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Protein

DNA helicase/primase complex-associated protein

Gene

UL102

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs. The primase-associated factor has no known catalytic activity in the complex and may serve to facilitate the formation of the replisome by directly interacting with the origin-binding protein and the polymerase.UniRule annotation

GO - Biological processi

  • bidirectional double-stranded viral DNA replication Source: UniProtKB
  • DNA replication Source: UniProtKB-KW

Keywordsi

Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA helicase/primase complex-associated proteinUniRule annotation
Short name:
HEPAUniRule annotation
Alternative name(s):
Primase-associated factorUniRule annotation
Gene namesi
Name:UL102
OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri10360 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008992 Componenti: Genome
  • UP000008991 Componenti: Genome

Subcellular locationi

  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001158651 – 873DNA helicase/primase complex-associated proteinAdd BLAST873

Interactioni

Subunit structurei

Associates with the primase and the helicase to form the helicase-primase complex. Interacts with the origin-binding protein. Interacts with the polymerase catalytic subunit.UniRule annotation

Protein-protein interaction databases

MINTiP16827

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae HEPA family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900002E

Family and domain databases

HAMAPiMF_04010 HSV_HEPA, 1 hit
InterProiView protein in InterPro
IPR004996 HSV_HEPA
PfamiView protein in Pfam
PF03324 Herpes_HEPA, 1 hit

Sequencei

Sequence statusi: Complete.

P16827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAQPPLHHR HHPYTLFGTS CHLSWYGLLE ASVPIVQCLF LDLGGGRAEP
60 70 80 90 100
RLHTFVVRGD RLPPAEVRAV HRASYAALAS AVTTDADERR RGLEQRSAVL
110 120 130 140 150
ARVLLEGSAL IRVLARTFTP VQIQTDASGV EILEAAPALG VETAALSNAL
160 170 180 190 200
SLFHVAKLVV IGSYPEVHEP RVVTHTAERV SEEYGTHAHK KLRRGYYAYD
210 220 230 240 250
LAMSFRVGTH KYVLERDDEA VLARLFEVRE VCFLRTCLRL VTPVGFVAVA
260 270 280 290 300
VTDEQCCLLL QSAWTHLYDV LFRGFAGQPP LRDYLGPDLF ETGAARSFFF
310 320 330 340 350
PGFPPVPVYA VHGLHTLMRE TALDAAAEVL SWCGLPDIVG SAGKLEVEPC
360 370 380 390 400
ALSLGVPEDE WQVFGTEAGG GAVRLNATAF RERPAGGDRR WLLPPLPRDD
410 420 430 440 450
GDGENNVVEV SSSTGGAHPP SDDATFTVHV RDATLHRVLI VDLVERVLAK
460 470 480 490 500
CVRARDFNPY VRYSHRLHTY AVCEKFIENL RFRSRRAFWQ IQSLLGYISE
510 520 530 540 550
HVTSACASAG LLWVLSRGHR EFYVYDGYSG HGPVSAEVCV RTVVDCYWRK
560 570 580 590 600
LFGGDDPGPT CRVQESAPGV LLVWGDERLV GPFNFFYGNG GAGGSPLHGV
610 620 630 640 650
VGGFAAGHCG GACCAGCVVT HRHSSGGGGS GVGDADHASG GGLDAAAGSG
660 670 680 690 700
HNGGSDRVSP STPPAALGGC CCAAGGDWLS AVGHVLGRLP ALLRERVSVS
710 720 730 740 750
ELEAVYREIL FRFVARRNDV DFWLLRFQPG ENEVRPHAGV IDCAPFHGVW
760 770 780 790 800
AEQGQIIVQS RDTALAADIG YGVYVDKAFA MLTACVEVWA RELLSSSTAS
810 820 830 840 850
TTACSSSSVL SSALPSVTSS SSGTATVSPP SCSSSSATWL EERDEWVRSL
860 870
AVDAQHAAKR VASEGLRFFR LNA
Length:873
Mass (Da):94,050
Last modified:February 15, 2005 - v2
Checksum:iC2DB3734306FA4CB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15T → A in AAA67889 (PubMed:7853511).Curated1
Sequence conflicti74S → T in AAA67889 (PubMed:7853511).Curated1
Sequence conflicti170P → S in AAA67889 (PubMed:7853511).Curated1
Sequence conflicti176T → A in AAA67889 (PubMed:7853511).Curated1
Sequence conflicti387G → S in AAA67889 (PubMed:7853511).Curated1
Sequence conflicti395 – 412PLPRD…VEVSS → RCRVTTATVKTTSWKSAR in AAA67889 (PubMed:7853511).CuratedAdd BLAST18
Sequence conflicti493S → G in AAA67889 (PubMed:7853511).Curated1
Sequence conflicti525Y → C in AAA67889 (PubMed:7853511).Curated1
Sequence conflicti625S → G in AAA67889 (PubMed:7853511).Curated1
Sequence conflicti859K → R in AAA67889 (PubMed:7853511).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA Translation: CAA35338.1 Sequence problems.
U18289 mRNA Translation: AAA67889.1
BK000394 Genomic DNA Translation: DAA00236.1
PIRiS09867

Similar proteinsi

Entry informationi

Entry nameiHEPA_HCMVA
AccessioniPrimary (citable) accession number: P16827
Secondary accession number(s): Q68286, Q7M6F6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 57 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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