Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Viral Fc-gamma receptor-like protein UL119

Gene

UL119/UL118

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Serves as a receptor for the Fc part of human IgG. May thus be involved in interfering with host Ig-mediated immune responses.1 Publication

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Modulation of host immunity by viral IgG Fc receptor-like protein, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Viral Fc-gamma receptor-like protein UL119
Alternative name(s):
gp68
Gene namesi
Name:UL119/UL118
OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri10360 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008992 Componenti: Genome
  • UP000008991 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 294Virion surfaceSequence analysisAdd BLAST271
Transmembranei295 – 317HelicalSequence analysisAdd BLAST23
Topological domaini318 – 345IntravirionSequence analysisAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003745724 – 345Viral Fc-gamma receptor-like protein UL119Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi48N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi95N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi179N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi217N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi225N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi241N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi244N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi260N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 190Ig-like V-typeAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi25 – 72Thr-richAdd BLAST48

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000J2.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCSVLAIALV VALLGDMHPG VKSSTTSAVT SPSNTTVTST TSISTSNNVT
60 70 80 90 100
SAVTTTVQTS TSSASTSVIA TTQKEGHLYT VNCEASYSHD QVSLNATCKV
110 120 130 140 150
ILLNNTKNPD ILSVTCYART DCKGPFTQVG YLSAFPPDNE GKLHLSYNAT
160 170 180 190 200
AQELLISGLR PQETTEYTCS FFSWGRHHNA TWDLFTYPIY AVYGTRLNAT
210 220 230 240 250
TMRVRVLLQE HEHCLLNGSS LYHPNSTVHL HQGNQLIPPW NISNVTYNGQ
260 270 280 290 300
RLREFVFYLN GTYTVVRLHV QIAGRSFTTT YVFIKSDPLF EDRLLAYGVL
310 320 330 340
AFLVFMVIIL LYVTYMLARR RDWSYKRLEE PVEEKKHPVP YFKQW
Length:345
Mass (Da):38,709
Last modified:February 15, 2005 - v2
Checksum:i1366F5857E5DF650
GO

Sequence cautioni

The sequence CAA35320 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA35321 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA. Translation: CAA35320.1. Sequence problems.
X17403 Genomic DNA. Translation: CAA35321.1. Sequence problems.
AY065993 mRNA. Translation: AAL49993.1.
BK000394 Genomic DNA. Translation: DAA00108.1.
PIRiS09885.
S09886.

Similar proteinsi

Entry informationi

Entry nameiUL119_HCMVA
AccessioniPrimary (citable) accession number: P16739
Secondary accession number(s): P16834, Q8QP99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 15, 2005
Last modified: May 10, 2017
This is version 69 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome