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Protein

Tripartite terminase subunit 2

Gene

TRM2

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid.UniRule annotation

GO - Biological processi

  • viral DNA genome packaging Source: CACAO

Keywordsi

Biological processViral genome packaging, Viral release from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite terminase subunit 2UniRule annotation
Gene namesi
Name:TRM2UniRule annotation
Ordered Locus Names:UL51
OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri10360 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008992 Componenti: Genome
  • UP000008991 Componenti: Genome

Subcellular locationi

  • Host nucleus UniRule annotation
  • Note: Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001153271 – 157Tripartite terminase subunit 2Add BLAST157

Proteomic databases

PRIDEiP16792

Interactioni

Subunit structurei

Associates with TRM1 and TRM3 to form the tripartite terminase complex.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae TRM2 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000Y6

Family and domain databases

HAMAPiMF_04015 HSV_TRM2, 1 hit
InterProiView protein in InterPro
IPR005208 Herpes_TT2
PfamiView protein in Pfam
PF03581 Herpes_UL33, 1 hit

Sequencei

Sequence statusi: Complete.

P16792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWAKQRVPF LDDDDGEEEN DVQDDVDSPV PTRPLVIDED AEPAAGTSGG
60 70 80 90 100
LEGGGGDDED GEDGHALPDL DDDLLLQFEP MLPRVYDLLL PSLDARLNFV
110 120 130 140 150
NAGQKYAAFL KYVHGDCATC SHGEILREKT QLLTAIVSKL MDINGILEGK

DESAPGK
Length:157
Mass (Da):16,968
Last modified:August 1, 1990 - v1
Checksum:i5999035AC654517D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17209 Genomic DNA Translation: AAA46005.1
X17403 Genomic DNA Translation: CAA35410.1
BK000394 Genomic DNA Translation: DAA00156.1
PIRiS09814

Similar proteinsi

Entry informationi

Entry nameiTRM2_HCMVA
AccessioniPrimary (citable) accession number: P16792
Secondary accession number(s): Q7M6N2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health