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Protein

Putative phosphonates utilization ATP-binding protein PhnK

Gene

phnK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Belongs to an operon involved in alkylphosphonate uptake and C-P lyase. Exact function not known. PhnK is not required for the ribophosphonate triphosphate (RPnTP) synthase reaction.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 45ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • organic phosphonate catabolic process Source: EcoCyc
  • transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:PHNK-MONOMER.
ECOL316407:JW5727-MONOMER.
MetaCyc:PHNK-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative phosphonates utilization ATP-binding protein PhnK
Gene namesi
Name:phnK
Ordered Locus Names:b4097, JW5727
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10720. phnK.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000927441 – 252Putative phosphonates utilization ATP-binding protein PhnKAdd BLAST252

Proteomic databases

PaxDbiP16678.
PRIDEiP16678.

Interactioni

Subunit structurei

Forms a complex with PhnG, PhnH, PhnI and PhnJ with the suggested composition PhnG4H2I2J2K.1 Publication

Protein-protein interaction databases

BioGridi4262020. 8 interactors.
DIPiDIP-10490N.
IntActiP16678. 6 interactors.
STRINGi511145.b4097.

Structurei

3D structure databases

ProteinModelPortaliP16678.
SMRiP16678.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 246ABC transporterPROSITE-ProRule annotationAdd BLAST241

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105ENV. Bacteria.
COG4107. LUCA.
InParanoidiP16678.
KOiK05781.
OMAiSTIGYTI.
PhylomeDBiP16678.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR012700. CP_lyase_PhnK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF037116. CP_lyase_PhnK. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02323. CP_lyasePhnK. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16678-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQPLLSVNN LTHLYAPGKG FSDVSFDLWP GEVLGIVGES GSGKTTLLKS
60 70 80 90 100
ISARLTPQQG EIHYENRSLY AMSEADRRRL LRTEWGVVHQ HPLDGLRRQV
110 120 130 140 150
SAGGNIGERL MATGARHYGD IRATAQKWLE EVEIPANRID DLPTTFSGGM
160 170 180 190 200
QQRLQIARNL VTHPKLVFMD EPTGGLDVSV QARLLDLLRG LVVELNLAVV
210 220 230 240 250
IVTHDLGVAR LLADRLLVMK QGQVVESGLT DRVLDDPHHP YTQLLVSSVL

QN
Length:252
Mass (Da):27,831
Last modified:August 1, 1990 - v1
Checksum:i3B8677F22C472A9F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47L → Q in AAA96996 (PubMed:7610040).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05260 Genomic DNA. Translation: AAA24349.1.
D90227 Genomic DNA. Translation: BAA14271.1.
U14003 Genomic DNA. Translation: AAA96996.1.
U00096 Genomic DNA. Translation: AAT48240.1.
AP009048 Genomic DNA. Translation: BAE78100.1.
PIRiS56325.
RefSeqiWP_001075514.1. NZ_LN832404.1.
YP_026282.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48240; AAT48240; b4097.
BAE78100; BAE78100; BAE78100.
GeneIDi948611.
KEGGiecj:JW5727.
eco:b4097.
PATRICi32123753. VBIEscCol129921_4225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05260 Genomic DNA. Translation: AAA24349.1.
D90227 Genomic DNA. Translation: BAA14271.1.
U14003 Genomic DNA. Translation: AAA96996.1.
U00096 Genomic DNA. Translation: AAT48240.1.
AP009048 Genomic DNA. Translation: BAE78100.1.
PIRiS56325.
RefSeqiWP_001075514.1. NZ_LN832404.1.
YP_026282.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP16678.
SMRiP16678.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262020. 8 interactors.
DIPiDIP-10490N.
IntActiP16678. 6 interactors.
STRINGi511145.b4097.

Proteomic databases

PaxDbiP16678.
PRIDEiP16678.

Protocols and materials databases

DNASUi948611.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48240; AAT48240; b4097.
BAE78100; BAE78100; BAE78100.
GeneIDi948611.
KEGGiecj:JW5727.
eco:b4097.
PATRICi32123753. VBIEscCol129921_4225.

Organism-specific databases

EchoBASEiEB0714.
EcoGeneiEG10720. phnK.

Phylogenomic databases

eggNOGiENOG4105ENV. Bacteria.
COG4107. LUCA.
InParanoidiP16678.
KOiK05781.
OMAiSTIGYTI.
PhylomeDBiP16678.

Enzyme and pathway databases

BioCyciEcoCyc:PHNK-MONOMER.
ECOL316407:JW5727-MONOMER.
MetaCyc:PHNK-MONOMER.

Miscellaneous databases

PROiP16678.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR012700. CP_lyase_PhnK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF037116. CP_lyase_PhnK. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02323. CP_lyasePhnK. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPHNK_ECOLI
AccessioniPrimary (citable) accession number: P16678
Secondary accession number(s): Q2M6K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.