SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P16794

- UL53_HCMVA

UniProt

P16794 - UL53_HCMVA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Virion egress protein UL31 homolog
Gene
UL53
Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a major role in virion nuclear egress, the first step of virion release from infected cell. Viral capsids are initially assembled within the nucleus, UL53/UL50 complex induces capsids budding and envelopment into the perinuclear space. Then UL53/UL50 complex promotes fusion of perinuclear virion envelope with the outer nuclear membrane, releasing viral capsid into the cytoplasm where it will engages budding sites in the Golgi or trans-Golgi network By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Virion egress protein UL31 homolog
Gene namesi
Name:UL53
OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri10360 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000008991: Genome, UP000008992: Genome

Subcellular locationi

Host nucleus inner membrane
Note: Remains attached to the nucleus inner membrane through interaction with UL50. Localizes also at the transient membrane of perinuclear virions.1 Publication

GO - Cellular componenti

  1. host cell nuclear inner membrane Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host membrane, Host nucleus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Virion egress protein UL31 homolog
PRO_0000116013Add
BLAST

Interactioni

Subunit structurei

Forms a complex with UL50 By similarity.

Structurei

3D structure databases

ProteinModelPortaliP16794.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR021152. Herpes_UL31.
[Graphical view]
PfamiPF02718. Herpes_UL31. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16794-1 [UniParc]FASTAAdd to Basket

« Hide

MSSVSGVRTP RERRSALRSL LRKRRQRELA SKVASTVNGA TSANNHGEPP    50
SPADARPRLT LHDLHDIFRE HPELELKYLN MMKMAITGKE SICLPFNFHS 100
HRQHTCLDIS PYGNEQVSRI ACTSCEDNRI LPTASDAMVA FINQTSNIMK 150
NRNFYYGFCK SSELLKLSTN QPPIFQIYYL LHAANHDIVP FMHAEDGRLH 200
MHVIFENPDV HIPCDCITQM LTAAREDYSV TLNIVRDHVV ISVLCHAVSA 250
SSVKIDVTIL QRKIDEMDIP NDVSESFERY KELIQELCQS SGNNLYEEAT 300
SSYAIRSPLT ASPLHVVSTN GCGPSSSSQS TPPHLHPPSQ ATQPHHYSHH 350
QSQSQQHHHR PQSPPPPLFL NSIRAP 376
Length:376
Mass (Da):42,313
Last modified:August 1, 1990 - v1
Checksum:iBF44D5F8DE2B88B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17209 Genomic DNA. Translation: AAA46007.1.
X17403 Genomic DNA. Translation: CAA35412.1.
BK000394 Genomic DNA. Translation: DAA00158.1.
PIRiS09816. QQBEW2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17209 Genomic DNA. Translation: AAA46007.1 .
X17403 Genomic DNA. Translation: CAA35412.1 .
BK000394 Genomic DNA. Translation: DAA00158.1 .
PIRi S09816. QQBEW2.

3D structure databases

ProteinModelPortali P16794.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR021152. Herpes_UL31.
[Graphical view ]
Pfami PF02718. Herpes_UL31. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Large-scale rearrangement of homologous regions in the genomes of HCMV and EBV."
    Kouzarides T., Bankier A.T., Satchwell S.C., Weston K.M., Tomlinson P., Barrell B.G.
    Virology 157:397-413(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169."
    Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.
    Curr. Top. Microbiol. Immunol. 154:125-169(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome."
    Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S.
    J. Gen. Virol. 84:17-28(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
  4. "Analysis of intracellular and intraviral localization of the human cytomegalovirus UL53 protein."
    Dal Monte P., Pignatelli S., Zini N., Maraldi N.M., Perret E., Prevost M.C., Landini M.P.
    J. Gen. Virol. 83:1005-1012(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  5. "Common and specific properties of herpesvirus UL34/UL31 protein family members revealed by protein complementation assay."
    Schnee M., Ruzsics Z., Bubeck A., Koszinowski U.H.
    J. Virol. 80:11658-11666(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL50.

Entry informationi

Entry nameiUL53_HCMVA
AccessioniPrimary (citable) accession number: P16794
Secondary accession number(s): Q7M6N0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: June 11, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi