P16752 (UL79_HCMVA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein UL79

Gene names

Name:

UL79

Organism

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) [Complete proteome]

Taxonomic identifier

10360 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Cytomegalovirus › Human cytomegalovirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays a role in the expression of late transcripts bridging viral DNA replication and late gene expression during infection. Ref.6
Subcellular location	Host nucleus. Note: Localizes in replication compartments during virus infection. Ref.6
Sequence similarities	Belongs to the herpesviridae UL79 family.

Ontologies

Keywords
Cellular component	Host nucleus
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 295	295	Protein UL79		PRO_0000116226
Regions
	Compositional bias	253 – 256	4	Poly-Gln

Sequences

	Sequence		Length	Mass (Da)
	P16752 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: 44C9B3033F45810F	FASTA	295	33,845
	10 20 30 40 50 60 MMARDEENPA VPRVRTGKFS FTCANHLILQ ISEKMSRGQP LSSLRLEELK IVRLICVLLF 70 80 90 100 110 120 HRGLETLLLR ETMNNLGVSD HAVLSRKTPQ PYWPHLYREL RQAFPGLDFE AAVFDETRAA 130 140 150 160 170 180 RLSQRLCHPR LSGGLLTRFV QRHTGLPVVF PEDLARNGNI LFSLGTLYGH RLFRLAAFFT 190 200 210 220 230 240 RHWGAEAYEP LIRIICQKMW YFYLIGTGKM RITPDAFEIQ RSRHETGIFT FIMEDYRTFA 250 260 270 280 290 GTLSRHPHRP HPQQQQHHHP GPPHPPLSHP ASSCLSPEAV LAARALHMPT LANDV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169." Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G. Curr. Top. Microbiol. Immunol. 154:125-169(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome." Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S. J. Gen. Virol. 84:17-28(2003) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION.
[3]	Erratum Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S. J. Gen. Virol. 84:1053-1053(2003)
[4]	"Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome." Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., Shenk T., Smith R.D., Nelson J.A. J. Virol. 78:10960-10966(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., Shenk T., Smith R.D., Nelson J.A. J. Virol. 78:13395-13395(2004)
[6]	"The human cytomegalovirus gene UL79 is required for the accumulation of late viral transcripts." Perng Y.C., Qian Z., Fehr A.R., Xuan B., Yu D. J. Virol. 85:4841-4852(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X17403 Genomic DNA. Translation: CAA35352.1. BK000394 Genomic DNA. Translation: DAA00175.1.
PIR	S09842.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR004290. Herpes_UL79. [Graphical view]
Pfam	PF03049. Herpes_UL79. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UL79_HCMVA

Accession

Primary (citable) accession number: P16752
Secondary accession number(s): Q7M6L3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	April 3, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program