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P16671 (CD36_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 158. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Platelet glycoprotein 4
Alternative name(s):
Fatty acid translocase
Short name=FAT
Glycoprotein IIIb
Short name=GPIIIB
Leukocyte differentiation antigen CD36
PAS IV
PAS-4
Platelet collagen receptor
Platelet glycoprotein IV
Short name=GPIV
Thrombospondin receptor
CD_antigen=CD36
Gene names
Name:CD36
Synonyms:GP3B, GP4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. Ref.20 Ref.22

Subunit structure

Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity. Ref.12

Subcellular location

Membrane; Multi-pass membrane protein.

Post-translational modification

N-glycosylated and O-glycosylated with a ratio of 2:1. Ref.8

Polymorphism

Genetic variations in CD36 are involved in susceptibility to malaria and influence the severity and outcome of malaria infection [MIM:611162].

Involvement in disease

Platelet glycoprotein IV deficiency (PG4D) [MIM:608404]: A disorder characterized by macrothrombocytopenia without notable hemostatic problems and bleeding tendency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.17 Ref.21

Coronary heart disease 7 (CHDS7) [MIM:610938]: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.23

Sequence similarities

Belongs to the CD36 family.

Sequence caution

The sequence AAM14636.2 differs from that shown. Reason: Frameshift at position 53.

Ontologies

Keywords
   Biological processCell adhesion
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DiseaseDisease mutation
   DomainTransmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processMyD88-dependent toll-like receptor signaling pathway

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

Traceable author statement. Source: Reactome

antigen processing and presentation of peptide antigen via MHC class I

Traceable author statement. Source: Reactome

apoptotic cell clearance

Inferred from electronic annotation. Source: Ensembl

blood coagulation

Traceable author statement. Source: Reactome

cGMP-mediated signaling

Inferred from direct assay PubMed 17416590. Source: BHF-UCL

cell adhesion

Traceable author statement PubMed 2468670. Source: ProtInc

cell surface receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

cellular lipid metabolic process

Traceable author statement. Source: Reactome

cellular response to bacterial lipopeptide

Inferred from electronic annotation. Source: Ensembl

cellular response to hydroperoxide

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

cellular response to lipoteichoic acid

Inferred from electronic annotation. Source: Ensembl

cholesterol transport

Inferred from sequence or structural similarity PubMed 12376530. Source: BHF-UCL

defense response to Gram-positive bacterium

Inferred from electronic annotation. Source: Ensembl

innate immune response

Traceable author statement. Source: Reactome

lipid metabolic process

Non-traceable author statement Ref.5. Source: ProtInc

lipid storage

Inferred from mutant phenotype PubMed 10772654. Source: BHF-UCL

lipoprotein transport

Inferred from mutant phenotype PubMed 10772654. Source: BHF-UCL

long-chain fatty acid import

Inferred from direct assay PubMed 22022213. Source: UniProtKB

low-density lipoprotein particle clearance

Inferred from mutant phenotype PubMed 10772654. Source: BHF-UCL

low-density lipoprotein particle mediated signaling

Inferred from electronic annotation. Source: Ensembl

negative regulation of growth of symbiont in host

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription factor import into nucleus

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

nitric oxide mediated signal transduction

Inferred from direct assay PubMed 17416590. Source: BHF-UCL

phagocytosis, recognition

Inferred from electronic annotation. Source: Ensembl

plasma lipoprotein particle clearance

Inferred from sequence or structural similarity PubMed 12376530. Source: BHF-UCL

plasma membrane long-chain fatty acid transport

Inferred from direct assay PubMed 17416590. Source: BHF-UCL

platelet activation

Traceable author statement. Source: Reactome

platelet degranulation

Traceable author statement. Source: Reactome

positive regulation of I-kappaB kinase/NF-kappaB signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of MAPK cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of blood coagulation

Inferred from electronic annotation. Source: Ensembl

positive regulation of blood microparticle formation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell-matrix adhesion

Inferred from direct assay PubMed 17416590. Source: BHF-UCL

positive regulation of cholesterol storage

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-12 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-6 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of macrophage cytokine production

Inferred from electronic annotation. Source: Ensembl

positive regulation of macrophage derived foam cell differentiation

Inferred from mutant phenotype PubMed 10772654. Source: BHF-UCL

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of phagocytosis, engulfment

Inferred from electronic annotation. Source: Ensembl

positive regulation of reactive oxygen species metabolic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of tumor necrosis factor production

Inferred from electronic annotation. Source: Ensembl

receptor-mediated endocytosis

Inferred from mutant phenotype PubMed 10772654. Source: GOC

regulation of removal of superoxide radicals

Inferred from electronic annotation. Source: Ensembl

response to stilbenoid

Inferred from electronic annotation. Source: Ensembl

small molecule metabolic process

Traceable author statement. Source: Reactome

toll-like receptor 2 signaling pathway

Traceable author statement. Source: Reactome

toll-like receptor 4 signaling pathway

Traceable author statement. Source: Reactome

toll-like receptor TLR1:TLR2 signaling pathway

Traceable author statement. Source: Reactome

toll-like receptor TLR6:TLR2 signaling pathway

Traceable author statement. Source: Reactome

toll-like receptor signaling pathway

Traceable author statement. Source: Reactome

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

cell surface

Inferred from direct assay PubMed 10772654. Source: BHF-UCL

endocytic vesicle membrane

Traceable author statement. Source: Reactome

external side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Traceable author statement PubMed 9568716. Source: BHF-UCL

membrane

Traceable author statement Ref.8. Source: ProtInc

membrane raft

Inferred from electronic annotation. Source: Ensembl

phagocytic vesicle

Traceable author statement. Source: Reactome

plasma membrane

Inferred from direct assay PubMed 22022213. Source: UniProtKB

platelet alpha granule membrane

Traceable author statement. Source: Reactome

   Molecular_functionhigh-density lipoprotein particle binding

Inferred from electronic annotation. Source: Ensembl

lipid binding

Inferred from direct assay PubMed 10772654. Source: BHF-UCL

lipoprotein particle binding

Inferred from direct assay PubMed 9568716. Source: UniProtKB

lipoteichoic acid receptor activity

Inferred from electronic annotation. Source: Ensembl

low-density lipoprotein particle binding

Inferred from direct assay PubMed 10772654. Source: BHF-UCL

low-density lipoprotein receptor activity

Inferred from mutant phenotype PubMed 10772654. Source: BHF-UCL

thrombospondin receptor activity

Inferred from sequence or structural similarity. Source: BHF-UCL

transforming growth factor beta binding

Inferred from sequence or structural similarity. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.8
Chain2 – 472471Platelet glycoprotein 4
PRO_0000144151

Regions

Topological domain2 – 76Cytoplasmic Potential
Transmembrane8 – 2922Helical; Potential
Topological domain30 – 439410Extracellular Potential
Transmembrane440 – 46122Helical; Potential
Topological domain462 – 47211Cytoplasmic Potential
Region93 – 12028Required for interaction with thrombospondins, THBS1 and THBS2

Amino acid modifications

Lipidation31S-palmitoyl cysteine Ref.13
Lipidation71S-palmitoyl cysteine Ref.13
Lipidation4641S-palmitoyl cysteine Ref.13
Lipidation4661S-palmitoyl cysteine Ref.13
Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation1021N-linked (GlcNAc...) Potential
Glycosylation1341N-linked (GlcNAc...) Potential
Glycosylation1631N-linked (GlcNAc...) Potential
Glycosylation2051N-linked (GlcNAc...) Ref.16
Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation2351N-linked (GlcNAc...) Potential
Glycosylation2471N-linked (GlcNAc...) Potential
Glycosylation3211N-linked (GlcNAc...) Ref.15
Glycosylation4171N-linked (GlcNAc...) Ref.14 Ref.16
Disulfide bond243 ↔ 311 By similarity
Disulfide bond272 ↔ 333 By similarity
Disulfide bond313 ↔ 322 By similarity

Natural variations

Natural variant901P → S in PG4D; type I; degradation in the cytoplasm due to defects in maturation. Ref.17 Ref.21
Corresponds to variant rs3765187 [ dbSNP | Ensembl ].
VAR_017913
Natural variant1231E → K in individuals from a malaria endemic area in West Africa. Ref.9
Corresponds to variant rs183461468 [ dbSNP | Ensembl ].
VAR_017914
Natural variant1271S → L. Ref.22
Corresponds to variant rs201765331 [ dbSNP | Ensembl ].
VAR_019049
Natural variant1541V → F. Ref.18
Corresponds to variant rs5957 [ dbSNP | Ensembl ].
VAR_013918
Natural variant1741T → A in individuals from a malaria endemic area in West Africa. Ref.9
VAR_017915
Natural variant2321G → GN in individuals from a malaria endemic area in West Africa. Ref.9
VAR_017916
Natural variant2541F → L in PG4D; type I. Ref.21
Corresponds to variant rs142186404 [ dbSNP | Ensembl ].
VAR_017917
Natural variant2711I → T in individuals from a malaria endemic area in West Africa. Ref.9
VAR_017918
Natural variant4131I → L in PG4D; type I. Ref.21
VAR_017919

Experimental info

Sequence conflict441L → R in AAD13993. Ref.4
Sequence conflict2381Y → D in AAD13993. Ref.4
Sequence conflict3741E → Q in AAA16068. Ref.3
Sequence conflict3741E → Q AA sequence Ref.11

Sequences

Sequence LengthMass (Da)Tools
P16671 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 543E748259A094FA

FASTA47253,053
        10         20         30         40         50         60 
MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DLLIQKTIKK QVVLEEGTIA FKNWVKTGTE 

        70         80         90        100        110        120 
VYRQFWIFDV QNPQEVMMNS SNIQVKQRGP YTYRVRFLAK ENVTQDAEDN TVSFLQPNGA 

       130        140        150        160        170        180 
IFEPSLSVGT EADNFTVLNL AVAAASHIYQ NQFVQMILNS LINKSKSSMF QVRTLRELLW 

       190        200        210        220        230        240 
GYRDPFLSLV PYPVTTTVGL FYPYNNTADG VYKVFNGKDN ISKVAIIDTY KGKRNLSYWE 

       250        260        270        280        290        300 
SHCDMINGTD AASFPPFVEK SQVLQFFSSD ICRSIYAVFE SDVNLKGIPV YRFVLPSKAF 

       310        320        330        340        350        360 
ASPVENPDNY CFCTEKIISK NCTSYGVLDI SKCKEGRPVY ISLPHFLYAS PDVSEPIDGL 

       370        380        390        400        410        420 
NPNEEEHRTY LDIEPITGFT LQFAKRLQVN LLVKPSEKIQ VLKNLKRNYI VPILWLNETG 

       430        440        450        460        470 
TIGDEKANMF RSQVTGKINL LGLIEMILLS VGVVMFVAFM ISYCACRSKT IK 

« Hide

References

« Hide 'large scale' references
[1]"CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes."
Oquendo P., Hundt E., Lawler J., Seed B.
Cell 58:95-101(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]Sugimoto Y., Tsuruo T.
Submitted (AUG-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Characterization of two alternatively spliced 5'-untranslated exons of the human CD36 gene in different cell types."
Taylor K.T., Tang Y., Sobieski D.A., Lipsky R.H.
Gene 133:205-212(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Cloning of the cDNA encoding human platelet CD36: comparison to PCR amplified fragments of monocyte, endothelial and HEL cells."
Wyler B., Daviet L., Bortkiewicz H., Bordet J.C., McGregor J.L.
Thromb. Haemost. 70:500-505(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Platelet.
[5]"Structural organization of the gene for human CD36 glycoprotein."
Armesilla A.L., Vega M.A.
J. Biol. Chem. 269:18985-18991(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]SeattleSNPs variation discovery resource
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skeletal muscle.
[8]"Isolation and characterization of platelet glycoprotein IV (CD36)."
Tandon N.N., Lipsky R.H., Burgess W.H., Jamieson G.A.
J. Biol. Chem. 264:7570-7575(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-37, GLYCOSYLATION.
Tissue: Platelet.
[9]"Variability of the CD36 gene in West Africa."
Gelhaus A., Scheding A., Browne E., Burchard G.D., Horstmann R.D.
Hum. Mutat. 18:444-450(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-203; 274-375 AND 419-472, VARIANTS LYS-123; ALA-174; ASN-232 INS AND THR-271.
[10]"Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2."
Fernandez-Ruiz E., Armesilla A.L., Sanchez-Madrid F., Vega M.A.
Genomics 17:759-761(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 144-203.
[11]"Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
Aboulaich N., Vainonen J.P., Stralfors P., Vener A.V.
Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 261-273 AND 369-385.
Tissue: Adipocyte.
[12]"Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding."
Asch A.S., Silbiger S., Heimer E., Nachman R.L.
Biochem. Biophys. Res. Commun. 182:1208-1217(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH THBS1 AND THBS2.
[13]"CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails."
Tao N., Wagner S.J., Lublin D.M.
J. Biol. Chem. 271:22315-22320(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PALMITOYLATION AT CYS-3; CYS-7; CYS-464 AND CYS-466.
[14]"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Lewandrowski U., Moebius J., Walter U., Sickmann A.
Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-417.
Tissue: Platelet.
[15]"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.
Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-321.
Tissue: Milk.
[16]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-205 AND ASN-417.
Tissue: Liver.
[17]"Molecular basis of CD36 deficiency. Evidence that a 478C-->T substitution (proline90-->serine) in CD36 cDNA accounts for CD36 deficiency."
Kashiwagi H., Tomiyama Y., Honda S., Kosugi S., Shiraga M., Nagao N., Sekiguchi S., Kanayama Y., Kurata Y., Matsuzawa Y.
J. Clin. Invest. 95:1040-1046(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT PG4D SER-90.
[18]"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT PHE-154.
[19]Erratum
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.
Nat. Genet. 23:373-373(1999)
[20]"Malaria susceptibility and CD36 mutation."
Aitman T.J., Cooper L.D., Norsworthy P.J., Wahid F.N., Gray J.K., Curtis B.R., McKeigue P.M., Kwiatkowski D., Greenwood B.M., Snow R.W., Hill A.V., Scott J.
Nature 405:1015-1016(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: ROLE IN MALARIA INFECTION.
[21]"Identification of cryptic splice site, exon skipping, and novel point mutations in type I CD36 deficiency."
Hanawa H., Watanabe K., Nakamura T., Ogawa Y., Toba K., Fuse I., Kodama M., Kato K., Fuse K., Aizawa Y.
J. Med. Genet. 39:286-291(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS PG4D SER-90; LEU-254 AND LEU-413.
[22]"CD36 polymorphism is associated with protection from cerebral malaria."
Omi K., Ohashi J., Patarapotikul J., Hananantachai H., Naka I., Looareesuwan S., Tokunaga K.
Am. J. Hum. Genet. 72:364-374(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LEU-127, ROLE IN MALARIA INFECTION.
[23]"A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians."
Ma X., Bacci S., Mlynarski W., Gottardo L., Soccio T., Menzaghi C., Iori E., Lager R.A., Shroff A.R., Gervino E.V., Nesto R.W., Johnstone M.T., Abumrad N.A., Avogaro A., Trischitta V., Doria A.
Hum. Mol. Genet. 13:2197-2205(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN CHDS7.
[24]Erratum
Ma X., Bacci S., Mlynarski W., Gottardo L., Soccio T., Menzaghi C., Iori E., Lager R.A., Shroff A.R., Gervino E.V., Nesto R.W., Johnstone M.T., Abumrad N.A., Avogaro A., Trischitta V., Doria A.
Hum. Mol. Genet. 14:3973-3973(2005)
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M24795 mRNA. Translation: AAA35534.1.
M98398 mRNA. Translation: AAA58412.1.
M98399 mRNA. Translation: AAA58413.1.
L06850 mRNA. Translation: AAA16068.1.
S67532 mRNA. Translation: AAD13993.1.
Z32770 expand/collapse EMBL AC list , Z32754, Z32755, Z32756, Z32757, Z32758, Z32759, Z32760, Z32761, Z32762, Z32763, Z32764 Genomic DNA. Translation: CAA83662.1.
AY095373 Genomic DNA. Translation: AAM14636.2. Frameshift.
BC008406 mRNA. Translation: AAH08406.1.
AF300626 Genomic DNA. Translation: AAG60625.1.
AF300627 Genomic DNA. Translation: AAG60626.1.
AF300628 Genomic DNA. Translation: AAG60627.1.
AF300633 Genomic DNA. Translation: AAG60632.1.
AF300634 Genomic DNA. Translation: AAG60633.1.
AF300635 Genomic DNA. Translation: AAG60634.1.
AF300639 Genomic DNA. Translation: AAG60638.1.
AF300640 Genomic DNA. Translation: AAG60639.1.
S67044 mRNA. Translation: AAB28992.1.
Z22924 Genomic DNA. Translation: CAA80504.1.
PIRA54870.
RefSeqNP_000063.2. NM_000072.3.
NP_001001547.1. NM_001001547.2.
NP_001001548.1. NM_001001548.2.
NP_001120915.1. NM_001127443.1.
NP_001120916.1. NM_001127444.1.
XP_005250770.1. XM_005250713.1.
XP_005250771.1. XM_005250714.1.
XP_005250772.1. XM_005250715.2.
UniGeneHs.120949.

3D structure databases

ProteinModelPortalP16671.
SMRP16671. Positions 38-434.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107386. 15 interactions.
IntActP16671. 7 interactions.

Chemistry

ChEMBLCHEMBL1744526.

Protein family/group databases

TCDB9.B.39.1.4. the long chain fatty acid translocase (lcfat) family.

PTM databases

PhosphoSiteP16671.

Polymorphism databases

DMDM115982.

Proteomic databases

PaxDbP16671.
PRIDEP16671.

Protocols and materials databases

DNASU948.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309881; ENSP00000308165; ENSG00000135218.
ENST00000394788; ENSP00000378268; ENSG00000135218.
ENST00000432207; ENSP00000411411; ENSG00000135218.
ENST00000435819; ENSP00000399421; ENSG00000135218.
ENST00000447544; ENSP00000415743; ENSG00000135218.
GeneID948.
KEGGhsa:948.
UCSCuc003uhc.3. human.

Organism-specific databases

CTD948.
GeneCardsGC07P080069.
HGNCHGNC:1663. CD36.
HPACAB025866.
HPA002018.
MIM173510. gene.
248310. phenotype.
608404. phenotype.
610938. phenotype.
611162. phenotype.
neXtProtNX_P16671.
PharmGKBPA26212.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG257244.
HOVERGENHBG002754.
InParanoidP16671.
KOK06259.
OMAKRNYIVP.
OrthoDBEOG79SDWX.
PhylomeDBP16671.
TreeFamTF317925.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.
REACT_111217. Metabolism.
REACT_160300. Binding and Uptake of Ligands by Scavenger Receptors.
REACT_604. Hemostasis.
REACT_6900. Immune System.

Gene expression databases

ArrayExpressP16671.
BgeeP16671.
GenevestigatorP16671.

Family and domain databases

InterProIPR002159. CD36.
IPR005428. CD36_antigen.
[Graphical view]
PANTHERPTHR11923. PTHR11923. 1 hit.
PfamPF01130. CD36. 1 hit.
[Graphical view]
PRINTSPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.
ProtoNetSearch...

Other

GeneWikiCD36.
GenomeRNAi948.
NextBio3938.
PROP16671.
SOURCESearch...

Entry information

Entry nameCD36_HUMAN
AccessionPrimary (citable) accession number: P16671
Secondary accession number(s): Q13966 expand/collapse secondary AC list , Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 158 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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