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P16735

- PORTL_HCMVA

UniProt

P16735 - PORTL_HCMVA

Protein

Portal protein UL6 homolog

Gene

UL104

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging. Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid. Binds to the molecular motor that translocate the viral DNA, termed terminase By similarity.By similarity

    GO - Biological processi

    1. DNA packaging Source: InterPro
    2. viral release from host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Viral genome packaging, Virus exit from host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Portal protein UL6 homolog
    Gene namesi
    Name:UL104
    OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
    Taxonomic identifieri10360 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000008991: Genome, UP000008992: Genome

    Subcellular locationi

    Virion. Host nucleus By similarity

    GO - Cellular componenti

    1. host cell nucleus Source: UniProtKB-SubCell
    2. virion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host nucleus, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 697697Portal protein UL6 homologPRO_0000115913Add
    BLAST

    Interactioni

    Subunit structurei

    Homododecamerizes. Interacts with putative terminase subunit UL89 and UL56 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP16735.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR002660. Herpes_UL6.
    [Graphical view]
    PfamiPF01763. Herpes_UL6. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P16735-1 [UniParc]FASTAAdd to Basket

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    MERNHWNEKS SGAKRSRERD LTLSTIRSIL AADERLRIKA SSYLGVGRGV    50
    DDEAVIDIFP TGQTMSFLRL LHGFLGTCRG QSMHQVLRDP CVLRKQLLYG 100
    VCKTLFDTIT VRRVAEEWKL HAALFPYRAL DEEDLEQYLL VWSASLRQSV 150
    QTGVLGALRD ILYQYADNDD YGLYVDWCVT VGLVPLLDVK TKPSEAAERA 200
    QFVRAAVQRA TETHPLAQDL LQANLALLLQ VAERLGAVRV ANAPEVRVFK 250
    KVRSERLEAQ LRGKHIRLYV AAEPLAYERD KLLFTTPVAH LHEEILRYDG 300
    LCRHQKICQL LNTFPVKVVT ASRHELNCKK LVEMMEQHDR GSDAKKSIMK 350
    FLLNVSDSKS RIGIEDSVES FLQDLTPSLV DQNRLLPARG PGGPGVVGPG 400
    GAVVGGPAGH VGLLPPPPGP AAPERDIRDL FKKQVIKCLE EQIQSQVDEI 450
    QDLRTLNQTW ENRVRELRDL LTRYASRRED SMSLGARDAE LYHLPVLEAV 500
    RKARDAAPFR PLAVEDNRLV ANSFFSQFVP GTESLERFLT QLWENEYFRT 550
    FRLRRLVTHQ GAEEAIVYSN YTVERVTLPY LCHILALGTL DPVPEAYLQL 600
    SFGEIVAAAY DDSKFCRYVE LICSREKARR RQMSREAAGG VPERGTASSG 650
    GPGTLERSAP RRLITADEER RGPERVGRFR NGGPDDPRRA GGPYGFH 697
    Length:697
    Mass (Da):78,521
    Last modified:December 16, 2008 - v2
    Checksum:i4A86400FDC16AAFA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17403 Genomic DNA. Translation: CAA35341.1.
    BK000394 Genomic DNA. Translation: DAA00099.2.
    PIRiS09870. QQBEK3.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17403 Genomic DNA. Translation: CAA35341.1 .
    BK000394 Genomic DNA. Translation: DAA00099.2 .
    PIRi S09870. QQBEK3.

    3D structure databases

    ProteinModelPortali P16735.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR002660. Herpes_UL6.
    [Graphical view ]
    Pfami PF01763. Herpes_UL6. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169."
      Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.
      Curr. Top. Microbiol. Immunol. 154:125-169(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome."
      Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S.
      J. Gen. Virol. 84:17-28(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
    3. Cited for: IDENTIFICATION.
    4. Davison A.J.
      Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 157.

    Entry informationi

    Entry nameiPORTL_HCMVA
    AccessioniPrimary (citable) accession number: P16735
    Secondary accession number(s): Q7M6T5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 58 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3