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Protein

FhuE receptor

Gene

fhuE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for the uptake of Fe3+ via coprogen, ferrioxamine B, and rhodotorulic acid.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciEcoCyc:EG10306-MONOMER.
ECOL316407:JW1088-MONOMER.
MetaCyc:EG10306-MONOMER.

Protein family/group databases

TCDBi1.B.14.1.1. the outer membrane receptor (omr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
FhuE receptor
Alternative name(s):
Outer-membrane receptor for Fe(III)-coprogen, Fe(III)-ferrioxamine B and Fe(III)-rhodotrulic acid
Gene namesi
Name:fhuE
Ordered Locus Names:b1102, JW1088
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10306. fhuE.

Subcellular locationi

GO - Cellular componenti

  • cell outer membrane Source: EcoCyc
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi44 – 441V → P: Abolishes transport activity. 1 Publication
Mutagenesisi46 – 461V → P: Abolishes transport activity. 1 Publication
Mutagenesisi163 – 1631G → A, V, N, D or H: Impaired transport and growth. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 36361 PublicationAdd
BLAST
Chaini37 – 729693FhuE receptorPRO_0000034749Add
BLAST

Proteomic databases

EPDiP16869.
PaxDbiP16869.
PRIDEiP16869.

Expressioni

Inductioni

For induction, the TonB and the ExbB proteins have to be active. Induced by hydroxyurea (PubMed:20005847).1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260942. 181 interactions.
STRINGi511145.b1102.

Structurei

3D structure databases

ProteinModelPortaliP16869.
SMRiP16869. Positions 55-700.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 498TonB box
Motifi712 – 72918TonB C-terminal boxAdd
BLAST

Sequence similaritiesi

Belongs to the TonB-dependent receptor family.Curated

Keywords - Domaini

Signal, TonB box, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105CNM. Bacteria.
COG4773. LUCA.
HOGENOMiHOG000217242.
InParanoidiP16869.
KOiK16088.
OMAiYDTNMEG.
PhylomeDBiP16869.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
InterProiIPR012910. Plug_dom.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010916. TonB_box_CS.
IPR010917. TonB_rcpt_CS.
IPR010105. TonB_sidphr_rcpt.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01783. TonB-siderophor. 1 hit.
PROSITEiPS00430. TONB_DEPENDENT_REC_1. 1 hit.
PS01156. TONB_DEPENDENT_REC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16869-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSTQFNRDN QYQAITKPSL LAGCIALALL PSAAFAAPAT EETVIVEGSA
60 70 80 90 100
TAPDDGENDY SVTSTSAGTK MQMTQRDIPQ SVTIVSQQRM EDQQLQTLGE
110 120 130 140 150
VMENTLGISK SQADSDRALY YSRGFQIDNY MVDGIPTYFE SRWNLGDALS
160 170 180 190 200
DMALFERVEV VRGATGLMTG TGNPSAAINM VRKHATSREF KGDVSAEYGS
210 220 230 240 250
WNKERYVADL QSPLTEDGKI RARIVGGYQN NDSWLDRYNS EKTFFSGIVD
260 270 280 290 300
ADLGDLTTLS AGYEYQRIDV NSPTWGGLPR WNTDGSSNSY DRARSTAPDW
310 320 330 340 350
AYNDKEINKV FMTLKQQFAD TWQATLNATH SEVEFDSKMM YVDAYVNKAD
360 370 380 390 400
GMLVGPYSNY GPGFDYVGGT GWNSGKRKVD ALDLFADGSY ELFGRQHNLM
410 420 430 440 450
FGGSYSKQNN RYFSSWANIF PDEIGSFYNF NGNFPQTDWS PQSLAQDDTT
460 470 480 490 500
HMKSLYAATR VTLADPLHLI LGARYTNWRV DTLTYSMEKN HTTPYAGLVF
510 520 530 540 550
DINDNWSTYA SYTSIFQPQN DRDSSGKYLA PITGNNYELG LKSDWMNSRL
560 570 580 590 600
TTTLAIFRIE QDNVAQSTGT PIPGSNGETA YKAVDGTVSK GVEFELNGAI
610 620 630 640 650
TDNWQLTFGA TRYIAEDNEG NAVNPNLPRT TVKMFTSYRL PVMPELTVGG
660 670 680 690 700
GVNWQNRVYT DTVTPYGTFR AEQGSYALVD LFTRYQVTKN FSLQGNVNNL
710 720
FDKTYDTNVE GSIVYGTPRN FSITGTYQF
Length:729
Mass (Da):81,233
Last modified:November 1, 1997 - v2
Checksum:i68ACEE7D110F76CD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti363 – 3631G → C in CAA35616 (PubMed:2162465).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17615 Genomic DNA. Translation: CAA35616.1.
U00096 Genomic DNA. Translation: AAC74186.1.
AP009048 Genomic DNA. Translation: BAA35909.1.
PIRiC64854.
RefSeqiNP_415620.1. NC_000913.3.
WP_000953441.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74186; AAC74186; b1102.
BAA35909; BAA35909; BAA35909.
GeneIDi945649.
KEGGiecj:JW1088.
eco:b1102.
PATRICi32117445. VBIEscCol129921_1145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17615 Genomic DNA. Translation: CAA35616.1.
U00096 Genomic DNA. Translation: AAC74186.1.
AP009048 Genomic DNA. Translation: BAA35909.1.
PIRiC64854.
RefSeqiNP_415620.1. NC_000913.3.
WP_000953441.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP16869.
SMRiP16869. Positions 55-700.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260942. 181 interactions.
STRINGi511145.b1102.

Protein family/group databases

TCDBi1.B.14.1.1. the outer membrane receptor (omr) family.

Proteomic databases

EPDiP16869.
PaxDbiP16869.
PRIDEiP16869.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74186; AAC74186; b1102.
BAA35909; BAA35909; BAA35909.
GeneIDi945649.
KEGGiecj:JW1088.
eco:b1102.
PATRICi32117445. VBIEscCol129921_1145.

Organism-specific databases

EchoBASEiEB0302.
EcoGeneiEG10306. fhuE.

Phylogenomic databases

eggNOGiENOG4105CNM. Bacteria.
COG4773. LUCA.
HOGENOMiHOG000217242.
InParanoidiP16869.
KOiK16088.
OMAiYDTNMEG.
PhylomeDBiP16869.

Enzyme and pathway databases

BioCyciEcoCyc:EG10306-MONOMER.
ECOL316407:JW1088-MONOMER.
MetaCyc:EG10306-MONOMER.

Miscellaneous databases

PROiP16869.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
InterProiIPR012910. Plug_dom.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010916. TonB_box_CS.
IPR010917. TonB_rcpt_CS.
IPR010105. TonB_sidphr_rcpt.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01783. TonB-siderophor. 1 hit.
PROSITEiPS00430. TONB_DEPENDENT_REC_1. 1 hit.
PS01156. TONB_DEPENDENT_REC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFHUE_ECOLI
AccessioniPrimary (citable) accession number: P16869
Secondary accession number(s): P77292
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.