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Protein

Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL

Gene

phnL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Together with PhnG, PhnH and PhnI is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate.1 Publication

Catalytic activityi

ATP + methylphosphonate = alpha-D-ribose 1-methylphosphonate 5-triphosphate + adenine.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi41 – 48ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • organic phosphonate catabolic process Source: EcoCyc

Keywordsi

Molecular functionTransferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:PHNL-MONOMER.
MetaCyc:PHNL-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL (EC:2.7.8.37)
Short name:
RPnTP synthase subunit PhnL
Gene namesi
Name:phnL
Ordered Locus Names:b4096, JW4057
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10721. phnL.

Subcellular locationi

GO - Cellular componenti

  • alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000927451 – 226Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnLAdd BLAST226

Proteomic databases

PaxDbiP16679.
PRIDEiP16679.

Interactioni

Protein-protein interaction databases

BioGridi4262019. 2 interactors.
IntActiP16679. 4 interactors.
STRINGi511145.b4096.

Structurei

3D structure databases

ProteinModelPortaliP16679.
SMRiP16679.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 226ABC transporterPROSITE-ProRule annotationAdd BLAST225

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated

Phylogenomic databases

eggNOGiENOG4105HRV. Bacteria.
COG4778. LUCA.
InParanoidiP16679.
KOiK05780.
OMAiKMIYGNY.
PhylomeDBiP16679.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR012701. CP_lyase_PhnL.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02324. CP_lyasePhnL. 1 hit.
PROSITEiView protein in PROSITE
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P16679-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINVQNVSKT FILHQQNGVR LPVLNRASLT VNAGECVVLH GHSGSGKSTL
60 70 80 90 100
LRSLYANYLP DEGQIQIKHG DEWVDLVTAP ARKVVEIRKT TVGWVSQFLR
110 120 130 140 150
VIPRISALEV VMQPLLDTGV PREACAAKAA RLLTRLNVPE RLWHLAPSTF
160 170 180 190 200
SGGEQQRVNI ARGFIVDYPI LLLDEPTASL DAKNSAAVVE LIREAKTRGA
210 220
AIVGIFHDEA VRNDVADRLH PMGASS
Length:226
Mass (Da):24,705
Last modified:August 1, 1990 - v1
Checksum:i195EC8BB5A2D21D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05260 Genomic DNA. Translation: AAA24350.1.
D90227 Genomic DNA. Translation: BAA14272.1.
U14003 Genomic DNA. Translation: AAA96995.1.
U00096 Genomic DNA. Translation: AAC77057.1.
AP009048 Genomic DNA. Translation: BAE78099.1.
PIRiD35719.
RefSeqiNP_418520.1. NC_000913.3.
WP_000611405.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77057; AAC77057; b4096.
BAE78099; BAE78099; BAE78099.
GeneIDi948612.
KEGGiecj:JW4057.
eco:b4096.
PATRICi32123751. VBIEscCol129921_4224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05260 Genomic DNA. Translation: AAA24350.1.
D90227 Genomic DNA. Translation: BAA14272.1.
U14003 Genomic DNA. Translation: AAA96995.1.
U00096 Genomic DNA. Translation: AAC77057.1.
AP009048 Genomic DNA. Translation: BAE78099.1.
PIRiD35719.
RefSeqiNP_418520.1. NC_000913.3.
WP_000611405.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP16679.
SMRiP16679.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262019. 2 interactors.
IntActiP16679. 4 interactors.
STRINGi511145.b4096.

Proteomic databases

PaxDbiP16679.
PRIDEiP16679.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77057; AAC77057; b4096.
BAE78099; BAE78099; BAE78099.
GeneIDi948612.
KEGGiecj:JW4057.
eco:b4096.
PATRICi32123751. VBIEscCol129921_4224.

Organism-specific databases

EchoBASEiEB0715.
EcoGeneiEG10721. phnL.

Phylogenomic databases

eggNOGiENOG4105HRV. Bacteria.
COG4778. LUCA.
InParanoidiP16679.
KOiK05780.
OMAiKMIYGNY.
PhylomeDBiP16679.

Enzyme and pathway databases

BioCyciEcoCyc:PHNL-MONOMER.
MetaCyc:PHNL-MONOMER.

Miscellaneous databases

PROiP16679.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR012701. CP_lyase_PhnL.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02324. CP_lyasePhnL. 1 hit.
PROSITEiView protein in PROSITE
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHNL_ECOLI
AccessioniPrimary (citable) accession number: P16679
Secondary accession number(s): Q2M6K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: March 15, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.