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Protein

Gap junction alpha-1 protein

Gene

gja1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-1 protein
Alternative name(s):
Connexin-43
Short name:
Cx43
Gene namesi
Name:gja1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-876609 gja1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 13CytoplasmicSequence analysisAdd BLAST12
Transmembranei14 – 36HelicalSequence analysisAdd BLAST23
Topological domaini37 – 76ExtracellularSequence analysisAdd BLAST40
Transmembranei77 – 99HelicalSequence analysisAdd BLAST23
Topological domaini100 – 154CytoplasmicSequence analysisAdd BLAST55
Transmembranei155 – 177HelicalSequence analysisAdd BLAST23
Topological domaini178 – 208ExtracellularSequence analysisAdd BLAST31
Transmembranei209 – 231HelicalSequence analysisAdd BLAST23
Topological domaini232 – 379CytoplasmicSequence analysisAdd BLAST148

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000578062 – 379Gap junction alpha-1 proteinAdd BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 192By similarity
Disulfide bondi187 ↔ 198By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed in most tissues. Highest levels found in eye and brain.

Developmental stagei

Appears during organogenesis.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with TMEM65.By similarity

Structurei

3D structure databases

ProteinModelPortaliP16863
SMRiP16863
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG009576
KOiK07372

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
1.20.5.1130, 1 hit
InterProiView protein in InterPro
IPR035091 Alpha_helix_dom_sf
IPR000500 Connexin
IPR002261 Connexin43
IPR013124 Connexin43_C
IPR034634 Connexin_C
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PTHR11984:SF33 PTHR11984:SF33, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PF03508 Connexin43, 1 hit
PRINTSiPR00206 CONNEXIN
PR01132 CONNEXINA1
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
SUPFAMiSSF118220 SSF118220, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16863-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWSALGRL LDKVQAYSTA GGKVWLSVLF IFRILLLGTA VESAWGDEQS
60 70 80 90 100
AFVCNTQQPG CENVCYDKSF PISHVRFWVL QIIFVSTPTL LYLAHVFYLM
110 120 130 140 150
RKEEKLNRKE EELKMVQNEG GNVDMHLKQI EIKKFKYGLE EHGKVKMRGG
160 170 180 190 200
LLRTYIISIL FKSVFEVGFI IIQWYMYGFS LSAIYTCKRD PCPHQVDCFL
210 220 230 240 250
SRPTEKTIFI WFMLIVSIVS LALNIIELFY VTYKSIKDGI KGKKDPFSAT
260 270 280 290 300
NDAVISGKEC GSPKYAYFNG CSSPTAPMSP PGYKLVTGER NPSSCRNYNK
310 320 330 340 350
QASEQNWANY SAEQNRMGQA GSTISNTHAQ PFDFSDEHQN TKKMAPGHEM
360 370
QPLTILDQRP SSRASSHASS RPRPDDLEI
Length:379
Mass (Da):42,961
Last modified:January 23, 2007 - v2
Checksum:i4FD12B031F595DDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17243 mRNA Translation: CAA35108.1
BC073407 mRNA Translation: AAH73407.1
PIRiA34575
RefSeqiNP_001079129.1, NM_001085660.1
XP_018117108.1, XM_018261619.1
UniGeneiXl.1109

Genome annotation databases

GeneIDi373664
KEGGixla:373664

Similar proteinsi

Entry informationi

Entry nameiCXA1_XENLA
AccessioniPrimary (citable) accession number: P16863
Secondary accession number(s): Q6GNU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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