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Protein

Virion egress protein UL31 homolog

Gene

UL53

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in virion nuclear egress, the first step of virion release from infected cell. Viral capsids are initially assembled within the nucleus, UL53/UL50 complex induces capsids budding and envelopment into the perinuclear space. Then UL53/UL50 complex promotes fusion of perinuclear virion envelope with the outer nuclear membrane, releasing viral capsid into the cytoplasm where it will engages budding sites in the Golgi or trans-Golgi network (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Virion egress protein UL31 homolog
Gene namesi
Name:UL53
OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri10360 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000008992 Componenti: Genome UP000008991 Componenti: Genome

Subcellular locationi

  • Host nucleus inner membrane 1 Publication

  • Note: Remains attached to the nucleus inner membrane through interaction with UL50. Localizes also at the transient membrane of perinuclear virions.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host membrane, Host nucleus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Virion egress protein UL31 homologPRO_0000116013Add
BLAST

Interactioni

Subunit structurei

Forms a complex with UL50.By similarity

Structurei

3D structure databases

ProteinModelPortaliP16794.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae UL31 family.Curated

Family and domain databases

InterProiIPR021152. Herpes_UL31.
[Graphical view]
PfamiPF02718. Herpes_UL31. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16794-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVSGVRTP RERRSALRSL LRKRRQRELA SKVASTVNGA TSANNHGEPP
60 70 80 90 100
SPADARPRLT LHDLHDIFRE HPELELKYLN MMKMAITGKE SICLPFNFHS
110 120 130 140 150
HRQHTCLDIS PYGNEQVSRI ACTSCEDNRI LPTASDAMVA FINQTSNIMK
160 170 180 190 200
NRNFYYGFCK SSELLKLSTN QPPIFQIYYL LHAANHDIVP FMHAEDGRLH
210 220 230 240 250
MHVIFENPDV HIPCDCITQM LTAAREDYSV TLNIVRDHVV ISVLCHAVSA
260 270 280 290 300
SSVKIDVTIL QRKIDEMDIP NDVSESFERY KELIQELCQS SGNNLYEEAT
310 320 330 340 350
SSYAIRSPLT ASPLHVVSTN GCGPSSSSQS TPPHLHPPSQ ATQPHHYSHH
360 370
QSQSQQHHHR PQSPPPPLFL NSIRAP
Length:376
Mass (Da):42,313
Last modified:August 1, 1990 - v1
Checksum:iBF44D5F8DE2B88B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17209 Genomic DNA. Translation: AAA46007.1.
X17403 Genomic DNA. Translation: CAA35412.1.
BK000394 Genomic DNA. Translation: DAA00158.1.
PIRiS09816. QQBEW2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17209 Genomic DNA. Translation: AAA46007.1.
X17403 Genomic DNA. Translation: CAA35412.1.
BK000394 Genomic DNA. Translation: DAA00158.1.
PIRiS09816. QQBEW2.

3D structure databases

ProteinModelPortaliP16794.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR021152. Herpes_UL31.
[Graphical view]
PfamiPF02718. Herpes_UL31. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Large-scale rearrangement of homologous regions in the genomes of HCMV and EBV."
    Kouzarides T., Bankier A.T., Satchwell S.C., Weston K.M., Tomlinson P., Barrell B.G.
    Virology 157:397-413(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169."
    Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.
    Curr. Top. Microbiol. Immunol. 154:125-169(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome."
    Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S.
    J. Gen. Virol. 84:17-28(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
  4. "Analysis of intracellular and intraviral localization of the human cytomegalovirus UL53 protein."
    Dal Monte P., Pignatelli S., Zini N., Maraldi N.M., Perret E., Prevost M.C., Landini M.P.
    J. Gen. Virol. 83:1005-1012(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  5. "Common and specific properties of herpesvirus UL34/UL31 protein family members revealed by protein complementation assay."
    Schnee M., Ruzsics Z., Bubeck A., Koszinowski U.H.
    J. Virol. 80:11658-11666(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL50.

Entry informationi

Entry nameiUL53_HCMVA
AccessioniPrimary (citable) accession number: P16794
Secondary accession number(s): Q7M6N0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: January 7, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.