beldman G., Venema G. Gene 89:77-84(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-79.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z11705 Genomic DNA. Translation: CAA77766.1. CP000100 Genomic DNA. Translation: ABB57116.1. M31544 Genomic DNA. Translation: AAB39039.1.
PIR	A56609.
RefSeq	YP_400103.1. NC_007604.1.
3D structure databases
ProteinModelPortal	P16891.
SMR	P16891. Positions 8-346.
ModBase	Search...
Protein-protein interaction databases
STRING	1140.Synpcc7942_1086.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABB57116; ABB57116; Synpcc7942_1086.
GeneID	3775036.
KEGG	syf:Synpcc7942_1086.
PATRIC	23787449. VBISynElo51371_1255.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0407.
HOGENOM	HOG000253896.
KO	K01599.
ProtClustDB	PRK00115.
Enzyme and pathway databases
BioCyc	SELO1140:GJWQ-1106-MONOMER.
UniPathway	UPA00251; UER00321.
Family and domain databases
HAMAP	MF_00218. URO-D.
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
PANTHER	PTHR21091:SF2. PTHR21091:SF2. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
TIGRFAMs	TIGR01464. hemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_SYNE7

Accession

Primary (citable) accession number: P16891
Secondary accession number(s): Q31PA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	April 1, 1993
Last modified:	May 1, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program