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P16824

- DUT_HCMVA

UniProt

P16824 - DUT_HCMVA

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00610; UER00666.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    Name:DUT
    Synonyms:UL72
    OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
    Taxonomic identifieri10360 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000008991: Genome, UP000008992: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. virion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182965Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP16824.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    InterProiIPR029054. dUTPase-like.
    IPR006882. Herpes_Orf11.
    [Graphical view]
    PfamiPF04797. Herpes_ORF11. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P16824-1 [UniParc]FASTAAdd to Basket

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    MLTMLTDRID SQLVLSRLPR SRFQRFWETP TLIMKEESAS SSGSIILAEK    50
    SVNMRYCVRF ASDSDFQTTF TLPQSTEEKY DKEQHPGEDE ASSPLPSPLK 100
    VPYKWMPSSF IVKQCHTQLA FYNKHIIWLS RERKVPTSLG VSLYIPEGFF 150
    GITFYKCLDA QFVCMPELLE SRLQVPQLDV VNLNDTFQSI FPGTIEGDIG 200
    VFPCFVPEPW QLMNLPPPNE HRFFSLRTRQ TLVIGPGHTQ TVYFDAAYVH 250
    APGICALIVG VRQFSQSDLI IRPTIWLPGT AAGVTVVNTS HTTVCISPHT 300
    TVAKAVFTTH RFTYLPVGSH PLGQMIVPPT PDIGFTHTPE HALLQRTPSP 350
    VDDDVDETEE DEKSSDAESP VNTNDVIFDV GPKPPRHP 388
    Length:388
    Mass (Da):43,575
    Last modified:August 1, 1990 - v1
    Checksum:iA747D7D4C1E80DA6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17403 Genomic DNA. Translation: CAA35387.1.
    BK000394 Genomic DNA. Translation: DAA00168.1.
    PIRiS09835.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17403 Genomic DNA. Translation: CAA35387.1 .
    BK000394 Genomic DNA. Translation: DAA00168.1 .
    PIRi S09835.

    3D structure databases

    ProteinModelPortali P16824.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00610 ; UER00666 .

    Family and domain databases

    InterProi IPR029054. dUTPase-like.
    IPR006882. Herpes_Orf11.
    [Graphical view ]
    Pfami PF04797. Herpes_ORF11. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169."
      Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.
      Curr. Top. Microbiol. Immunol. 154:125-169(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome."
      Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S.
      J. Gen. Virol. 84:17-28(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
    3. Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiDUT_HCMVA
    AccessioniPrimary (citable) accession number: P16824
    Secondary accession number(s): Q7M6M0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3