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P16863 (CXA1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gap junction alpha-1 protein
Alternative name(s):
Connexin-43
Short name=Cx43
Gene names
Name:gja1
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Subunit structure

A connexon is composed of a hexamer of connexins.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junctiongap junction.

Tissue specificity

Expressed in most tissues. Highest levels found in eye and brain.

Developmental stage

Appears during organogenesis.

Sequence similarities

Belongs to the connexin family. Alpha-type (group II) subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 379378Gap junction alpha-1 protein
PRO_0000057806

Regions

Topological domain2 – 1312Cytoplasmic Potential
Transmembrane14 – 3623Helical; Potential
Topological domain37 – 7640Extracellular Potential
Transmembrane77 – 9923Helical; Potential
Topological domain100 – 15455Cytoplasmic Potential
Transmembrane155 – 17723Helical; Potential
Topological domain178 – 20831Extracellular Potential
Transmembrane209 – 23123Helical; Potential
Topological domain232 – 379148Cytoplasmic Potential

Amino acid modifications

Disulfide bond54 ↔ 192 By similarity
Disulfide bond187 ↔ 198 By similarity

Sequences

Sequence LengthMass (Da)Tools
P16863 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 4FD12B031F595DDD

FASTA37942,961
        10         20         30         40         50         60 
MGDWSALGRL LDKVQAYSTA GGKVWLSVLF IFRILLLGTA VESAWGDEQS AFVCNTQQPG 

        70         80         90        100        110        120 
CENVCYDKSF PISHVRFWVL QIIFVSTPTL LYLAHVFYLM RKEEKLNRKE EELKMVQNEG 

       130        140        150        160        170        180 
GNVDMHLKQI EIKKFKYGLE EHGKVKMRGG LLRTYIISIL FKSVFEVGFI IIQWYMYGFS 

       190        200        210        220        230        240 
LSAIYTCKRD PCPHQVDCFL SRPTEKTIFI WFMLIVSIVS LALNIIELFY VTYKSIKDGI 

       250        260        270        280        290        300 
KGKKDPFSAT NDAVISGKEC GSPKYAYFNG CSSPTAPMSP PGYKLVTGER NPSSCRNYNK 

       310        320        330        340        350        360 
QASEQNWANY SAEQNRMGQA GSTISNTHAQ PFDFSDEHQN TKKMAPGHEM QPLTILDQRP 

       370 
SSRASSHASS RPRPDDLEI 

« Hide

References

« Hide 'large scale' references
[1]"Differential regulation of the levels of three gap junction mRNAs in Xenopus embryos."
Gimlich R.L., Kumar N.M., Gilula N.B.
J. Cell Biol. 110:597-605(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X17243 mRNA. Translation: CAA35108.1.
BC073407 mRNA. Translation: AAH73407.1.
PIRA34575.
RefSeqNP_001079129.1. NM_001085660.1.
UniGeneXl.1109.

3D structure databases

ProteinModelPortalP16863.
SMRP16863. Positions 258-379.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID373664.
KEGGxla:373664.

Organism-specific databases

CTD2697.
XenbaseXB-GENE-876609. gja1.

Phylogenomic databases

HOVERGENHBG009576.
KOK07372.

Family and domain databases

InterProIPR000500. Connexin.
IPR002261. Connexin43.
IPR013124. Connexin43_C.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERPTHR11984. PTHR11984. 1 hit.
PfamPF00029. Connexin. 1 hit.
PF03508. Connexin43. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSPR00206. CONNEXIN.
PR01132. CONNEXINA1.
SMARTSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCXA1_XENLA
AccessionPrimary (citable) accession number: P16863
Secondary accession number(s): Q6GNU5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families