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Protein

Interleukin-7 receptor subunit alpha

Gene

Il7r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

GO - Molecular functioni

GO - Biological processi

  • B cell homeostasis Source: GOC-OWL
  • B cell proliferation Source: MGI
  • cell growth Source: MGI
  • cell morphogenesis Source: MGI
  • homeostasis of number of cells Source: MGI
  • immunoglobulin production Source: MGI
  • lymph node development Source: MGI
  • negative regulation of T cell mediated cytotoxicity Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of T cell differentiation in thymus Source: MGI
  • regulation of cell size Source: MGI
  • T cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-1266695. Interleukin-7 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-7 receptor subunit alpha
Short name:
IL-7 receptor subunit alpha
Short name:
IL-7R subunit alpha
Short name:
IL-7R-alpha
Short name:
IL-7RA
Alternative name(s):
CD_antigen: CD127
Gene namesi
Name:Il7r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96562. Il7r.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 239ExtracellularSequence analysisAdd BLAST219
Transmembranei240 – 264HelicalSequence analysisAdd BLAST25
Topological domaini265 – 459CytoplasmicSequence analysisAdd BLAST195

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001091021 – 459Interleukin-7 receptor subunit alphaAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 571 Publication
Glycosylationi60N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi74 ↔ 821 Publication
Disulfide bondi108 ↔ 1181 Publication
Glycosylationi115N-linked (GlcNAc...)Sequence analysis1
Glycosylationi177N-linked (GlcNAc...)Sequence analysis1
Modified residuei282Phosphothreonine; by PKCSequence analysis1

Post-translational modificationi

N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP16872.
PaxDbiP16872.
PRIDEiP16872.

PTM databases

iPTMnetiP16872.
PhosphoSitePlusiP16872.

Expressioni

Tissue specificityi

Spleen, thymus and fetal liver.

Gene expression databases

BgeeiENSMUSG00000003882.
CleanExiMM_IL7R.
GenevisibleiP16872. MM.

Interactioni

Subunit structurei

The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.1 Publication

Protein-protein interaction databases

DIPiDIP-59472N.
STRINGi10090.ENSMUSP00000003981.

Structurei

Secondary structure

1459
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi40 – 51Combined sources12
Beta strandi53 – 60Combined sources8
Beta strandi69 – 79Combined sources11
Beta strandi81 – 84Combined sources4
Beta strandi86 – 88Combined sources3
Beta strandi91 – 97Combined sources7
Beta strandi101 – 103Combined sources3
Beta strandi105 – 111Combined sources7
Beta strandi114 – 121Combined sources8
Helixi123 – 125Combined sources3
Beta strandi126 – 128Combined sources3
Beta strandi133 – 140Combined sources8
Turni141 – 144Combined sources4
Beta strandi145 – 151Combined sources7
Helixi153 – 156Combined sources4
Beta strandi157 – 159Combined sources3
Beta strandi163 – 174Combined sources12
Beta strandi179 – 191Combined sources13
Helixi192 – 194Combined sources3
Beta strandi200 – 209Combined sources10
Beta strandi225 – 228Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NN5X-ray1.90B21-239[»]
4NN6X-ray2.54B21-239[»]
4NN7X-ray3.78B21-239[»]
ProteinModelPortaliP16872.
SMRiP16872.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 232Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST102

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi218 – 222WSXWS motif5
Motifi272 – 280Box 1 motif9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi184 – 189Ser/Thr-rich6

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGXR. Eukaryota.
ENOG410YWZG. LUCA.
GeneTreeiENSGT00510000048500.
HOGENOMiHOG000089950.
HOVERGENiHBG055773.
InParanoidiP16872.
KOiK05072.
OMAiMYEIKVR.
OrthoDBiEOG091G0N4J.
TreeFamiTF336573.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16872-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMALGRAFAI VFCLIQAVSG ESGNAQDGDL EDADADDHSF WCHSQLEVDG
60 70 80 90 100
SQHLLTCAFN DSDINTANLE FQICGALLRV KCLTLNKLQD IYFIKTSEFL
110 120 130 140 150
LIGSSNICVK LGQKNLTCKN MAINTIVKAE APSDLKVVYR KEANDFLVTF
160 170 180 190 200
NAPHLKKKYL KKVKHDVAYR PARGESNWTH VSLFHTRTTI PQRKLRPKAM
210 220 230 240 250
YEIKVRSIPH NDYFKGFWSE WSPSSTFETP EPKNQGGWDP VLPSVTILSL
260 270 280 290 300
FSVFLLVILA HVLWKKRIKP VVWPSLPDHK KTLEQLCKKP KTSLNVSFNP
310 320 330 340 350
ESFLDCQIHE VKGVEARDEV ESFLPNDLPA QPEELETQGH RAAVHSANRS
360 370 380 390 400
PETSVSPPET VRRESPLRCL ARNLSTCNAP PLLSSRSPDY RDGDRNRPPV
410 420 430 440 450
YQDLLPNSGN TNVPVPVPQP LPFQSGILIP VSQRQPISTS SVLNQEEAYV

TMSSFYQNK
Length:459
Mass (Da):51,605
Last modified:July 27, 2011 - v2
Checksum:i52ADF78C8C01D2EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti299 – 302NPES → IPEI in AAA39304 (PubMed:2317865).Curated4
Sequence conflicti322S → I in AAA39304 (PubMed:2317865).Curated1
Sequence conflicti431V → F in AAA39304 (PubMed:2317865).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29697 mRNA. Translation: AAA39304.1.
AF078906 mRNA. Translation: AAF06717.1.
AK042264 mRNA. Translation: BAC31208.1.
CH466581 Genomic DNA. Translation: EDL03312.1.
CCDSiCCDS27376.1.
PIRiD34791.
RefSeqiNP_032398.3. NM_008372.4.
UniGeneiMm.389.

Genome annotation databases

EnsembliENSMUST00000003981; ENSMUSP00000003981; ENSMUSG00000003882.
GeneIDi16197.
KEGGimmu:16197.
UCSCiuc007vfo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29697 mRNA. Translation: AAA39304.1.
AF078906 mRNA. Translation: AAF06717.1.
AK042264 mRNA. Translation: BAC31208.1.
CH466581 Genomic DNA. Translation: EDL03312.1.
CCDSiCCDS27376.1.
PIRiD34791.
RefSeqiNP_032398.3. NM_008372.4.
UniGeneiMm.389.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NN5X-ray1.90B21-239[»]
4NN6X-ray2.54B21-239[»]
4NN7X-ray3.78B21-239[»]
ProteinModelPortaliP16872.
SMRiP16872.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59472N.
STRINGi10090.ENSMUSP00000003981.

PTM databases

iPTMnetiP16872.
PhosphoSitePlusiP16872.

Proteomic databases

EPDiP16872.
PaxDbiP16872.
PRIDEiP16872.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003981; ENSMUSP00000003981; ENSMUSG00000003882.
GeneIDi16197.
KEGGimmu:16197.
UCSCiuc007vfo.2. mouse.

Organism-specific databases

CTDi3575.
MGIiMGI:96562. Il7r.

Phylogenomic databases

eggNOGiENOG410IGXR. Eukaryota.
ENOG410YWZG. LUCA.
GeneTreeiENSGT00510000048500.
HOGENOMiHOG000089950.
HOVERGENiHBG055773.
InParanoidiP16872.
KOiK05072.
OMAiMYEIKVR.
OrthoDBiEOG091G0N4J.
TreeFamiTF336573.

Enzyme and pathway databases

ReactomeiR-MMU-1266695. Interleukin-7 signaling.

Miscellaneous databases

ChiTaRSiIl7r. mouse.
PROiP16872.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003882.
CleanExiMM_IL7R.
GenevisibleiP16872. MM.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL7RA_MOUSE
AccessioniPrimary (citable) accession number: P16872
Secondary accession number(s): Q9R0C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.