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Protein

Phosphonates-binding periplasmic protein

Gene

phnD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Phosphonate binding protein that is part of the phosphonate uptake system. Exhibits high affinity for 2-aminoethylphosphonate, and somewhat less affinity to ethylphosphonate, methylphosphonate, phosphonoacetate and phenylphosphonate.1 Publication

GO - Molecular functioni

  • alkylphosphonate transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • alkylphosphonate transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Phosphonate transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:PHND-MONOMER.
ECOL316407:JW4066-MONOMER.
MetaCyc:PHND-MONOMER.

Protein family/group databases

TCDBi3.A.1.9.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphonates-binding periplasmic protein
Gene namesi
Name:phnD
Synonyms:psiD
Ordered Locus Names:b4105, JW4066
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10714. phnD.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 338312Phosphonates-binding periplasmic proteinPRO_0000031836Add
BLAST

Proteomic databases

PaxDbiP16682.
PRIDEiP16682.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (PhnC), two transmembrane proteins (PhnE) and a solute-binding protein (PhnD).Curated

Protein-protein interaction databases

BioGridi4263091. 115 interactions.
DIPiDIP-10483N.
IntActiP16682. 3 interactions.
STRINGi511145.b4105.

Structurei

3D structure databases

ProteinModelPortaliP16682.
SMRiP16682. Positions 31-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105EHI. Bacteria.
COG3221. LUCA.
HOGENOMiHOG000284940.
InParanoidiP16682.
KOiK02044.
OMAiSSHEVNA.
PhylomeDBiP16682.

Family and domain databases

InterProiIPR005770. PhnD.
IPR017797. Phosphnate-bd.
[Graphical view]
PANTHERiPTHR30043:SF4. PTHR30043:SF4. 3 hits.
TIGRFAMsiTIGR01098. 3A0109s03R. 1 hit.
TIGR03431. PhnD. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16682-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAKIIASLA FTSMFSLSTL LSPAHAEEQE KALNFGIIST ESQQNLKPQW
60 70 80 90 100
TPFLQDMEKK LGVKVNAFFA PDYAGIIQGM RFNKVDIAWY GNLSAMEAVD
110 120 130 140 150
RANGQVFAQT VAADGSPGYW SVLIVNKDSP INNLNDLLAK RKDLTFGNGD
160 170 180 190 200
PNSTSGFLVP GYYVFAKNNI SASDFKRTVN AGHETNALAV ANKQVDVATN
210 220 230 240 250
NTENLDKLKT SAPEKLKELK VIWKSPLIPG DPIVWRKNLS ETTKDKIYDF
260 270 280 290 300
FMNYGKTPEE KAVLERLGWA PFRASSDLQL VPIRQLALFK EMQGVKSNKG
310 320 330
LNEQDKLAKT TEIQAQLDDL DRLNNALSAM SSVSKAVQ
Length:338
Mass (Da):37,371
Last modified:November 1, 1991 - v2
Checksum:i84B4366AE8D1BF62
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti312 – 3121E → A in strain: B.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05260 Genomic DNA. Translation: AAA24340.1.
D90227 Genomic DNA. Translation: BAA14263.1.
U14003 Genomic DNA. Translation: AAA97004.1.
U00096 Genomic DNA. Translation: AAC77066.1.
AP009048 Genomic DNA. Translation: BAE78107.1.
PIRiS56333.
RefSeqiNP_418529.1. NC_000913.3.
WP_000992002.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77066; AAC77066; b4105.
BAE78107; BAE78107; BAE78107.
GeneIDi948624.
KEGGiecj:JW4066.
eco:b4105.
PATRICi32123769. VBIEscCol129921_4233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05260 Genomic DNA. Translation: AAA24340.1.
D90227 Genomic DNA. Translation: BAA14263.1.
U14003 Genomic DNA. Translation: AAA97004.1.
U00096 Genomic DNA. Translation: AAC77066.1.
AP009048 Genomic DNA. Translation: BAE78107.1.
PIRiS56333.
RefSeqiNP_418529.1. NC_000913.3.
WP_000992002.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP16682.
SMRiP16682. Positions 31-330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263091. 115 interactions.
DIPiDIP-10483N.
IntActiP16682. 3 interactions.
STRINGi511145.b4105.

Protein family/group databases

TCDBi3.A.1.9.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP16682.
PRIDEiP16682.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77066; AAC77066; b4105.
BAE78107; BAE78107; BAE78107.
GeneIDi948624.
KEGGiecj:JW4066.
eco:b4105.
PATRICi32123769. VBIEscCol129921_4233.

Organism-specific databases

EchoBASEiEB0708.
EcoGeneiEG10714. phnD.

Phylogenomic databases

eggNOGiENOG4105EHI. Bacteria.
COG3221. LUCA.
HOGENOMiHOG000284940.
InParanoidiP16682.
KOiK02044.
OMAiSSHEVNA.
PhylomeDBiP16682.

Enzyme and pathway databases

BioCyciEcoCyc:PHND-MONOMER.
ECOL316407:JW4066-MONOMER.
MetaCyc:PHND-MONOMER.

Miscellaneous databases

PROiP16682.

Family and domain databases

InterProiIPR005770. PhnD.
IPR017797. Phosphnate-bd.
[Graphical view]
PANTHERiPTHR30043:SF4. PTHR30043:SF4. 3 hits.
TIGRFAMsiTIGR01098. 3A0109s03R. 1 hit.
TIGR03431. PhnD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHND_ECOLI
AccessioniPrimary (citable) accession number: P16682
Secondary accession number(s): Q2M6J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1991
Last modified: September 7, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The sequence shown is that of strain K12.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.