P16871 (IL7RA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-7 receptor subunit alpha
Short name=IL-7 receptor subunit alpha
Short name=IL-7R subunit alpha
Short name=IL-7R-alpha
Short name=IL-7RA

Alternative name(s):
CDw127
CD_antigen=CD127

Gene names

Name:

IL7R

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	459 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
Subunit structure	The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R. Ref.8
Subcellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 4: Secreted.
Domain	The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation.
Post-translational modification	N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form. Ref.8
Involvement in disease	Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.3 Ref.5 Ref.6 Ref.7 Ref.9 Multiple sclerosis 3 (MS3) [MIM:612595]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. A polymorphism at position 244 strongly influences susceptibility to multiple sclerosis. Overtransmission of the major 'C' allele coding for Thr-244 is detected in offspring affected with multiple sclerosis. In vitro analysis of transcripts from minigenes containing either 'C' allele (Thr-244) or 'T' allele (Ile-244) shows that the 'C' allele results in an approximately two-fold increase in the skipping of exon 6, leading to increased production of a soluble form of IL7R. Thus, the multiple sclerosis associated 'C' risk allele of IL7R would probably decrease membrane-bound expression of IL7R. As this risk allele is common in the general population, some additional triggers are probably required for the development and progression of MS. Ref.10
Sequence similarities	Belongs to the type I cytokine receptor family. Type 4 subfamily. Contains 1 fibronectin type-III domain.
Sequence caution	The sequence AAH20717.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation SCID
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	B cell proliferation Inferred from electronic annotation. Source: Compara T cell differentiation Inferred from electronic annotation. Source: Compara cell growth Inferred from electronic annotation. Source: Compara cell morphogenesis Inferred from electronic annotation. Source: Compara homeostasis of number of cells Inferred from electronic annotation. Source: Compara immune response Traceable author statement Ref.3. Source: ProtInc immunoglobulin production Inferred from electronic annotation. Source: Compara lymph node development Inferred from electronic annotation. Source: Compara negative regulation of T cell mediated cytotoxicity Inferred from electronic annotation. Source: Compara positive regulation of T cell differentiation in thymus Inferred from electronic annotation. Source: Compara positive regulation of gene expression Inferred from electronic annotation. Source: Compara regulation of DNA recombination Traceable author statement PubMed 9495344. Source: ProtInc regulation of cell size Inferred from electronic annotation. Source: Compara
Cellular_component	external side of plasma membrane Inferred from electronic annotation. Source: Compara extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	antigen binding Traceable author statement PubMed 9495344. Source: ProtInc interleukin-7 receptor activity Traceable author statement PubMed 8266077. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
IL7	P13232	3	EBI-80490,EBI-80516

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P16871-1)

Also known as: H20;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 3 (identifier: P16871-2)

Also known as: H1;

The sequence of this isoform differs from the canonical sequence as follows:
     293-459: NLNVSFNPES...VTMSSFYQNQ → VSVFGA

Isoform 4 (identifier: P16871-3)

Also known as: H6; Secreted;

The sequence of this isoform differs from the canonical sequence as follows:
     237-459: EMDPILLTIS...VTMSSFYQNQ → LSLSYGPVSPIIRRLWNIFVRNQEK

Isoform 2 (identifier: P16871-4)

Also known as: Secreted;

The sequence of this isoform differs from the canonical sequence as follows:
     237-252: EMDPILLTISILSFFS → LSLSYGPVSPIIRQEL
     253-459: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 20

20

Chain

21 – 459

439

Interleukin-7 receptor subunit alpha

PRO_0000010909

Regions

Topological domain

21 – 239

219

Extracellular Potential

Transmembrane

240 – 264

25

Helical; Potential

Topological domain

265 – 459

195

Cytoplasmic Potential

Domain

128 – 224

97

Fibronectin type-III

Motif

217 – 221

5

WSXWS motif

Motif

272 – 280

9

Box 1 motif

Compositional bias

184 – 189

6

Ser/Thr-rich

Amino acid modifications

Modified residue

282

1

Phosphothreonine; by PKC Potential

Glycosylation

49

1

N-linked (GlcNAc...) Ref.8

Glycosylation

65

1

N-linked (GlcNAc...) Ref.8

Glycosylation

151

1

N-linked (GlcNAc...) Ref.8

Glycosylation

182

1

N-linked (GlcNAc...) Potential

Glycosylation

232

1

N-linked (GlcNAc...) Potential

Glycosylation

233

1

N-linked (GlcNAc...) Potential

Disulfide bond

42 ↔ 57

Ref.8

Disulfide bond

74 ↔ 82

Ref.8

Disulfide bond

108 ↔ 118

Ref.8

Natural variations

Alternative sequence

237 – 459

223

EMDPI…FYQNQ → LSLSYGPVSPIIRRLWNIFV RNQEK in isoform 4.

VSP_001713

Alternative sequence

237 – 252

16

EMDPI…LSFFS → LSLSYGPVSPIIRQEL in isoform 2.

VSP_012618

Alternative sequence

253 – 459

207

Missing in isoform 2.

VSP_012619

Alternative sequence

293 – 459

167

NLNVS…FYQNQ → VSVFGA in isoform 3.

VSP_001714

Natural variant

66

1

T → I in T(-)/B(+)/NK(+) SCID. Ref.3 Ref.5 Ref.6 Ref.7
Corresponds to variant rs1494558 [ dbSNP | Ensembl ].

VAR_021286

Natural variant

113

1

E → D. Ref.5
Corresponds to variant rs11567735 [ dbSNP | Ensembl ].

VAR_021287

Natural variant

132

1

P → S in T(-)/B(+)/NK(+) SCID. Ref.9

VAR_034870

Natural variant

138

1

I → V in T(-)/B(+)/NK(+) SCID. Ref.3 Ref.5 Ref.6 Ref.7
Corresponds to variant rs1494555 [ dbSNP | Ensembl ].

VAR_021288

Natural variant

244

1

T → I. Ref.3 Ref.5 Ref.10
Corresponds to variant rs6897932 [ dbSNP | Ensembl ].

VAR_021289

Natural variant

356

1

I → V. Ref.1 Ref.2 Ref.4 Ref.7
Corresponds to variant rs3194051 [ dbSNP | Ensembl ].

VAR_021290

Natural variant

414

1

T → M.
Corresponds to variant rs2229232 [ dbSNP | Ensembl ].

VAR_047742

Experimental info

Sequence conflict

39

1

S → T in AAH67539. Ref.7

Sequence conflict

52

1

Q → R in AAH67538. Ref.7

Sequence conflict

384

1

S → P in AAH67537. Ref.7

Sequence conflict

386

1

R → G in AAH67539. Ref.7

Secondary structure

1

.

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459

Helix Strand Turn

Details...

Helix

35 – 38

4

Beta strand

40 – 49

10

Beta strand

52 – 61

10

Beta strand

69 – 79

11

Beta strand

81 – 84

4

Beta strand

86 – 88

3

Beta strand

91 – 97

7

Beta strand

102 – 111

10

Beta strand

114 – 122

9

Helix

123 – 125

3

Beta strand

133 – 140

8

Turn

141 – 144

4

Beta strand

145 – 151

7

Helix

153 – 156

4

Beta strand

158 – 160

3

Beta strand

163 – 173

11

Beta strand

179 – 191

13

Helix

192 – 194

3

Beta strand

200 – 209

10

Beta strand

211 – 213

3

Beta strand

224 – 227

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (H20) [UniParc]. Last modified November 25, 2008. Version 2. Checksum: EE556426C22A182B	FASTA	459	51,581
	10 20 30 40 50 60 MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG SQHSLTCAFE 70 80 90 100 110 120 DPDVNTTNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL LIGKSNICVK VGEKSLTCKK 130 140 150 160 170 180 IDLTTIVKPE APFDLSVIYR EGANDFVVTF NTSHLQKKYV KVLMHDVAYR QEKDENKWTH 190 200 210 220 230 240 VNLSSTKLTL LQRKLQPAAM YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGEMDP 250 260 270 280 290 300 ILLTISILSF FSVALLVILA CVLWKKRIKP IVWPSLPDHK KTLEHLCKKP RKNLNVSFNP 310 320 330 340 350 360 ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP SEDVVITPES 370 380 390 400 410 420 FGRDSSLTCL AGNVSACDAP ILSSSRSLDC RESGKNGPHV YQDLLLSLGT TNSTLPPPFS 430 440 450 LQSGILTLNP VAQGQPILTS LGSNQEEAYV TMSSFYQNQ
	Isoform 3 (H1) [UniParc]. Checksum: B724534E0AFFC77B	FASTA	298	34,020
	10 20 30 40 50 60 MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG SQHSLTCAFE 70 80 90 100 110 120 DPDVNTTNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL LIGKSNICVK VGEKSLTCKK 130 140 150 160 170 180 IDLTTIVKPE APFDLSVIYR EGANDFVVTF NTSHLQKKYV KVLMHDVAYR QEKDENKWTH 190 200 210 220 230 240 VNLSSTKLTL LQRKLQPAAM YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGEMDP 250 260 270 280 290 ILLTISILSF FSVALLVILA CVLWKKRIKP IVWPSLPDHK KTLEHLCKKP RKVSVFGA
	Isoform 4 (H6) (Secreted) [UniParc]. Checksum: C77F2DB55E9DB48D	FASTA	261	29,938
	10 20 30 40 50 60 MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG SQHSLTCAFE 70 80 90 100 110 120 DPDVNTTNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL LIGKSNICVK VGEKSLTCKK 130 140 150 160 170 180 IDLTTIVKPE APFDLSVIYR EGANDFVVTF NTSHLQKKYV KVLMHDVAYR QEKDENKWTH 190 200 210 220 230 240 VNLSSTKLTL LQRKLQPAAM YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGLSLS 250 260 YGPVSPIIRR LWNIFVRNQE K
	Isoform 2 (Secreted) [UniParc]. Checksum: D37499B0E8BE412A	FASTA	252	28,724
	10 20 30 40 50 60 MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG SQHSLTCAFE 70 80 90 100 110 120 DPDVNTTNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL LIGKSNICVK VGEKSLTCKK 130 140 150 160 170 180 IDLTTIVKPE APFDLSVIYR EGANDFVVTF NTSHLQKKYV KVLMHDVAYR QEKDENKWTH 190 200 210 220 230 240 VNLSSTKLTL LQRKLQPAAM YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGLSLS 250 YGPVSPIIRQ EL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily." Goodwin R.G., Friend D., Ziegler S.F., Jerzy R., Falk B.A., Gimpel S., Cosman D., Dower S.K., March C.J., Namen A.E., Park L.S. Cell 60:941-951(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, VARIANT VAL-356. Tissue: B-cell.
[2]	"Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter." Pleiman C.M., Gimpel S.D., Park L.S., Harada H., Taniguchi T., Ziegler S.F. Mol. Cell. Biol. 11:3052-3059(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-356.
[3]	"Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency." Puel A., Ziegler S.F., Buckley R.H., Leonard W.J. Nat. Genet. 20:394-397(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS T(-)/B(+)/NK(+) SCID ILE-66 AND VAL-138, VARIANT ILE-244.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT VAL-356. Tissue: Spleen.
[5]	SeattleSNPs variation discovery resource Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS T(-)/B(+)/NK(+) SCID ILE-66 AND VAL-138, VARIANTS ASP-113 AND ILE-244.
[6]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS T(-)/B(+)/NK(+) SCID ILE-66 AND VAL-138.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS T(-)/B(+)/NK(+) SCID ILE-66 AND VAL-138, VARIANT VAL-356. Tissue: Testis.
[8]	"Structural and biophysical studies of the human IL-7/IL-7Ralpha complex." McElroy C.A., Dohm J.A., Walsh S.T. Structure 17:54-65(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 21-239 IN COMPLEX WITH IL7, SUBUNIT, GLYCOSYLATION AT ASN-49; ASN-65 AND ASN-151, DISULFIDE BONDS.
[9]	"A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency." Roifman C.M., Zhang J., Chitayat D., Sharfe N. Blood 96:2803-2807(2000) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT T(-)/B(+)/NK(+) SCID SER-132.
[10]	"Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis." Gregory S.G., Schmidt S., Seth P., Oksenberg J.R., Hart J., Prokop A., Caillier S.J., Ban M., Goris A., Barcellos L.F., Lincoln R., McCauley J.L., Sawcer S.J., Compston D.A., Dubois B., Hauser S.L., Garcia-Blanco M.A., Pericak-Vance M.A., Haines J.L. Nat. Genet. 39:1083-1091(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT ILE-244, ASSOCIATION WITH MS3.
+	Additional computationally mapped references.

Web resources

IL7Rbase

IL7R mutation db

GeneReviews

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M29696 mRNA. Translation: AAA59157.1.
AF043129 , AF043123, AF043124, AF043125, AF043126, AF043127, AF043128 Genomic DNA. Translation: AAC83204.1.
AK301220 mRNA. Translation: BAG62793.1.
AK315251 mRNA. Translation: BAG37673.1.
AY449709 Genomic DNA. Translation: AAR08908.1.
BC020717 mRNA. Translation: AAH20717.1. Sequence problems.
BC067537 mRNA. Translation: AAH67537.1.
BC067538 mRNA. Translation: AAH67538.1.
BC067539 mRNA. Translation: AAH67539.1.
BC067540 mRNA. Translation: AAH67540.1.
BC069999 mRNA. Translation: AAH69999.1.

IPI

IPI00216518.
IPI00292014.
IPI00419824.
IPI00963850.

PIR

A34791.
B34791.
C34791.

RefSeq

NP_002176.2. NM_002185.3.

UniGene

Hs.591742.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3DI2	X-ray	2.70	B/D	21-239	[»]
3DI3	X-ray	2.90	B	21-239	[»]
3UP1	X-ray	2.15	A/B	21-239	[»]

ProteinModelPortal

P16871.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-3045N.

IntAct

P16871. 2 interactions.

PTM databases

PhosphoSite

P16871.

Polymorphism databases

DMDM

215274000.

Proteomic databases

PaxDb

P16871.

PRIDE

P16871.

Protocols and materials databases

DNASU

3575.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000303115; ENSP00000306157; ENSG00000168685.

GeneID

3575.

KEGG

hsa:3575.

UCSC

uc003jjs.3. human.

Organism-specific databases

CTD

3575.

GeneCards

GC05P035892.

H-InvDB

HIX0024815.

HGNC

HGNC:6024. IL7R.

HPA

CAB010215.

MIM

146661. gene.
608971. phenotype.
612595. phenotype.

neXtProt

NX_P16871.

Orphanet

169154. Severe combined immunodeficiency T- B+ due to IL-7Ralpha deficiency.

PharmGKB

PA29840.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG39823.

HOVERGEN

HBG055773.

InParanoid

P16871.

KO

K05072.

Enzyme and pathway databases

Reactome

REACT_6900. Immune System.

Gene expression databases

ArrayExpress

P16871.

Bgee

P16871.

CleanEx

HS_IL7R.

Genevestigator

P16871.

GermOnline

ENSG00000168685. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.

InterPro

IPR003961. Fibronectin_type3.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]

Pfam

PF00041. fn3. 1 hit.
[Graphical view]

SUPFAM

SSF49265. FN_III-like. 1 hit.

PROSITE

PS50853. FN3. False negative.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P16871.

GenomeRNAi

3575.

NextBio

13972.

SOURCE

Search...

Entry information

Entry name

IL7RA_HUMAN

Accession

Primary (citable) accession number: P16871
Secondary accession number(s): B2RCS6 , B4DVT1, Q05CU8, Q6NSP4, Q6NWM0, Q6NWM1, Q6NWM2, Q6NWM3, Q6SV45, Q9UPC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 141 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.