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Protein

Interleukin-7 receptor subunit alpha

Gene

Il7r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

GO - Molecular functioni

GO - Biological processi

  • B cell proliferation Source: MGI
  • cell morphogenesis Source: MGI
  • homeostasis of number of cells Source: MGI
  • immunoglobulin production Source: MGI
  • lymph node development Source: MGI
  • negative regulation of T cell apoptotic process Source: MGI
  • negative regulation of T cell mediated cytotoxicity Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of STAT cascade Source: MGI
  • positive regulation of T cell differentiation in thymus Source: MGI
  • regulation of cell size Source: MGI
  • T cell differentiation Source: MGI

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-1266695 Interleukin-7 signaling
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-7 receptor subunit alpha
Short name:
IL-7 receptor subunit alpha
Short name:
IL-7R subunit alpha
Short name:
IL-7R-alpha
Short name:
IL-7RA
Alternative name(s):
CD_antigen: CD127
Gene namesi
Name:Il7r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96562 Il7r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 239ExtracellularSequence analysisAdd BLAST219
Transmembranei240 – 264HelicalSequence analysisAdd BLAST25
Topological domaini265 – 459CytoplasmicSequence analysisAdd BLAST195

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001091021 – 459Interleukin-7 receptor subunit alphaAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 571 Publication
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi74 ↔ 821 Publication
Disulfide bondi108 ↔ 1181 Publication
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei282Phosphothreonine; by PKCSequence analysis1

Post-translational modificationi

N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP16872
PaxDbiP16872
PRIDEiP16872

PTM databases

iPTMnetiP16872
PhosphoSitePlusiP16872

Expressioni

Tissue specificityi

Spleen, thymus and fetal liver.

Gene expression databases

BgeeiENSMUSG00000003882
CleanExiMM_IL7R
GenevisibleiP16872 MM

Interactioni

Subunit structurei

The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.1 Publication

Protein-protein interaction databases

DIPiDIP-59472N
IntActiP16872, 3 interactors
STRINGi10090.ENSMUSP00000003981

Structurei

Secondary structure

1459
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi40 – 51Combined sources12
Beta strandi53 – 60Combined sources8
Beta strandi69 – 79Combined sources11
Beta strandi81 – 84Combined sources4
Beta strandi86 – 88Combined sources3
Beta strandi91 – 97Combined sources7
Beta strandi101 – 103Combined sources3
Beta strandi105 – 111Combined sources7
Beta strandi114 – 121Combined sources8
Helixi123 – 125Combined sources3
Beta strandi126 – 128Combined sources3
Beta strandi133 – 140Combined sources8
Turni141 – 144Combined sources4
Beta strandi145 – 151Combined sources7
Helixi153 – 156Combined sources4
Beta strandi157 – 159Combined sources3
Beta strandi163 – 174Combined sources12
Beta strandi179 – 191Combined sources13
Helixi192 – 194Combined sources3
Beta strandi200 – 209Combined sources10
Beta strandi225 – 228Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NN5X-ray1.90B21-239[»]
4NN6X-ray2.54B21-239[»]
4NN7X-ray3.78B21-239[»]
5J12X-ray3.55B21-239[»]
ProteinModelPortaliP16872
SMRiP16872
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 232Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST102

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi218 – 222WSXWS motif5
Motifi272 – 280Box 1 motif9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi184 – 189Ser/Thr-rich6

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGXR Eukaryota
ENOG410YWZG LUCA
GeneTreeiENSGT00510000048500
HOGENOMiHOG000089950
HOVERGENiHBG055773
InParanoidiP16872
KOiK05072
OMAiMYEIKVR
OrthoDBiEOG091G0N4J
TreeFamiTF336573

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003531 Hempt_rcpt_S_F1_CS
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00041 fn3, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS01355 HEMATOPO_REC_S_F1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16872-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMALGRAFAI VFCLIQAVSG ESGNAQDGDL EDADADDHSF WCHSQLEVDG
60 70 80 90 100
SQHLLTCAFN DSDINTANLE FQICGALLRV KCLTLNKLQD IYFIKTSEFL
110 120 130 140 150
LIGSSNICVK LGQKNLTCKN MAINTIVKAE APSDLKVVYR KEANDFLVTF
160 170 180 190 200
NAPHLKKKYL KKVKHDVAYR PARGESNWTH VSLFHTRTTI PQRKLRPKAM
210 220 230 240 250
YEIKVRSIPH NDYFKGFWSE WSPSSTFETP EPKNQGGWDP VLPSVTILSL
260 270 280 290 300
FSVFLLVILA HVLWKKRIKP VVWPSLPDHK KTLEQLCKKP KTSLNVSFNP
310 320 330 340 350
ESFLDCQIHE VKGVEARDEV ESFLPNDLPA QPEELETQGH RAAVHSANRS
360 370 380 390 400
PETSVSPPET VRRESPLRCL ARNLSTCNAP PLLSSRSPDY RDGDRNRPPV
410 420 430 440 450
YQDLLPNSGN TNVPVPVPQP LPFQSGILIP VSQRQPISTS SVLNQEEAYV

TMSSFYQNK
Length:459
Mass (Da):51,605
Last modified:July 27, 2011 - v2
Checksum:i52ADF78C8C01D2EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti299 – 302NPES → IPEI in AAA39304 (PubMed:2317865).Curated4
Sequence conflicti322S → I in AAA39304 (PubMed:2317865).Curated1
Sequence conflicti431V → F in AAA39304 (PubMed:2317865).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29697 mRNA Translation: AAA39304.1
AF078906 mRNA Translation: AAF06717.1
AK042264 mRNA Translation: BAC31208.1
CH466581 Genomic DNA Translation: EDL03312.1
CCDSiCCDS27376.1
PIRiD34791
RefSeqiNP_032398.3, NM_008372.4
UniGeneiMm.389

Genome annotation databases

EnsembliENSMUST00000003981; ENSMUSP00000003981; ENSMUSG00000003882
GeneIDi16197
KEGGimmu:16197
UCSCiuc007vfo.2 mouse

Similar proteinsi

Entry informationi

Entry nameiIL7RA_MOUSE
AccessioniPrimary (citable) accession number: P16872
Secondary accession number(s): Q9R0C1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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