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Protein

Portal protein UL6 homolog

Gene

UL104

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging. Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid. Binds to the molecular motor that translocate the viral DNA, termed terminase (By similarity).By similarity

GO - Biological processi

  1. DNA packaging Source: InterPro
  2. viral release from host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Viral genome packaging, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Portal protein UL6 homolog
Gene namesi
Name:UL104
OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri10360 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000008991: Genome, UP000008992: Genome

Subcellular locationi

Virion. Host nucleus By similarity

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-SubCell
  2. virion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 697697Portal protein UL6 homologPRO_0000115913Add
BLAST

Interactioni

Subunit structurei

Homododecamerizes. Interacts with putative terminase subunit UL89 and UL56 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP16735.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR002660. Herpes_UL6.
[Graphical view]
PfamiPF01763. Herpes_UL6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16735-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERNHWNEKS SGAKRSRERD LTLSTIRSIL AADERLRIKA SSYLGVGRGV
60 70 80 90 100
DDEAVIDIFP TGQTMSFLRL LHGFLGTCRG QSMHQVLRDP CVLRKQLLYG
110 120 130 140 150
VCKTLFDTIT VRRVAEEWKL HAALFPYRAL DEEDLEQYLL VWSASLRQSV
160 170 180 190 200
QTGVLGALRD ILYQYADNDD YGLYVDWCVT VGLVPLLDVK TKPSEAAERA
210 220 230 240 250
QFVRAAVQRA TETHPLAQDL LQANLALLLQ VAERLGAVRV ANAPEVRVFK
260 270 280 290 300
KVRSERLEAQ LRGKHIRLYV AAEPLAYERD KLLFTTPVAH LHEEILRYDG
310 320 330 340 350
LCRHQKICQL LNTFPVKVVT ASRHELNCKK LVEMMEQHDR GSDAKKSIMK
360 370 380 390 400
FLLNVSDSKS RIGIEDSVES FLQDLTPSLV DQNRLLPARG PGGPGVVGPG
410 420 430 440 450
GAVVGGPAGH VGLLPPPPGP AAPERDIRDL FKKQVIKCLE EQIQSQVDEI
460 470 480 490 500
QDLRTLNQTW ENRVRELRDL LTRYASRRED SMSLGARDAE LYHLPVLEAV
510 520 530 540 550
RKARDAAPFR PLAVEDNRLV ANSFFSQFVP GTESLERFLT QLWENEYFRT
560 570 580 590 600
FRLRRLVTHQ GAEEAIVYSN YTVERVTLPY LCHILALGTL DPVPEAYLQL
610 620 630 640 650
SFGEIVAAAY DDSKFCRYVE LICSREKARR RQMSREAAGG VPERGTASSG
660 670 680 690
GPGTLERSAP RRLITADEER RGPERVGRFR NGGPDDPRRA GGPYGFH
Length:697
Mass (Da):78,521
Last modified:December 16, 2008 - v2
Checksum:i4A86400FDC16AAFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA. Translation: CAA35341.1.
BK000394 Genomic DNA. Translation: DAA00099.2.
PIRiS09870. QQBEK3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA. Translation: CAA35341.1.
BK000394 Genomic DNA. Translation: DAA00099.2.
PIRiS09870. QQBEK3.

3D structure databases

ProteinModelPortaliP16735.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR002660. Herpes_UL6.
[Graphical view]
PfamiPF01763. Herpes_UL6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169."
    Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.
    Curr. Top. Microbiol. Immunol. 154:125-169(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome."
    Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S.
    J. Gen. Virol. 84:17-28(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
  3. Cited for: IDENTIFICATION.
  4. Davison A.J.
    Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 157.

Entry informationi

Entry nameiPORTL_HCMVA
AccessioniPrimary (citable) accession number: P16735
Secondary accession number(s): Q7M6T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: December 16, 2008
Last modified: January 7, 2015
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.