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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Gene

PLCG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei327PROSITE-ProRule annotation1
Active sitei372PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transducer

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciMetaCyc:HS06773-MONOMER.
ZFISH:HS06773-MONOMER.
BRENDAi3.1.4.11. 2681.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-HSA-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-2424491. DAP12 signaling.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-5607764. CLEC7A (Dectin-1) signaling.
R-HSA-5621480. Dectin-2 family.
R-HSA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
SignaLinkiP16885.
SIGNORiP16885.

Chemistry databases

SwissLipidsiSLP:000000647.

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase C-gamma-2
Phospholipase C-IV
Short name:
PLC-IV
Phospholipase C-gamma-2
Short name:
PLC-gamma-2
Gene namesi
Name:PLCG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:9066. PLCG2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Familial cold autoinflammatory syndrome 3 (FCAS3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant immune disorder characterized by the development of cutaneous urticaria, erythema, and pruritis in response to cold exposure. Affected individuals have variable additional immunologic defects, including antibody deficiency, decreased numbers of B-cells, defective B-cells, increased susceptibility to infection, and increased risk of autoimmune disorders.
See also OMIM:614468
Autoinflammation, antibody deficiency, and immune dysregulation PLCG2-associated (APLAID)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant systemic disorder characterized by recurrent blistering skin lesions with a dense inflammatory infiltrate and variable involvement of other tissues, including joints, the eye, and the gastrointestinal tract. Affected individuals have a mild humoral immune deficiency associated with recurrent sinopulmonary infections, but no evidence of circulating autoantibodies.
See also OMIM:614878
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069211707S → Y in APLAID; results in increased epidermal growth factor-stimulated production of intracellular IP3 and increased intracellular calcium release; is a hypermorphic mutation. 1 PublicationCorresponds to variant rs397514562dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi5336.
MalaCardsiPLCG2.
MIMi614468. phenotype.
614878. phenotype.
OpenTargetsiENSG00000197943.
Orphaneti324530. Autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation.
300359. PLCG2-associated antibody deficiency and immune dysregulation.
PharmGKBiPA33393.

Chemistry databases

ChEMBLiCHEMBL4100.
GuidetoPHARMACOLOGYi1408.

Polymorphism and mutation databases

BioMutaiPLCG2.
DMDMi215274231.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000885011 – 12651-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2Add BLAST1265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei753Phosphotyrosine; by BTKCombined sources2 Publications1
Modified residuei759Phosphotyrosine; by BTKCombined sources2 Publications1
Modified residuei1197Phosphotyrosine; by BTKBy similarity1
Modified residuei1217PhosphotyrosineCombined sources1
Modified residuei1245PhosphotyrosineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues by CSF1R (By similarity). Phosphorylated on tyrosine residues by BTK and SYK; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity.By similarity2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP16885.
MaxQBiP16885.
PaxDbiP16885.
PeptideAtlasiP16885.
PRIDEiP16885.

PTM databases

iPTMnetiP16885.
PhosphoSitePlusiP16885.

Expressioni

Gene expression databases

BgeeiENSG00000197943.
CleanExiHS_PLCG2.
ExpressionAtlasiP16885. baseline and differential.
GenevisibleiP16885. HS.

Organism-specific databases

HPAiCAB004280.
HPA020099.
HPA020100.

Interactioni

Subunit structurei

Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ARP102756EBI-617403,EBI-608057
EGFRP005335EBI-617403,EBI-297353
EPORP192353EBI-617403,EBI-617321
ERBB2P046263EBI-617403,EBI-641062
FSBPO95073-22EBI-617403,EBI-10696047
GAB1Q1348015EBI-617403,EBI-517684
KITP107218EBI-617403,EBI-1379503
PIK3R1P279862EBI-617403,EBI-79464
PSMD3O432422EBI-617403,EBI-357622
SH2D1BO147962EBI-617403,EBI-3923013

Protein-protein interaction databases

BioGridi111352. 41 interactors.
IntActiP16885. 37 interactors.
MINTiMINT-1199011.
STRINGi9606.ENSP00000352336.

Chemistry databases

BindingDBiP16885.

Structurei

Secondary structure

11265
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi478 – 485Combined sources8
Turni486 – 489Combined sources4
Beta strandi490 – 499Combined sources10
Beta strandi502 – 505Combined sources4
Helixi509 – 514Combined sources6
Beta strandi850 – 854Combined sources5
Helixi855 – 857Combined sources3
Beta strandi858 – 862Combined sources5
Beta strandi867 – 869Combined sources3
Beta strandi870 – 882Combined sources13
Beta strandi886 – 892Combined sources7
Helixi893 – 907Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K2JNMR-A471-913[»]
2W2WX-ray3.30A/B/C/D/E/F/G/H/I/J/K/L471-913[»]
2W2XX-ray2.30C/D471-913[»]
ProteinModelPortaliP16885.
SMRiP16885.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16885.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 131PHPROSITE-ProRule annotationAdd BLAST112
Domaini312 – 456PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST145
Domaini532 – 635SH2 1PROSITE-ProRule annotationAdd BLAST104
Domaini646 – 735SH2 2PROSITE-ProRule annotationAdd BLAST90
Domaini769 – 829SH3PROSITE-ProRule annotationAdd BLAST61
Domaini930 – 1044PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST115
Domaini1059 – 1152C2PROSITE-ProRule annotationAdd BLAST94

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation
Contains 1 PI-PLC Y-box domain.PROSITE-ProRule annotation
Contains 2 SH2 domains.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG1264. Eukaryota.
ENOG410XPXE. LUCA.
GeneTreeiENSGT00730000110782.
HOGENOMiHOG000230864.
HOVERGENiHBG053611.
InParanoidiP16885.
KOiK05859.
OMAiMLMRIPR.
OrthoDBiEOG091G07R3.
PhylomeDBiP16885.
TreeFamiTF313216.

Family and domain databases

Gene3Di2.30.29.30. 3 hits.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
3.30.505.10. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR016279. PLC-gamma.
IPR028381. PLC-gamma2.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 2 hits.
PTHR10336:SF25. PTHR10336:SF25. 2 hits.
PfamiPF00168. C2. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF00017. SH2. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000952. PLC-gamma. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 2 hits.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16885-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTVNVDSL AEYEKSQIKR ALELGTVMTV FSFRKSTPER RTVQVIMETR
60 70 80 90 100
QVAWSKTADK IEGFLDIMEI KEIRPGKNSK DFERAKAVRQ KEDCCFTILY
110 120 130 140 150
GTQFVLSTLS LAADSKEDAV NWLSGLKILH QEAMNASTPT IIESWLRKQI
160 170 180 190 200
YSVDQTRRNS ISLRELKTIL PLINFKVSSA KFLKDKFVEI GAHKDELSFE
210 220 230 240 250
QFHLFYKKLM FEQQKSILDE FKKDSSVFIL GNTDRPDASA VYLHDFQRFL
260 270 280 290 300
IHEQQEHWAQ DLNKVRERMT KFIDDTMRET AEPFLFVDEF LTYLFSRENS
310 320 330 340 350
IWDEKYDAVD MQDMNNPLSH YWISSSHNTY LTGDQLRSES SPEAYIRCLR
360 370 380 390 400
MGCRCIELDC WDGPDGKPVI YHGWTRTTKI KFDDVVQAIK DHAFVTSSFP
410 420 430 440 450
VILSIEEHCS VEQQRHMAKA FKEVFGDLLL TKPTEASADQ LPSPSQLREK
460 470 480 490 500
IIIKHKKLGP RGDVDVNMED KKDEHKQQGE LYMWDSIDQK WTRHYCAIAD
510 520 530 540 550
AKLSFSDDIE QTMEEEVPQD IPPTELHFGE KWFHKKVEKR TSAEKLLQEY
560 570 580 590 600
CMETGGKDGT FLVRESETFP NDYTLSFWRS GRVQHCRIRS TMEGGTLKYY
610 620 630 640 650
LTDNLTFSSI YALIQHYRET HLRCAEFELR LTDPVPNPNP HESKPWYYDS
660 670 680 690 700
LSRGEAEDML MRIPRDGAFL IRKREGSDSY AITFRARGKV KHCRINRDGR
710 720 730 740 750
HFVLGTSAYF ESLVELVSYY EKHSLYRKMR LRYPVTPELL ERYNMERDIN
760 770 780 790 800
SLYDVSRMYV DPSEINPSMP QRTVKALYDY KAKRSDELSF CRGALIHNVS
810 820 830 840 850
KEPGGWWKGD YGTRIQQYFP SNYVEDISTA DFEELEKQII EDNPLGSLCR
860 870 880 890 900
GILDLNTYNV VKAPQGKNQK SFVFILEPKQ QGDPPVEFAT DRVEELFEWF
910 920 930 940 950
QSIREITWKI DTKENNMKYW EKNQSIAIEL SDLVVYCKPT SKTKDNLENP
960 970 980 990 1000
DFREIRSFVE TKADSIIRQK PVDLLKYNQK GLTRVYPKGQ RVDSSNYDPF
1010 1020 1030 1040 1050
RLWLCGSQMV ALNFQTADKY MQMNHALFSL NGRTGYVLQP ESMRTEKYDP
1060 1070 1080 1090 1100
MPPESQRKIL MTLTVKVLGA RHLPKLGRSI ACPFVEVEIC GAEYDNNKFK
1110 1120 1130 1140 1150
TTVVNDNGLS PIWAPTQEKV TFEIYDPNLA FLRFVVYEED MFSDPNFLAH
1160 1170 1180 1190 1200
ATYPIKAVKS GFRSVPLKNG YSEDIELASL LVFCEMRPVL ESEEELYSSC
1210 1220 1230 1240 1250
RQLRRRQEEL NNQLFLYDTH QNLRNANRDA LVKEFSVNEN QLQLYQEKCN
1260
KRLREKRVSN SKFYS
Length:1,265
Mass (Da):147,870
Last modified:November 25, 2008 - v4
Checksum:i1D56BCBF51D7A0D3
GO

Sequence cautioni

The sequence AAA60112 differs from that shown. Reason: Frameshift at position 1242.Curated
The sequence AAQ76815 differs from that shown. Reason: Frameshift at position 1242.Curated
The sequence BAD92151 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA32194 differs from that shown. Reason: Frameshift at position 1242.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti606 – 610TFSSI → RFRRM in CAA32194 (PubMed:2849563).Curated5
Sequence conflicti606 – 610TFSSI → RFRRM in AAA60112 (PubMed:2849563).Curated5
Sequence conflicti606 – 610TFSSI → RFRRM in AAQ76815 (PubMed:16533400).Curated5
Sequence conflicti623R → P in AAA60112 (PubMed:2849563).Curated1
Sequence conflicti623R → P in CAA32194 (PubMed:2849563).Curated1
Sequence conflicti623R → P in AAQ76815 (PubMed:16533400).Curated1
Sequence conflicti745M → T in AAA60112 (PubMed:2849563).Curated1
Sequence conflicti745M → T in CAA32194 (PubMed:2849563).Curated1
Sequence conflicti745M → T in AAQ76815 (PubMed:16533400).Curated1
Sequence conflicti880Q → E in AAA60112 (PubMed:2849563).Curated1
Sequence conflicti880Q → E in CAA32194 (PubMed:2849563).Curated1
Sequence conflicti880Q → E in AAQ76815 (PubMed:16533400).Curated1
Sequence conflicti912T → S in AAA60112 (PubMed:2849563).Curated1
Sequence conflicti912T → S in CAA32194 (PubMed:2849563).Curated1
Sequence conflicti912T → S in AAQ76815 (PubMed:16533400).Curated1
Sequence conflicti1095D → G in AAA60112 (PubMed:2849563).Curated1
Sequence conflicti1095D → G in CAA32194 (PubMed:2849563).Curated1
Sequence conflicti1095D → G in AAQ76815 (PubMed:16533400).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031560244H → R.1 PublicationCorresponds to variant rs11548656dbSNPEnsembl.1
Natural variantiVAR_031561268R → W.Corresponds to variant rs1143687dbSNPEnsembl.1
Natural variantiVAR_047427541T → A.Corresponds to variant rs11548657dbSNPEnsembl.1
Natural variantiVAR_074310665R → W Found in patients with chronic lymphocytic leukemia; associated with BTK mutation S-481; unknown pathological significance; results in resistance to ibrutinib therapy. 1 Publication1
Natural variantiVAR_069211707S → Y in APLAID; results in increased epidermal growth factor-stimulated production of intracellular IP3 and increased intracellular calcium release; is a hypermorphic mutation. 1 PublicationCorresponds to variant rs397514562dbSNPEnsembl.1
Natural variantiVAR_074311845L → F Found in patients with chronic lymphocytic leukemia; associated with BTK mutation S-481; unknown pathological significance; results in resistance to ibrutinib therapy. 1 Publication1
Natural variantiVAR_047428883D → Y.1 PublicationCorresponds to variant rs17856213dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37238 mRNA. Translation: AAA60112.1. Frameshift.
X14034 mRNA. Translation: CAA32194.1. Frameshift.
AB208914 mRNA. Translation: BAD92151.1. Different initiation.
AY364256 mRNA. Translation: AAQ76815.1. Frameshift.
AC092142 Genomic DNA. No translation available.
AC098966 Genomic DNA. No translation available.
AC099524 Genomic DNA. No translation available.
CH471114 Genomic DNA. Translation: EAW95524.1.
CH471114 Genomic DNA. Translation: EAW95525.1.
BC007565 mRNA. Translation: AAH07565.1.
BC011772 mRNA. Translation: AAH11772.1.
BC014561 mRNA. Translation: AAH14561.1.
BC018646 mRNA. Translation: AAH18646.1.
CCDSiCCDS42204.1.
PIRiS02004.
RefSeqiNP_002652.2. NM_002661.4.
UniGeneiHs.372303.
Hs.413111.
Hs.586906.

Genome annotation databases

EnsembliENST00000564138; ENSP00000482457; ENSG00000197943.
GeneIDi5336.
KEGGihsa:5336.
UCSCiuc002fgt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37238 mRNA. Translation: AAA60112.1. Frameshift.
X14034 mRNA. Translation: CAA32194.1. Frameshift.
AB208914 mRNA. Translation: BAD92151.1. Different initiation.
AY364256 mRNA. Translation: AAQ76815.1. Frameshift.
AC092142 Genomic DNA. No translation available.
AC098966 Genomic DNA. No translation available.
AC099524 Genomic DNA. No translation available.
CH471114 Genomic DNA. Translation: EAW95524.1.
CH471114 Genomic DNA. Translation: EAW95525.1.
BC007565 mRNA. Translation: AAH07565.1.
BC011772 mRNA. Translation: AAH11772.1.
BC014561 mRNA. Translation: AAH14561.1.
BC018646 mRNA. Translation: AAH18646.1.
CCDSiCCDS42204.1.
PIRiS02004.
RefSeqiNP_002652.2. NM_002661.4.
UniGeneiHs.372303.
Hs.413111.
Hs.586906.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K2JNMR-A471-913[»]
2W2WX-ray3.30A/B/C/D/E/F/G/H/I/J/K/L471-913[»]
2W2XX-ray2.30C/D471-913[»]
ProteinModelPortaliP16885.
SMRiP16885.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111352. 41 interactors.
IntActiP16885. 37 interactors.
MINTiMINT-1199011.
STRINGi9606.ENSP00000352336.

Chemistry databases

BindingDBiP16885.
ChEMBLiCHEMBL4100.
GuidetoPHARMACOLOGYi1408.
SwissLipidsiSLP:000000647.

PTM databases

iPTMnetiP16885.
PhosphoSitePlusiP16885.

Polymorphism and mutation databases

BioMutaiPLCG2.
DMDMi215274231.

Proteomic databases

EPDiP16885.
MaxQBiP16885.
PaxDbiP16885.
PeptideAtlasiP16885.
PRIDEiP16885.

Protocols and materials databases

DNASUi5336.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000564138; ENSP00000482457; ENSG00000197943.
GeneIDi5336.
KEGGihsa:5336.
UCSCiuc002fgt.4. human.

Organism-specific databases

CTDi5336.
DisGeNETi5336.
GeneCardsiPLCG2.
HGNCiHGNC:9066. PLCG2.
HPAiCAB004280.
HPA020099.
HPA020100.
MalaCardsiPLCG2.
MIMi600220. gene.
614468. phenotype.
614878. phenotype.
neXtProtiNX_P16885.
OpenTargetsiENSG00000197943.
Orphaneti324530. Autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation.
300359. PLCG2-associated antibody deficiency and immune dysregulation.
PharmGKBiPA33393.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1264. Eukaryota.
ENOG410XPXE. LUCA.
GeneTreeiENSGT00730000110782.
HOGENOMiHOG000230864.
HOVERGENiHBG053611.
InParanoidiP16885.
KOiK05859.
OMAiMLMRIPR.
OrthoDBiEOG091G07R3.
PhylomeDBiP16885.
TreeFamiTF313216.

Enzyme and pathway databases

BioCyciMetaCyc:HS06773-MONOMER.
ZFISH:HS06773-MONOMER.
BRENDAi3.1.4.11. 2681.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-HSA-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-2424491. DAP12 signaling.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-5607764. CLEC7A (Dectin-1) signaling.
R-HSA-5621480. Dectin-2 family.
R-HSA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
SignaLinkiP16885.
SIGNORiP16885.

Miscellaneous databases

EvolutionaryTraceiP16885.
GeneWikiiPLCG2.
GenomeRNAii5336.
PROiP16885.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197943.
CleanExiHS_PLCG2.
ExpressionAtlasiP16885. baseline and differential.
GenevisibleiP16885. HS.

Family and domain databases

Gene3Di2.30.29.30. 3 hits.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
3.30.505.10. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR016279. PLC-gamma.
IPR028381. PLC-gamma2.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 2 hits.
PTHR10336:SF25. PTHR10336:SF25. 2 hits.
PfamiPF00168. C2. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF00017. SH2. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000952. PLC-gamma. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 2 hits.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLCG2_HUMAN
AccessioniPrimary (citable) accession number: P16885
Secondary accession number(s): D3DUL3
, Q3ZTS2, Q59H45, Q969T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 198 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.