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Protein

Interleukin-7 receptor subunit alpha

Gene

Il7r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

GO - Molecular functioni

  1. cytokine receptor activity Source: InterPro

GO - Biological processi

  1. B cell proliferation Source: MGI
  2. cell growth Source: MGI
  3. cell morphogenesis Source: MGI
  4. homeostasis of number of cells Source: MGI
  5. immunoglobulin production Source: MGI
  6. lymph node development Source: MGI
  7. negative regulation of T cell mediated cytotoxicity Source: MGI
  8. positive regulation of gene expression Source: MGI
  9. positive regulation of T cell differentiation in thymus Source: MGI
  10. regulation of cell size Source: MGI
  11. T cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_198701. Interleukin-7 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-7 receptor subunit alpha
Short name:
IL-7 receptor subunit alpha
Short name:
IL-7R subunit alpha
Short name:
IL-7R-alpha
Short name:
IL-7RA
Alternative name(s):
CD_antigen: CD127
Gene namesi
Name:Il7r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:96562. Il7r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 239219ExtracellularSequence AnalysisAdd
BLAST
Transmembranei240 – 26425HelicalSequence AnalysisAdd
BLAST
Topological domaini265 – 459195CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 459439Interleukin-7 receptor subunit alphaPRO_0000010910Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 571 Publication
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi74 ↔ 821 Publication
Disulfide bondi108 ↔ 1181 Publication
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
Modified residuei282 – 2821Phosphothreonine; by PKCSequence Analysis

Post-translational modificationi

N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP16872.

PTM databases

PhosphoSiteiP16872.

Expressioni

Tissue specificityi

Spleen, thymus and fetal liver.

Gene expression databases

BgeeiP16872.
CleanExiMM_IL7R.
ExpressionAtlasiP16872. baseline and differential.
GenevestigatoriP16872.

Interactioni

Subunit structurei

The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.1 Publication

Protein-protein interaction databases

DIPiDIP-59472N.
STRINGi10090.ENSMUSP00000003981.

Structurei

Secondary structure

1
459
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi40 – 5112Combined sources
Beta strandi53 – 608Combined sources
Beta strandi69 – 7911Combined sources
Beta strandi81 – 844Combined sources
Beta strandi86 – 883Combined sources
Beta strandi91 – 977Combined sources
Beta strandi101 – 1033Combined sources
Beta strandi105 – 1117Combined sources
Beta strandi114 – 1218Combined sources
Helixi123 – 1253Combined sources
Beta strandi126 – 1283Combined sources
Beta strandi133 – 1408Combined sources
Turni141 – 1444Combined sources
Beta strandi145 – 1517Combined sources
Helixi153 – 1564Combined sources
Beta strandi157 – 1593Combined sources
Beta strandi163 – 17412Combined sources
Beta strandi179 – 19113Combined sources
Helixi192 – 1943Combined sources
Beta strandi200 – 20910Combined sources
Beta strandi225 – 2284Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NN5X-ray1.90B21-239[»]
4NN6X-ray2.54B21-239[»]
4NN7X-ray3.78B21-239[»]
ProteinModelPortaliP16872.
SMRiP16872. Positions 36-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini131 – 232102Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi218 – 2225WSXWS motif
Motifi272 – 2809Box 1 motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi184 – 1896Ser/Thr-rich

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39823.
GeneTreeiENSGT00510000048500.
HOGENOMiHOG000089950.
HOVERGENiHBG055773.
InParanoidiP16872.
KOiK05072.
OMAiMYEIKVR.
OrthoDBiEOG7SJD5X.
TreeFamiTF336573.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16872-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMALGRAFAI VFCLIQAVSG ESGNAQDGDL EDADADDHSF WCHSQLEVDG
60 70 80 90 100
SQHLLTCAFN DSDINTANLE FQICGALLRV KCLTLNKLQD IYFIKTSEFL
110 120 130 140 150
LIGSSNICVK LGQKNLTCKN MAINTIVKAE APSDLKVVYR KEANDFLVTF
160 170 180 190 200
NAPHLKKKYL KKVKHDVAYR PARGESNWTH VSLFHTRTTI PQRKLRPKAM
210 220 230 240 250
YEIKVRSIPH NDYFKGFWSE WSPSSTFETP EPKNQGGWDP VLPSVTILSL
260 270 280 290 300
FSVFLLVILA HVLWKKRIKP VVWPSLPDHK KTLEQLCKKP KTSLNVSFNP
310 320 330 340 350
ESFLDCQIHE VKGVEARDEV ESFLPNDLPA QPEELETQGH RAAVHSANRS
360 370 380 390 400
PETSVSPPET VRRESPLRCL ARNLSTCNAP PLLSSRSPDY RDGDRNRPPV
410 420 430 440 450
YQDLLPNSGN TNVPVPVPQP LPFQSGILIP VSQRQPISTS SVLNQEEAYV

TMSSFYQNK
Length:459
Mass (Da):51,605
Last modified:July 27, 2011 - v2
Checksum:i52ADF78C8C01D2EE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti299 – 3024NPES → IPEI in AAA39304. (PubMed:2317865)Curated
Sequence conflicti322 – 3221S → I in AAA39304. (PubMed:2317865)Curated
Sequence conflicti431 – 4311V → F in AAA39304. (PubMed:2317865)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29697 mRNA. Translation: AAA39304.1.
AF078906 mRNA. Translation: AAF06717.1.
AK042264 mRNA. Translation: BAC31208.1.
CH466581 Genomic DNA. Translation: EDL03312.1.
CCDSiCCDS27376.1.
PIRiD34791.
RefSeqiNP_032398.3. NM_008372.4.
UniGeneiMm.389.

Genome annotation databases

EnsembliENSMUST00000003981; ENSMUSP00000003981; ENSMUSG00000003882.
GeneIDi16197.
KEGGimmu:16197.
UCSCiuc007vfo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29697 mRNA. Translation: AAA39304.1.
AF078906 mRNA. Translation: AAF06717.1.
AK042264 mRNA. Translation: BAC31208.1.
CH466581 Genomic DNA. Translation: EDL03312.1.
CCDSiCCDS27376.1.
PIRiD34791.
RefSeqiNP_032398.3. NM_008372.4.
UniGeneiMm.389.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NN5X-ray1.90B21-239[»]
4NN6X-ray2.54B21-239[»]
4NN7X-ray3.78B21-239[»]
ProteinModelPortaliP16872.
SMRiP16872. Positions 36-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59472N.
STRINGi10090.ENSMUSP00000003981.

PTM databases

PhosphoSiteiP16872.

Proteomic databases

PRIDEiP16872.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003981; ENSMUSP00000003981; ENSMUSG00000003882.
GeneIDi16197.
KEGGimmu:16197.
UCSCiuc007vfo.2. mouse.

Organism-specific databases

CTDi3575.
MGIiMGI:96562. Il7r.

Phylogenomic databases

eggNOGiNOG39823.
GeneTreeiENSGT00510000048500.
HOGENOMiHOG000089950.
HOVERGENiHBG055773.
InParanoidiP16872.
KOiK05072.
OMAiMYEIKVR.
OrthoDBiEOG7SJD5X.
TreeFamiTF336573.

Enzyme and pathway databases

ReactomeiREACT_198701. Interleukin-7 signaling.

Miscellaneous databases

ChiTaRSiIl7r. mouse.
NextBioi289125.
PROiP16872.
SOURCEiSearch...

Gene expression databases

BgeeiP16872.
CleanExiMM_IL7R.
ExpressionAtlasiP16872. baseline and differential.
GenevestigatoriP16872.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily."
    Goodwin R.G., Friend D., Ziegler S.F., Jerzy R., Falk B.A., Gimpel S., Cosman D., Dower S.K., March C.J., Namen A.E., Park L.S.
    Cell 60:941-951(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Restoration of lymphoid populations in a murine model of X-linked severe combined immunodeficiency by a gene-therapy approach."
    Lo M., Bloom M.L., Imada K., Berg M., Bollenbacher J.M., Bloom E.T., Kelsall B.L., Leonard W.J.
    Blood 94:3027-3036(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter."
    Pleiman C.M., Gimpel S.D., Park L.S., Harada H., Taniguchi T., Ziegler S.F.
    Mol. Cell. Biol. 11:3052-3059(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 231-239 AND 264-272.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 21-239 IN COMPLEX WITH CRLF2 AND TSLP, DISULFIDE BONDS.

Entry informationi

Entry nameiIL7RA_MOUSE
AccessioniPrimary (citable) accession number: P16872
Secondary accession number(s): Q9R0C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 27, 2011
Last modified: February 4, 2015
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.