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Protein

Natriuretic peptides B

Gene

NPPB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.1 Publication

GO - Molecular functioni

  • diuretic hormone activity Source: UniProtKB
  • hormone activity Source: UniProtKB
  • peptide hormone receptor binding Source: Ensembl
  • receptor binding Source: UniProtKB

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • body fluid secretion Source: UniProtKB
  • cell growth involved in cardiac muscle cell development Source: Ensembl
  • cell surface receptor signaling pathway Source: UniProtKB
  • cellular response to mechanical stimulus Source: Ensembl
  • cGMP biosynthetic process Source: UniProtKB
  • inflammatory response Source: Ensembl
  • killing of cells of other organism Source: UniProtKB
  • negative regulation of angiogenesis Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • negative regulation of smooth muscle cell proliferation Source: Ensembl
  • negative regulation of systemic arterial blood pressure Source: Ensembl
  • positive regulation of collecting lymphatic vessel constriction Source: Ensembl
  • positive regulation of renal sodium excretion Source: UniProtKB
  • positive regulation of urine volume Source: UniProtKB
  • protein folding Source: CAFA
  • receptor guanylyl cyclase signaling pathway Source: UniProtKB
  • regulation of blood pressure Source: UniProtKB
  • regulation of blood vessel diameter Source: UniProtKB
  • regulation of vascular permeability Source: UniProtKB
  • response to calcium ion Source: Ensembl
  • response to drug Source: Ensembl
  • response to hypoxia Source: Ensembl
  • response to lipopolysaccharide Source: Ensembl
  • response to organic cyclic compound Source: Ensembl
  • response to peptide hormone Source: Ensembl

Keywordsi

Molecular functionHormone, Vasoactive

Enzyme and pathway databases

SIGNORiP16860.

Names & Taxonomyi

Protein namesi
Recommended name:
Natriuretic peptides B
Alternative name(s):
Gamma-brain natriuretic peptide
Cleaved into the following 16 chains:
Gene namesi
Name:NPPB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000120937.8.
HGNCiHGNC:7940. NPPB.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Available under the name Nesiritide (Scios). Used for the treatment of heart failure.

Organism-specific databases

DisGeNETi4879.
OpenTargetsiENSG00000120937.
PharmGKBiPA31734.

Chemistry databases

DrugBankiDB01136. Carvedilol.
DB06412. Oxymetholone.

Polymorphism and mutation databases

BioMutaiNPPB.
DMDMi113836.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000000153127 – 134Natriuretic peptides BAdd BLAST108
PeptideiPRO_0000001532103 – 134Brain natriuretic peptide 32Add BLAST32
PeptideiPRO_0000364993103 – 132BNP(1-30)Add BLAST30
PeptideiPRO_0000364994103 – 131BNP(1-29)Add BLAST29
PeptideiPRO_0000364995103 – 130BNP(1-28)Add BLAST28
PeptideiPRO_0000364996104 – 133BNP(2-31)Add BLAST30
PeptideiPRO_0000364997105 – 134BNP(3-32)Add BLAST30
PeptideiPRO_0000364998105 – 132BNP(3-30)Add BLAST28
PeptideiPRO_0000364999105 – 131BNP(3-29)Add BLAST27
PeptideiPRO_0000365000106 – 134BNP(4-32)Add BLAST29
PeptideiPRO_0000365001106 – 133BNP(4-31)Add BLAST28
PeptideiPRO_0000365002106 – 132BNP(4-30)Add BLAST27
PeptideiPRO_0000365003106 – 131BNP(4-29)Add BLAST26
PeptideiPRO_0000365004106 – 129BNP(4-27)Add BLAST24
PeptideiPRO_0000365005107 – 134BNP(5-32)Add BLAST28
PeptideiPRO_0000365006107 – 133BNP(5-31)Add BLAST27
PeptideiPRO_0000365007107 – 131BNP(5-29)Add BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62O-linked (HexNAc...) threonine; Partial1 Publication1
Glycosylationi63O-linked (HexNAc...) serine1 Publication1
Glycosylationi70O-linked (HexNAc...) serine1 Publication1
Glycosylationi74O-linked (HexNAc...) threonine1 Publication1
Glycosylationi79O-linked (HexNAc...) serine1 Publication1
Glycosylationi84O-linked (HexNAc...) threonine; Partial1 Publication1
Glycosylationi97O-linked (HexNAc...) threonine1 Publication1
Disulfide bondi112 ↔ 1281 Publication

Post-translational modificationi

The brain natriuretic peptide 32 form is cleaved at Pro-104 by the prolyl endopeptidase FAP (seprase) activity (in vitro).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei104 – 105Cleavage; by FAP1 Publication2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP16860.
PeptideAtlasiP16860.
PRIDEiP16860.

PTM databases

iPTMnetiP16860.
PhosphoSitePlusiP16860.

Miscellaneous databases

PMAP-CutDBiP16860.

Expressioni

Tissue specificityi

Brain and also in atria, but at much lower levels than ANP.

Gene expression databases

BgeeiENSG00000120937.
CleanExiHS_NPPB.
GenevisibleiP16860. HS.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • diuretic hormone activity Source: UniProtKB
  • hormone activity Source: UniProtKB
  • peptide hormone receptor binding Source: Ensembl
  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110939. 19 interactors.
IntActiP16860. 10 interactors.
MINTiMINT-1434895.
STRINGi9606.ENSP00000365651.

Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi121 – 123Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YK1X-ray2.90E111-131[»]
3N56X-ray3.10C/D103-134[»]
DisProtiDP00551.
ProteinModelPortaliP16860.
SMRiP16860.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16860.

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2F8. Eukaryota.
ENOG410ZE1B. LUCA.
GeneTreeiENSGT00510000049822.
HOGENOMiHOG000033937.
HOVERGENiHBG004227.
InParanoidiP16860.
KOiK12335.
OMAiSGCFGRK.
OrthoDBiEOG091G0T3N.
PhylomeDBiP16860.
TreeFamiTF106304.

Family and domain databases

InterProiView protein in InterPro
IPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
IPR002408. Natriuretic_peptide_brain.
PfamiView protein in Pfam
PF00212. ANP. 1 hit.
PRINTSiPR00712. BNATPEPTIDE.
SMARTiView protein in SMART
SM00183. NAT_PEP. 1 hit.
PROSITEiView protein in PROSITE
PS00263. NATRIURETIC_PEPTIDE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16860-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPQTAPSRA LLLLLFLHLA FLGGRSHPLG SPGSASDLET SGLQEQRNHL
60 70 80 90 100
QGKLSELQVE QTSLEPLQES PRPTGVWKSR EVATEGIRGH RKMVLYTLRA
110 120 130
PRSPKMVQGS GCFGRKMDRI SSSSGLGCKV LRRH
Length:134
Mass (Da):14,726
Last modified:August 1, 1990 - v1
Checksum:iDC884D9408462146
GO

Sequence cautioni

P16860: The sequence BAA90441 differs from that shown. Reason: Frameshift at position 44.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01458025R → L. Corresponds to variant dbSNP:rs5227Ensembl.1
Natural variantiVAR_01458147R → H. Corresponds to variant dbSNP:rs5229Ensembl.1
Natural variantiVAR_01458293M → L. Corresponds to variant dbSNP:rs5230Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31776 Genomic DNA. Translation: AAA35603.1.
M25296 mRNA. Translation: AAA36355.1.
AB037521 Genomic DNA. Translation: BAA90441.1. Frameshift.
CR541976 mRNA. Translation: CAG46774.1.
CR542003 mRNA. Translation: CAG46800.1.
EU326309 Genomic DNA. Translation: ACA05917.1.
AL021155 Genomic DNA. No translation available.
CH471130 Genomic DNA. Translation: EAW71718.1.
BC025785 mRNA. Translation: AAH25785.1.
CCDSiCCDS140.1.
PIRiA36736. AWHUB.
RefSeqiNP_002512.1. NM_002521.2.
UniGeneiHs.219140.

Genome annotation databases

EnsembliENST00000376468; ENSP00000365651; ENSG00000120937.
GeneIDi4879.
KEGGihsa:4879.
UCSCiuc001atj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiANFB_HUMAN
AccessioniPrimary (citable) accession number: P16860
Secondary accession number(s): B0ZBE9, Q6FGY0, Q9P2Q7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: September 27, 2017
This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families