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Protein

Gap junction alpha-1 protein

Gene

gja1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-1 protein
Alternative name(s):
Connexin-43
Short name:
Cx43
Gene namesi
Name:gja1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-876609. gja1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1312CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei14 – 3623HelicalSequence AnalysisAdd
BLAST
Topological domaini37 – 7640ExtracellularSequence AnalysisAdd
BLAST
Transmembranei77 – 9923HelicalSequence AnalysisAdd
BLAST
Topological domaini100 – 15455CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei155 – 17723HelicalSequence AnalysisAdd
BLAST
Topological domaini178 – 20831ExtracellularSequence AnalysisAdd
BLAST
Transmembranei209 – 23123HelicalSequence AnalysisAdd
BLAST
Topological domaini232 – 379148CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 379378Gap junction alpha-1 proteinPRO_0000057806Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 192By similarity
Disulfide bondi187 ↔ 198By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed in most tissues. Highest levels found in eye and brain.

Developmental stagei

Appears during organogenesis.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Structurei

3D structure databases

ProteinModelPortaliP16863.
SMRiP16863. Positions 258-379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG009576.
KOiK07372.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002261. Connexin43.
IPR013124. Connexin43_C.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF03508. Connexin43. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01132. CONNEXINA1.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16863-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWSALGRL LDKVQAYSTA GGKVWLSVLF IFRILLLGTA VESAWGDEQS
60 70 80 90 100
AFVCNTQQPG CENVCYDKSF PISHVRFWVL QIIFVSTPTL LYLAHVFYLM
110 120 130 140 150
RKEEKLNRKE EELKMVQNEG GNVDMHLKQI EIKKFKYGLE EHGKVKMRGG
160 170 180 190 200
LLRTYIISIL FKSVFEVGFI IIQWYMYGFS LSAIYTCKRD PCPHQVDCFL
210 220 230 240 250
SRPTEKTIFI WFMLIVSIVS LALNIIELFY VTYKSIKDGI KGKKDPFSAT
260 270 280 290 300
NDAVISGKEC GSPKYAYFNG CSSPTAPMSP PGYKLVTGER NPSSCRNYNK
310 320 330 340 350
QASEQNWANY SAEQNRMGQA GSTISNTHAQ PFDFSDEHQN TKKMAPGHEM
360 370
QPLTILDQRP SSRASSHASS RPRPDDLEI
Length:379
Mass (Da):42,961
Last modified:January 23, 2007 - v2
Checksum:i4FD12B031F595DDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17243 mRNA. Translation: CAA35108.1.
BC073407 mRNA. Translation: AAH73407.1.
PIRiA34575.
RefSeqiNP_001079129.1. NM_001085660.1.
UniGeneiXl.1109.

Genome annotation databases

GeneIDi373664.
KEGGixla:373664.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17243 mRNA. Translation: CAA35108.1.
BC073407 mRNA. Translation: AAH73407.1.
PIRiA34575.
RefSeqiNP_001079129.1. NM_001085660.1.
UniGeneiXl.1109.

3D structure databases

ProteinModelPortaliP16863.
SMRiP16863. Positions 258-379.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373664.
KEGGixla:373664.

Organism-specific databases

CTDi2697.
XenbaseiXB-GENE-876609. gja1.

Phylogenomic databases

HOVERGENiHBG009576.
KOiK07372.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002261. Connexin43.
IPR013124. Connexin43_C.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF03508. Connexin43. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01132. CONNEXINA1.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential regulation of the levels of three gap junction mRNAs in Xenopus embryos."
    Gimlich R.L., Kumar N.M., Gilula N.B.
    J. Cell Biol. 110:597-605(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiCXA1_XENLA
AccessioniPrimary (citable) accession number: P16863
Secondary accession number(s): Q6GNU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.