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Protein

Thiosulfate-binding protein

Gene

cysP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. This protein specifically binds thiosulfate and is involved in its transmembrane transport.

GO - Molecular functioni

GO - Biological processi

  • sulfur compound metabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Sulfate transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:CYSP-MONOMER.
ECOL316407:JW2418-MONOMER.
MetaCyc:CYSP-MONOMER.

Protein family/group databases

TCDBi3.A.1.6.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiosulfate-binding protein
Gene namesi
Name:cysP
Ordered Locus Names:b2425, JW2418
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10195. cysP.

Subcellular locationi

GO - Cellular componenti

  • outer membrane-bounded periplasmic space Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 338313Thiosulfate-binding proteinPRO_0000031681Add
BLAST

Proteomic databases

EPDiP16700.
PaxDbiP16700.
PRIDEiP16700.

2D gel databases

SWISS-2DPAGEP16700.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).Curated

Protein-protein interaction databases

BioGridi4263209. 14 interactions.
DIPiDIP-9384N.
IntActiP16700. 4 interactions.
STRINGi511145.b2425.

Structurei

3D structure databases

ProteinModelPortaliP16700.
SMRiP16700. Positions 27-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108J2H. Bacteria.
COG4150. LUCA.
HOGENOMiHOG000260057.
InParanoidiP16700.
KOiK02048.
OMAiVDQSHAG.
PhylomeDBiP16700.

Family and domain databases

CDDicd01005. PBP2_CysP. 1 hit.
InterProiIPR000957. Sulphate/thiosulphate-bd_CS.
IPR005669. Thiosulph/SO4-bd.
[Graphical view]
PANTHERiPTHR30368. PTHR30368. 1 hit.
TIGRFAMsiTIGR00971. 3a0106s03. 1 hit.
PROSITEiPS00401. PROK_SULFATE_BIND_1. 1 hit.
PS00757. PROK_SULFATE_BIND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16700-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVNLLKKNS LALVASLLLA GHVQATELLN SSYDVSRELF AALNPPFEQQ
60 70 80 90 100
WAKDNGGDKL TIKQSHAGSS KQALAILQGL KADVVTYNQV TDVQILHDKG
110 120 130 140 150
KLIPADWQSR LPNNSSPFYS TMGFLVRKGN PKNIHDWNDL VRSDVKLIFP
160 170 180 190 200
NPKTSGNARY TYLAAWGAAD KADGGDKGKT EQFMTQFLKN VEVFDTGGRG
210 220 230 240 250
ATTTFAERGL GDVLISFESE VNNIRKQYEA QGFEVVIPKT NILAEFPVAW
260 270 280 290 300
VDKNVQANGT EKAAKAYLNW LYSPQAQTII TDYYYRVNNP EVMDKLKDKF
310 320 330
PQTELFRVED KFGSWPEVMK THFTSGGELD KLLAAGRN
Length:338
Mass (Da):37,615
Last modified:August 1, 1990 - v1
Checksum:i79BCD531AFA01DC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32101 Genomic DNA. Translation: AAA23636.1.
U00096 Genomic DNA. Translation: AAC75478.1.
AP009048 Genomic DNA. Translation: BAA16299.1.
PIRiA35403. JGECT.
RefSeqiNP_416920.1. NC_000913.3.
WP_000290230.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75478; AAC75478; b2425.
BAA16299; BAA16299; BAA16299.
GeneIDi946883.
KEGGiecj:JW2418.
eco:b2425.
PATRICi32120235. VBIEscCol129921_2520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32101 Genomic DNA. Translation: AAA23636.1.
U00096 Genomic DNA. Translation: AAC75478.1.
AP009048 Genomic DNA. Translation: BAA16299.1.
PIRiA35403. JGECT.
RefSeqiNP_416920.1. NC_000913.3.
WP_000290230.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP16700.
SMRiP16700. Positions 27-332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263209. 14 interactions.
DIPiDIP-9384N.
IntActiP16700. 4 interactions.
STRINGi511145.b2425.

Protein family/group databases

TCDBi3.A.1.6.1. the atp-binding cassette (abc) superfamily.

2D gel databases

SWISS-2DPAGEP16700.

Proteomic databases

EPDiP16700.
PaxDbiP16700.
PRIDEiP16700.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75478; AAC75478; b2425.
BAA16299; BAA16299; BAA16299.
GeneIDi946883.
KEGGiecj:JW2418.
eco:b2425.
PATRICi32120235. VBIEscCol129921_2520.

Organism-specific databases

EchoBASEiEB0192.
EcoGeneiEG10195. cysP.

Phylogenomic databases

eggNOGiENOG4108J2H. Bacteria.
COG4150. LUCA.
HOGENOMiHOG000260057.
InParanoidiP16700.
KOiK02048.
OMAiVDQSHAG.
PhylomeDBiP16700.

Enzyme and pathway databases

BioCyciEcoCyc:CYSP-MONOMER.
ECOL316407:JW2418-MONOMER.
MetaCyc:CYSP-MONOMER.

Miscellaneous databases

PROiP16700.

Family and domain databases

CDDicd01005. PBP2_CysP. 1 hit.
InterProiIPR000957. Sulphate/thiosulphate-bd_CS.
IPR005669. Thiosulph/SO4-bd.
[Graphical view]
PANTHERiPTHR30368. PTHR30368. 1 hit.
TIGRFAMsiTIGR00971. 3a0106s03. 1 hit.
PROSITEiPS00401. PROK_SULFATE_BIND_1. 1 hit.
PS00757. PROK_SULFATE_BIND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYSP_ECOLI
AccessioniPrimary (citable) accession number: P16700
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: September 7, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.