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Reviewed, UniProtKB/Swiss-Prot P16879 (FES_MOUSE)

Last modified November 3, 2009. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Proto-oncogene tyrosine-protein kinase Fes/Fps
      Short name=C-Fes
    EC=2.7.10.2
Gene names
Name: Fes
Synonyms: Fps
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length822 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Disruption phenotype

Mice are fertile and healthy, display slightly reduced numbers of myeloid cells and are more sensitive to lipopolysaccharide (LPS). Ref.2

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.

Contains 1 FCH domain.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 822822Proto-oncogene tyrosine-protein kinase Fes/Fps
PRO_0000088089

Regions

Domain1 – 9696FCH
Domain460 – 54990SH2
Domain561 – 818258Protein kinase
Nucleotide binding567 – 5759ATP By similarity

Sites

Active site6831Proton acceptor By similarity
Binding site5901ATP By similarity

Amino acid modifications

Modified residue7131Phosphotyrosine; by autocatalysis Ref.6

Experimental info

Sequence conflict110 – 1112QH → HS in CAA31138. Ref.1
Sequence conflict413 – 4142Missing in CAA31138. Ref.1
Sequence conflict413 – 4142Missing in AAN33122. Ref.2
Sequence conflict4671R → W in CAA31138. Ref.1
Sequence conflict4771S → T in CAA31138. Ref.1
Sequence conflict4771S → T in AAN33122. Ref.2
Sequence conflict5001Q → H in CAA31138. Ref.1
Sequence conflict5001Q → H in AAN33122. Ref.2
Sequence conflict5091S → L in CAA31138. Ref.1
Sequence conflict5091S → L in AAN33122. Ref.2
Sequence conflict6641V → M in CAA31138. Ref.1
Sequence conflict716 – 7172SA → CS in CAA31138. Ref.1
Sequence conflict716 – 7172SA → CS in AAA40012. Ref.5
Sequence conflict7491L → P in AAA40012. Ref.5

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Sequences

Sequence LengthMass (Da)Tools
P16879-1 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: 939280C56ACF25EE

FASTA82293,779
        10         20         30         40         50         60 
MGFSSELCSP QGHGAVQQMQ EAELRLLEGM RKWMAQRVKS DREYAGLLHH MSLQDSGGQS 

        70         80         90        100        110        120 
WSSGPDSPVS QSWAEITSQT ENLSRVLRQH AEDLNSGPLS KLSVLIRERQ HLRKTYNEQW 

       130        140        150        160        170        180 
QQLQQELTKT HSQDIEKLKT QYRTLVRDST QARRKYQEAS KDKDRDKAKD KYVRSLWKLF 

       190        200        210        220        230        240 
AHHNRYVLGV RAAQLHHHHH HRFMLPGLLQ SLQDLHEEMA GILKDILQEY LEISSLVQDD 

       250        260        270        280        290        300 
VASIHRELAA AAARIQPEFE YLGFLRQYGS TPDVPPCVTF DESLLEDGEQ LEPGELQLNE 

       310        320        330        340        350        360 
LTLESVQHTL TSVTDELAVA TKEVLSRQEM VSQLQRELQS EEQNTHPRER VQLLSKRQML 

       370        380        390        400        410        420 
QEAIQGLQIA LCSQDKLQAQ QELLQSKMEQ LGTGEPPAVP LLQDDRHSTS STEQEREGGR 

       430        440        450        460        470        480 
TPTLEILKSH FSGIFRPKFS IPPPLQLVPE VQKPLYEQLW YHGAIPRAEV AELLTHSGDF 

       490        500        510        520        530        540 
LVRESQGKQE YVLSVMWDGQ PRHFIIQSSD NLYRLEGDGF PSIPLLITHL LSSQQPLTKK 

       550        560        570        580        590        600 
SGVVLFRAVP KDKWVLKHED LVLGEQIGRG NFGEVFSGRL RADNTPVAVK SCRETLPPDL 

       610        620        630        640        650        660 
KAKFLQEARI LKQYNHPNIV RLIGVCTQKQ PIYIVMELVQ GGDFLTFLRT EGARLRVKTL 

       670        680        690        700        710        720 
LQMVGDAAAG MEYLESKCCI HRDLAARNCL VTEKNVLKIS DFGMSREEAD GIYAASAGLR 

       730        740        750        760        770        780 
QVPVKWTAPE ALNYGRYSSE SDVWSFGILL WETFSLGASP YPNLTNQQTR EFVEKGHRLP 

       790        800        810        820 
CPELCPDAVF RLMEQCWAYE PGQRPSFSII CQELHSIRKR HR

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References

« Hide 'large scale' references
[1]"Isolation and structural analysis of murine c-fes cDNA clones."
Wilks A.F., Kurban R.R.
Oncogene 3:289-294(1988) [PubMed: 3060793] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Enhanced endotoxin sensitivity in fps/fes-null mice with minimal defects in hematopoietic homeostasis."
Zirngibl R.A., Senis Y., Greer P.A.
Mol. Cell. Biol. 22:2472-2486(2002) [PubMed: 11909942] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISRUPTION PHENOTYPE.
Strain: 129/SvJ.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Spleen.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family."
Wilks A.F., Kurban R.R., Hovens C.M., Ralph S.J.
Gene 85:67-74(1989) [PubMed: 2482828] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 680-749.
[6]"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
J. Immunol. 179:5864-5876(2007) [PubMed: 17947660] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-713, MASS SPECTROMETRY.
Tissue: Mast cell.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X12616 mRNA. Translation: CAA31138.1.
AF542394 Genomic DNA. Translation: AAN33122.1.
M33421 mRNA. Translation: AAA40012.1.
AK143639 mRNA. Translation: BAE25475.1.
AK170418 mRNA. Translation: BAE41784.1.
BC129919 mRNA. Translation: AAI29920.1.
IPIIPI00109075.
PIRI48347.
RefSeqNP_034324.2.
UniGeneMm.48757

3D structure databases

HSSPHSSP built from PDB template 1FGK based on UniProtKB P11362.
ModBaseSearch...

Protein-protein interaction databases

STRINGP16879.

PTM databases

PhosphoSiteP16879.

Proteomic databases

PRIDEP16879.

Genome annotation databases

EnsemblENSMUST00000080932; ENSMUSP00000079733; ENSMUSG00000053158; Mus musculus. [Genome view]
GeneID14159.
KEGGmmu:14159.
UCSCuc009ias.1. mouse.

Organism-specific databases

CTD14159.
MGIMGI:95514. Fes.

Phylogenomic databases

HOVERGENP16879.
OMACWAYEPG.

Enzyme and pathway databases

BRENDA2.7.10.2. 244.

Gene expression databases

ArrayExpressP16879.
BgeeP16879.
CleanExMM_FES.
GenevestigatorP16879.
GermOnlineENSMUSG00000053158. Mus musculus.

Family and domain databases

InterProIPR001060. FCH.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR000980. SH2.
IPR001245. Tyr_pkinase.
IPR008266. Tyr_pkinase_AS.
[Graphical view]
Gene3DG3DSA:3.30.505.10. SH2. 1 hit.
PfamPF00611. FCH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
ProDomPD000001. Prot_kinase. 1 hit.
PD000093. SH2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00055. FCH. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
PROSITEPS50133. FCH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio285286.
SOURCESearch...

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Entry information

Entry nameFES_MOUSE
AccessionPrimary (citable) accession number: P16879
Secondary accession number(s): Q3TD20, Q62122, Q8CG02
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 15, 2008
Last modified: November 3, 2009
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents