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Protein

UL37 immediate early glycoprotein

Gene

UL37

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Isoform vMIA sequesters proapoptotic BAX at the outer mitochondrial membrane and prevents cytochrome c release and subsequent initiation of the proapoptotic cascade. Also provoques a calcium efflux from host endoplasmic reticulum and F-actin cytoskeleton disruption. Participates in the increase of host mitochondrial biogenesis, thus promoting viral replication by efficient use of newly made mitochondria.
Isoform gpUL37 may play a role in escape from the host antiviral response.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Modulation of host cell apoptosis by virus

Names & Taxonomyi

Protein namesi
Recommended name:
UL37 immediate early glycoprotein
Gene namesi
Name:UL37
OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri10360 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008992 Componenti: Genome
  • UP000008991 Componenti: Genome

Subcellular locationi

Isoform gpUL37 :
Isoform vMIA :
Isoform pUL37m :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei433 – 459HelicalSequence analysisAdd BLAST27

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Host mitochondrion, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000003745523 – 487UL37 immediate early glycoproteinAdd BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi206N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi210N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi219N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi223N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi242N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi246N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi275N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi281N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi294N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi297N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi306N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi333N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi337N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi343N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi379N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi384N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi391N-linked (GlcNAc...); by hostSequence analysis1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei193 – 194Cleavage site2

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP16778.

Interactioni

Subunit structurei

Isoform vMIA interacts with host BAX. Isoform vMIA interacts with host RSAD2/viperin; this interaction results in RSAD2/viperin relocalization from the endoplasmic reticulum to the mitochondria, actin cytoskeleton disruption and enhancement of infection.2 Publications

Protein-protein interaction databases

DIPiDIP-60096N.

Structurei

Secondary structure

1487
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi138 – 145Combined sources8
Beta strandi146 – 148Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LR1NMR-B130-150[»]
SMRiP16778.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi97 – 108Poly-GluAdd BLAST12

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR010880. Herpes_UL37_HHV-5-rel.
[Graphical view]
PfamiPF07413. Herpes_UL37_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform gpUL37 (identifier: P16778-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPVYVNLLG SVGLLAFWYF SYRWIQRKRL EDPLPPWLRK KKACALTRRS
60 70 80 90 100
RHRLRRQHGV IDGENSETER SVDLVAALLA EAGEESVTED TEREDTEEER
110 120 130 140 150
EDEEEENEAR TPEVNPIDAE GLSGLAREAC EALKKALRRH RFLWQRRQRA
160 170 180 190 200
RMLQHNGPQQ SHHAAVFCRV HGLRGFQVSV WLLLTLLWST GHGVSVRCTY
210 220 230 240 250
HGTDVNRTSN TTSMNCHLNC TRNHTQIYNG PCLGTEARLP LNVTFNQSRR
260 270 280 290 300
KWHSVMLKFG FQYHLEGWFP LRVLNESREI NVTEVHGEVA CFRNDTNVTV
310 320 330 340 350
GQLTLNFTGH SYVLRAIAHT SPFESYVRWE ETNVTDNATS SENTTTVMST
360 370 380 390 400
LTKYAESDYI FLQDMCPRFL KRTVKLTRNK TKHNVTVTGN NMTTLPVWTP
410 420 430 440 450
ECKGWTYWTT LSVMWRNRRS ALLRAKSRAL GHWALLSICT VAAGSIALLS
460 470 480
LFCILLIGLR RDLLEDFRYI CRDEGSSSTK NDVHRIV
Length:487
Mass (Da):56,125
Last modified:May 30, 2000 - v2
Checksum:iFA39A37C51FFB4A3
GO
Isoform vMIA (identifier: P16778-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-163: H → Q
     164-487: Missing.

Show »
Length:163
Mass (Da):19,115
Checksum:iB657342BB57AEC21
GO
Isoform pUL37m (identifier: P16778-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-262: Missing.

Show »
Length:402
Mass (Da):46,435
Checksum:iBDFD81E69DC4753E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044014163H → Q in isoform vMIA. Curated1
Alternative sequenceiVSP_044015164 – 487Missing in isoform vMIA. CuratedAdd BLAST324
Alternative sequenceiVSP_044016178 – 262Missing in isoform pUL37m. CuratedAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA. Translation: CAA35396.1.
BK000394 Genomic DNA. Translation: DAA00142.1.
PIRiS09801. QQBEU5.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA. Translation: CAA35396.1.
BK000394 Genomic DNA. Translation: DAA00142.1.
PIRiS09801. QQBEU5.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LR1NMR-B130-150[»]
SMRiP16778.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60096N.

Proteomic databases

PRIDEiP16778.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR010880. Herpes_UL37_HHV-5-rel.
[Graphical view]
PfamiPF07413. Herpes_UL37_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVGLI_HCMVA
AccessioniPrimary (citable) accession number: P16778
Secondary accession number(s): P87887, Q7M6P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.