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P16794 (UL53_HCMVA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 26, 2013. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Virion egress protein UL31 homolog
Gene names
Name:UL53
OrganismHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) [Complete proteome]
Taxonomic identifier10360 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a major role in virion nuclear egress, the first step of virion release from infected cell. Viral capsids are initially assembled within the nucleus, UL53/UL50 complex induces capsids budding and envelopment into the perinuclear space. Then UL53/UL50 complex promotes fusion of perinuclear virion envelope with the outer nuclear membrane, releasing viral capsid into the cytoplasm where it will engages budding sites in the Golgi or trans-Golgi network By similarity.

Subunit structure

Forms a complex with UL50 By similarity.

Subcellular location

Host nucleus inner membrane. Note: Remains attached to the nucleus inner membrane through interaction with UL50. Localizes also at the transient membrane of perinuclear virions. Ref.5

Sequence similarities

Belongs to the herpesviridae UL31 family.

Ontologies

Keywords
   Cellular componentHost membrane
Host nucleus
Membrane
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componenthost cell nuclear inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Virion egress protein UL31 homolog
PRO_0000116013

Sequences

Sequence LengthMass (Da)Tools
P16794 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: BF44D5F8DE2B88B9

FASTA37642,313
        10         20         30         40         50         60 
MSSVSGVRTP RERRSALRSL LRKRRQRELA SKVASTVNGA TSANNHGEPP SPADARPRLT 

        70         80         90        100        110        120 
LHDLHDIFRE HPELELKYLN MMKMAITGKE SICLPFNFHS HRQHTCLDIS PYGNEQVSRI 

       130        140        150        160        170        180 
ACTSCEDNRI LPTASDAMVA FINQTSNIMK NRNFYYGFCK SSELLKLSTN QPPIFQIYYL 

       190        200        210        220        230        240 
LHAANHDIVP FMHAEDGRLH MHVIFENPDV HIPCDCITQM LTAAREDYSV TLNIVRDHVV 

       250        260        270        280        290        300 
ISVLCHAVSA SSVKIDVTIL QRKIDEMDIP NDVSESFERY KELIQELCQS SGNNLYEEAT 

       310        320        330        340        350        360 
SSYAIRSPLT ASPLHVVSTN GCGPSSSSQS TPPHLHPPSQ ATQPHHYSHH QSQSQQHHHR 

       370 
PQSPPPPLFL NSIRAP 

« Hide

References

« Hide 'large scale' references
[1]"Large-scale rearrangement of homologous regions in the genomes of HCMV and EBV."
Kouzarides T., Bankier A.T., Satchwell S.C., Weston K.M., Tomlinson P., Barrell B.G.
Virology 157:397-413(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169."
Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.
Curr. Top. Microbiol. Immunol. 154:125-169(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome."
Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S.
J. Gen. Virol. 84:17-28(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
[4]Erratum
Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S.
J. Gen. Virol. 84:1053-1053(2003)
[5]"Analysis of intracellular and intraviral localization of the human cytomegalovirus UL53 protein."
Dal Monte P., Pignatelli S., Zini N., Maraldi N.M., Perret E., Prevost M.C., Landini M.P.
J. Gen. Virol. 83:1005-1012(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[6]"Common and specific properties of herpesvirus UL34/UL31 protein family members revealed by protein complementation assay."
Schnee M., Ruzsics Z., Bubeck A., Koszinowski U.H.
J. Virol. 80:11658-11666(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UL50.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M17209 Genomic DNA. Translation: AAA46007.1.
X17403 Genomic DNA. Translation: CAA35412.1.
BK000394 Genomic DNA. Translation: DAA00158.1.
PIRQQBEW2. S09816.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR021152. Herpes_UL31.
[Graphical view]
PfamPF02718. Herpes_UL31. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUL53_HCMVA
AccessionPrimary (citable) accession number: P16794
Secondary accession number(s): Q7M6N0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: June 26, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families