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Protein

FhuE receptor

Gene

fhuE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for the uptake of Fe3+ via coprogen, ferrioxamine B, and rhodotorulic acid.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

BioCyciEcoCyc:EG10306-MONOMER.
MetaCyc:EG10306-MONOMER.

Protein family/group databases

TCDBi1.B.14.1.1. the outer membrane receptor (omr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
FhuE receptor
Alternative name(s):
Outer-membrane receptor for Fe(III)-coprogen, Fe(III)-ferrioxamine B and Fe(III)-rhodotrulic acid
Gene namesi
Name:fhuE
Ordered Locus Names:b1102, JW1088
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10306. fhuE.

Subcellular locationi

GO - Cellular componenti

  • cell outer membrane Source: EcoCyc
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi44V → P: Abolishes transport activity. 1 Publication1
Mutagenesisi46V → P: Abolishes transport activity. 1 Publication1
Mutagenesisi163G → A, V, N, D or H: Impaired transport and growth. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 361 PublicationAdd BLAST36
ChainiPRO_000003474937 – 729FhuE receptorAdd BLAST693

Proteomic databases

EPDiP16869.
PaxDbiP16869.
PRIDEiP16869.

Expressioni

Inductioni

For induction, the TonB and the ExbB proteins have to be active. Induced by hydroxyurea (PubMed:20005847).1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260942. 181 interactors.
STRINGi316385.ECDH10B_1174.

Structurei

3D structure databases

ProteinModelPortaliP16869.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 49TonB box8
Motifi712 – 729TonB C-terminal boxAdd BLAST18

Sequence similaritiesi

Belongs to the TonB-dependent receptor family.Curated

Keywords - Domaini

Signal, TonB box, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105CNM. Bacteria.
COG4773. LUCA.
HOGENOMiHOG000217242.
InParanoidiP16869.
KOiK16088.
PhylomeDBiP16869.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
InterProiView protein in InterPro
IPR012910. Plug_dom.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010916. TonB_box_CS.
IPR010917. TonB_rcpt_CS.
IPR010105. TonB_sidphr_rcpt.
PfamiView protein in Pfam
PF07715. Plug. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
TIGRFAMsiTIGR01783. TonB-siderophor. 1 hit.
PROSITEiView protein in PROSITE
PS00430. TONB_DEPENDENT_REC_1. 1 hit.
PS01156. TONB_DEPENDENT_REC_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16869-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSTQFNRDN QYQAITKPSL LAGCIALALL PSAAFAAPAT EETVIVEGSA
60 70 80 90 100
TAPDDGENDY SVTSTSAGTK MQMTQRDIPQ SVTIVSQQRM EDQQLQTLGE
110 120 130 140 150
VMENTLGISK SQADSDRALY YSRGFQIDNY MVDGIPTYFE SRWNLGDALS
160 170 180 190 200
DMALFERVEV VRGATGLMTG TGNPSAAINM VRKHATSREF KGDVSAEYGS
210 220 230 240 250
WNKERYVADL QSPLTEDGKI RARIVGGYQN NDSWLDRYNS EKTFFSGIVD
260 270 280 290 300
ADLGDLTTLS AGYEYQRIDV NSPTWGGLPR WNTDGSSNSY DRARSTAPDW
310 320 330 340 350
AYNDKEINKV FMTLKQQFAD TWQATLNATH SEVEFDSKMM YVDAYVNKAD
360 370 380 390 400
GMLVGPYSNY GPGFDYVGGT GWNSGKRKVD ALDLFADGSY ELFGRQHNLM
410 420 430 440 450
FGGSYSKQNN RYFSSWANIF PDEIGSFYNF NGNFPQTDWS PQSLAQDDTT
460 470 480 490 500
HMKSLYAATR VTLADPLHLI LGARYTNWRV DTLTYSMEKN HTTPYAGLVF
510 520 530 540 550
DINDNWSTYA SYTSIFQPQN DRDSSGKYLA PITGNNYELG LKSDWMNSRL
560 570 580 590 600
TTTLAIFRIE QDNVAQSTGT PIPGSNGETA YKAVDGTVSK GVEFELNGAI
610 620 630 640 650
TDNWQLTFGA TRYIAEDNEG NAVNPNLPRT TVKMFTSYRL PVMPELTVGG
660 670 680 690 700
GVNWQNRVYT DTVTPYGTFR AEQGSYALVD LFTRYQVTKN FSLQGNVNNL
710 720
FDKTYDTNVE GSIVYGTPRN FSITGTYQF
Length:729
Mass (Da):81,233
Last modified:November 1, 1997 - v2
Checksum:i68ACEE7D110F76CD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti363G → C in CAA35616 (PubMed:2162465).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17615 Genomic DNA. Translation: CAA35616.1.
U00096 Genomic DNA. Translation: AAC74186.1.
AP009048 Genomic DNA. Translation: BAA35909.1.
PIRiC64854.
RefSeqiNP_415620.1. NC_000913.3.
WP_000953441.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74186; AAC74186; b1102.
BAA35909; BAA35909; BAA35909.
GeneIDi945649.
KEGGiecj:JW1088.
eco:b1102.
PATRICifig|1411691.4.peg.1166.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFHUE_ECOLI
AccessioniPrimary (citable) accession number: P16869
Secondary accession number(s): P77292
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1997
Last modified: July 5, 2017
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families