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Protein

Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL

Gene

phnL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Together with PhnG, PhnH and PhnI is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate.1 Publication

Catalytic activityi

ATP + methylphosphonate = alpha-D-ribose 1-methylphosphonate 5-triphosphate + adenine.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 488ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • organic phosphonate catabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:PHNL-MONOMER.
ECOL316407:JW4057-MONOMER.
MetaCyc:PHNL-MONOMER.
RETL1328306-WGS:GSTH-170-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL (EC:2.7.8.37)
Short name:
RPnTP synthase subunit PhnL
Gene namesi
Name:phnL
Ordered Locus Names:b4096, JW4057
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10721. phnL.

Subcellular locationi

GO - Cellular componenti

  • alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnLPRO_0000092745Add
BLAST

Proteomic databases

PaxDbiP16679.
PRIDEiP16679.

Interactioni

Protein-protein interaction databases

BioGridi4262019. 2 interactions.
IntActiP16679. 4 interactions.
STRINGi511145.b4096.

Structurei

3D structure databases

ProteinModelPortaliP16679.
SMRiP16679. Positions 23-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 226225ABC transporterPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105HRV. Bacteria.
COG4778. LUCA.
InParanoidiP16679.
KOiK05780.
OMAiKMIYGNY.
PhylomeDBiP16679.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR012701. CP_lyase_PhnL.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02324. CP_lyasePhnL. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16679-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINVQNVSKT FILHQQNGVR LPVLNRASLT VNAGECVVLH GHSGSGKSTL
60 70 80 90 100
LRSLYANYLP DEGQIQIKHG DEWVDLVTAP ARKVVEIRKT TVGWVSQFLR
110 120 130 140 150
VIPRISALEV VMQPLLDTGV PREACAAKAA RLLTRLNVPE RLWHLAPSTF
160 170 180 190 200
SGGEQQRVNI ARGFIVDYPI LLLDEPTASL DAKNSAAVVE LIREAKTRGA
210 220
AIVGIFHDEA VRNDVADRLH PMGASS
Length:226
Mass (Da):24,705
Last modified:August 1, 1990 - v1
Checksum:i195EC8BB5A2D21D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05260 Genomic DNA. Translation: AAA24350.1.
D90227 Genomic DNA. Translation: BAA14272.1.
U14003 Genomic DNA. Translation: AAA96995.1.
U00096 Genomic DNA. Translation: AAC77057.1.
AP009048 Genomic DNA. Translation: BAE78099.1.
PIRiD35719.
RefSeqiNP_418520.1. NC_000913.3.
WP_000611405.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77057; AAC77057; b4096.
BAE78099; BAE78099; BAE78099.
GeneIDi948612.
KEGGiecj:JW4057.
eco:b4096.
PATRICi32123751. VBIEscCol129921_4224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05260 Genomic DNA. Translation: AAA24350.1.
D90227 Genomic DNA. Translation: BAA14272.1.
U14003 Genomic DNA. Translation: AAA96995.1.
U00096 Genomic DNA. Translation: AAC77057.1.
AP009048 Genomic DNA. Translation: BAE78099.1.
PIRiD35719.
RefSeqiNP_418520.1. NC_000913.3.
WP_000611405.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP16679.
SMRiP16679. Positions 23-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262019. 2 interactions.
IntActiP16679. 4 interactions.
STRINGi511145.b4096.

Proteomic databases

PaxDbiP16679.
PRIDEiP16679.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77057; AAC77057; b4096.
BAE78099; BAE78099; BAE78099.
GeneIDi948612.
KEGGiecj:JW4057.
eco:b4096.
PATRICi32123751. VBIEscCol129921_4224.

Organism-specific databases

EchoBASEiEB0715.
EcoGeneiEG10721. phnL.

Phylogenomic databases

eggNOGiENOG4105HRV. Bacteria.
COG4778. LUCA.
InParanoidiP16679.
KOiK05780.
OMAiKMIYGNY.
PhylomeDBiP16679.

Enzyme and pathway databases

BioCyciEcoCyc:PHNL-MONOMER.
ECOL316407:JW4057-MONOMER.
MetaCyc:PHNL-MONOMER.
RETL1328306-WGS:GSTH-170-MONOMER.

Miscellaneous databases

PROiP16679.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR012701. CP_lyase_PhnL.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02324. CP_lyasePhnL. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPHNL_ECOLI
AccessioniPrimary (citable) accession number: P16679
Secondary accession number(s): Q2M6K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: September 7, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.