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P16863

- CXA1_XENLA

UniProt

P16863 - CXA1_XENLA

Protein

Gap junction alpha-1 protein

Gene

gja1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

    GO - Molecular functioni

    1. transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. cell-cell signaling Source: InterPro
    2. heart development Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gap junction alpha-1 protein
    Alternative name(s):
    Connexin-43
    Short name:
    Cx43
    Gene namesi
    Name:gja1
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-876609. gja1.

    Subcellular locationi

    GO - Cellular componenti

    1. connexon complex Source: InterPro
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Gap junction, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 379378Gap junction alpha-1 proteinPRO_0000057806Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 192By similarity
    Disulfide bondi187 ↔ 198By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed in most tissues. Highest levels found in eye and brain.

    Developmental stagei

    Appears during organogenesis.

    Interactioni

    Subunit structurei

    A connexon is composed of a hexamer of connexins.

    Structurei

    3D structure databases

    ProteinModelPortaliP16863.
    SMRiP16863. Positions 258-379.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 1312CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini37 – 7640ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini100 – 15455CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini178 – 20831ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini232 – 379148CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei155 – 17723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei209 – 23123HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG009576.
    KOiK07372.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR002261. Connexin43.
    IPR013124. Connexin43_C.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PfamiPF00029. Connexin. 1 hit.
    PF03508. Connexin43. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    PRINTSiPR00206. CONNEXIN.
    PR01132. CONNEXINA1.
    SMARTiSM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view]
    PROSITEiPS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P16863-1 [UniParc]FASTAAdd to Basket

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    MGDWSALGRL LDKVQAYSTA GGKVWLSVLF IFRILLLGTA VESAWGDEQS    50
    AFVCNTQQPG CENVCYDKSF PISHVRFWVL QIIFVSTPTL LYLAHVFYLM 100
    RKEEKLNRKE EELKMVQNEG GNVDMHLKQI EIKKFKYGLE EHGKVKMRGG 150
    LLRTYIISIL FKSVFEVGFI IIQWYMYGFS LSAIYTCKRD PCPHQVDCFL 200
    SRPTEKTIFI WFMLIVSIVS LALNIIELFY VTYKSIKDGI KGKKDPFSAT 250
    NDAVISGKEC GSPKYAYFNG CSSPTAPMSP PGYKLVTGER NPSSCRNYNK 300
    QASEQNWANY SAEQNRMGQA GSTISNTHAQ PFDFSDEHQN TKKMAPGHEM 350
    QPLTILDQRP SSRASSHASS RPRPDDLEI 379
    Length:379
    Mass (Da):42,961
    Last modified:January 23, 2007 - v2
    Checksum:i4FD12B031F595DDD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17243 mRNA. Translation: CAA35108.1.
    BC073407 mRNA. Translation: AAH73407.1.
    PIRiA34575.
    RefSeqiNP_001079129.1. NM_001085660.1.
    UniGeneiXl.1109.

    Genome annotation databases

    GeneIDi373664.
    KEGGixla:373664.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17243 mRNA. Translation: CAA35108.1 .
    BC073407 mRNA. Translation: AAH73407.1 .
    PIRi A34575.
    RefSeqi NP_001079129.1. NM_001085660.1.
    UniGenei Xl.1109.

    3D structure databases

    ProteinModelPortali P16863.
    SMRi P16863. Positions 258-379.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 373664.
    KEGGi xla:373664.

    Organism-specific databases

    CTDi 2697.
    Xenbasei XB-GENE-876609. gja1.

    Phylogenomic databases

    HOVERGENi HBG009576.
    KOi K07372.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR002261. Connexin43.
    IPR013124. Connexin43_C.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    Pfami PF00029. Connexin. 1 hit.
    PF03508. Connexin43. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    PRINTSi PR00206. CONNEXIN.
    PR01132. CONNEXINA1.
    SMARTi SM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    PROSITEi PS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential regulation of the levels of three gap junction mRNAs in Xenopus embryos."
      Gimlich R.L., Kumar N.M., Gilula N.B.
      J. Cell Biol. 110:597-605(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiCXA1_XENLA
    AccessioniPrimary (citable) accession number: P16863
    Secondary accession number(s): Q6GNU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3