P16794 (UL53_HCMVA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Virion egress protein UL53

Alternative name(s):
Primary envelopment factor UL53
Protein HFRF2

Gene names

Name:

UL53

Organism

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) [Complete proteome]

Taxonomic identifier

10360 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Cytomegalovirus › Human cytomegalovirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a major role in virion nuclear egress, the first step of virion release from infected cell. Viral capsids are initially assembled within the nucleus, UL53/UL50 complex induces capsids budding and envelopment into the perinuclear space. Then UL53/UL50 complex promotes fusion of perinuclear virion envelope with the outer nuclear membrane, releasing viral capsid into the cytoplasm where it will engages budding sites in the Golgi or trans-Golgi network By similarity.
Subunit structure	Forms a complex with UL50 By similarity.
Subcellular location	Host nucleus inner membrane. Note: Remains attached to the nucleus inner membrane through interaction with UL50. Localizes also at the transient membrane of perinuclear virions. Ref.5
Sequence similarities	Belongs to the herpesviridae UL31 family.

Ontologies

Keywords
Cellular component	Host membrane Host nucleus Membrane
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	host cell nuclear inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	Virion egress protein UL53		PRO_0000116013

Sequences

	Sequence		Length	Mass (Da)
	P16794 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: BF44D5F8DE2B88B9	FASTA	376	42,313
	10 20 30 40 50 60 MSSVSGVRTP RERRSALRSL LRKRRQRELA SKVASTVNGA TSANNHGEPP SPADARPRLT 70 80 90 100 110 120 LHDLHDIFRE HPELELKYLN MMKMAITGKE SICLPFNFHS HRQHTCLDIS PYGNEQVSRI 130 140 150 160 170 180 ACTSCEDNRI LPTASDAMVA FINQTSNIMK NRNFYYGFCK SSELLKLSTN QPPIFQIYYL 190 200 210 220 230 240 LHAANHDIVP FMHAEDGRLH MHVIFENPDV HIPCDCITQM LTAAREDYSV TLNIVRDHVV 250 260 270 280 290 300 ISVLCHAVSA SSVKIDVTIL QRKIDEMDIP NDVSESFERY KELIQELCQS SGNNLYEEAT 310 320 330 340 350 360 SSYAIRSPLT ASPLHVVSTN GCGPSSSSQS TPPHLHPPSQ ATQPHHYSHH QSQSQQHHHR 370 PQSPPPPLFL NSIRAP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Large-scale rearrangement of homologous regions in the genomes of HCMV and EBV." Kouzarides T., Bankier A.T., Satchwell S.C., Weston K.M., Tomlinson P., Barrell B.G. Virology 157:397-413(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169." Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G. Curr. Top. Microbiol. Immunol. 154:125-169(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome." Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S. J. Gen. Virol. 84:17-28(2003) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION.
[4]	Erratum Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S. J. Gen. Virol. 84:1053-1053(2003)
[5]	"Analysis of intracellular and intraviral localization of the human cytomegalovirus UL53 protein." Dal Monte P., Pignatelli S., Zini N., Maraldi N.M., Perret E., Prevost M.C., Landini M.P. J. Gen. Virol. 83:1005-1012(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[6]	"Common and specific properties of herpesvirus UL34/UL31 protein family members revealed by protein complementation assay." Schnee M., Ruzsics Z., Bubeck A., Koszinowski U.H. J. Virol. 80:11658-11666(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH UL50.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M17209 Genomic DNA. Translation: AAA46007.1. X17403 Genomic DNA. Translation: CAA35412.1. BK000394 Genomic DNA. Translation: DAA00158.1.
PIR	QQBEW2. S09816.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR021152. Herpes_UL31. [Graphical view]
Pfam	PF02718. Herpes_UL31. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UL53_HCMVA

Accession

Primary (citable) accession number: P16794
Secondary accession number(s): Q7M6N0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	April 3, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program