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Protein

Tripartite terminase subunit 2

Gene

TRM2

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid.UniRule annotation

GO - Biological processi

  • viral DNA genome packaging Source: CACAO
  • viral release from host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Viral genome packaging, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite terminase subunit 2UniRule annotation
Gene namesi
Name:TRM2UniRule annotation
Ordered Locus Names:UL51
OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri10360 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008992 Componenti: Genome
  • UP000008991 Componenti: Genome

Subcellular locationi

  • Host nucleus UniRule annotation

  • Note: Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 157157Tripartite terminase subunit 2PRO_0000115327Add
BLAST

Interactioni

Subunit structurei

Associates with TRM1 and TRM3 to form the tripartite terminase complex.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae TRM2 protein family.UniRule annotation

Family and domain databases

HAMAPiMF_04015. HSV_TRM2.
InterProiIPR005208. Herpes_UL33.
[Graphical view]
PfamiPF03581. Herpes_UL33. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWAKQRVPF LDDDDGEEEN DVQDDVDSPV PTRPLVIDED AEPAAGTSGG
60 70 80 90 100
LEGGGGDDED GEDGHALPDL DDDLLLQFEP MLPRVYDLLL PSLDARLNFV
110 120 130 140 150
NAGQKYAAFL KYVHGDCATC SHGEILREKT QLLTAIVSKL MDINGILEGK

DESAPGK
Length:157
Mass (Da):16,968
Last modified:August 1, 1990 - v1
Checksum:i5999035AC654517D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17209 Genomic DNA. Translation: AAA46005.1.
X17403 Genomic DNA. Translation: CAA35410.1.
BK000394 Genomic DNA. Translation: DAA00156.1.
PIRiS09814.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17209 Genomic DNA. Translation: AAA46005.1.
X17403 Genomic DNA. Translation: CAA35410.1.
BK000394 Genomic DNA. Translation: DAA00156.1.
PIRiS09814.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_04015. HSV_TRM2.
InterProiIPR005208. Herpes_UL33.
[Graphical view]
PfamiPF03581. Herpes_UL33. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Large-scale rearrangement of homologous regions in the genomes of HCMV and EBV."
    Kouzarides T., Bankier A.T., Satchwell S.C., Weston K.M., Tomlinson P., Barrell B.G.
    Virology 157:397-413(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169."
    Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.
    Curr. Top. Microbiol. Immunol. 154:125-169(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome."
    Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S.
    J. Gen. Virol. 84:17-28(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
  4. Cited for: IDENTIFICATION.

Entry informationi

Entry nameiTRM2_HCMVA
AccessioniPrimary (citable) accession number: P16792
Secondary accession number(s): Q7M6N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 11, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.