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P16671

- CD36_HUMAN

UniProt

P16671 - CD36_HUMAN

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Protein

Platelet glycoprotein 4

Gene

CD36

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. As a coreceptor for TLR4-TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei463 – 4631Critical for TLR4-TLR6 dimerization and signaling1 Publication

GO - Molecular functioni

  1. high-density lipoprotein particle binding Source: Ensembl
  2. lipid binding Source: BHF-UCL
  3. lipoprotein particle binding Source: UniProtKB
  4. lipoteichoic acid receptor activity Source: Ensembl
  5. low-density lipoprotein particle binding Source: BHF-UCL
  6. low-density lipoprotein receptor activity Source: BHF-UCL
  7. thrombospondin receptor activity Source: BHF-UCL
  8. transforming growth factor beta binding Source: BHF-UCL

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  4. apoptotic cell clearance Source: Ensembl
  5. blood coagulation Source: Reactome
  6. cell adhesion Source: ProtInc
  7. cell surface receptor signaling pathway Source: Ensembl
  8. cellular lipid metabolic process Source: Reactome
  9. cellular response to bacterial lipopeptide Source: Ensembl
  10. cellular response to hydroperoxide Source: Ensembl
  11. cellular response to lipopolysaccharide Source: Ensembl
  12. cellular response to lipoteichoic acid Source: Ensembl
  13. cGMP-mediated signaling Source: BHF-UCL
  14. cholesterol transport Source: BHF-UCL
  15. defense response to Gram-positive bacterium Source: Ensembl
  16. innate immune response Source: Reactome
  17. lipid metabolic process Source: ProtInc
  18. lipid storage Source: BHF-UCL
  19. lipoprotein transport Source: BHF-UCL
  20. long-chain fatty acid import Source: UniProtKB
  21. low-density lipoprotein particle clearance Source: BHF-UCL
  22. low-density lipoprotein particle mediated signaling Source: Ensembl
  23. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
  24. negative regulation of growth of symbiont in host Source: Ensembl
  25. negative regulation of transcription factor import into nucleus Source: Ensembl
  26. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  27. nitric oxide mediated signal transduction Source: BHF-UCL
  28. phagocytosis, recognition Source: Ensembl
  29. plasma lipoprotein particle clearance Source: BHF-UCL
  30. plasma membrane long-chain fatty acid transport Source: BHF-UCL
  31. platelet activation Source: Reactome
  32. platelet degranulation Source: Reactome
  33. positive regulation of blood coagulation Source: Ensembl
  34. positive regulation of blood microparticle formation Source: Ensembl
  35. positive regulation of cell-matrix adhesion Source: BHF-UCL
  36. positive regulation of cholesterol storage Source: Ensembl
  37. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  38. positive regulation of interleukin-12 production Source: Ensembl
  39. positive regulation of interleukin-6 production Source: Ensembl
  40. positive regulation of macrophage cytokine production Source: Ensembl
  41. positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  42. positive regulation of MAPK cascade Source: Ensembl
  43. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  44. positive regulation of phagocytosis, engulfment Source: Ensembl
  45. positive regulation of reactive oxygen species metabolic process Source: Ensembl
  46. positive regulation of tumor necrosis factor production Source: Ensembl
  47. regulation of removal of superoxide radicals Source: Ensembl
  48. response to stilbenoid Source: Ensembl
  49. small molecule metabolic process Source: Reactome
  50. toll-like receptor 2 signaling pathway Source: Reactome
  51. toll-like receptor 4 signaling pathway Source: Reactome
  52. toll-like receptor signaling pathway Source: Reactome
  53. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
  54. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion, Transport

Enzyme and pathway databases

ReactomeiREACT_111174. Cross-presentation of particulate exogenous antigens (phagosomes).
REACT_116145. PPARA activates gene expression.
REACT_163679. Scavenging by Class B Receptors.
REACT_27161. Transcriptional regulation of white adipocyte differentiation.
REACT_6788. MyD88:Mal cascade initiated on plasma membrane.
REACT_8006. Toll Like Receptor TLR6:TLR2 Cascade.

Protein family/group databases

TCDBi9.B.39.1.4. the long chain fatty acid translocase (lcfat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein 4
Alternative name(s):
Fatty acid translocase
Short name:
FAT
Glycoprotein IIIb
Short name:
GPIIIB
Leukocyte differentiation antigen CD36
PAS IV
PAS-4
Platelet collagen receptor
Platelet glycoprotein IV
Short name:
GPIV
Thrombospondin receptor
CD_antigen: CD36
Gene namesi
Name:CD36
Synonyms:GP3B, GP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:1663. CD36.

Subcellular locationi

Cell membrane; Multi-pass membrane protein
Note: Upon ligand-binding, internalized through dynamin-dependent endocytosis.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 76CytoplasmicSequence Analysis
Transmembranei8 – 2922HelicalSequence AnalysisAdd
BLAST
Topological domaini30 – 439410ExtracellularSequence AnalysisAdd
BLAST
Transmembranei440 – 46122HelicalSequence AnalysisAdd
BLAST
Topological domaini462 – 47211CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: BHF-UCL
  2. endocytic vesicle membrane Source: Reactome
  3. external side of plasma membrane Source: Ensembl
  4. extracellular space Source: UniProt
  5. Golgi apparatus Source: Ensembl
  6. integral component of plasma membrane Source: BHF-UCL
  7. membrane Source: ProtInc
  8. membrane raft Source: Ensembl
  9. phagocytic vesicle Source: Reactome
  10. plasma membrane Source: UniProtKB
  11. platelet alpha granule membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Platelet glycoprotein IV deficiency (PG4D) [MIM:608404]: A disorder characterized by macrothrombocytopenia without notable hemostatic problems and bleeding tendency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti90 – 901P → S in PG4D; type I; degradation in the cytoplasm due to defects in maturation. 2 Publications
Corresponds to variant rs3765187 [ dbSNP | Ensembl ].
VAR_017913
Natural varianti254 – 2541F → L in PG4D; type I. 1 Publication
Corresponds to variant rs142186404 [ dbSNP | Ensembl ].
VAR_017917
Natural varianti413 – 4131I → L in PG4D; type I. 1 Publication
VAR_017919
Coronary heart disease 7 (CHDS7) [MIM:610938]: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries.1 Publication
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi462 – 47211SYCACRSKTIK → AAAAAAAAAAA: No effect on cell surface location. Loss of oxLDL-induced NF-kappa-B activation. 1 PublicationAdd
BLAST
Mutagenesisi463 – 4631Y → A: No effect on cell surface location. Loss of oxLDL-induced NF-kappa-B activation. Loss of complex formation with TLR4 and TLR6. 1 Publication
Mutagenesisi464 – 4641C → S: No effect on cell surface location, nor on oxLDL-induced NF-kappa-B activation. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi248310. phenotype.
608404. phenotype.
610938. phenotype.
611162. phenotype.
PharmGKBiPA26212.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 472471Platelet glycoprotein 4PRO_0000144151Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi3 – 31S-palmitoyl cysteine1 Publication
Lipidationi7 – 71S-palmitoyl cysteine1 Publication
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi205 – 2051N-linked (GlcNAc...)1 Publication
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi235 – 2351N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi243 ↔ 311By similarity
Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi272 ↔ 333By similarity
Disulfide bondi313 ↔ 322By similarity
Glycosylationi321 – 3211N-linked (GlcNAc...)1 Publication
Glycosylationi417 – 4171N-linked (GlcNAc...)2 Publications
Lipidationi464 – 4641S-palmitoyl cysteine1 Publication
Lipidationi466 – 4661S-palmitoyl cysteine1 Publication

Post-translational modificationi

N-glycosylated and O-glycosylated with a ratio of 2:1.4 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP16671.
PaxDbiP16671.
PRIDEiP16671.

PTM databases

PhosphoSiteiP16671.

Expressioni

Gene expression databases

BgeeiP16671.
ExpressionAtlasiP16671. baseline and differential.
GenevestigatoriP16671.

Organism-specific databases

HPAiCAB025866.
HPA002018.

Interactioni

Subunit structurei

Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity. Upon interaction with a ligand, such as oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, rapidly forms a complex with TLR4 and TLR6; the complex is internalized and triggers an inflammatory signal. Through its C-terminus, interacts with PTK2, PXN and LYN, but not with SRC. LYN kinase activity is required for facilitating TLR4-TLR6 heterodimerization and signal initiation.2 Publications

Protein-protein interaction databases

BioGridi107386. 15 interactions.
IntActiP16671. 7 interactions.

Structurei

3D structure databases

ProteinModelPortaliP16671.
SMRiP16671. Positions 39-432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 12028Required for interaction with thrombospondins, THBS1 and THBS2Add
BLAST
Regioni460 – 47213Interaction with PTK2, PXN and LYN1 PublicationAdd
BLAST

Sequence similaritiesi

Belongs to the CD36 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257244.
GeneTreeiENSGT00530000062927.
HOVERGENiHBG002754.
InParanoidiP16671.
KOiK06259.
OMAiKRNYIVP.
OrthoDBiEOG79SDWX.
PhylomeDBiP16671.
TreeFamiTF317925.

Family and domain databases

InterProiIPR002159. CD36.
IPR005428. CD36_antigen.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P16671-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DLLIQKTIKK QVVLEEGTIA
60 70 80 90 100
FKNWVKTGTE VYRQFWIFDV QNPQEVMMNS SNIQVKQRGP YTYRVRFLAK
110 120 130 140 150
ENVTQDAEDN TVSFLQPNGA IFEPSLSVGT EADNFTVLNL AVAAASHIYQ
160 170 180 190 200
NQFVQMILNS LINKSKSSMF QVRTLRELLW GYRDPFLSLV PYPVTTTVGL
210 220 230 240 250
FYPYNNTADG VYKVFNGKDN ISKVAIIDTY KGKRNLSYWE SHCDMINGTD
260 270 280 290 300
AASFPPFVEK SQVLQFFSSD ICRSIYAVFE SDVNLKGIPV YRFVLPSKAF
310 320 330 340 350
ASPVENPDNY CFCTEKIISK NCTSYGVLDI SKCKEGRPVY ISLPHFLYAS
360 370 380 390 400
PDVSEPIDGL NPNEEEHRTY LDIEPITGFT LQFAKRLQVN LLVKPSEKIQ
410 420 430 440 450
VLKNLKRNYI VPILWLNETG TIGDEKANMF RSQVTGKINL LGLIEMILLS
460 470
VGVVMFVAFM ISYCACRSKT IK
Length:472
Mass (Da):53,053
Last modified:January 23, 2007 - v2
Checksum:i543E748259A094FA
GO
Isoform 2 (identifier: P16671-2) [UniParc]FASTAAdd to Basket

Also known as: ex8-del

The sequence of this isoform differs from the canonical sequence as follows:
     274-288: SIYAVFESDVNLKGI → ETCVHFTSSFSVCKS
     289-472: Missing.

Show »
Length:288
Mass (Da):32,265
Checksum:iC82FFEF32AF7A690
GO
Isoform 3 (identifier: P16671-3) [UniParc]FASTAAdd to Basket

Also known as: ex6-7-del

The sequence of this isoform differs from the canonical sequence as follows:
     234-272: Missing.

Show »
Length:433
Mass (Da):48,600
Checksum:i9D4A561C95F1ED4D
GO
Isoform 4 (identifier: P16671-4) [UniParc]FASTAAdd to Basket

Also known as: ex4-del

The sequence of this isoform differs from the canonical sequence as follows:
     144-203: Missing.

Show »
Length:412
Mass (Da):46,090
Checksum:i33D8CA7991537066
GO

Sequence cautioni

The sequence AAM14636.2 differs from that shown. Reason: Frameshift at position 53. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441L → R in AAD13993. (PubMed:7505064)Curated
Sequence conflicti238 – 2381Y → D in AAD13993. (PubMed:7505064)Curated
Sequence conflicti374 – 3741E → Q in AAA16068. (PubMed:7693552)Curated
Sequence conflicti374 – 3741E → Q AA sequence (PubMed:15242332)Curated

Polymorphismi

Genetic variations in CD36 are involved in susceptibility to malaria and influence the severity and outcome of malaria infection [MIMi:611162].

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti90 – 901P → S in PG4D; type I; degradation in the cytoplasm due to defects in maturation. 2 Publications
Corresponds to variant rs3765187 [ dbSNP | Ensembl ].
VAR_017913
Natural varianti123 – 1231E → K in individuals from a malaria endemic area in West Africa. 1 Publication
Corresponds to variant rs183461468 [ dbSNP | Ensembl ].
VAR_017914
Natural varianti127 – 1271S → L.1 Publication
Corresponds to variant rs201765331 [ dbSNP | Ensembl ].
VAR_019049
Natural varianti154 – 1541V → F.1 Publication
Corresponds to variant rs5957 [ dbSNP | Ensembl ].
VAR_013918
Natural varianti174 – 1741T → A in individuals from a malaria endemic area in West Africa. 1 Publication
VAR_017915
Natural varianti232 – 2321G → GN in individuals from a malaria endemic area in West Africa. 1 Publication
VAR_017916
Natural varianti254 – 2541F → L in PG4D; type I. 1 Publication
Corresponds to variant rs142186404 [ dbSNP | Ensembl ].
VAR_017917
Natural varianti271 – 2711I → T in individuals from a malaria endemic area in West Africa. 1 Publication
VAR_017918
Natural varianti386 – 3861R → W.1 Publication
Corresponds to variant rs148910227 [ dbSNP | Ensembl ].
VAR_071161
Natural varianti413 – 4131I → L in PG4D; type I. 1 Publication
VAR_017919
Natural varianti470 – 4701T → I.1 Publication
Corresponds to variant rs200771788 [ dbSNP | Ensembl ].
VAR_071162

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei144 – 20360Missing in isoform 4. 1 PublicationVSP_055976Add
BLAST
Alternative sequencei234 – 27239Missing in isoform 3. 1 PublicationVSP_055977Add
BLAST
Alternative sequencei274 – 28815SIYAV…NLKGI → ETCVHFTSSFSVCKS in isoform 2. 1 PublicationVSP_055978Add
BLAST
Alternative sequencei289 – 472184Missing in isoform 2. 1 PublicationVSP_055979Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24795 mRNA. Translation: AAA35534.1.
M98398 mRNA. Translation: AAA58412.1.
M98399 mRNA. Translation: AAA58413.1.
L06850 mRNA. Translation: AAA16068.1.
S67532 mRNA. Translation: AAD13993.1.
Z32770
, Z32754, Z32755, Z32756, Z32757, Z32758, Z32759, Z32760, Z32761, Z32762, Z32763, Z32764 Genomic DNA. Translation: CAA83662.1.
AY095373 Genomic DNA. Translation: AAM14636.2. Frameshift.
HM217023 mRNA. Translation: ADI80543.1.
HM217024 mRNA. Translation: ADI80544.1.
HM217025 mRNA. Translation: ADI80545.1.
HM217026 mRNA. Translation: ADI80546.1.
AC004862 Genomic DNA. No translation available.
AC073182 Genomic DNA. No translation available.
AC073850 Genomic DNA. No translation available.
AC092108 Genomic DNA. No translation available.
AC124834 Genomic DNA. No translation available.
BC008406 mRNA. Translation: AAH08406.1.
AF300626 Genomic DNA. Translation: AAG60625.1.
AF300627 Genomic DNA. Translation: AAG60626.1.
AF300628 Genomic DNA. Translation: AAG60627.1.
AF300633 Genomic DNA. Translation: AAG60632.1.
AF300634 Genomic DNA. Translation: AAG60633.1.
AF300635 Genomic DNA. Translation: AAG60634.1.
AF300639 Genomic DNA. Translation: AAG60638.1.
AF300640 Genomic DNA. Translation: AAG60639.1.
S67044 mRNA. Translation: AAB28992.1.
Z22924 Genomic DNA. Translation: CAA80504.1.
CCDSiCCDS34673.1. [P16671-1]
PIRiA54870.
RefSeqiNP_000063.2. NM_000072.3. [P16671-1]
NP_001001547.1. NM_001001547.2. [P16671-1]
NP_001001548.1. NM_001001548.2. [P16671-1]
NP_001120915.1. NM_001127443.1. [P16671-1]
NP_001120916.1. NM_001127444.1. [P16671-1]
NP_001276837.1. NM_001289908.1. [P16671-3]
NP_001276838.1. NM_001289909.1. [P16671-4]
NP_001276840.1. NM_001289911.1.
XP_005250770.1. XM_005250713.1. [P16671-1]
XP_005250771.1. XM_005250714.1. [P16671-1]
XP_005250772.1. XM_005250715.2. [P16671-1]
UniGeneiHs.120949.

Genome annotation databases

EnsembliENST00000309881; ENSP00000308165; ENSG00000135218. [P16671-1]
ENST00000394788; ENSP00000378268; ENSG00000135218. [P16671-1]
ENST00000432207; ENSP00000411411; ENSG00000135218. [P16671-1]
ENST00000433696; ENSP00000401863; ENSG00000135218. [P16671-3]
ENST00000435819; ENSP00000399421; ENSG00000135218. [P16671-1]
ENST00000447544; ENSP00000415743; ENSG00000135218. [P16671-1]
ENST00000538969; ENSP00000439543; ENSG00000135218. [P16671-4]
ENST00000544133; ENSP00000441956; ENSG00000135218. [P16671-2]
GeneIDi948.
KEGGihsa:948.
UCSCiuc003uhc.3. human. [P16671-1]

Polymorphism databases

DMDMi115982.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CD36 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24795 mRNA. Translation: AAA35534.1 .
M98398 mRNA. Translation: AAA58412.1 .
M98399 mRNA. Translation: AAA58413.1 .
L06850 mRNA. Translation: AAA16068.1 .
S67532 mRNA. Translation: AAD13993.1 .
Z32770
, Z32754 , Z32755 , Z32756 , Z32757 , Z32758 , Z32759 , Z32760 , Z32761 , Z32762 , Z32763 , Z32764 Genomic DNA. Translation: CAA83662.1 .
AY095373 Genomic DNA. Translation: AAM14636.2 . Frameshift.
HM217023 mRNA. Translation: ADI80543.1 .
HM217024 mRNA. Translation: ADI80544.1 .
HM217025 mRNA. Translation: ADI80545.1 .
HM217026 mRNA. Translation: ADI80546.1 .
AC004862 Genomic DNA. No translation available.
AC073182 Genomic DNA. No translation available.
AC073850 Genomic DNA. No translation available.
AC092108 Genomic DNA. No translation available.
AC124834 Genomic DNA. No translation available.
BC008406 mRNA. Translation: AAH08406.1 .
AF300626 Genomic DNA. Translation: AAG60625.1 .
AF300627 Genomic DNA. Translation: AAG60626.1 .
AF300628 Genomic DNA. Translation: AAG60627.1 .
AF300633 Genomic DNA. Translation: AAG60632.1 .
AF300634 Genomic DNA. Translation: AAG60633.1 .
AF300635 Genomic DNA. Translation: AAG60634.1 .
AF300639 Genomic DNA. Translation: AAG60638.1 .
AF300640 Genomic DNA. Translation: AAG60639.1 .
S67044 mRNA. Translation: AAB28992.1 .
Z22924 Genomic DNA. Translation: CAA80504.1 .
CCDSi CCDS34673.1. [P16671-1 ]
PIRi A54870.
RefSeqi NP_000063.2. NM_000072.3. [P16671-1 ]
NP_001001547.1. NM_001001547.2. [P16671-1 ]
NP_001001548.1. NM_001001548.2. [P16671-1 ]
NP_001120915.1. NM_001127443.1. [P16671-1 ]
NP_001120916.1. NM_001127444.1. [P16671-1 ]
NP_001276837.1. NM_001289908.1. [P16671-3 ]
NP_001276838.1. NM_001289909.1. [P16671-4 ]
NP_001276840.1. NM_001289911.1.
XP_005250770.1. XM_005250713.1. [P16671-1 ]
XP_005250771.1. XM_005250714.1. [P16671-1 ]
XP_005250772.1. XM_005250715.2. [P16671-1 ]
UniGenei Hs.120949.

3D structure databases

ProteinModelPortali P16671.
SMRi P16671. Positions 39-432.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107386. 15 interactions.
IntActi P16671. 7 interactions.

Chemistry

ChEMBLi CHEMBL1744526.

Protein family/group databases

TCDBi 9.B.39.1.4. the long chain fatty acid translocase (lcfat) family.

PTM databases

PhosphoSitei P16671.

Polymorphism databases

DMDMi 115982.

Proteomic databases

MaxQBi P16671.
PaxDbi P16671.
PRIDEi P16671.

Protocols and materials databases

DNASUi 948.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309881 ; ENSP00000308165 ; ENSG00000135218 . [P16671-1 ]
ENST00000394788 ; ENSP00000378268 ; ENSG00000135218 . [P16671-1 ]
ENST00000432207 ; ENSP00000411411 ; ENSG00000135218 . [P16671-1 ]
ENST00000433696 ; ENSP00000401863 ; ENSG00000135218 . [P16671-3 ]
ENST00000435819 ; ENSP00000399421 ; ENSG00000135218 . [P16671-1 ]
ENST00000447544 ; ENSP00000415743 ; ENSG00000135218 . [P16671-1 ]
ENST00000538969 ; ENSP00000439543 ; ENSG00000135218 . [P16671-4 ]
ENST00000544133 ; ENSP00000441956 ; ENSG00000135218 . [P16671-2 ]
GeneIDi 948.
KEGGi hsa:948.
UCSCi uc003uhc.3. human. [P16671-1 ]

Organism-specific databases

CTDi 948.
GeneCardsi GC07P080069.
HGNCi HGNC:1663. CD36.
HPAi CAB025866.
HPA002018.
MIMi 173510. gene.
248310. phenotype.
608404. phenotype.
610938. phenotype.
611162. phenotype.
neXtProti NX_P16671.
PharmGKBi PA26212.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG257244.
GeneTreei ENSGT00530000062927.
HOVERGENi HBG002754.
InParanoidi P16671.
KOi K06259.
OMAi KRNYIVP.
OrthoDBi EOG79SDWX.
PhylomeDBi P16671.
TreeFami TF317925.

Enzyme and pathway databases

Reactomei REACT_111174. Cross-presentation of particulate exogenous antigens (phagosomes).
REACT_116145. PPARA activates gene expression.
REACT_163679. Scavenging by Class B Receptors.
REACT_27161. Transcriptional regulation of white adipocyte differentiation.
REACT_6788. MyD88:Mal cascade initiated on plasma membrane.
REACT_8006. Toll Like Receptor TLR6:TLR2 Cascade.

Miscellaneous databases

ChiTaRSi CD36. human.
GeneWikii CD36.
GenomeRNAii 948.
NextBioi 35495887.
PROi P16671.
SOURCEi Search...

Gene expression databases

Bgeei P16671.
ExpressionAtlasi P16671. baseline and differential.
Genevestigatori P16671.

Family and domain databases

InterProi IPR002159. CD36.
IPR005428. CD36_antigen.
[Graphical view ]
PANTHERi PTHR11923. PTHR11923. 1 hit.
Pfami PF01130. CD36. 1 hit.
[Graphical view ]
PRINTSi PR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes."
    Oquendo P., Hundt E., Lawler J., Seed B.
    Cell 58:95-101(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. Sugimoto Y., Tsuruo T.
    Submitted (AUG-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Characterization of two alternatively spliced 5'-untranslated exons of the human CD36 gene in different cell types."
    Taylor K.T., Tang Y., Sobieski D.A., Lipsky R.H.
    Gene 133:205-212(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Cloning of the cDNA encoding human platelet CD36: comparison to PCR amplified fragments of monocyte, endothelial and HEL cells."
    Wyler B., Daviet L., Bortkiewicz H., Bordet J.C., McGregor J.L.
    Thromb. Haemost. 70:500-505(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Platelet.
  5. "Structural organization of the gene for human CD36 glycoprotein."
    Armesilla A.L., Vega M.A.
    J. Biol. Chem. 269:18985-18991(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. SeattleSNPs variation discovery resource
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "Frequency of CD36 deficiency and identification of novel CD36 gene mutations in the Chinese population."
    Wu G.-G., Curtis B.R., He B.-R., Zhou Z.-L., Zhou Y., Yang Y.-L., Li H.-Y., Shen W.-D., Liu J.-L., Zhao T.-M.
    Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANTS TRP-386 AND ILE-470.
  8. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skeletal muscle.
  10. "Isolation and characterization of platelet glycoprotein IV (CD36)."
    Tandon N.N., Lipsky R.H., Burgess W.H., Jamieson G.A.
    J. Biol. Chem. 264:7570-7575(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-37, GLYCOSYLATION.
    Tissue: Platelet.
  11. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-203; 274-375 AND 419-472, VARIANTS LYS-123; ALA-174; ASN-232 INS AND THR-271.
  12. "Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2."
    Fernandez-Ruiz E., Armesilla A.L., Sanchez-Madrid F., Vega M.A.
    Genomics 17:759-761(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 144-203 (ISOFORM 1/2).
  13. "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
    Aboulaich N., Vainonen J.P., Stralfors P., Vener A.V.
    Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 261-273 AND 369-385.
    Tissue: Adipocyte.
  14. "Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding."
    Asch A.S., Silbiger S., Heimer E., Nachman R.L.
    Biochem. Biophys. Res. Commun. 182:1208-1217(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH THBS1 AND THBS2.
  15. "CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails."
    Tao N., Wagner S.J., Lublin D.M.
    J. Biol. Chem. 271:22315-22320(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-3; CYS-7; CYS-464 AND CYS-466.
  16. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
    Lewandrowski U., Moebius J., Walter U., Sickmann A.
    Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-417.
    Tissue: Platelet.
  17. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
    Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.
    Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-321.
    Tissue: Milk.
  18. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-205 AND ASN-417.
    Tissue: Liver.
  19. "CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer."
    Stewart C.R., Stuart L.M., Wilkinson K., van Gils J.M., Deng J., Halle A., Rayner K.J., Boyer L., Zhong R., Frazier W.A., Lacy-Hulbert A., El Khoury J., Golenbock D.T., Moore K.J.
    Nat. Immunol. 11:155-161(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH LYN; PTK2; PXN; TLR4 AND TLR6, SUBCELLULAR LOCATION, MUTAGENESIS OF 462-SER--LYS-473; TYR-463 AND CYS-464.
  20. "Molecular basis of CD36 deficiency. Evidence that a 478C-->T substitution (proline90-->serine) in CD36 cDNA accounts for CD36 deficiency."
    Kashiwagi H., Tomiyama Y., Honda S., Kosugi S., Shiraga M., Nagao N., Sekiguchi S., Kanayama Y., Kurata Y., Matsuzawa Y.
    J. Clin. Invest. 95:1040-1046(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT PG4D SER-90.
  21. Cited for: VARIANT PHE-154.
  22. Cited for: ROLE IN MALARIA INFECTION.
  23. "Identification of cryptic splice site, exon skipping, and novel point mutations in type I CD36 deficiency."
    Hanawa H., Watanabe K., Nakamura T., Ogawa Y., Toba K., Fuse I., Kodama M., Kato K., Fuse K., Aizawa Y.
    J. Med. Genet. 39:286-291(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS PG4D SER-90; LEU-254 AND LEU-413.
  24. "CD36 polymorphism is associated with protection from cerebral malaria."
    Omi K., Ohashi J., Patarapotikul J., Hananantachai H., Naka I., Looareesuwan S., Tokunaga K.
    Am. J. Hum. Genet. 72:364-374(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LEU-127, ROLE IN MALARIA INFECTION.
  25. "A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians."
    Ma X., Bacci S., Mlynarski W., Gottardo L., Soccio T., Menzaghi C., Iori E., Lager R.A., Shroff A.R., Gervino E.V., Nesto R.W., Johnstone M.T., Abumrad N.A., Avogaro A., Trischitta V., Doria A.
    Hum. Mol. Genet. 13:2197-2205(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN CHDS7.

Entry informationi

Entry nameiCD36_HUMAN
AccessioniPrimary (citable) accession number: P16671
Secondary accession number(s): D9IX66
, D9IX67, D9IX68, D9IX69, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 164 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3