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P16871 (IL7RA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 151. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-7 receptor subunit alpha

Short name=IL-7 receptor subunit alpha
Short name=IL-7R subunit alpha
Short name=IL-7R-alpha
Short name=IL-7RA
Alternative name(s):
CDw127
CD_antigen=CD127
Gene names
Name:IL7R
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

Subunit structure

The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R. Ref.8

Subcellular location

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Isoform 3: Cell membrane; Single-pass type I membrane protein.

Isoform 4: Secreted.

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Post-translational modification

N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form. Ref.8

Involvement in disease

Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.3 Ref.5 Ref.6 Ref.7 Ref.9

Multiple sclerosis 3 (MS3) [MIM:612595]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. A polymorphism at position 244 strongly influences susceptibility to multiple sclerosis. Overtransmission of the major 'C' allele coding for Thr-244 is detected in offspring affected with multiple sclerosis. In vitro analysis of transcripts from minigenes containing either 'C' allele (Thr-244) or 'T' allele (Ile-244) shows that the 'C' allele results in an approximately two-fold increase in the skipping of exon 6, leading to increased production of a soluble form of IL7R. Thus, the multiple sclerosis associated 'C' risk allele of IL7R would probably decrease membrane-bound expression of IL7R. As this risk allele is common in the general population, some additional triggers are probably required for the development and progression of MS. Ref.10

Sequence similarities

Belongs to the type I cytokine receptor family. Type 4 subfamily.

Contains 1 fibronectin type-III domain.

Sequence caution

The sequence AAH20717.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
Secreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseDisease mutation
SCID
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processB cell proliferation

Inferred from electronic annotation. Source: Ensembl

T cell differentiation

Inferred from electronic annotation. Source: Ensembl

cell growth

Inferred from electronic annotation. Source: Ensembl

cell morphogenesis

Inferred from electronic annotation. Source: Ensembl

cell surface receptor signaling pathway

Traceable author statement Ref.3. Source: ProtInc

homeostasis of number of cells

Inferred from electronic annotation. Source: Ensembl

immune response

Traceable author statement Ref.3. Source: ProtInc

immunoglobulin production

Inferred from electronic annotation. Source: Ensembl

interleukin-7-mediated signaling pathway

Traceable author statement PubMed 8266077. Source: GOC

lymph node development

Inferred from electronic annotation. Source: Ensembl

negative regulation of T cell mediated cytotoxicity

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell differentiation in thymus

Inferred from electronic annotation. Source: Ensembl

positive regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

regulation of DNA recombination

Traceable author statement PubMed 9495344. Source: ProtInc

regulation of cell size

Inferred from electronic annotation. Source: Ensembl

signal transduction

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentexternal side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionantigen binding

Traceable author statement PubMed 9495344. Source: ProtInc

interleukin-7 receptor activity

Traceable author statement PubMed 8266077. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

IL7P132323EBI-80490,EBI-80516

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P16871-1)

Also known as: H20;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 3 (identifier: P16871-2)

Also known as: H1;

The sequence of this isoform differs from the canonical sequence as follows:
     293-459: NLNVSFNPES...VTMSSFYQNQ → VSVFGA
Isoform 4 (identifier: P16871-3)

Also known as: H6; Secreted;

The sequence of this isoform differs from the canonical sequence as follows:
     237-459: EMDPILLTIS...VTMSSFYQNQ → LSLSYGPVSPIIRRLWNIFVRNQEK
Isoform 2 (identifier: P16871-4)

Also known as: Secreted;

The sequence of this isoform differs from the canonical sequence as follows:
     237-252: EMDPILLTISILSFFS → LSLSYGPVSPIIRQEL
     253-459: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020
Chain21 – 459439Interleukin-7 receptor subunit alpha
PRO_0000010909

Regions

Topological domain21 – 239219Extracellular Potential
Transmembrane240 – 26425Helical; Potential
Topological domain265 – 459195Cytoplasmic Potential
Domain131 – 231101Fibronectin type-III
Motif217 – 2215WSXWS motif
Motif272 – 2809Box 1 motif
Compositional bias184 – 1896Ser/Thr-rich

Amino acid modifications

Modified residue2821Phosphothreonine; by PKC Potential
Glycosylation491N-linked (GlcNAc...) Ref.8
Glycosylation651N-linked (GlcNAc...) Ref.8
Glycosylation1511N-linked (GlcNAc...) Ref.8
Glycosylation1821N-linked (GlcNAc...) Potential
Glycosylation2321N-linked (GlcNAc...) Potential
Glycosylation2331N-linked (GlcNAc...) Potential
Disulfide bond42 ↔ 57 Ref.8
Disulfide bond74 ↔ 82 Ref.8
Disulfide bond108 ↔ 118 Ref.8

Natural variations

Alternative sequence237 – 459223EMDPI…FYQNQ → LSLSYGPVSPIIRRLWNIFV RNQEK in isoform 4.
VSP_001713
Alternative sequence237 – 25216EMDPI…LSFFS → LSLSYGPVSPIIRQEL in isoform 2.
VSP_012618
Alternative sequence253 – 459207Missing in isoform 2.
VSP_012619
Alternative sequence293 – 459167NLNVS…FYQNQ → VSVFGA in isoform 3.
VSP_001714
Natural variant661T → I in T(-)/B(+)/NK(+) SCID. Ref.3 Ref.5 Ref.6 Ref.7
Corresponds to variant rs1494558 [ dbSNP | Ensembl ].
VAR_021286
Natural variant1131E → D. Ref.5
Corresponds to variant rs11567735 [ dbSNP | Ensembl ].
VAR_021287
Natural variant1321P → S in T(-)/B(+)/NK(+) SCID. Ref.9
VAR_034870
Natural variant1381I → V in T(-)/B(+)/NK(+) SCID. Ref.3 Ref.5 Ref.6 Ref.7
Corresponds to variant rs1494555 [ dbSNP | Ensembl ].
VAR_021288
Natural variant2441T → I. Ref.3 Ref.5 Ref.10
Corresponds to variant rs6897932 [ dbSNP | Ensembl ].
VAR_021289
Natural variant3561I → V. Ref.1 Ref.2 Ref.4 Ref.7
Corresponds to variant rs3194051 [ dbSNP | Ensembl ].
VAR_021290
Natural variant4141T → M.
Corresponds to variant rs2229232 [ dbSNP | Ensembl ].
VAR_047742

Experimental info

Sequence conflict391S → T in AAH67539. Ref.7
Sequence conflict521Q → R in AAH67538. Ref.7
Sequence conflict3841S → P in AAH67537. Ref.7
Sequence conflict3861R → G in AAH67539. Ref.7

Secondary structure

....................................... 459
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (H20) [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: EE556426C22A182B

FASTA45951,581
        10         20         30         40         50         60 
MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG SQHSLTCAFE 

        70         80         90        100        110        120 
DPDVNTTNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL LIGKSNICVK VGEKSLTCKK 

       130        140        150        160        170        180 
IDLTTIVKPE APFDLSVIYR EGANDFVVTF NTSHLQKKYV KVLMHDVAYR QEKDENKWTH 

       190        200        210        220        230        240 
VNLSSTKLTL LQRKLQPAAM YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGEMDP 

       250        260        270        280        290        300 
ILLTISILSF FSVALLVILA CVLWKKRIKP IVWPSLPDHK KTLEHLCKKP RKNLNVSFNP 

       310        320        330        340        350        360 
ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP SEDVVITPES 

       370        380        390        400        410        420 
FGRDSSLTCL AGNVSACDAP ILSSSRSLDC RESGKNGPHV YQDLLLSLGT TNSTLPPPFS 

       430        440        450 
LQSGILTLNP VAQGQPILTS LGSNQEEAYV TMSSFYQNQ 

« Hide

Isoform 3 (H1) [UniParc].

Checksum: B724534E0AFFC77B
Show »

FASTA29834,020
Isoform 4 (H6) (Secreted) [UniParc].

Checksum: C77F2DB55E9DB48D
Show »

FASTA26129,938
Isoform 2 (Secreted) [UniParc].

Checksum: D37499B0E8BE412A
Show »

FASTA25228,724

References

« Hide 'large scale' references
[1]"Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily."
Goodwin R.G., Friend D., Ziegler S.F., Jerzy R., Falk B.A., Gimpel S., Cosman D., Dower S.K., March C.J., Namen A.E., Park L.S.
Cell 60:941-951(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, VARIANT VAL-356.
Tissue: B-cell.
[2]"Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter."
Pleiman C.M., Gimpel S.D., Park L.S., Harada H., Taniguchi T., Ziegler S.F.
Mol. Cell. Biol. 11:3052-3059(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-356.
[3]"Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency."
Puel A., Ziegler S.F., Buckley R.H., Leonard W.J.
Nat. Genet. 20:394-397(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS T(-)/B(+)/NK(+) SCID ILE-66 AND VAL-138, VARIANT ILE-244.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT VAL-356.
Tissue: Spleen.
[5]SeattleSNPs variation discovery resource
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS T(-)/B(+)/NK(+) SCID ILE-66 AND VAL-138, VARIANTS ASP-113 AND ILE-244.
[6]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS T(-)/B(+)/NK(+) SCID ILE-66 AND VAL-138.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS T(-)/B(+)/NK(+) SCID ILE-66 AND VAL-138, VARIANT VAL-356.
Tissue: Testis.
[8]"Structural and biophysical studies of the human IL-7/IL-7Ralpha complex."
McElroy C.A., Dohm J.A., Walsh S.T.
Structure 17:54-65(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 21-239 IN COMPLEX WITH IL7, SUBUNIT, GLYCOSYLATION AT ASN-49; ASN-65 AND ASN-151, DISULFIDE BONDS.
[9]"A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency."
Roifman C.M., Zhang J., Chitayat D., Sharfe N.
Blood 96:2803-2807(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT T(-)/B(+)/NK(+) SCID SER-132.
[10]"Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis."
Gregory S.G., Schmidt S., Seth P., Oksenberg J.R., Hart J., Prokop A., Caillier S.J., Ban M., Goris A., Barcellos L.F., Lincoln R., McCauley J.L., Sawcer S.J., Compston D.A., Dubois B., Hauser S.L., Garcia-Blanco M.A., Pericak-Vance M.A., Haines J.L.
Nat. Genet. 39:1083-1091(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ILE-244, ASSOCIATION WITH MS3.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M29696 mRNA. Translation: AAA59157.1.
AF043129 expand/collapse EMBL AC list , AF043123, AF043124, AF043125, AF043126, AF043127, AF043128 Genomic DNA. Translation: AAC83204.1.
AK301220 mRNA. Translation: BAG62793.1.
AK315251 mRNA. Translation: BAG37673.1.
AY449709 Genomic DNA. Translation: AAR08908.1.
BC020717 mRNA. Translation: AAH20717.1. Sequence problems.
BC067537 mRNA. Translation: AAH67537.1.
BC067538 mRNA. Translation: AAH67538.1.
BC067539 mRNA. Translation: AAH67539.1.
BC067540 mRNA. Translation: AAH67540.1.
BC069999 mRNA. Translation: AAH69999.1.
PIRA34791.
B34791.
C34791.
RefSeqNP_002176.2. NM_002185.3.
UniGeneHs.591742.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3DI2X-ray2.70B/D21-239[»]
3DI3X-ray2.90B21-239[»]
3UP1X-ray2.15A/B21-239[»]
ProteinModelPortalP16871.
SMRP16871. Positions 32-232.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109789. 94 interactions.
DIPDIP-3045N.
IntActP16871. 2 interactions.

PTM databases

PhosphoSiteP16871.

Polymorphism databases

DMDM215274000.

Proteomic databases

PaxDbP16871.
PRIDEP16871.

Protocols and materials databases

DNASU3575.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000303115; ENSP00000306157; ENSG00000168685.
GeneID3575.
KEGGhsa:3575.
UCSCuc003jjs.4. human. [P16871-1]

Organism-specific databases

CTD3575.
GeneCardsGC05P035892.
H-InvDBHIX0024815.
HGNCHGNC:6024. IL7R.
HPACAB010215.
MIM146661. gene.
608971. phenotype.
612595. phenotype.
neXtProtNX_P16871.
Orphanet39041. Omenn syndrome.
169154. T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency.
PharmGKBPA29840.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39823.
HOVERGENHBG055773.
InParanoidP16871.
KOK05072.
PhylomeDBP16871.
TreeFamTF336573.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.
SignaLinkP16871.

Gene expression databases

ArrayExpressP16871.
BgeeP16871.
CleanExHS_IL7R.
GenevestigatorP16871.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR003961. Fibronectin_type3.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamPF00041. fn3. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 1 hit.
PROSITEPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP16871.
GeneWikiInterleukin-7_receptor-%CE%B1.
GenomeRNAi3575.
NextBio13972.
PROP16871.
SOURCESearch...

Entry information

Entry nameIL7RA_HUMAN
AccessionPrimary (citable) accession number: P16871
Secondary accession number(s): B2RCS6 expand/collapse secondary AC list , B4DVT1, Q05CU8, Q6NSP4, Q6NWM0, Q6NWM1, Q6NWM2, Q6NWM3, Q6SV45, Q9UPC1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 25, 2008
Last modified: April 16, 2014
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries