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Reviewed, UniProtKB/Swiss-Prot P16671 (CD36_HUMAN)

Last modified November 24, 2009. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Platelet glycoprotein 4
Alternative name(s):
    Platelet glycoprotein IV
      Short name=GPIV
    Glycoprotein IIIb
      Short name=GPIIIB
    Leukocyte differentiation antigen CD36
    PAS IV
    PAS-4
    Platelet collagen receptor
    Fatty acid translocase
      Short name=FAT
    Thrombospondin receptor
    CD_antigen=CD36
Gene names
Name: CD36
Synonyms: GP3B, GP4
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Ref.19 Ref.21

Subcellular location

Membrane; Multi-pass membrane protein.

Post-translational modification

N-glycosylated and O-glycosylated with a ratio of 2:1. Ref.8 Ref.13 Ref.14 Ref.15

Polymorphism

Genetic variation in CD36 influences the severity and outcome of malaria infection.

Involvement in disease

Defects in CD36 are the cause of platelet glycoprotein IV deficiency [MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Ref.16 Ref.20

Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [MIM:610938]. Ref.22

Sequence similarities

Belongs to the CD36 family.

Sequence caution

The sequence AAM14636.2 differs from that shown. Reason: Frameshift at position 53.

Ontologies

Keywords
   Biological processCell adhesion
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DiseaseDisease mutation
   DomainTransmembrane
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological processblood coagulation

Traceable author statement. Source: ProtInc

cGMP-mediated signaling

Inferred from direct assay. Source: UniProtKB

cell adhesion

Traceable author statement. Source: ProtInc

cholesterol transport

Inferred from sequence or structural similarity. Source: UniProtKB

lipid metabolic process Ref.5

Non-traceable author statement. Source: ProtInc

lipid storage

Inferred from mutant phenotype. Source: UniProtKB

lipoprotein catabolic process

Inferred from mutant phenotype. Source: UniProtKB

lipoprotein particle clearance

Inferred from sequence or structural similarity. Source: UniProtKB

lipoprotein transport

Inferred from mutant phenotype. Source: UniProtKB

nitric oxide mediated signal transduction

Inferred from direct assay. Source: UniProtKB

plasma membrane long-chain fatty acid transport

Inferred from direct assay. Source: UniProtKB

positive regulation of cell-matrix adhesion

Inferred from direct assay. Source: UniProtKB

positive regulation of macrophage derived foam cell differentiation

Inferred from mutant phenotype. Source: UniProtKB

   Cellular componentGolgi apparatus

Inferred from direct assay. Source: HPA

cell surface

Inferred from direct assay. Source: UniProtKB

integral to plasma membrane Ref.8

Traceable author statement. Source: UniProtKB

membrane fraction Ref.8

Traceable author statement. Source: ProtInc

platelet alpha granule membrane

Inferred from Experiment. Source: Reactome

   Molecular functionlipid binding

Inferred from direct assay. Source: UniProtKB

low-density lipoprotein receptor activity

Inferred from mutant phenotype. Source: UniProtKB

thrombospondin receptor activity

Inferred from sequence or structural similarity. Source: UniProtKB

transforming growth factor beta binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.8
Chain2 – 472471Platelet glycoprotein 4
PRO_0000144151

Regions

Topological domain2 – 76Cytoplasmic Potential
Transmembrane8 – 2922 Potential
Topological domain30 – 439410Extracellular Potential
Transmembrane440 – 46122 Potential
Topological domain462 – 47211Cytoplasmic Potential

Amino acid modifications

Lipidation31S-palmitoyl cysteine Ref.12
Lipidation71S-palmitoyl cysteine Ref.12
Lipidation4641S-palmitoyl cysteine Ref.12
Lipidation4661S-palmitoyl cysteine Ref.12
Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation1021N-linked (GlcNAc...) Potential
Glycosylation1341N-linked (GlcNAc...) Potential
Glycosylation1631N-linked (GlcNAc...) Potential
Glycosylation2051N-linked (GlcNAc...) Ref.15
Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation2351N-linked (GlcNAc...) Potential
Glycosylation2471N-linked (GlcNAc...) Potential
Glycosylation3211N-linked (GlcNAc...) Ref.14
Glycosylation4171N-linked (GlcNAc...) Ref.13 Ref.15
Disulfide bond243 ↔ 311 By similarity
Disulfide bond272 ↔ 333 By similarity
Disulfide bond313 ↔ 322 By similarity

Natural variations

Natural variant901P → S in platelet glycoprotein IV deficiency; type I; degradation in the cytoplasm due to defects in maturation. dbSNP rs3765187. Ref.16 Ref.20
VAR_017913
Natural variant1231E → K in individuals from a malaria endemic area in West Africa. Ref.9
VAR_017914
Natural variant1271S → L
VAR_019049
Natural variant1541V → F: dbSNP rs5957. Ref.17
VAR_013918
Natural variant1741T → A in individuals from a malaria endemic area in West Africa. Ref.9
VAR_017915
Natural variant2321G → GN in individuals from a malaria endemic area in West Africa. Ref.9
VAR_017916
Natural variant2541F → L in platelet glycoprotein IV deficiency; type I. Ref.20
VAR_017917
Natural variant2711I → T in individuals from a malaria endemic area in West Africa. Ref.9
VAR_017918
Natural variant4131I → L in platelet glycoprotein IV deficiency; type I. Ref.20
VAR_017919

Experimental info

Sequence conflict441L → R in AAD13993. Ref.4
Sequence conflict2381Y → D in AAD13993. Ref.4
Sequence conflict3741E → Q Ref.3
Sequence conflict3741E → Q Ref.11

Sequences

Sequence LengthMass (Da)Tools
P16671-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 543E748259A094FA

FASTA47253,053
        10         20         30         40         50         60 
MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DLLIQKTIKK QVVLEEGTIA FKNWVKTGTE 

        70         80         90        100        110        120 
VYRQFWIFDV QNPQEVMMNS SNIQVKQRGP YTYRVRFLAK ENVTQDAEDN TVSFLQPNGA 

       130        140        150        160        170        180 
IFEPSLSVGT EADNFTVLNL AVAAASHIYQ NQFVQMILNS LINKSKSSMF QVRTLRELLW 

       190        200        210        220        230        240 
GYRDPFLSLV PYPVTTTVGL FYPYNNTADG VYKVFNGKDN ISKVAIIDTY KGKRNLSYWE 

       250        260        270        280        290        300 
SHCDMINGTD AASFPPFVEK SQVLQFFSSD ICRSIYAVFE SDVNLKGIPV YRFVLPSKAF 

       310        320        330        340        350        360 
ASPVENPDNY CFCTEKIISK NCTSYGVLDI SKCKEGRPVY ISLPHFLYAS PDVSEPIDGL 

       370        380        390        400        410        420 
NPNEEEHRTY LDIEPITGFT LQFAKRLQVN LLVKPSEKIQ VLKNLKRNYI VPILWLNETG 

       430        440        450        460        470 
TIGDEKANMF RSQVTGKINL LGLIEMILLS VGVVMFVAFM ISYCACRSKT IK 

« Hide

References

« Hide 'large scale' references
[1]"CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes."
Oquendo P., Hundt E., Lawler J., Seed B.
Cell 58:95-101(1989) [PubMed: 2473841] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]Sugimoto Y., Tsuruo T.
Submitted (AUG-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Characterization of two alternatively spliced 5'-untranslated exons of the human CD36 gene in different cell types."
Taylor K.T., Tang Y., Sobieski D.A., Lipsky R.H.
Gene 133:205-212(1993) [PubMed: 7693552] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Cloning of the cDNA encoding human platelet CD36: comparison to PCR amplified fragments of monocyte, endothelial and HEL cells."
Wyler B., Daviet L., Bortkiewicz H., Bordet J.C., McGregor J.L.
Thromb. Haemost. 70:500-505(1993) [PubMed: 7505064] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Platelet.
[5]"Structural organization of the gene for human CD36 glycoprotein."
Armesilla A.L., Vega M.A.
J. Biol. Chem. 269:18985-18991(1994) [PubMed: 7518447] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]SeattleSNPs variation discovery resource
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skeletal muscle.
[8]"Isolation and characterization of platelet glycoprotein IV (CD36)."
Tandon N.N., Lipsky R.H., Burgess W.H., Jamieson G.A.
J. Biol. Chem. 264:7570-7575(1989) [PubMed: 2468669] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-37, GLYCOSYLATION.
Tissue: Platelet.
[9]"Variability of the CD36 gene in West Africa."
Gelhaus A., Scheding A., Browne E., Burchard G.D., Horstmann R.D.
Hum. Mutat. 18:444-450(2001) [PubMed: 11668637] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-203; 274-375 AND 419-472, VARIANTS LYS-123; ALA-174; ASN-232 INS AND THR-271.
[10]"Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2."
Fernandez-Ruiz E., Armesilla A.L., Sanchez-Madrid F., Vega M.A.
Genomics 17:759-761(1993) [PubMed: 7503937] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 144-203.
[11]"Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
Aboulaich N., Vainonen J.P., Stralfors P., Vener A.V.
Biochem. J. 383:237-248(2004) [PubMed: 15242332] [Abstract]
Cited for: PROTEIN SEQUENCE OF 261-273 AND 369-385.
Tissue: Adipocyte.
[12]"CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails."
Tao N., Wagner S.J., Lublin D.M.
J. Biol. Chem. 271:22315-22320(1996) [PubMed: 8798390] [Abstract]
Cited for: PALMITOYLATION AT CYS-3; CYS-7; CYS-464 AND CYS-466.
[13]"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Lewandrowski U., Moebius J., Walter U., Sickmann A.
Mol. Cell. Proteomics 5:226-233(2006) [PubMed: 16263699] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-417, MASS SPECTROMETRY.
Tissue: Platelet.
[14]"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.
Proteomics 8:3833-3847(2008) [PubMed: 18780401] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-321, MASS SPECTROMETRY.
Tissue: Milk.
[15]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-205 AND ASN-417, MASS SPECTROMETRY.
Tissue: Liver.
[16]"Molecular basis of CD36 deficiency. Evidence that a 478C-->T substitution (proline90-->serine) in CD36 cDNA accounts for CD36 deficiency."
Kashiwagi H., Tomiyama Y., Honda S., Kosugi S., Shiraga M., Nagao N., Sekiguchi S., Kanayama Y., Kurata Y., Matsuzawa Y.
J. Clin. Invest. 95:1040-1046(1995) [PubMed: 7533783] [Abstract]
Cited for: VARIANT PLATELET GLYCOPROTEIN IV DEFICIENCY SER-90.
[17]"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.
Nat. Genet. 22:231-238(1999) [PubMed: 10391209] [Abstract]
Cited for: VARIANT PHE-154.
[18]Erratum
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.
Nat. Genet. 23:373-373(1999)
[19]"Malaria susceptibility and CD36 mutation."
Aitman T.J., Cooper L.D., Norsworthy P.J., Wahid F.N., Gray J.K., Curtis B.R., McKeigue P.M., Kwiatkowski D., Greenwood B.M., Snow R.W., Hill A.V., Scott J.
Nature 405:1015-1016(2000) [PubMed: 10890433] [Abstract]
Cited for: ROLE IN MALARIA INFECTION.
[20]"Identification of cryptic splice site, exon skipping, and novel point mutations in type I CD36 deficiency."
Hanawa H., Watanabe K., Nakamura T., Ogawa Y., Toba K., Fuse I., Kodama M., Kato K., Fuse K., Aizawa Y.
J. Med. Genet. 39:286-291(2002) [PubMed: 11950861] [Abstract]
Cited for: VARIANTS PLATELET GLYCOPROTEIN IV DEFICIENCY SER-90; LEU-254 AND LEU-413.
[21]"CD36 polymorphism is associated with protection from cerebral malaria."
Omi K., Ohashi J., Patarapotikul J., Hananantachai H., Naka I., Looareesuwan S., Tokunaga K.
Am. J. Hum. Genet. 72:364-374(2003) [PubMed: 12506336] [Abstract]
Cited for: VARIANT LEU-127, ROLE IN MALARIA INFECTION.
[22]"A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians."
Ma X., Bacci S., Mlynarski W., Gottardo L., Soccio T., Menzaghi C., Iori E., Lager R.A., Shroff A.R., Gervino E.V., Nesto R.W., Johnstone M.T., Abumrad N.A., Avogaro A., Trischitta V., Doria A.
Hum. Mol. Genet. 13:2197-2205(2004) [PubMed: 15282206] [Abstract]
Cited for: INVOLVEMENT IN CHDS7.
[23]Erratum
Ma X., Bacci S., Mlynarski W., Gottardo L., Soccio T., Menzaghi C., Iori E., Lager R.A., Shroff A.R., Gervino E.V., Nesto R.W., Johnstone M.T., Abumrad N.A., Avogaro A., Trischitta V., Doria A.
Hum. Mol. Genet. 14:3973-3973(2005)
+Additional computationally mapped references.

Cross-references

Sequence databases

M24795 mRNA. Translation: AAA35534.1.
M98398 mRNA. Translation: AAA58412.1.
M98399 mRNA. Translation: AAA58413.1.
L06850 mRNA. Translation: AAA16068.1.
S67532 mRNA. Translation: AAD13993.1.
Z32770 expand/collapse EMBL AC list , Z32754, Z32755, Z32756, Z32757, Z32758, Z32759, Z32760, Z32761, Z32762, Z32763, Z32764 Genomic DNA. Translation: CAA83662.1.
AY095373 Genomic DNA. Translation: AAM14636.2. Frameshift.
BC008406 mRNA. Translation: AAH08406.1.
AF300626 Genomic DNA. Translation: AAG60625.1.
AF300627 Genomic DNA. Translation: AAG60626.1.
AF300628 Genomic DNA. Translation: AAG60627.1.
AF300633 Genomic DNA. Translation: AAG60632.1.
AF300634 Genomic DNA. Translation: AAG60633.1.
AF300635 Genomic DNA. Translation: AAG60634.1.
AF300639 Genomic DNA. Translation: AAG60638.1.
AF300640 Genomic DNA. Translation: AAG60639.1.
S67044 mRNA. Translation: AAB28992.1.
Z22924 Genomic DNA. Translation: CAA80504.1.
IPIIPI00418495.
PIRA54870.
RefSeqNP_000063.2.
NP_001001547.1.
NP_001001548.1.
NP_001120915.1.
NP_001120916.1.
UniGeneHs.120949

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP16671.

PTM databases

PhosphoSiteP16671.

Proteomic databases

PRIDEP16671.

Genome annotation databases

EnsemblENST00000309881; ENSP00000308165; ENSG00000135218; Homo sapiens. [Genome view]
ENST00000394788; ENSP00000378268; ENSG00000135218; Homo sapiens. [Genome view]
ENST00000394791; ENSP00000378271; ENSG00000135218; Homo sapiens. [Genome view]
ENST00000432207; ENSP00000411411; ENSG00000135218; Homo sapiens. [Genome view]
ENST00000433696; ENSP00000401863; ENSG00000135218; Homo sapiens. [Genome view]
ENST00000435819; ENSP00000399421; ENSG00000135218; Homo sapiens. [Genome view]
ENST00000447544; ENSP00000415743; ENSG00000135218; Homo sapiens. [Genome view]
GeneID948.
KEGGhsa:948.
UCSCuc003uhc.1. human.

Organism-specific databases

CTD948.
GeneCardsGC07P080069.
H-InvDBHIX0006805.
HGNCHGNC:1663. CD36.
HPACAB025866.
HPA002018.
MIM173510. gene.
248310. phenotype.
608404. phenotype.
610938. phenotype.
Orphanet73271. Bleeding diathesis due to glycoprotein VI deficiency or integrin alpha2-beta1 deficiency.
PharmGKBPA26212.
GenAtlasSearch...

Phylogenomic databases

HOVERGENP16671.
OMAFLSLVPY
OrthoDBEOG9HB151

Enzyme and pathway databases

ReactomeREACT_602. Metabolism of lipids and lipoproteins.
REACT_604. Hemostasis.

Gene expression databases

ArrayExpressP16671.
BgeeP16671.
GenevestigatorP16671.
GermOnlineENSG00000135218. Homo sapiens.

Family and domain databases

InterProIPR002159. CD36.
IPR005428. CD36_antigen.
[Graphical view]
PANTHERPTHR11923. CD36. 1 hit.
PfamPF01130. CD36. 1 hit.
[Graphical view]
PRINTSPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.
ProtoNetSearch...

Other Resources

NextBio3938.
SOURCESearch...

Entry information

Entry nameCD36_HUMAN
AccessionPrimary (citable) accession number: P16671
Secondary accession number(s): Q13966 expand/collapse secondary AC list , Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: November 24, 2009
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents