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Protein

Putative phosphonates transport system permease protein PhnE

Gene

phnE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Part of the binding-protein-dependent transport system for phosphonates; probably responsible for the translocation of the substrate across the membrane.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Phosphonate transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7822-MONOMER.
EcoCyc:PHNE-MONOMER.
ECOL316407:JW4065-MONOMER.
MetaCyc:PHNE-MONOMER.

Protein family/group databases

TCDBi3.A.1.9.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative phosphonates transport system permease protein PhnE
Gene namesi
Name:phnE
Ordered Locus Names:b4104, JW4065
ORF Names:b4103
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11283. phnE.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei75 – 9521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei123 – 14321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei176 – 19621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei205 – 22521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei230 – 25021HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Putative phosphonates transport system permease protein PhnEPRO_0000060173Add
BLAST

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (PhnC), two transmembrane proteins (PhnE) and a solute-binding protein (PhnD).Curated

Structurei

3D structure databases

ProteinModelPortaliP16683.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 251183ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000095580.
InParanoidiP16683.
OMAiMALFIHT.
PhylomeDBiP16683.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
IPR005769. PhnE/PtxC.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR01097. PhnE. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTITIAPPK RSWFSLLSWA VVLAVLVVSW QGAEMAPLTL IKDGGNMATF
60 70 80 90 100
AADFFPPDFS QWQDYLTEMA VTLQIAVWGT ALAVVLSIPF GLMSAENLVP
110 120 130 140 150
WWVYQPVRRL MDACRAINEM VFAMLFVVAV GLGPFAGVLA LFIHTTGVLS
160 170 180 190 200
KLLSEAVEAI EPGPVEGIRA TGANKLEEIL YGVLPQVMPL LISYSLYRFE
210 220 230 240 250
SNVRSATVVG MVGAGGIGVT LWEAIRGFQF QQTCALMVLI IVTVSLLDFL

SQRLRKHFI
Length:259
Mass (Da):28,384
Last modified:January 15, 2008 - v2
Checksum:iE6438A442CC3A842
GO

Sequence cautioni

The sequence AAA24341 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAA97002 differs from that shown. Reason: Frameshift at position 155. Curated
The sequence AAA97003 differs from that shown. Reason: Frameshift at position 155. Curated
The sequence BAA14264 differs from that shown. Reason: Frameshift at position 155. Curated
The sequence BAA14265 differs from that shown. Reason: Frameshift at position 155. Curated
The sequence BAE78106 differs from that shown. Reason: Frameshift at position 155. Curated
The sequence U00096 differs from that shown. Reason: Frameshift at position 155. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05260 Genomic DNA. Translation: AAA24341.1. Different initiation.
D90227 Genomic DNA. Translation: BAA14264.1. Frameshift.
D90227 Genomic DNA. Translation: BAA14265.1. Frameshift.
U14003 Genomic DNA. Translation: AAA97003.1. Frameshift.
U14003 Genomic DNA. Translation: AAA97002.1. Frameshift.
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAE78106.1. Frameshift.
PIRiF35718.

Genome annotation databases

EnsemblBacteriaiBAE78106; BAE78106; BAE78106.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05260 Genomic DNA. Translation: AAA24341.1. Different initiation.
D90227 Genomic DNA. Translation: BAA14264.1. Frameshift.
D90227 Genomic DNA. Translation: BAA14265.1. Frameshift.
U14003 Genomic DNA. Translation: AAA97003.1. Frameshift.
U14003 Genomic DNA. Translation: AAA97002.1. Frameshift.
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAE78106.1. Frameshift.
PIRiF35718.

3D structure databases

ProteinModelPortaliP16683.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi3.A.1.9.1. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE78106; BAE78106; BAE78106.

Organism-specific databases

EchoBASEiEB1260.
EcoGeneiEG11283. phnE.

Phylogenomic databases

HOGENOMiHOG000095580.
InParanoidiP16683.
OMAiMALFIHT.
PhylomeDBiP16683.

Enzyme and pathway databases

BioCyciEcoCyc:G7822-MONOMER.
EcoCyc:PHNE-MONOMER.
ECOL316407:JW4065-MONOMER.
MetaCyc:PHNE-MONOMER.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
IPR005769. PhnE/PtxC.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR01097. PhnE. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPHNE_ECOLI
AccessioniPrimary (citable) accession number: P16683
Secondary accession number(s): P76792
, Q2M6K0, Q47479, Q47716
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 15, 2008
Last modified: September 7, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The sequence shown is that of strain B.

Caution

Could be the product of a pseudogene. In strain K12 the phnE gene has an 8-bp insertion, absent from the strain B gene, which causes a frameshift mutation.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.