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P16872 (IL7RA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 134. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-7 receptor subunit alpha

Short name=IL-7 receptor subunit alpha
Short name=IL-7R subunit alpha
Short name=IL-7R-alpha
Short name=IL-7RA
Alternative name(s):
CD_antigen=CD127
Gene names
Name:Il7r
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

Subunit structure

The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Spleen, thymus and fetal liver.

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Post-translational modification

N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form By similarity.

Sequence similarities

Belongs to the type I cytokine receptor family. Type 4 subfamily.

Contains 1 fibronectin type-III domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processB cell proliferation

Inferred from mutant phenotype PubMed 15909309. Source: MGI

T cell differentiation

Inferred from mutant phenotype PubMed 9215624. Source: MGI

cell growth

Inferred from mutant phenotype PubMed 9215624. Source: MGI

cell morphogenesis

Inferred from genetic interaction PubMed 15909309. Source: MGI

homeostasis of number of cells

Inferred from mutant phenotype PubMed 9215624PubMed 9215626. Source: MGI

immunoglobulin production

Inferred from genetic interaction PubMed 15909309. Source: MGI

lymph node development

Inferred from mutant phenotype PubMed 12732660. Source: MGI

negative regulation of T cell mediated cytotoxicity

Inferred from mutant phenotype PubMed 9215624. Source: MGI

positive regulation of T cell differentiation in thymus

Inferred from mutant phenotype PubMed 9215626. Source: MGI

positive regulation of gene expression

Inferred from mutant phenotype PubMed 18958875. Source: MGI

regulation of cell size

Inferred from direct assay PubMed 15909309. Source: MGI

   Cellular_componentexternal side of plasma membrane

Inferred from direct assay PubMed 12714519PubMed 15294943PubMed 15909309PubMed 18958875PubMed 19934022. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functioncytokine receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020
Chain21 – 459439Interleukin-7 receptor subunit alpha
PRO_0000010910

Regions

Topological domain21 – 239219Extracellular Potential
Transmembrane240 – 26425Helical; Potential
Topological domain265 – 459195Cytoplasmic Potential
Domain131 – 232102Fibronectin type-III
Motif218 – 2225WSXWS motif
Motif272 – 2809Box 1 motif
Compositional bias184 – 1896Ser/Thr-rich

Amino acid modifications

Modified residue2821Phosphothreonine; by PKC Potential
Glycosylation601N-linked (GlcNAc...) Potential
Glycosylation1151N-linked (GlcNAc...) Potential
Glycosylation1771N-linked (GlcNAc...) Potential
Disulfide bond42 ↔ 57 By similarity
Disulfide bond74 ↔ 82 By similarity
Disulfide bond108 ↔ 118 By similarity

Experimental info

Sequence conflict299 – 3024NPES → IPEI in AAA39304. Ref.1
Sequence conflict3221S → I in AAA39304. Ref.1
Sequence conflict4311V → F in AAA39304. Ref.1

Secondary structure

...................................... 459
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P16872 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 52ADF78C8C01D2EE

FASTA45951,605
        10         20         30         40         50         60 
MMALGRAFAI VFCLIQAVSG ESGNAQDGDL EDADADDHSF WCHSQLEVDG SQHLLTCAFN 

        70         80         90        100        110        120 
DSDINTANLE FQICGALLRV KCLTLNKLQD IYFIKTSEFL LIGSSNICVK LGQKNLTCKN 

       130        140        150        160        170        180 
MAINTIVKAE APSDLKVVYR KEANDFLVTF NAPHLKKKYL KKVKHDVAYR PARGESNWTH 

       190        200        210        220        230        240 
VSLFHTRTTI PQRKLRPKAM YEIKVRSIPH NDYFKGFWSE WSPSSTFETP EPKNQGGWDP 

       250        260        270        280        290        300 
VLPSVTILSL FSVFLLVILA HVLWKKRIKP VVWPSLPDHK KTLEQLCKKP KTSLNVSFNP 

       310        320        330        340        350        360 
ESFLDCQIHE VKGVEARDEV ESFLPNDLPA QPEELETQGH RAAVHSANRS PETSVSPPET 

       370        380        390        400        410        420 
VRRESPLRCL ARNLSTCNAP PLLSSRSPDY RDGDRNRPPV YQDLLPNSGN TNVPVPVPQP 

       430        440        450 
LPFQSGILIP VSQRQPISTS SVLNQEEAYV TMSSFYQNK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily."
Goodwin R.G., Friend D., Ziegler S.F., Jerzy R., Falk B.A., Gimpel S., Cosman D., Dower S.K., March C.J., Namen A.E., Park L.S.
Cell 60:941-951(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Restoration of lymphoid populations in a murine model of X-linked severe combined immunodeficiency by a gene-therapy approach."
Lo M., Bloom M.L., Imada K., Berg M., Bollenbacher J.M., Bloom E.T., Kelsall B.L., Leonard W.J.
Blood 94:3027-3036(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Thymus.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter."
Pleiman C.M., Gimpel S.D., Park L.S., Harada H., Taniguchi T., Ziegler S.F.
Mol. Cell. Biol. 11:3052-3059(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 231-239 AND 264-272.
[6]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M29697 mRNA. Translation: AAA39304.1.
AF078906 mRNA. Translation: AAF06717.1.
AK042264 mRNA. Translation: BAC31208.1.
CH466581 Genomic DNA. Translation: EDL03312.1.
CCDSCCDS27376.1.
PIRD34791.
RefSeqNP_032398.3. NM_008372.4.
UniGeneMm.389.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4NN5X-ray1.90B21-239[»]
4NN6X-ray2.54B21-239[»]
4NN7X-ray3.78B21-239[»]
ProteinModelPortalP16872.
SMRP16872. Positions 36-232.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-59472N.
STRING10090.ENSMUSP00000003981.

PTM databases

PhosphoSiteP16872.

Proteomic databases

PRIDEP16872.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000003981; ENSMUSP00000003981; ENSMUSG00000003882.
GeneID16197.
KEGGmmu:16197.
UCSCuc007vfo.2. mouse.

Organism-specific databases

CTD3575.
MGIMGI:96562. Il7r.

Phylogenomic databases

eggNOGNOG39823.
GeneTreeENSGT00510000048500.
HOGENOMHOG000089950.
HOVERGENHBG055773.
InParanoidQ9R0C1.
KOK05072.
OMAMYEIKVR.
OrthoDBEOG7SJD5X.
TreeFamTF336573.

Gene expression databases

ArrayExpressP16872.
BgeeP16872.
CleanExMM_IL7R.
GenevestigatorP16872.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR003961. Fibronectin_type3.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamPF00041. fn3. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 1 hit.
PROSITEPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIL7R. mouse.
NextBio289125.
PROP16872.
SOURCESearch...

Entry information

Entry nameIL7RA_MOUSE
AccessionPrimary (citable) accession number: P16872
Secondary accession number(s): Q9R0C1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot