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P16735 (PORTL_HCMVA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Portal protein UL6 homolog
Gene names
Name:UL104
OrganismHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) [Complete proteome]
Taxonomic identifier10360 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length697 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging. Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid. Binds to the molecular motor that translocate the viral DNA, termed terminase By similarity.

Subunit structure

Homododecamerizes. Interacts with putative terminase subunit UL89 and UL56 By similarity.

Subcellular location

Virion. Host nucleus By similarity.

Sequence similarities

Belongs to the herpesviridae portal protein family.

Ontologies

Keywords
   Biological processViral genome packaging
Virus exit from host cell
   Cellular componentHost nucleus
Virion
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA packaging

Inferred from electronic annotation. Source: InterPro

viral release from host cell

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

virion

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 697697Portal protein UL6 homolog
PRO_0000115913

Sequences

Sequence LengthMass (Da)Tools
P16735 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: 4A86400FDC16AAFA

FASTA69778,521
        10         20         30         40         50         60 
MERNHWNEKS SGAKRSRERD LTLSTIRSIL AADERLRIKA SSYLGVGRGV DDEAVIDIFP 

        70         80         90        100        110        120 
TGQTMSFLRL LHGFLGTCRG QSMHQVLRDP CVLRKQLLYG VCKTLFDTIT VRRVAEEWKL 

       130        140        150        160        170        180 
HAALFPYRAL DEEDLEQYLL VWSASLRQSV QTGVLGALRD ILYQYADNDD YGLYVDWCVT 

       190        200        210        220        230        240 
VGLVPLLDVK TKPSEAAERA QFVRAAVQRA TETHPLAQDL LQANLALLLQ VAERLGAVRV 

       250        260        270        280        290        300 
ANAPEVRVFK KVRSERLEAQ LRGKHIRLYV AAEPLAYERD KLLFTTPVAH LHEEILRYDG 

       310        320        330        340        350        360 
LCRHQKICQL LNTFPVKVVT ASRHELNCKK LVEMMEQHDR GSDAKKSIMK FLLNVSDSKS 

       370        380        390        400        410        420 
RIGIEDSVES FLQDLTPSLV DQNRLLPARG PGGPGVVGPG GAVVGGPAGH VGLLPPPPGP 

       430        440        450        460        470        480 
AAPERDIRDL FKKQVIKCLE EQIQSQVDEI QDLRTLNQTW ENRVRELRDL LTRYASRRED 

       490        500        510        520        530        540 
SMSLGARDAE LYHLPVLEAV RKARDAAPFR PLAVEDNRLV ANSFFSQFVP GTESLERFLT 

       550        560        570        580        590        600 
QLWENEYFRT FRLRRLVTHQ GAEEAIVYSN YTVERVTLPY LCHILALGTL DPVPEAYLQL 

       610        620        630        640        650        660 
SFGEIVAAAY DDSKFCRYVE LICSREKARR RQMSREAAGG VPERGTASSG GPGTLERSAP 

       670        680        690 
RRLITADEER RGPERVGRFR NGGPDDPRRA GGPYGFH 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169."
Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.
Curr. Top. Microbiol. Immunol. 154:125-169(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome."
Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S.
J. Gen. Virol. 84:17-28(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
[3]Erratum
Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S.
J. Gen. Virol. 84:1053-1053(2003)
[4]"Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome."
Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., Shenk T., Smith R.D., Nelson J.A.
J. Virol. 78:10960-10966(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., Shenk T., Smith R.D., Nelson J.A.
J. Virol. 78:13395-13395(2004)
[6]Davison A.J.
Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 157.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X17403 Genomic DNA. Translation: CAA35341.1.
BK000394 Genomic DNA. Translation: DAA00099.2.
PIRQQBEK3. S09870.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002660. Herpes_UL6.
[Graphical view]
PfamPF01763. Herpes_UL6. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePORTL_HCMVA
AccessionPrimary (citable) accession number: P16735
Secondary accession number(s): Q7M6T5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: December 16, 2008
Last modified: February 19, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families