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Protein

Protein UL35

Gene

UL35

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays important role in immediate-early gene expression through interaction with UL82. Forms nuclear bodies in host nucleus, independently of PML. In turn, UL35 nuclear bodies associate with and remodel PML bodies.
Isoform UL35a promotes cytoplasmic UL82 accumulation and inhibits UL35-containing nuclear bodies formation.

GO - Biological processi

  • DNA-templated viral transcription Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Protein UL35
Gene namesi
Name:UL35
OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri10360 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008992 Componenti: Genome
  • UP000008991 Componenti: Genome

Subcellular locationi

Isoform UL35:
Isoform UL35a:

GO - Cellular componenti

  • host cell cytoplasm Source: UniProtKB-SubCell
  • host cell nucleus Source: UniProtKB
  • viral tegument Source: UniProtKB-SubCell

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001153181 – 640Protein UL35Add BLAST640

Proteomic databases

PRIDEiP16766.

Interactioni

Subunit structurei

Interacts with UL82 (both isoforms). Isoform UL35 interacts with isoform UL35a.1 Publication

Structurei

3D structure databases

SMRiP16766.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi501 – 513Poly-SerAdd BLAST13
Compositional biasi591 – 597Poly-Arg7

Sequence similaritiesi

Belongs to the herpesviridae pp85 family.Curated

Phylogenomic databases

OrthoDBiVOG0900007M.

Family and domain databases

InterProiView protein in InterPro
IPR006731. Herpes_pp85.
PfamiView protein in Pfam
PF04637. Herpes_pp85. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform UL35 (identifier: P16766-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQGSRAPSG PPLPVLPVDD WLNFRVDLFG DEHRRLLLEM LTQGCSNFVG
60 70 80 90 100
LLNFGVPSPV YALEALVDFQ VRNAFMKVKP VAQEIIRICI LANHYRNSRD
110 120 130 140 150
VLRDLRTQLD VLYSDPLKTR LLRGLIRLCR AAQTGVKPED ISVHLGADDV
160 170 180 190 200
TFGVLKRALV RLHRVRDALG LRASPEAEAR YPRLTTYNLL FHPPPFTTVE
210 220 230 240 250
AVDLCAENLS DVTQRRNRPL RCLTSIKRPG SRTLEDALND MYLLLTLRHL
260 270 280 290 300
QLRHALELQM MQDWVVERCN RLCDALYFCY TQAPETRQTF VTLVRGLELA
310 320 330 340 350
RQHSSPAFQP MLYNLLQLLT QLHEANVYLC PGYLHFSAYK LLKKIQSVSD
360 370 380 390 400
ARERGEFGDE DEEQENDGEP REAQLDLEAD PTAREGELFF FSKNLYGNGE
410 420 430 440 450
VFRVPEQPSR YLRRRMFVER PETLQIFYNF HEGKITTETY HLQRIYSMMI
460 470 480 490 500
EGASRQTGLT PKRFMELLDR APLGQESEPE ITEHRDLFAD VFRRPVTDAA
510 520 530 540 550
SSSSASSSSS SASPNSVSLP SARSSSTRTT TPASTYTSAG TSSTTGLLLS
560 570 580 590 600
SSLSGSHGIS SADLEQPPRQ RRRMVSVTLF SPYSVAYSHH RRHRRRRSPP
610 620 630 640
PAPRGPAHTR FQGPDSMPST SYGSDVEDPR DDLAENLRHL
Length:640
Mass (Da):72,529
Last modified:August 1, 1990 - v1
Checksum:i8FCCFA3C9F631C1C
GO
Isoform UL35a (identifier: P16766-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-447: Missing.

Show »
Length:193
Mass (Da):20,898
Checksum:i2D5D47BA7E80B033
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0440131 – 447Missing in isoform UL35a. CuratedAdd BLAST447

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA. Translation: CAA35394.1.
BK000394 Genomic DNA. Translation: DAA00140.1.
PIRiS09798. QQBEU2.

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiUL35_HCMVA
AccessioniPrimary (citable) accession number: P16766
Secondary accession number(s): Q7M6P8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 10, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families