Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphonates import ATP-binding protein PhnC

Gene

phnC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system.2 Publications

Catalytic activityi

ATP + H2O + phosphonate(Out) = ADP + phosphate + phosphonate(In).UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi37 – 44ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

  • alkylphosphonate transport Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Phosphonate transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:PHNC-MONOMER.
ECOL316407:JW4067-MONOMER.
MetaCyc:PHNC-MONOMER.

Protein family/group databases

TCDBi3.A.1.9.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphonates import ATP-binding protein PhnCUniRule annotation (EC:3.6.3.28UniRule annotation)
Gene namesi
Name:phnCUniRule annotation
Ordered Locus Names:b4106, JW4067
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10713. phnC.

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000927061 – 262Phosphonates import ATP-binding protein PhnCAdd BLAST262

Proteomic databases

PaxDbiP16677.
PRIDEiP16677.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (PhnC), two transmembrane proteins (PhnE) and a solute-binding protein (PhnD).UniRule annotation

Protein-protein interaction databases

IntActiP16677. 1 interactor.
STRINGi511145.b4106.

Structurei

3D structure databases

ProteinModelPortaliP16677.
SMRiP16677.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 253ABC transporterUniRule annotationAdd BLAST249

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family. [View classification]UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5T. Bacteria.
COG3638. LUCA.
InParanoidiP16677.
KOiK02041.
OMAiGMAHFAH.
PhylomeDBiP16677.

Family and domain databases

CDDicd03256. ABC_PhnC_transporter. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR012693. ABC_transpr_PhnC.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02315. ABC_phnC. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51249. PHNC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTIIRVEKL AKTFNQHQAL HAVDLNIHHG EMVALLGPSG SGKSTLLRHL
60 70 80 90 100
SGLITGDKSV GSHIELLGRT VQREGRLARD IRKSRAHTGY IFQQFNLVNR
110 120 130 140 150
LSVLENVLIG ALGSTPFWRT CFSWFTGEQK QRALQALTRV GMVHFAHQRV
160 170 180 190 200
STLSGGQQQR VAIARALMQQ AKVILADEPI ASLDPESARI VMDTLRDINQ
210 220 230 240 250
NDGITVVVTL HQVDYALRYC ERIVALRQGH VFYDGSSQQF DNERFDHLYR
260
SINRVEENAK AA
Length:262
Mass (Da):29,431
Last modified:November 1, 1991 - v2
Checksum:i393EF8F30FD18D6C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti60V → A in strain: B. 1
Natural varianti87H → N in strain: B. 1
Natural varianti127G → R in strain: B. 1
Natural varianti255V → I in strain: B. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05260 Genomic DNA. Translation: AAA24339.1.
D90227 Genomic DNA. Translation: BAA14262.1.
U14003 Genomic DNA. Translation: AAA97005.1.
U00096 Genomic DNA. Translation: AAC77067.1.
AP009048 Genomic DNA. Translation: BAE78108.1.
PIRiA65220.
RefSeqiNP_418530.1. NC_000913.3.
WP_001193409.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77067; AAC77067; b4106.
BAE78108; BAE78108; BAE78108.
GeneIDi948623.
KEGGiecj:JW4067.
eco:b4106.
PATRICi32123771. VBIEscCol129921_4234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05260 Genomic DNA. Translation: AAA24339.1.
D90227 Genomic DNA. Translation: BAA14262.1.
U14003 Genomic DNA. Translation: AAA97005.1.
U00096 Genomic DNA. Translation: AAC77067.1.
AP009048 Genomic DNA. Translation: BAE78108.1.
PIRiA65220.
RefSeqiNP_418530.1. NC_000913.3.
WP_001193409.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP16677.
SMRiP16677.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP16677. 1 interactor.
STRINGi511145.b4106.

Protein family/group databases

TCDBi3.A.1.9.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP16677.
PRIDEiP16677.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77067; AAC77067; b4106.
BAE78108; BAE78108; BAE78108.
GeneIDi948623.
KEGGiecj:JW4067.
eco:b4106.
PATRICi32123771. VBIEscCol129921_4234.

Organism-specific databases

EchoBASEiEB0707.
EcoGeneiEG10713. phnC.

Phylogenomic databases

eggNOGiENOG4105D5T. Bacteria.
COG3638. LUCA.
InParanoidiP16677.
KOiK02041.
OMAiGMAHFAH.
PhylomeDBiP16677.

Enzyme and pathway databases

BioCyciEcoCyc:PHNC-MONOMER.
ECOL316407:JW4067-MONOMER.
MetaCyc:PHNC-MONOMER.

Miscellaneous databases

PROiP16677.

Family and domain databases

CDDicd03256. ABC_PhnC_transporter. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR012693. ABC_transpr_PhnC.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02315. ABC_phnC. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51249. PHNC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPHNC_ECOLI
AccessioniPrimary (citable) accession number: P16677
Secondary accession number(s): Q2M6J8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1991
Last modified: November 30, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Phosphonates utilization is cryptic in strain K12.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.