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Protein

Envelopment polyprotein

Gene

GP

Organism
Hantaan virus (strain Lee) (Lee virus) (Korean hemorrhagic fever virus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Glycoprotein N and Glycoprotein C interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. Gn contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelopment polyprotein
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Glycoprotein NBy similarity
Short name:
Gn
Alternative name(s):
Glycoprotein G1
Glycoprotein CBy similarity
Short name:
Gc
Alternative name(s):
Glycoprotein G2
Gene namesi
Name:GP
OrganismiHantaan virus (strain Lee) (Lee virus) (Korean hemorrhagic fever virus)
Taxonomic identifieri11601 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiApodemus agrarius (Eurasian field mouse) [TaxID: 39030]
Homo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Glycoprotein N :
  • Virion membrane By similarity
  • Host Golgi apparatus membrane By similarity; Single-pass type I membrane protein By similarity
  • Host endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity

  • Note: Interaction between Glycoprotein N and Glycoprotein C is essential for proper targeting of Glycoprotein N to the Golgi complex, where virion budding occurs.By similarity
Glycoprotein C :
  • Virion membrane By similarity
  • Host Golgi apparatus membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 485LumenalSequence analysisAdd BLAST467
Transmembranei486 – 506HelicalSequence analysisAdd BLAST21
Topological domaini507 – 648CytoplasmicSequence analysisAdd BLAST142
Topological domaini649 – 1105LumenalSequence analysisAdd BLAST457
Transmembranei1106 – 1126HelicalSequence analysisAdd BLAST21
Topological domaini1127 – 1135CytoplasmicSequence analysis9

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003681219 – 1135Envelopment polyproteinAdd BLAST1117
ChainiPRO_000003681319 – 648Glycoprotein NBy similarityAdd BLAST630
ChainiPRO_0000036814649 – 1135Glycoprotein CBy similarityAdd BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi235N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi347N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi399N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi928N-linked (GlcNAc...); by hostSequence analysis1

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein Glycoprotein N and glycoprotein Glycoprotein C.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei648 – 649Cleavage; by host signal peptidaseBy similarity2

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Glycoprotein N and Glycoprotein C interacts with each other.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini611 – 634ITAMPROSITE-ProRule annotationAdd BLAST24

Sequence similaritiesi

Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016402. Envelope_glycoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamiPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
ProDomiPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS51056. ITAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16853-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIWKWLVMA SLVWPVLTLR NVYDMKIECP HTVSFGENSV IGYVELPPMP
60 70 80 90 100
LADTAQLVPE SSCSMDNHQS LNTITKYTQV SWRGKADQSQ SSQTSFETVS
110 120 130 140 150
TEVDLKGTCV LKHKMVEESY RSRKSITCYD LSCNSTYCKP TLYMIVPIHA
160 170 180 190 200
CNMMKSCLIA LGPYRVQVVY ERTYCMTGVL IEGKCFVPDQ SVVSIIKHGI
210 220 230 240 250
FDIASVHIVC FFVAVKGNTY KIFEQVKKSF ESTCNDTENK VQGYYICIVG
260 270 280 290 300
GNSAPIYVPT LDDFRSMEAF TGIFRSPHGE DHDLAGEETA TYSIVGPANA
310 320 330 340 350
KVPHSASSDT LSLIAFSGIP SDSSLSILTS STEAKHVFSP GLFPKLNHTN
360 370 380 390 400
CDKGAIPLMW TGMIDLPGYY EAIHPCTVFC VLSGPGASCE AFSEGGIFNI
410 420 430 440 450
TYPMCLVSKQ NRFRLTEQQV NFVCQRVDVD IVVYCNGQRK VILTKTLVIG
460 470 480 490 500
QCIYTITSLF SLLPGVAHSI AVELCVPGFH GWATAALLVT FCFGWVLIPA
510 520 530 540 550
ITFIILTILK FIANIFHTSN QENRLKSVLR KIKEEFEKTK GSMVCDVCKY
560 570 580 590 600
ECETYKELKA HGVSCPQSQC PYCFTHCEPT EAAFQAHYKV CQVTHRFRDD
610 620 630 640 650
LKKTVTPQNF TPGCYRTLNL FRYKSRCYIF TMWIFLLVLE SILWAASASE
660 670 680 690 700
TPLTPVWNDN AHGVGSVPMH TDLELDFSLT SSSKYTYRRK LTNPLEEAQS
710 720 730 740 750
IDLHIEIEEQ TIGVDVHALG HWFDGRLNLK TSFHCYGACT KYEYPWHTAK
760 770 780 790 800
CHYERDYQYE TSWGCNPSDC PGVGTGCTAC GLYLDRLKPV GSAYKIITIR
810 820 830 840 850
YSRRVCVQFG EENLCKIIDM NDCFVSRHVK VCIIGTVSKF SQGDTLLFFG
860 870 880 890 900
PLEGGGLIFK HWCTSTCQFG DPGDIMSPRD KGFLCPEFPG SFRKKCNFAT
910 920 930 940 950
TPICEYDGNM VSGYKKVMAT IDSFQSFNTS TMHFTDERIE WKDPDGMLRD
960 970 980 990 1000
HINILVTKDI DFDNLGENPC KIGLQTSSIE GAWGSGVGFT LTCLVSLTEC
1010 1020 1030 1040 1050
PTFLTSIKAC DKAICYGAES VTLTRGQNTV KVSGKGGHSG STFKCCHGED
1060 1070 1080 1090 1100
CSQIGLHAAA PHLDKVNGIS EMENSKEYDD GAPQCGIKCW FVKSGEWISG
1110 1120 1130
IFSGNWIVLI VLCVFLLFSL VLLSILCPVR KHKKS
Length:1,135
Mass (Da):126,470
Last modified:August 1, 1990 - v1
Checksum:iB9C759ED6592265A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00377 Genomic RNA. Translation: BAA00280.1.
PIRiJS0605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00377 Genomic RNA. Translation: BAA00280.1.
PIRiJS0605.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR016402. Envelope_glycoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamiPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
ProDomiPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS51056. ITAM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP_HANTL
AccessioniPrimary (citable) accession number: P16853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.