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P16872

- IL7RA_MOUSE

UniProt

P16872 - IL7RA_MOUSE

Protein

Interleukin-7 receptor subunit alpha

Gene

Il7r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

    GO - Molecular functioni

    1. cytokine receptor activity Source: InterPro

    GO - Biological processi

    1. B cell proliferation Source: MGI
    2. cell growth Source: MGI
    3. cell morphogenesis Source: MGI
    4. homeostasis of number of cells Source: MGI
    5. immunoglobulin production Source: MGI
    6. lymph node development Source: MGI
    7. negative regulation of T cell mediated cytotoxicity Source: MGI
    8. positive regulation of gene expression Source: MGI
    9. positive regulation of T cell differentiation in thymus Source: MGI
    10. regulation of cell size Source: MGI
    11. T cell differentiation Source: MGI

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_198701. Interleukin-7 signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-7 receptor subunit alpha
    Short name:
    IL-7 receptor subunit alpha
    Short name:
    IL-7R subunit alpha
    Short name:
    IL-7R-alpha
    Short name:
    IL-7RA
    Alternative name(s):
    CD_antigen: CD127
    Gene namesi
    Name:Il7r
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:96562. Il7r.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Add
    BLAST
    Chaini21 – 459439Interleukin-7 receptor subunit alphaPRO_0000010910Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi42 ↔ 57By similarity
    Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi74 ↔ 82By similarity
    Disulfide bondi108 ↔ 118By similarity
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
    Modified residuei282 – 2821Phosphothreonine; by PKCSequence Analysis

    Post-translational modificationi

    N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiP16872.

    PTM databases

    PhosphoSiteiP16872.

    Expressioni

    Tissue specificityi

    Spleen, thymus and fetal liver.

    Gene expression databases

    ArrayExpressiP16872.
    BgeeiP16872.
    CleanExiMM_IL7R.
    GenevestigatoriP16872.

    Interactioni

    Subunit structurei

    The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

    Protein-protein interaction databases

    DIPiDIP-59472N.
    STRINGi10090.ENSMUSP00000003981.

    Structurei

    Secondary structure

    1
    459
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi40 – 5112
    Beta strandi53 – 608
    Beta strandi69 – 7911
    Beta strandi81 – 844
    Beta strandi86 – 883
    Beta strandi91 – 977
    Beta strandi101 – 1033
    Beta strandi105 – 1117
    Beta strandi114 – 1218
    Helixi123 – 1253
    Beta strandi126 – 1283
    Beta strandi133 – 1408
    Turni141 – 1444
    Beta strandi145 – 1517
    Helixi153 – 1564
    Beta strandi157 – 1593
    Beta strandi163 – 17412
    Beta strandi179 – 19113
    Helixi192 – 1943
    Beta strandi200 – 20910
    Beta strandi225 – 2284

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4NN5X-ray1.90B21-239[»]
    4NN6X-ray2.54B21-239[»]
    4NN7X-ray3.78B21-239[»]
    ProteinModelPortaliP16872.
    SMRiP16872. Positions 36-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 239219ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini265 – 459195CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei240 – 26425HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini131 – 232102Fibronectin type-IIIPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi218 – 2225WSXWS motif
    Motifi272 – 2809Box 1 motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi184 – 1896Ser/Thr-rich

    Domaini

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.

    Sequence similaritiesi

    Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39823.
    GeneTreeiENSGT00510000048500.
    HOGENOMiHOG000089950.
    HOVERGENiHBG055773.
    InParanoidiQ9R0C1.
    KOiK05072.
    OMAiMYEIKVR.
    OrthoDBiEOG7SJD5X.
    TreeFamiTF336573.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR003531. Hempt_rcpt_S_F1_CS.
    IPR013783. Ig-like_fold.
    [Graphical view]
    PfamiPF00041. fn3. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    PROSITEiPS50853. FN3. 1 hit.
    PS01355. HEMATOPO_REC_S_F1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P16872-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMALGRAFAI VFCLIQAVSG ESGNAQDGDL EDADADDHSF WCHSQLEVDG    50
    SQHLLTCAFN DSDINTANLE FQICGALLRV KCLTLNKLQD IYFIKTSEFL 100
    LIGSSNICVK LGQKNLTCKN MAINTIVKAE APSDLKVVYR KEANDFLVTF 150
    NAPHLKKKYL KKVKHDVAYR PARGESNWTH VSLFHTRTTI PQRKLRPKAM 200
    YEIKVRSIPH NDYFKGFWSE WSPSSTFETP EPKNQGGWDP VLPSVTILSL 250
    FSVFLLVILA HVLWKKRIKP VVWPSLPDHK KTLEQLCKKP KTSLNVSFNP 300
    ESFLDCQIHE VKGVEARDEV ESFLPNDLPA QPEELETQGH RAAVHSANRS 350
    PETSVSPPET VRRESPLRCL ARNLSTCNAP PLLSSRSPDY RDGDRNRPPV 400
    YQDLLPNSGN TNVPVPVPQP LPFQSGILIP VSQRQPISTS SVLNQEEAYV 450
    TMSSFYQNK 459
    Length:459
    Mass (Da):51,605
    Last modified:July 27, 2011 - v2
    Checksum:i52ADF78C8C01D2EE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti299 – 3024NPES → IPEI in AAA39304. (PubMed:2317865)Curated
    Sequence conflicti322 – 3221S → I in AAA39304. (PubMed:2317865)Curated
    Sequence conflicti431 – 4311V → F in AAA39304. (PubMed:2317865)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29697 mRNA. Translation: AAA39304.1.
    AF078906 mRNA. Translation: AAF06717.1.
    AK042264 mRNA. Translation: BAC31208.1.
    CH466581 Genomic DNA. Translation: EDL03312.1.
    CCDSiCCDS27376.1.
    PIRiD34791.
    RefSeqiNP_032398.3. NM_008372.4.
    UniGeneiMm.389.

    Genome annotation databases

    EnsembliENSMUST00000003981; ENSMUSP00000003981; ENSMUSG00000003882.
    GeneIDi16197.
    KEGGimmu:16197.
    UCSCiuc007vfo.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29697 mRNA. Translation: AAA39304.1 .
    AF078906 mRNA. Translation: AAF06717.1 .
    AK042264 mRNA. Translation: BAC31208.1 .
    CH466581 Genomic DNA. Translation: EDL03312.1 .
    CCDSi CCDS27376.1.
    PIRi D34791.
    RefSeqi NP_032398.3. NM_008372.4.
    UniGenei Mm.389.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4NN5 X-ray 1.90 B 21-239 [» ]
    4NN6 X-ray 2.54 B 21-239 [» ]
    4NN7 X-ray 3.78 B 21-239 [» ]
    ProteinModelPortali P16872.
    SMRi P16872. Positions 36-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59472N.
    STRINGi 10090.ENSMUSP00000003981.

    PTM databases

    PhosphoSitei P16872.

    Proteomic databases

    PRIDEi P16872.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000003981 ; ENSMUSP00000003981 ; ENSMUSG00000003882 .
    GeneIDi 16197.
    KEGGi mmu:16197.
    UCSCi uc007vfo.2. mouse.

    Organism-specific databases

    CTDi 3575.
    MGIi MGI:96562. Il7r.

    Phylogenomic databases

    eggNOGi NOG39823.
    GeneTreei ENSGT00510000048500.
    HOGENOMi HOG000089950.
    HOVERGENi HBG055773.
    InParanoidi Q9R0C1.
    KOi K05072.
    OMAi MYEIKVR.
    OrthoDBi EOG7SJD5X.
    TreeFami TF336573.

    Enzyme and pathway databases

    Reactomei REACT_198701. Interleukin-7 signaling.

    Miscellaneous databases

    ChiTaRSi IL7R. mouse.
    NextBioi 289125.
    PROi P16872.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P16872.
    Bgeei P16872.
    CleanExi MM_IL7R.
    Genevestigatori P16872.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR003531. Hempt_rcpt_S_F1_CS.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    Pfami PF00041. fn3. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    PROSITEi PS50853. FN3. 1 hit.
    PS01355. HEMATOPO_REC_S_F1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily."
      Goodwin R.G., Friend D., Ziegler S.F., Jerzy R., Falk B.A., Gimpel S., Cosman D., Dower S.K., March C.J., Namen A.E., Park L.S.
      Cell 60:941-951(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Restoration of lymphoid populations in a murine model of X-linked severe combined immunodeficiency by a gene-therapy approach."
      Lo M., Bloom M.L., Imada K., Berg M., Bollenbacher J.M., Bloom E.T., Kelsall B.L., Leonard W.J.
      Blood 94:3027-3036(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Thymus.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter."
      Pleiman C.M., Gimpel S.D., Park L.S., Harada H., Taniguchi T., Ziegler S.F.
      Mol. Cell. Biol. 11:3052-3059(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 231-239 AND 264-272.
    6. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiIL7RA_MOUSE
    AccessioniPrimary (citable) accession number: P16872
    Secondary accession number(s): Q9R0C1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3