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P16853

- GP_HANTL

UniProt

P16853 - GP_HANTL

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Protein

Envelope glycoprotein

Gene

GP

Organism
Hantaan virus (strain Lee) (Lee virus) (Korean hemorrhagic fever virus)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei648 – 6492Cleavage; by host signal peptidaseBy similarity

GO - Biological processi

  1. endocytosis involved in viral entry into host cell Source: UniProtKB-KW
  2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  3. signal transduction Source: InterPro
  4. suppression by virus of host innate immune response Source: UniProtKB-KW
  5. suppression by virus of host TRAF activity Source: UniProtKB-KW
  6. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiHantaan virus (strain Lee) (Lee virus) (Korean hemorrhagic fever virus)
Taxonomic identifieri11601 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiApodemus agrarius (Eurasian field mouse) [TaxID: 39030]
Homo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

GO - Cellular componenti

  1. host cell endoplasmic reticulum Source: UniProtKB-KW
  2. host cell Golgi apparatus Source: UniProtKB-KW
  3. host cell membrane Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. viral envelope Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 11351117Envelope glycoproteinPRO_0000036812Add
BLAST
Chaini19 – 648630Glycoprotein G1By similarityPRO_0000036813Add
BLAST
Chaini649 – 1135487Glycoprotein G2By similarityPRO_0000036814Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi134 – 1341N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi235 – 2351N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi347 – 3471N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi399 – 3991N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi928 – 9281N-linked (GlcNAc...); by hostSequence Analysis

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other.By similarity

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 485467LumenalSequence AnalysisAdd
BLAST
Topological domaini507 – 648142CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini649 – 1105457LumenalSequence AnalysisAdd
BLAST
Topological domaini1127 – 11359CytoplasmicSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei486 – 50621HelicalSequence AnalysisAdd
BLAST
Transmembranei1106 – 112621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini611 – 63424ITAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamiPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
ProDomiPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS51056. ITAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16853 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MGIWKWLVMA SLVWPVLTLR NVYDMKIECP HTVSFGENSV IGYVELPPMP
60 70 80 90 100
LADTAQLVPE SSCSMDNHQS LNTITKYTQV SWRGKADQSQ SSQTSFETVS
110 120 130 140 150
TEVDLKGTCV LKHKMVEESY RSRKSITCYD LSCNSTYCKP TLYMIVPIHA
160 170 180 190 200
CNMMKSCLIA LGPYRVQVVY ERTYCMTGVL IEGKCFVPDQ SVVSIIKHGI
210 220 230 240 250
FDIASVHIVC FFVAVKGNTY KIFEQVKKSF ESTCNDTENK VQGYYICIVG
260 270 280 290 300
GNSAPIYVPT LDDFRSMEAF TGIFRSPHGE DHDLAGEETA TYSIVGPANA
310 320 330 340 350
KVPHSASSDT LSLIAFSGIP SDSSLSILTS STEAKHVFSP GLFPKLNHTN
360 370 380 390 400
CDKGAIPLMW TGMIDLPGYY EAIHPCTVFC VLSGPGASCE AFSEGGIFNI
410 420 430 440 450
TYPMCLVSKQ NRFRLTEQQV NFVCQRVDVD IVVYCNGQRK VILTKTLVIG
460 470 480 490 500
QCIYTITSLF SLLPGVAHSI AVELCVPGFH GWATAALLVT FCFGWVLIPA
510 520 530 540 550
ITFIILTILK FIANIFHTSN QENRLKSVLR KIKEEFEKTK GSMVCDVCKY
560 570 580 590 600
ECETYKELKA HGVSCPQSQC PYCFTHCEPT EAAFQAHYKV CQVTHRFRDD
610 620 630 640 650
LKKTVTPQNF TPGCYRTLNL FRYKSRCYIF TMWIFLLVLE SILWAASASE
660 670 680 690 700
TPLTPVWNDN AHGVGSVPMH TDLELDFSLT SSSKYTYRRK LTNPLEEAQS
710 720 730 740 750
IDLHIEIEEQ TIGVDVHALG HWFDGRLNLK TSFHCYGACT KYEYPWHTAK
760 770 780 790 800
CHYERDYQYE TSWGCNPSDC PGVGTGCTAC GLYLDRLKPV GSAYKIITIR
810 820 830 840 850
YSRRVCVQFG EENLCKIIDM NDCFVSRHVK VCIIGTVSKF SQGDTLLFFG
860 870 880 890 900
PLEGGGLIFK HWCTSTCQFG DPGDIMSPRD KGFLCPEFPG SFRKKCNFAT
910 920 930 940 950
TPICEYDGNM VSGYKKVMAT IDSFQSFNTS TMHFTDERIE WKDPDGMLRD
960 970 980 990 1000
HINILVTKDI DFDNLGENPC KIGLQTSSIE GAWGSGVGFT LTCLVSLTEC
1010 1020 1030 1040 1050
PTFLTSIKAC DKAICYGAES VTLTRGQNTV KVSGKGGHSG STFKCCHGED
1060 1070 1080 1090 1100
CSQIGLHAAA PHLDKVNGIS EMENSKEYDD GAPQCGIKCW FVKSGEWISG
1110 1120 1130
IFSGNWIVLI VLCVFLLFSL VLLSILCPVR KHKKS
Length:1,135
Mass (Da):126,470
Last modified:August 1, 1990 - v1
Checksum:iB9C759ED6592265A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00377 Genomic RNA. Translation: BAA00280.1.
PIRiJS0605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00377 Genomic RNA. Translation: BAA00280.1 .
PIRi JS0605.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view ]
Pfami PF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view ]
PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
ProDomi PD001813. Hanta_G2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS51056. ITAM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Conservation of antigenic properties and sequences encoding the envelope proteins of prototype Hantaan virus and two virus isolates from Korean haemorrhagic fever patients."
    Schmaljohn C.S., Arikawa J., Hasty S.E., Rasmussen L., Lee H.W., Lee P.W., Dalrymple J.M.
    J. Gen. Virol. 69:1949-1955(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiGP_HANTL
AccessioniPrimary (citable) accession number: P16853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3