ID   UL79_HCMVA              Reviewed;         295 AA.
AC   P16752; Q7M6L3;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   24-JAN-2024, entry version 63.
DE   RecName: Full=Protein UL79;
GN   Name=UL79;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Cytomegalovirus;
OC   Cytomegalovirus humanbeta5; Human cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [3]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=15452216; DOI=10.1128/jvi.78.20.10960-10966.2004;
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RT   "Identification of proteins in human cytomegalovirus (HCMV) particles: the
RT   HCMV proteome.";
RL   J. Virol. 78:10960-10966(2004).
RN   [5]
RP   ERRATUM OF PUBMED:15452216.
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RL   J. Virol. 78:13395-13395(2004).
RN   [6]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=21367901; DOI=10.1128/jvi.02344-10;
RA   Perng Y.C., Qian Z., Fehr A.R., Xuan B., Yu D.;
RT   "The human cytomegalovirus gene UL79 is required for the accumulation of
RT   late viral transcripts.";
RL   J. Virol. 85:4841-4852(2011).
RN   [7]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=34339482; DOI=10.1371/journal.ppat.1009796;
RA   Li M., Hu Q., Collins G., Parida M., Ball C.B., Price D.H., Meier J.L.;
RT   "Cytomegalovirus late transcription factor target sequence diversity
RT   orchestrates viral early to late transcription.";
RL   PLoS Pathog. 17:e1009796-e1009796(2021).
CC   -!- FUNCTION: Plays a role in the expression of late transcripts bridging
CC       viral DNA replication and late gene expression during infection
CC       (PubMed:21367901). Functions concordantly with UL87 to initiate
CC       transcription from over half of all active viral promoters in late
CC       infection, without affecting host transcription. Acts on and binds to
CC       viral early-late and late kinetic-class promoters (PubMed:34339482).
CC       {ECO:0000269|PubMed:21367901, ECO:0000269|PubMed:34339482}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:21367901,
CC       ECO:0000269|PubMed:34339482}. Note=Localizes in replication
CC       compartments during virus infection.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL79 family. {ECO:0000305}.
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DR   EMBL; X17403; CAA35352.1; -; Genomic_DNA.
DR   EMBL; BK000394; DAA00175.1; -; Genomic_DNA.
DR   PIR; S09842; S09842.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004290; Herpes_UL79.
DR   Pfam; PF03049; Herpes_UL79; 1.
PE   3: Inferred from homology;
KW   Host nucleus; Reference proteome.
FT   CHAIN           1..295
FT                   /note="Protein UL79"
FT                   /id="PRO_0000116226"
FT   REGION          243..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        256..270
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   295 AA;  33845 MW;  44C9B3033F45810F CRC64;
     MMARDEENPA VPRVRTGKFS FTCANHLILQ ISEKMSRGQP LSSLRLEELK IVRLICVLLF
     HRGLETLLLR ETMNNLGVSD HAVLSRKTPQ PYWPHLYREL RQAFPGLDFE AAVFDETRAA
     RLSQRLCHPR LSGGLLTRFV QRHTGLPVVF PEDLARNGNI LFSLGTLYGH RLFRLAAFFT
     RHWGAEAYEP LIRIICQKMW YFYLIGTGKM RITPDAFEIQ RSRHETGIFT FIMEDYRTFA
     GTLSRHPHRP HPQQQQHHHP GPPHPPLSHP ASSCLSPEAV LAARALHMPT LANDV
//