##gff-version 3
P16870	UniProtKB	Signal peptide	1	25	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
P16870	UniProtKB	Propeptide	26	42	.	.	.	ID=PRO_0000004384;Note=Activation peptide	
P16870	UniProtKB	Chain	43	476	.	.	.	ID=PRO_0000004385;Note=Carboxypeptidase E	
P16870	UniProtKB	Domain	52	372	.	.	.	Note=Peptidase M14;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01379	
P16870	UniProtKB	Active site	342	342	.	.	.	Note=Proton donor/acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01379	
P16870	UniProtKB	Binding site	114	114	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01379	
P16870	UniProtKB	Binding site	117	117	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01379	
P16870	UniProtKB	Binding site	248	248	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01379	
P16870	UniProtKB	Glycosylation	139	139	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P16870	UniProtKB	Glycosylation	390	390	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P16870	UniProtKB	Alternative sequence	1	36	.	.	.	ID=VSP_040959;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
P16870	UniProtKB	Natural variant	121	476	.	.	.	ID=VAR_085993;Note=In BDVS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34383079;Dbxref=PMID:34383079	
P16870	UniProtKB	Natural variant	135	476	.	.	.	ID=VAR_085994;Note=In BDVS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32936766;Dbxref=PMID:32936766	
P16870	UniProtKB	Natural variant	235	235	.	.	.	ID=VAR_048599;Note=W->R;Dbxref=dbSNP:rs34516004	
P16870	UniProtKB	Natural variant	297	297	.	.	.	ID=VAR_036011;Note=In a colorectal cancer sample%3B somatic mutation. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs541147146,PMID:16959974	
P16870	UniProtKB	Sequence conflict	287	287	.	.	.	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P16870	UniProtKB	Sequence conflict	391	391	.	.	.	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305