P16793 (UL52_HCMVA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Packaging protein UL52

Alternative name(s):
Protein HFRF1

Gene names

Name:

UL52

Organism

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) [Complete proteome]

Taxonomic identifier

10360 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Cytomegalovirus › Human cytomegalovirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	668 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays a role in efficient localization of neo-synthesized capsids to nuclear replication compartments, thereby controlling cleavage and packaging of virus genomic DNA. Ref.5
Subcellular location	Host cytoplasm. Host nucleus Ref.5.
Sequence similarities	Belongs to the herpesviridae UL32 protein family.
Caution	Was originally thought to be an envelope glycoprotein.

Ontologies

Keywords
Cellular component	Host cytoplasm Host nucleus
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell viral envelope Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 668	668	Packaging protein UL52		PRO_0000116022
Regions
	Compositional bias	84 – 91	8	Poly-Ala
	Compositional bias	402 – 408	7	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	P16793 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: 29F675F40F3ED818	FASTA	668	74,121
	10 20 30 40 50 60 MNPSTHVSSN GPTTPPHGPH TTFLPPTSPA PSTSSVAAAT LCSPQRQAVS RYSGWSTEYT 70 80 90 100 110 120 QWHSDLTTEL LWHAHPRQVP MDEALAAAAA ASYQVNPQHP ANRYRHYEFQ TLSLGTSEVD 130 140 150 160 170 180 ELLNCCAEET TCGGTQSTVL TNATNTTSCG GAVAGSSNVG PAGASAACDL DAELAGLETS 190 200 210 220 230 240 AADFEQLRRL CAPLAIDTRC NLCAIISICL KQDCDQSWLL EYSLLCFKCS YAPRAALSTL 250 260 270 280 290 300 IIMSEFTHLL QQHFSDLRID DLFRHHVLTV FDFHLHFFIN RCFEKQVGDA VDNENVTLNH 310 320 330 340 350 360 LAVVRAMVMG EDTVPYNKPR RHPQQKQKNN PYHVEVPQEL IDNFLEHSSP SRDRFVQLLF 370 380 390 400 410 420 YMWAGTGVMS TTPLTELTHT KFARLDALST ASEREDARMM IEEEEDEEGG EKGGDDPGRH 430 440 450 460 470 480 NGGGTSGGFS ESTLKKNVGP IYLCPVPAFF TKNQTSTVCL LCELMACSYY DNVVLRELYR 490 500 510 520 530 540 RVVSYCQNNV KMVDRIQLVL ADLLRECTSP LGAAHEDVAR CGLEAPTSPG GDSDYHGLSG 550 560 570 580 590 600 VDGALARPDP VFCHVLRQAG VTGIYKHFFC DPQCAGNIRV TNEAVLFGRL HPHHVQEVKL 610 620 630 640 650 660 AICHDNYYIS RLPRRVWLCI TLFKAFQITK RTYKGKVHLA DFMRDFTQLL ESCDIKLVDP TYVIDKYV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Large-scale rearrangement of homologous regions in the genomes of HCMV and EBV." Kouzarides T., Bankier A.T., Satchwell S.C., Weston K.M., Tomlinson P., Barrell B.G. Virology 157:397-413(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169." Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G. Curr. Top. Microbiol. Immunol. 154:125-169(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome." Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S. J. Gen. Virol. 84:17-28(2003) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION.
[4]	Erratum Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S. J. Gen. Virol. 84:1053-1053(2003)
[5]	"The essential human cytomegalovirus gene UL52 is required for cleavage-packaging of the viral genome." Borst E.M., Wagner K., Binz A., Sodeik B., Messerle M. J. Virol. 82:2065-2078(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M17209 Genomic DNA. Translation: AAA46006.1. X17403 Genomic DNA. Translation: CAA35411.1. BK000394 Genomic DNA. Translation: DAA00157.1.
PIR	QQBEW1. S09815.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002597. Herpes_env. [Graphical view]
Pfam	PF01673. Herpes_env. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UL52_HCMVA

Accession

Primary (citable) accession number: P16793
Secondary accession number(s): Q7M6N1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	April 3, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program