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Protein

Probable transcriptional regulator PhnF

Gene

phnF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Belongs to an operon involved in alkylphosphonate uptake and C-P lyase. Exact function not known. By similarity could be a transcriptional regulator.

Miscellaneous

The sequence shown is that of strains K12 and B.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi38 – 57H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processAlkylphosphonate uptake, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG10715-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable transcriptional regulator PhnF
Gene namesi
Name:phnF
Ordered Locus Names:b4102, JW4063
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10715 phnF

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506671 – 241Probable transcriptional regulator PhnFAdd BLAST241

Proteomic databases

PaxDbiP16684
PRIDEiP16684

Interactioni

Protein-protein interaction databases

BioGridi4263093, 10 interactors
IntActiP16684, 2 interactors
STRINGi316385.ECDH10B_4293

Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi87 – 93Combined sources7
Beta strandi104 – 112Combined sources9
Helixi115 – 121Combined sources7
Beta strandi127 – 138Combined sources12
Beta strandi141 – 151Combined sources11
Helixi153 – 155Combined sources3
Helixi156 – 159Combined sources4
Helixi167 – 175Combined sources9
Beta strandi179 – 190Combined sources12
Helixi194 – 199Combined sources6
Beta strandi206 – 216Combined sources11
Beta strandi223 – 231Combined sources9
Turni232 – 234Combined sources3
Beta strandi235 – 240Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FA1X-ray1.70A/B85-241[»]
ProteinModelPortaliP16684
SMRiP16684
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16684

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 78HTH gntR-typePROSITE-ProRule annotationAdd BLAST68

Phylogenomic databases

eggNOGiENOG4107RJJ Bacteria
COG2188 LUCA
HOGENOMiHOG000228717
InParanoidiP16684
KOiK02043
OMAiVRNYVYL
PhylomeDBiP16684

Family and domain databases

CDDicd07377 WHTH_GntR, 1 hit
Gene3Di1.10.10.10, 1 hit
3.40.1410.10, 1 hit
InterProiView protein in InterPro
IPR028978 Chorismate_lyase_/UTRA_dom_sf
IPR012702 CP_lyase_PhnF
IPR000524 Tscrpt_reg_HTH_GntR
IPR011663 UTRA
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00392 GntR, 1 hit
PF07702 UTRA, 1 hit
PRINTSiPR00035 HTHGNTR
SMARTiView protein in SMART
SM00345 HTH_GNTR, 1 hit
SM00866 UTRA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF64288 SSF64288, 1 hit
TIGRFAMsiTIGR02325 C_P_lyase_phnF, 1 hit
PROSITEiView protein in PROSITE
PS50949 HTH_GNTR, 1 hit

Sequencei

Sequence statusi: Complete.

P16684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLSTHPTSY PTRYQEIAAK LEQELRQHYR CGDYLPAEQQ LAARFEVNRH
60 70 80 90 100
TLRRAIDQLV EKGWVQRRQG VGVLVLMRPF DYPLNAQARF SQNLLDQGSH
110 120 130 140 150
PTSEKLLSVL RPASGHVADA LGITEGENVI HLRTLRRVNG VALCLIDHYF
160 170 180 190 200
ADLTLWPTLQ RFDSGSLHDF LREQTGIALR RSQTRISARR AQAKECQRLE
210 220 230 240
IPNMSPLLCV RTLNHRDGES SPAEYSVSLT RADMIEFTME H
Length:241
Mass (Da):27,621
Last modified:August 1, 1990 - v1
Checksum:iF1A24763A84D574A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05260 Genomic DNA Translation: AAA24343.1
D90227 Genomic DNA Translation: BAA14266.1
U14003 Genomic DNA Translation: AAA97001.1
U00096 Genomic DNA Translation: AAC77063.1
AP009048 Genomic DNA Translation: BAE78105.1
PIRiG35718
RefSeqiNP_418526.1, NC_000913.3
WP_001295387.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77063; AAC77063; b4102
BAE78105; BAE78105; BAE78105
GeneIDi948617
KEGGiecj:JW4063
eco:b4102
PATRICifig|1411691.4.peg.2598

Similar proteinsi

Entry informationi

Entry nameiPHNF_ECOLI
AccessioniPrimary (citable) accession number: P16684
Secondary accession number(s): Q2M6K1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: March 28, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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