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Protein

Protein UL84

Gene

UL84

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays an essential role in viral DNA replication. May participate in the DNA replication initiation by interacting with the origin of lytic replication, oriLyt and subsequently recruiting other viral/cellular factors. Additionally, interacts with and shuttles IRS1 viral mRNA from the host nucleus to the cytoplasm.2 Publications

Names & Taxonomyi

Protein namesi
Recommended name:
Protein UL84
Gene namesi
Name:UL84
OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri10360 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008992 Componenti: Genome
  • UP000008991 Componenti: Genome

Subcellular locationi

  • Host nucleus 1 Publication
  • Host cytoplasm 1 Publication

  • Note: Shuttles between host nucleus and cytoplasm. In the nucleus, colocalizes with UL44 and IE2 in the viral DNA replication compartments.

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001162971 – 586Protein UL84Add BLAST586

Proteomic databases

PRIDEiP16727.

Interactioni

Subunit structurei

Interacts with the DNA polymerase accessory subunit UL44. Interacts with HCMV major transcription-activating enzyme IE2. Interacts with host HNRNPK.3 Publications

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi161 – 170Nuclear localization signal10
Motifi228 – 237Nuclear export signal 1 (NES 1)10
Motifi359 – 366Nuclear export signal 2 (NES 2)8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 19Arg-rich (basic)Add BLAST11
Compositional biasi20 – 26Poly-Gly7
Compositional biasi53 – 58Poly-Thr6
Compositional biasi162 – 170Lys-rich (basic)9
Compositional biasi171 – 182Asp/Glu-rich (acidic)Add BLAST12

Sequence similaritiesi

Belongs to the HHV-5 UL84 protein family.Curated

Phylogenomic databases

OrthoDBiVOG0900007T.

Family and domain databases

InterProiView protein in InterPro
IPR010436. Herpes_UL84.
PfamiView protein in Pfam
PF06284. Cytomega_UL84. 1 hit.

Sequencei

Sequence statusi: Complete.

P16727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRVDPNLRN RARRPRARRG GGGGVGSNSS RHSGKCRRQR RALSAPPLTF
60 70 80 90 100
LATTTTTTMM GVASTDDDSL LLKTPDELDK YSGSPQTILT LTDKHDIRQP
110 120 130 140 150
RVHRGTYHLI QLHLDLRPEE LRDPFQILLS TPLQLGEAND ESQTAPATLQ
160 170 180 190 200
EEETAASHEP EKKKEKQEKK EEDEDDRNDD RERGILCVVS NEDSDVRPAF
210 220 230 240 250
SLFPARPGCH ILRSVIDQQL TRMAIVRLSL NLFALRIITP LLKRLPLRRK
260 270 280 290 300
AAHHTALHDC LALHLPELTF EPTLDINNVT ENAASVADTA ESTDADLTPT
310 320 330 340 350
LTVRVRHALC WHRVEGGISG PRGLTSRISA RLSETTAKTL GPSVFGRLEL
360 370 380 390 400
DPNESPPDLT LSSLTLYQDG ILRFNVTCDR TEAPADPVAF RLRLRRETVR
410 420 430 440 450
RPFFSDAPLP YFVPPRSGAA DEGLEVRVPY ELTLKNSHTL RIYRRFYGPY
460 470 480 490 500
LGVFVPHNRQ GLKMPVTVWL PRSWLELTVL VSDENGATFP RDALLGRLYF
510 520 530 540 550
ISSKHTLNRG CLSAMTHQVK STLHSRSTSH SPSQQQLSVL GASIALEDLL
560 570 580
PMRLASPETE PQDCKLTENT TEKTSPVTLA MVCGDL
Length:586
Mass (Da):65,428
Last modified:August 1, 1990 - v1
Checksum:i54AB912D6077223F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA. Translation: CAA35358.1.
BK000394 Genomic DNA. Translation: DAA00181.1.
PIRiS09848. WMBEDE.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA. Translation: CAA35358.1.
BK000394 Genomic DNA. Translation: DAA00181.1.
PIRiS09848. WMBEDE.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP16727.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG0900007T.

Family and domain databases

InterProiView protein in InterPro
IPR010436. Herpes_UL84.
PfamiView protein in Pfam
PF06284. Cytomega_UL84. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUL84_HCMVA
AccessioniPrimary (citable) accession number: P16727
Secondary accession number(s): Q7M6K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 10, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.