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Protein

Envelope protein A28 homolog

Gene

HM3

Organism
Sheeppox virus (strain KS-1) (SPPV) (Capripoxvirus (strain KS-1))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Envelope protein required for virus entry into host cell and for cell-cell fusion (syncytium formation).By similarity

GO - Biological processi

Keywordsi

Biological processFusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope protein A28 homolog
Alternative name(s):
Protein HM3
Gene namesi
ORF Names:HM3
OrganismiSheeppox virus (strain KS-1) (SPPV) (Capripoxvirus (strain KS-1))
Taxonomic identifieri10269 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeCapripoxvirus
Virus hostiOvis aries (Sheep) [TaxID: 9940]

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini22 – 140Virion surfaceSequence analysisAdd BLAST119

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000992871 – 140Envelope protein A28 homologAdd BLAST140

Post-translational modificationi

Contains two intramolecular disulfide bonds. They are created by the viral disulfide bond formation pathway, a poxvirus-specific pathway that operates on the cytoplasmic side of the MV membranes (By similarity).By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Keywords - Developmental stagei

Late protein

Family & Domainsi

Sequence similaritiesi

Belongs to the poxviridae A28 protein family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR007664 Poxvirus_A28
PfamiView protein in Pfam
PF04584 Pox_A28, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010756 Pox_A28, 1 hit

Sequencei

Sequence statusi: Complete.

P16718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAITIFFII LSTVAVCIII FQLYSIYLNY DNIKEFNSAH SAFEFSKSVN
60 70 80 90 100
TLSLDRTIKD PNDDIYDPKQ KWRCVKLDND YVSVSMFGFK SNGSEIRKFK
110 120 130 140
NLESCIDYTF SQSTHSDIKN PCILQNGIKS KECIFLKSMF
Length:140
Mass (Da):16,203
Last modified:August 1, 1990 - v1
Checksum:iAB22777F3A99094A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30039 Genomic DNA Translation: AAC32899.1
PIRiC33325 WMVZM3
RefSeqiNP_659690.1, NC_004002.1

Genome annotation databases

GeneIDi944593
KEGGivg:944593

Similar proteinsi

Entry informationi

Entry nameiA28_SHEVK
AccessioniPrimary (citable) accession number: P16718
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 1, 2015
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

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