P16735 (PORTL_HCMVA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Portal protein UL104

Gene names

Name:

UL104

Organism

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) [Complete proteome]

Taxonomic identifier

10360 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Cytomegalovirus › Human cytomegalovirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	697 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging. Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid. Binds to the molecular motor that translocate the viral DNA, termed terminase By similarity.
Subunit structure	Homododecamerizes. Interacts with putative terminase subunit UL89 and UL56 By similarity.
Subcellular location	Virion. Host nucleus By similarity.
Sequence similarities	Belongs to the herpesviridae portal protein family.

Ontologies

Keywords
Biological process	Viral genome packaging
Cellular component	Host nucleus Virion
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA packaging Inferred from electronic annotation. Source: InterPro
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell virion Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 697	697	Portal protein UL104		PRO_0000115913

Sequences

	Sequence		Length	Mass (Da)
	P16735 [UniParc]. Last modified December 16, 2008. Version 2. Checksum: 4A86400FDC16AAFA	FASTA	697	78,521
	10 20 30 40 50 60 MERNHWNEKS SGAKRSRERD LTLSTIRSIL AADERLRIKA SSYLGVGRGV DDEAVIDIFP 70 80 90 100 110 120 TGQTMSFLRL LHGFLGTCRG QSMHQVLRDP CVLRKQLLYG VCKTLFDTIT VRRVAEEWKL 130 140 150 160 170 180 HAALFPYRAL DEEDLEQYLL VWSASLRQSV QTGVLGALRD ILYQYADNDD YGLYVDWCVT 190 200 210 220 230 240 VGLVPLLDVK TKPSEAAERA QFVRAAVQRA TETHPLAQDL LQANLALLLQ VAERLGAVRV 250 260 270 280 290 300 ANAPEVRVFK KVRSERLEAQ LRGKHIRLYV AAEPLAYERD KLLFTTPVAH LHEEILRYDG 310 320 330 340 350 360 LCRHQKICQL LNTFPVKVVT ASRHELNCKK LVEMMEQHDR GSDAKKSIMK FLLNVSDSKS 370 380 390 400 410 420 RIGIEDSVES FLQDLTPSLV DQNRLLPARG PGGPGVVGPG GAVVGGPAGH VGLLPPPPGP 430 440 450 460 470 480 AAPERDIRDL FKKQVIKCLE EQIQSQVDEI QDLRTLNQTW ENRVRELRDL LTRYASRRED 490 500 510 520 530 540 SMSLGARDAE LYHLPVLEAV RKARDAAPFR PLAVEDNRLV ANSFFSQFVP GTESLERFLT 550 560 570 580 590 600 QLWENEYFRT FRLRRLVTHQ GAEEAIVYSN YTVERVTLPY LCHILALGTL DPVPEAYLQL 610 620 630 640 650 660 SFGEIVAAAY DDSKFCRYVE LICSREKARR RQMSREAAGG VPERGTASSG GPGTLERSAP 670 680 690 RRLITADEER RGPERVGRFR NGGPDDPRRA GGPYGFH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169." Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G. Curr. Top. Microbiol. Immunol. 154:125-169(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome." Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S. J. Gen. Virol. 84:17-28(2003) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION.
[3]	Erratum Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S. J. Gen. Virol. 84:1053-1053(2003)
[4]	"Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome." Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., Shenk T., Smith R.D., Nelson J.A. J. Virol. 78:10960-10966(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., Shenk T., Smith R.D., Nelson J.A. J. Virol. 78:13395-13395(2004)
[6]	Davison A.J. Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 157.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X17403 Genomic DNA. Translation: CAA35341.1. BK000394 Genomic DNA. Translation: DAA00099.2.
PIR	QQBEK3. S09870.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002660. Herpes_UL6. [Graphical view]
Pfam	PF01763. Herpes_UL6. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PORTL_HCMVA

Accession

Primary (citable) accession number: P16735
Secondary accession number(s): Q7M6T5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	December 16, 2008
Last modified:	April 3, 2013
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program