P16872 (IL7RA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-7 receptor subunit alpha
Short name=IL-7 receptor subunit alpha
Short name=IL-7R subunit alpha
Short name=IL-7R-alpha
Short name=IL-7RA

Alternative name(s):
CD_antigen=CD127

Gene names

Name:

Il7r

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	459 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
Subunit structure	The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Spleen, thymus and fetal liver.
Domain	The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation.
Post-translational modification	N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form By similarity.
Sequence similarities	Belongs to the type I cytokine receptor family. Type 4 subfamily. Contains 1 fibronectin type-III domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	B cell proliferation Inferred from mutant phenotype PubMed 15909309. Source: MGI T cell differentiation Inferred from mutant phenotype PubMed 9215624. Source: MGI cell growth Inferred from mutant phenotype PubMed 9215624. Source: MGI cell morphogenesis Inferred from genetic interaction PubMed 15909309. Source: MGI cytokine-mediated signaling pathway Inferred from electronic annotation. Source: GOC homeostasis of number of cells Inferred from mutant phenotype PubMed 9215624PubMed 9215626. Source: MGI immunoglobulin production Inferred from genetic interaction PubMed 15909309. Source: MGI lymph node development Inferred from mutant phenotype PubMed 12732660. Source: MGI negative regulation of T cell mediated cytotoxicity Inferred from mutant phenotype PubMed 9215624. Source: MGI positive regulation of T cell differentiation in thymus Inferred from mutant phenotype PubMed 9215626. Source: MGI positive regulation of gene expression Inferred from mutant phenotype PubMed 18958875. Source: MGI regulation of cell size Inferred from direct assay PubMed 15909309. Source: MGI
Cellular_component	external side of plasma membrane Inferred from direct assay PubMed 12714519PubMed 15294943PubMed 15909309PubMed 18958875PubMed 19934022. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cytokine receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20
	Chain	21 – 459	439	Interleukin-7 receptor subunit alpha		PRO_0000010910
Regions
	Topological domain	21 – 239	219	Extracellular Potential
	Transmembrane	240 – 264	25	Helical; Potential
	Topological domain	265 – 459	195	Cytoplasmic Potential
	Domain	128 – 225	98	Fibronectin type-III
	Motif	218 – 222	5	WSXWS motif
	Motif	272 – 280	9	Box 1 motif
	Compositional bias	184 – 189	6	Ser/Thr-rich
Amino acid modifications
	Modified residue	282	1	Phosphothreonine; by PKC Potential
	Glycosylation	60	1	N-linked (GlcNAc...) Potential
	Glycosylation	115	1	N-linked (GlcNAc...) Potential
	Glycosylation	177	1	N-linked (GlcNAc...) Potential
	Disulfide bond	42 ↔ 57		By similarity
	Disulfide bond	74 ↔ 82		By similarity
	Disulfide bond	108 ↔ 118		By similarity
Experimental info
	Sequence conflict	299 – 302	4	NPES → IPEI in AAA39304. Ref.1
	Sequence conflict	322	1	S → I in AAA39304. Ref.1
	Sequence conflict	431	1	V → F in AAA39304. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P16872 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 52ADF78C8C01D2EE	FASTA	459	51,605
	10 20 30 40 50 60 MMALGRAFAI VFCLIQAVSG ESGNAQDGDL EDADADDHSF WCHSQLEVDG SQHLLTCAFN 70 80 90 100 110 120 DSDINTANLE FQICGALLRV KCLTLNKLQD IYFIKTSEFL LIGSSNICVK LGQKNLTCKN 130 140 150 160 170 180 MAINTIVKAE APSDLKVVYR KEANDFLVTF NAPHLKKKYL KKVKHDVAYR PARGESNWTH 190 200 210 220 230 240 VSLFHTRTTI PQRKLRPKAM YEIKVRSIPH NDYFKGFWSE WSPSSTFETP EPKNQGGWDP 250 260 270 280 290 300 VLPSVTILSL FSVFLLVILA HVLWKKRIKP VVWPSLPDHK KTLEQLCKKP KTSLNVSFNP 310 320 330 340 350 360 ESFLDCQIHE VKGVEARDEV ESFLPNDLPA QPEELETQGH RAAVHSANRS PETSVSPPET 370 380 390 400 410 420 VRRESPLRCL ARNLSTCNAP PLLSSRSPDY RDGDRNRPPV YQDLLPNSGN TNVPVPVPQP 430 440 450 LPFQSGILIP VSQRQPISTS SVLNQEEAYV TMSSFYQNK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily." Goodwin R.G., Friend D., Ziegler S.F., Jerzy R., Falk B.A., Gimpel S., Cosman D., Dower S.K., March C.J., Namen A.E., Park L.S. Cell 60:941-951(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Restoration of lymphoid populations in a murine model of X-linked severe combined immunodeficiency by a gene-therapy approach." Lo M., Bloom M.L., Imada K., Berg M., Bollenbacher J.M., Bloom E.T., Kelsall B.L., Leonard W.J. Blood 94:3027-3036(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Thymus.
[4]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter." Pleiman C.M., Gimpel S.D., Park L.S., Harada H., Taniguchi T., Ziegler S.F. Mol. Cell. Biol. 11:3052-3059(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 231-239 AND 264-272.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M29697 mRNA. Translation: AAA39304.1. AF078906 mRNA. Translation: AAF06717.1. AK042264 mRNA. Translation: BAC31208.1. CH466581 Genomic DNA. Translation: EDL03312.1.
IPI	IPI00109063.
PIR	D34791.
RefSeq	NP_032398.3. NM_008372.4.
UniGene	Mm.389.
3D structure databases
ProteinModelPortal	P16872.
SMR	P16872. Positions 36-231.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-59472N.
STRING	10090.ENSMUSP00000003981.
PTM databases
PhosphoSite	P16872.
Proteomic databases
PRIDE	P16872.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000003981; ENSMUSP00000003981; ENSMUSG00000003882.
GeneID	16197.
KEGG	mmu:16197.
Organism-specific databases
CTD	3575.
MGI	MGI:96562. Il7r.
Phylogenomic databases
eggNOG	NOG39823.
GeneTree	ENSGT00510000048500.
HOGENOM	HOG000089950.
HOVERGEN	HBG055773.
InParanoid	Q9R0C1.
KO	K05072.
OMA	MYEIKVR.
OrthoDB	EOG4H464W.
Enzyme and pathway databases
Reactome	REACT_107772. Immune System.
Gene expression databases
ArrayExpress	P16872.
Bgee	P16872.
CleanEx	MM_IL7R.
Genevestigator	P16872.
GermOnline	ENSMUSG00000003882. Mus musculus.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR003961. Fibronectin_type3. IPR003531. Hempt_rcpt_S_F1_CS. IPR013783. Ig-like_fold. [Graphical view]
Pfam	PF00041. fn3. 1 hit. [Graphical view]
SMART	SM00060. FN3. 1 hit. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 1 hit.
PROSITE	PS50853. FN3. False negative. PS01355. HEMATOPO_REC_S_F1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	IL7R. mouse.
NextBio	289125.
SOURCE	Search...

Entry information

Entry name

IL7RA_MOUSE

Accession

Primary (citable) accession number: P16872
Secondary accession number(s): Q9R0C1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	July 27, 2011
Last modified:	April 3, 2013
This is version 121 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program