Reviewed, UniProtKB/Swiss-Prot P16871 (IL7RA_HUMAN)

Names and origin

Protein names

Recommended name:
    Interleukin-7 receptor subunit alpha
      Short name=IL-7R-alpha
Alternative name(s):
    CDw127
    CD_antigen=CD127

Gene names

Name:

IL7R

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	459 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
Subunit structure	The IL7 receptor is an heterodimer of IL7R and IL2RG. The TSLP receptor is an heterodimer of CRLF2 and IL7R.
Subcellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 4: Secreted.
Domain	The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation.
Involvement in disease	Defects in IL7R are a cause of autosomal recessive severe combined immunodeficiency T-cell-negative/B-cell-positive/NK cell-positive (T-/B+/NK+ SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Ref.3 Ref.5 Ref.7 Ref.8 Ref.9 A genetic variation in transmembrane domain of IL7R is associated with susceptibility to multiple sclerosis (MS) [MIM:126200]. Overtransmission of the major 'C' allele coding for Thr-244 are detected in offspring affected with multiple sclerosis. In vitro analysis of transcripts from minigenes containing either 'C' allele (Thr-244) or 'T' allele (Ile-244) shows that the 'C' allele results in an approximately two-fold increase in the skipping of exon 6, leading to increased production of a soluble form of IL7R. Thus, the multiple sclerosis associated 'C' risk allele of IL7R would probably decrease membrane-bound expression of IL7R. As this risk allele is common in the general population, some additional triggers are probably required for the development and progression of MS. Ref.10
Sequence similarities	Belongs to the type I cytokine receptor family. Type 4 subfamily. Contains 1 fibronectin type-III domain.
Sequence caution	The sequence AAH20717.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation SCID
Domain	Signal Transmembrane
Molecular function	Receptor
PTM	Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	cell surface receptor linked signal transduction Ref.3 Traceable author statement. Source: ProtInc regulation of DNA recombination Traceable author statement. Source: ProtInc
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	antigen binding Traceable author statement. Source: ProtInc interleukin-7 receptor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
IL7	P13232	3	EBI-80490,EBI-80516

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P16871-1)

Also known as: H20;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 3 (identifier: P16871-2)

Also known as: H1;

The sequence of this isoform differs from the canonical sequence as follows:
     293-459: NLNVSFNPES...VTMSSFYQNQ → VSVFGA

Isoform 4 (identifier: P16871-3)

Also known as: H6; Secreted;

The sequence of this isoform differs from the canonical sequence as follows:
     237-459: EMDPILLTIS...VTMSSFYQNQ → LSLSYGPVSPIIRRLWNIFVRNQEK

Isoform 2 (identifier: P16871-4)

Also known as: Secreted;

The sequence of this isoform differs from the canonical sequence as follows:
     237-252: EMDPILLTISILSFFS → LSLSYGPVSPIIRQEL
     253-459: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 20

20

Chain

21 – 459

439

Interleukin-7 receptor subunit alpha

PRO_0000010909

Regions

Topological domain

21 – 239

219

Extracellular Potential

Transmembrane

240 – 264

25

Potential

Topological domain

265 – 459

195

Cytoplasmic Potential

Domain

128 – 224

97

Fibronectin type-III

Motif

217 – 221

5

WSXWS motif

Motif

272 – 280

9

Box 1 motif

Compositional bias

184 – 189

6

Ser/Thr-rich

Amino acid modifications

Modified residue

159

1

Phosphotyrosine Ref.8

Modified residue

169

1

Phosphotyrosine Ref.8

Modified residue

282

1

Phosphothreonine; by PKC Potential

Glycosylation

49

1

N-linked (GlcNAc...) Potential

Glycosylation

65

1

N-linked (GlcNAc...) Potential

Glycosylation

151

1

N-linked (GlcNAc...) Potential

Glycosylation

182

1

N-linked (GlcNAc...) Potential

Glycosylation

232

1

N-linked (GlcNAc...) Potential

Glycosylation

233

1

N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence

237 – 459

223

EMDPI…FYQNQ → LSLSYGPVSPIIRRLWNIFV RNQEK in isoform 4.

VSP_001713

Alternative sequence

237 – 252

16

EMDPI…LSFFS → LSLSYGPVSPIIRQEL in isoform 2.

VSP_012618

Alternative sequence

253 – 459

207

Missing in isoform 2.

VSP_012619

Alternative sequence

293 – 459

167

NLNVS…FYQNQ → VSVFGA in isoform 3.

VSP_001714

Natural variant

66

1

T → I in T(-)/B(+)/NK(+) SCID. dbSNP rs1494558. Ref.3 Ref.5 Ref.7

VAR_021286

Natural variant

113

1

E → D: dbSNP rs11567735. Ref.5

VAR_021287

Natural variant

132

1

P → S in T(-)/B(+)/NK(+) SCID. Ref.9

VAR_034870

Natural variant

138

1

I → V in T(-)/B(+)/NK(+) SCID. dbSNP rs1494555. Ref.3 Ref.5 Ref.7

VAR_021288

Natural variant

244

1

T → I Associated with MS. dbSNP rs6897932. Ref.3 Ref.5 Ref.10

VAR_021289

Natural variant

356

1

I → V: dbSNP rs3194051. Ref.7 Ref.1 Ref.2 Ref.4

VAR_021290

Natural variant

414

1

T → M: dbSNP rs2229232.

VAR_047742

Experimental info

Sequence conflict

39

1

S → T in AAH67539. Ref.5

Sequence conflict

52

1

Q → R in AAH67538. Ref.5

Sequence conflict

384

1

S → P in AAH67537. Ref.5

Sequence conflict

386

1

R → G in AAH67539. Ref.5

Secondary structure

1

.

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459

Helix Strand Turn

Details...

Beta strand

40 – 45

6

Beta strand

53 – 61

9

Beta strand

70 – 74

5

Beta strand

77 – 81

5

Beta strand

86 – 88

3

Beta strand

91 – 97

7

Beta strand

105 – 110

6

Beta strand

115 – 121

7

Beta strand

125 – 127

3

Beta strand

133 – 136

4

Beta strand

145 – 151

7

Helix

153 – 156

4

Beta strand

158 – 160

3

Beta strand

163 – 171

9

Beta strand

179 – 191

13

Helix

192 – 194

3

Beta strand

197 – 209

13

Beta strand

224 – 228

5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (H20) [UniParc]. Last modified November 25, 2008. Version 2. Checksum: EE556426C22A182B	FASTA	459	51,581
	10 20 30 40 50 60 MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG SQHSLTCAFE 70 80 90 100 110 120 DPDVNTTNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL LIGKSNICVK VGEKSLTCKK 130 140 150 160 170 180 IDLTTIVKPE APFDLSVIYR EGANDFVVTF NTSHLQKKYV KVLMHDVAYR QEKDENKWTH 190 200 210 220 230 240 VNLSSTKLTL LQRKLQPAAM YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGEMDP 250 260 270 280 290 300 ILLTISILSF FSVALLVILA CVLWKKRIKP IVWPSLPDHK KTLEHLCKKP RKNLNVSFNP 310 320 330 340 350 360 ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP SEDVVITPES 370 380 390 400 410 420 FGRDSSLTCL AGNVSACDAP ILSSSRSLDC RESGKNGPHV YQDLLLSLGT TNSTLPPPFS 430 440 450 LQSGILTLNP VAQGQPILTS LGSNQEEAYV TMSSFYQNQ
	Isoform 3 (H1). Checksum: B724534E0AFFC77B	FASTA	298	34,020
	10 20 30 40 50 60 MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG SQHSLTCAFE 70 80 90 100 110 120 DPDVNTTNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL LIGKSNICVK VGEKSLTCKK 130 140 150 160 170 180 IDLTTIVKPE APFDLSVIYR EGANDFVVTF NTSHLQKKYV KVLMHDVAYR QEKDENKWTH 190 200 210 220 230 240 VNLSSTKLTL LQRKLQPAAM YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGEMDP 250 260 270 280 290 ILLTISILSF FSVALLVILA CVLWKKRIKP IVWPSLPDHK KTLEHLCKKP RKVSVFGA
	Isoform 4 (H6) (Secreted). Checksum: C77F2DB55E9DB48D	FASTA	261	29,938
	10 20 30 40 50 60 MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG SQHSLTCAFE 70 80 90 100 110 120 DPDVNTTNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL LIGKSNICVK VGEKSLTCKK 130 140 150 160 170 180 IDLTTIVKPE APFDLSVIYR EGANDFVVTF NTSHLQKKYV KVLMHDVAYR QEKDENKWTH 190 200 210 220 230 240 VNLSSTKLTL LQRKLQPAAM YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGLSLS 250 260 YGPVSPIIRR LWNIFVRNQE K
	Isoform 2 (Secreted). Checksum: D37499B0E8BE412A	FASTA	252	28,724
	10 20 30 40 50 60 MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG SQHSLTCAFE 70 80 90 100 110 120 DPDVNTTNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL LIGKSNICVK VGEKSLTCKK 130 140 150 160 170 180 IDLTTIVKPE APFDLSVIYR EGANDFVVTF NTSHLQKKYV KVLMHDVAYR QEKDENKWTH 190 200 210 220 230 240 VNLSSTKLTL LQRKLQPAAM YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGLSLS 250 YGPVSPIIRQ EL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily." Goodwin R.G., Friend D., Ziegler S.F., Jerzy R., Falk B.A., Gimpel S., Cosman D., Dower S.K., March C.J., Namen A.E., Park L.S. Cell 60:941-951(1990) [PubMed: 2317865] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, VARIANT VAL-356. Tissue: B-cell.
[2]	"Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter." Pleiman C.M., Gimpel S.D., Park L.S., Harada H., Taniguchi T., Ziegler S.F. Mol. Cell. Biol. 11:3052-3059(1991) [PubMed: 2038316] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-356.
[3]	"Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency." Puel A., Ziegler S.F., Buckley R.H., Leonard W.J. Nat. Genet. 20:394-397(1998) [PubMed: 9843216] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS T(-)/B(+)/NK(+) SCID ILE-66 AND VAL-138, VARIANT ILE-244.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT VAL-356. Tissue: Spleen.
[5]	SeattleSNPs variation discovery resource Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS T(-)/B(+)/NK(+) SCID ILE-66 AND VAL-138, VARIANTS ASP-113 AND ILE-244.
[6]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed: 15372022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS T(-)/B(+)/NK(+) SCID ILE-66 AND VAL-138.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS T(-)/B(+)/NK(+) SCID ILE-66 AND VAL-138, VARIANT VAL-356. Tissue: Testis.
[8]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-159 AND TYR-169, MASS SPECTROMETRY. Tissue: Epithelium.
[9]	"A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency." Roifman C.M., Zhang J., Chitayat D., Sharfe N. Blood 96:2803-2807(2000) [PubMed: 11023514] [Abstract] Cited for: VARIANT T(-)/B(+)/NK(+) SCID SER-132.
[10]	"Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis." Gregory S.G., Schmidt S., Seth P., Oksenberg J.R., Hart J., Prokop A., Caillier S.J., Ban M., Goris A., Barcellos L.F., Lincoln R., McCauley J.L., Sawcer S.J., Compston D.A., Dubois B., Hauser S.L., Garcia-Blanco M.A., Pericak-Vance M.A., Haines J.L. Nat. Genet. 39:1083-1091(2007) [PubMed: 17660817] [Abstract] Cited for: VARIANT ILE-244, ASSOCIATION WITH MS.
+	Additional computationally mapped references.

Web resources

IL7Rbase

IL7R mutation db

GeneReviews

SeattleSNPs

Cross-references

Sequence databases

EMBLGenBankDDBJ

M29696 mRNA. Translation: AAA59157.1.
AF043129 , AF043123, AF043124, AF043125, AF043126, AF043127, AF043128 Genomic DNA. Translation: AAC83204.1.
AK301220 mRNA. Translation: BAG62793.1.
AK315251 mRNA. Translation: BAG37673.1.
AY449709 Genomic DNA. Translation: AAR08908.1.
BC020717 mRNA. Translation: AAH20717.1. Sequence problems.
BC067537 mRNA. Translation: AAH67537.1.
BC067538 mRNA. Translation: AAH67538.1.
BC067539 mRNA. Translation: AAH67539.1.
BC067540 mRNA. Translation: AAH67540.1.
BC069999 mRNA. Translation: AAH69999.1.

IPI

IPI00216518.
IPI00292014.
IPI00419824.
IPI00549649.

PIR

A34791.
B34791.
C34791.

RefSeq

NP_002176.2.

UniGene

Hs.591742
Hs.635723

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3DI2	X-ray	2.70	B/D	21-239	[»]
3DI3	X-ray	2.90	B	21-239	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP:3045N.

IntAct

P16871. 1 interaction.

STRING

P16871.

PTM databases

PhosphoSite

P16871.

Genome annotation databases

Ensembl

ENST00000303115; ENSP00000306157; ENSG00000168685; Homo sapiens. [Genome view]

GeneID

3575.

KEGG

hsa:3575.

Organism-specific databases

CTD

3575.

GeneCards

GC05P035892.

H-InvDB

HIX0024815.

HGNC

HGNC:6024. IL7R.

HPA

CAB010215.

MIM

126200. phenotype.
146661. gene.
608971. phenotype.

Orphanet

101974. Severe combined immunodeficiency T- B+.

PharmGKB

PA29840.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

P16871.

HOVERGEN

P16871.

Gene expression databases

ArrayExpress

P16871.

Bgee

P16871.

CleanEx

HS_IL7R.

Genevestigator

P16871.

GermOnline

ENSG00000168685. Homo sapiens.

Family and domain databases

InterPro

IPR008957. Fibronectin_typ-III-like_fold.
IPR003961. FN_III.
IPR003531. Hempt_rcpt_S_F1_CS.
[Graphical view]

Gene3D

G3DSA:2.60.40.30. FN_III-like. 1 hit.

Pfam

PF00041. fn3. 1 hit.
[Graphical view]

PROSITE

PS50853. FN3. False negative.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

13972.

SOURCE

Search...

Entry information

Entry name

IL7RA_HUMAN

Accession

Primary (citable) accession number: P16871
Secondary accession number(s): B2RCS6 , B4DVT1, Q05CU8, Q6NSP4, Q6NWM0, Q6NWM1, Q6NWM2, Q6NWM3, Q6SV45, Q9UPC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	November 25, 2008
Last modified:	November 24, 2009
This is version 110 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.