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P16671

- CD36_HUMAN

UniProt

P16671 - CD36_HUMAN

Protein

Platelet glycoprotein 4

Gene

CD36

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 162 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects.2 Publications

    GO - Molecular functioni

    1. high-density lipoprotein particle binding Source: Ensembl
    2. lipid binding Source: BHF-UCL
    3. lipoprotein particle binding Source: UniProtKB
    4. lipoteichoic acid receptor activity Source: Ensembl
    5. low-density lipoprotein particle binding Source: BHF-UCL
    6. low-density lipoprotein receptor activity Source: BHF-UCL
    7. thrombospondin receptor activity Source: BHF-UCL
    8. transforming growth factor beta binding Source: BHF-UCL

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    3. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    4. apoptotic cell clearance Source: Ensembl
    5. blood coagulation Source: Reactome
    6. cell adhesion Source: ProtInc
    7. cell surface receptor signaling pathway Source: Ensembl
    8. cellular lipid metabolic process Source: Reactome
    9. cellular response to bacterial lipopeptide Source: Ensembl
    10. cellular response to hydroperoxide Source: Ensembl
    11. cellular response to lipopolysaccharide Source: Ensembl
    12. cellular response to lipoteichoic acid Source: Ensembl
    13. cGMP-mediated signaling Source: BHF-UCL
    14. cholesterol transport Source: BHF-UCL
    15. defense response to Gram-positive bacterium Source: Ensembl
    16. innate immune response Source: Reactome
    17. lipid metabolic process Source: ProtInc
    18. lipid storage Source: BHF-UCL
    19. lipoprotein transport Source: BHF-UCL
    20. long-chain fatty acid import Source: UniProtKB
    21. low-density lipoprotein particle clearance Source: BHF-UCL
    22. low-density lipoprotein particle mediated signaling Source: Ensembl
    23. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
    24. negative regulation of growth of symbiont in host Source: Ensembl
    25. negative regulation of transcription factor import into nucleus Source: Ensembl
    26. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    27. nitric oxide mediated signal transduction Source: BHF-UCL
    28. phagocytosis, recognition Source: Ensembl
    29. plasma lipoprotein particle clearance Source: BHF-UCL
    30. plasma membrane long-chain fatty acid transport Source: BHF-UCL
    31. platelet activation Source: Reactome
    32. platelet degranulation Source: Reactome
    33. positive regulation of blood coagulation Source: Ensembl
    34. positive regulation of blood microparticle formation Source: Ensembl
    35. positive regulation of cell-matrix adhesion Source: BHF-UCL
    36. positive regulation of cholesterol storage Source: Ensembl
    37. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    38. positive regulation of interleukin-12 production Source: Ensembl
    39. positive regulation of interleukin-6 production Source: Ensembl
    40. positive regulation of macrophage cytokine production Source: Ensembl
    41. positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
    42. positive regulation of MAPK cascade Source: Ensembl
    43. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    44. positive regulation of phagocytosis, engulfment Source: Ensembl
    45. positive regulation of reactive oxygen species metabolic process Source: Ensembl
    46. positive regulation of tumor necrosis factor production Source: Ensembl
    47. receptor-mediated endocytosis Source: GOC
    48. regulation of removal of superoxide radicals Source: Ensembl
    49. response to stilbenoid Source: Ensembl
    50. small molecule metabolic process Source: Reactome
    51. toll-like receptor 2 signaling pathway Source: Reactome
    52. toll-like receptor 4 signaling pathway Source: Reactome
    53. toll-like receptor signaling pathway Source: Reactome
    54. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
    55. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Cell adhesion, Transport

    Enzyme and pathway databases

    ReactomeiREACT_111174. Cross-presentation of particulate exogenous antigens (phagosomes).
    REACT_116145. PPARA activates gene expression.
    REACT_163679. Scavenging by Class B Receptors.
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.
    REACT_6788. MyD88:Mal cascade initiated on plasma membrane.
    REACT_8006. Toll Like Receptor TLR6:TLR2 Cascade.

    Protein family/group databases

    TCDBi9.B.39.1.4. the long chain fatty acid translocase (lcfat) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Platelet glycoprotein 4
    Alternative name(s):
    Fatty acid translocase
    Short name:
    FAT
    Glycoprotein IIIb
    Short name:
    GPIIIB
    Leukocyte differentiation antigen CD36
    PAS IV
    PAS-4
    Platelet collagen receptor
    Platelet glycoprotein IV
    Short name:
    GPIV
    Thrombospondin receptor
    CD_antigen: CD36
    Gene namesi
    Name:CD36
    Synonyms:GP3B, GP4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:1663. CD36.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: BHF-UCL
    2. endocytic vesicle membrane Source: Reactome
    3. external side of plasma membrane Source: Ensembl
    4. extracellular space Source: UniProt
    5. Golgi apparatus Source: Ensembl
    6. integral component of plasma membrane Source: BHF-UCL
    7. membrane Source: ProtInc
    8. membrane raft Source: Ensembl
    9. phagocytic vesicle Source: Reactome
    10. plasma membrane Source: UniProtKB
    11. platelet alpha granule membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Platelet glycoprotein IV deficiency (PG4D) [MIM:608404]: A disorder characterized by macrothrombocytopenia without notable hemostatic problems and bleeding tendency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti90 – 901P → S in PG4D; type I; degradation in the cytoplasm due to defects in maturation. 2 Publications
    Corresponds to variant rs3765187 [ dbSNP | Ensembl ].
    VAR_017913
    Natural varianti254 – 2541F → L in PG4D; type I. 1 Publication
    Corresponds to variant rs142186404 [ dbSNP | Ensembl ].
    VAR_017917
    Natural varianti413 – 4131I → L in PG4D; type I. 1 Publication
    VAR_017919
    Coronary heart disease 7 (CHDS7) [MIM:610938]: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi248310. phenotype.
    608404. phenotype.
    610938. phenotype.
    611162. phenotype.
    PharmGKBiPA26212.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 472471Platelet glycoprotein 4PRO_0000144151Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi3 – 31S-palmitoyl cysteine1 Publication
    Lipidationi7 – 71S-palmitoyl cysteine1 Publication
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi205 – 2051N-linked (GlcNAc...)2 Publications
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi235 – 2351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi243 ↔ 311By similarity
    Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi272 ↔ 333By similarity
    Disulfide bondi313 ↔ 322By similarity
    Glycosylationi321 – 3211N-linked (GlcNAc...)2 Publications
    Glycosylationi417 – 4171N-linked (GlcNAc...)3 Publications
    Lipidationi464 – 4641S-palmitoyl cysteine1 Publication
    Lipidationi466 – 4661S-palmitoyl cysteine1 Publication

    Post-translational modificationi

    N-glycosylated and O-glycosylated with a ratio of 2:1.4 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiP16671.
    PaxDbiP16671.
    PRIDEiP16671.

    PTM databases

    PhosphoSiteiP16671.

    Expressioni

    Gene expression databases

    ArrayExpressiP16671.
    BgeeiP16671.
    GenevestigatoriP16671.

    Organism-specific databases

    HPAiCAB025866.
    HPA002018.

    Interactioni

    Subunit structurei

    Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity.1 Publication

    Protein-protein interaction databases

    BioGridi107386. 15 interactions.
    IntActiP16671. 7 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP16671.
    SMRiP16671. Positions 38-434.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 76CytoplasmicSequence Analysis
    Topological domaini30 – 439410ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini462 – 47211CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2922HelicalSequence AnalysisAdd
    BLAST
    Transmembranei440 – 46122HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni93 – 12028Required for interaction with thrombospondins, THBS1 and THBS2Add
    BLAST

    Sequence similaritiesi

    Belongs to the CD36 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257244.
    HOVERGENiHBG002754.
    InParanoidiP16671.
    KOiK06259.
    OMAiKRNYIVP.
    OrthoDBiEOG79SDWX.
    PhylomeDBiP16671.
    TreeFamiTF317925.

    Family and domain databases

    InterProiIPR002159. CD36.
    IPR005428. CD36_antigen.
    [Graphical view]
    PANTHERiPTHR11923. PTHR11923. 1 hit.
    PfamiPF01130. CD36. 1 hit.
    [Graphical view]
    PRINTSiPR01610. CD36ANTIGEN.
    PR01609. CD36FAMILY.

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P16671-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DLLIQKTIKK QVVLEEGTIA    50
    FKNWVKTGTE VYRQFWIFDV QNPQEVMMNS SNIQVKQRGP YTYRVRFLAK 100
    ENVTQDAEDN TVSFLQPNGA IFEPSLSVGT EADNFTVLNL AVAAASHIYQ 150
    NQFVQMILNS LINKSKSSMF QVRTLRELLW GYRDPFLSLV PYPVTTTVGL 200
    FYPYNNTADG VYKVFNGKDN ISKVAIIDTY KGKRNLSYWE SHCDMINGTD 250
    AASFPPFVEK SQVLQFFSSD ICRSIYAVFE SDVNLKGIPV YRFVLPSKAF 300
    ASPVENPDNY CFCTEKIISK NCTSYGVLDI SKCKEGRPVY ISLPHFLYAS 350
    PDVSEPIDGL NPNEEEHRTY LDIEPITGFT LQFAKRLQVN LLVKPSEKIQ 400
    VLKNLKRNYI VPILWLNETG TIGDEKANMF RSQVTGKINL LGLIEMILLS 450
    VGVVMFVAFM ISYCACRSKT IK 472
    Length:472
    Mass (Da):53,053
    Last modified:January 23, 2007 - v2
    Checksum:i543E748259A094FA
    GO
    Isoform 2 (identifier: P16671-2) [UniParc]FASTAAdd to Basket

    Also known as: ex8-del

    The sequence of this isoform differs from the canonical sequence as follows:
         274-288: SIYAVFESDVNLKGI → ETCVHFTSSFSVCKS
         289-472: Missing.

    Show »
    Length:288
    Mass (Da):32,265
    Checksum:iC82FFEF32AF7A690
    GO
    Isoform 3 (identifier: P16671-3) [UniParc]FASTAAdd to Basket

    Also known as: ex6-7-del

    The sequence of this isoform differs from the canonical sequence as follows:
         234-272: Missing.

    Show »
    Length:433
    Mass (Da):48,600
    Checksum:i9D4A561C95F1ED4D
    GO
    Isoform 4 (identifier: P16671-4) [UniParc]FASTAAdd to Basket

    Also known as: ex4-del

    The sequence of this isoform differs from the canonical sequence as follows:
         144-203: Missing.

    Show »
    Length:412
    Mass (Da):46,090
    Checksum:i33D8CA7991537066
    GO

    Sequence cautioni

    The sequence AAM14636.2 differs from that shown. Reason: Frameshift at position 53.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti44 – 441L → R in AAD13993. (PubMed:7505064)Curated
    Sequence conflicti238 – 2381Y → D in AAD13993. (PubMed:7505064)Curated
    Sequence conflicti374 – 3741E → Q in AAA16068. (PubMed:7693552)Curated
    Sequence conflicti374 – 3741E → Q AA sequence (PubMed:15242332)Curated

    Polymorphismi

    Genetic variations in CD36 are involved in susceptibility to malaria and influence the severity and outcome of malaria infection [MIMi:611162].

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti90 – 901P → S in PG4D; type I; degradation in the cytoplasm due to defects in maturation. 2 Publications
    Corresponds to variant rs3765187 [ dbSNP | Ensembl ].
    VAR_017913
    Natural varianti123 – 1231E → K in individuals from a malaria endemic area in West Africa. 1 Publication
    Corresponds to variant rs183461468 [ dbSNP | Ensembl ].
    VAR_017914
    Natural varianti127 – 1271S → L.1 Publication
    Corresponds to variant rs201765331 [ dbSNP | Ensembl ].
    VAR_019049
    Natural varianti154 – 1541V → F.1 Publication
    Corresponds to variant rs5957 [ dbSNP | Ensembl ].
    VAR_013918
    Natural varianti174 – 1741T → A in individuals from a malaria endemic area in West Africa. 1 Publication
    VAR_017915
    Natural varianti232 – 2321G → GN in individuals from a malaria endemic area in West Africa. 1 Publication
    VAR_017916
    Natural varianti254 – 2541F → L in PG4D; type I. 1 Publication
    Corresponds to variant rs142186404 [ dbSNP | Ensembl ].
    VAR_017917
    Natural varianti271 – 2711I → T in individuals from a malaria endemic area in West Africa. 1 Publication
    VAR_017918
    Natural varianti386 – 3861R → W.1 Publication
    Corresponds to variant rs148910227 [ dbSNP | Ensembl ].
    VAR_071161
    Natural varianti413 – 4131I → L in PG4D; type I. 1 Publication
    VAR_017919
    Natural varianti470 – 4701T → I.1 Publication
    Corresponds to variant rs200771788 [ dbSNP | Ensembl ].
    VAR_071162

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei144 – 20360Missing in isoform 4. 1 PublicationVSP_055976Add
    BLAST
    Alternative sequencei234 – 27239Missing in isoform 3. 1 PublicationVSP_055977Add
    BLAST
    Alternative sequencei274 – 28815SIYAV…NLKGI → ETCVHFTSSFSVCKS in isoform 2. 1 PublicationVSP_055978Add
    BLAST
    Alternative sequencei289 – 472184Missing in isoform 2. 1 PublicationVSP_055979Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24795 mRNA. Translation: AAA35534.1.
    M98398 mRNA. Translation: AAA58412.1.
    M98399 mRNA. Translation: AAA58413.1.
    L06850 mRNA. Translation: AAA16068.1.
    S67532 mRNA. Translation: AAD13993.1.
    Z32770
    , Z32754, Z32755, Z32756, Z32757, Z32758, Z32759, Z32760, Z32761, Z32762, Z32763, Z32764 Genomic DNA. Translation: CAA83662.1.
    AY095373 Genomic DNA. Translation: AAM14636.2. Frameshift.
    HM217023 mRNA. Translation: ADI80543.1.
    HM217024 mRNA. Translation: ADI80544.1.
    HM217025 mRNA. Translation: ADI80545.1.
    HM217026 mRNA. Translation: ADI80546.1.
    AC004862 Genomic DNA. No translation available.
    AC073182 Genomic DNA. No translation available.
    AC073850 Genomic DNA. No translation available.
    AC092108 Genomic DNA. No translation available.
    AC124834 Genomic DNA. No translation available.
    BC008406 mRNA. Translation: AAH08406.1.
    AF300626 Genomic DNA. Translation: AAG60625.1.
    AF300627 Genomic DNA. Translation: AAG60626.1.
    AF300628 Genomic DNA. Translation: AAG60627.1.
    AF300633 Genomic DNA. Translation: AAG60632.1.
    AF300634 Genomic DNA. Translation: AAG60633.1.
    AF300635 Genomic DNA. Translation: AAG60634.1.
    AF300639 Genomic DNA. Translation: AAG60638.1.
    AF300640 Genomic DNA. Translation: AAG60639.1.
    S67044 mRNA. Translation: AAB28992.1.
    Z22924 Genomic DNA. Translation: CAA80504.1.
    CCDSiCCDS34673.1.
    PIRiA54870.
    RefSeqiNP_000063.2. NM_000072.3.
    NP_001001547.1. NM_001001547.2.
    NP_001001548.1. NM_001001548.2.
    NP_001120915.1. NM_001127443.1.
    NP_001120916.1. NM_001127444.1.
    NP_001276837.1. NM_001289908.1.
    NP_001276838.1. NM_001289909.1.
    NP_001276840.1. NM_001289911.1.
    XP_005250770.1. XM_005250713.1.
    XP_005250771.1. XM_005250714.1.
    XP_005250772.1. XM_005250715.2.
    UniGeneiHs.120949.

    Genome annotation databases

    EnsembliENST00000309881; ENSP00000308165; ENSG00000135218.
    ENST00000394788; ENSP00000378268; ENSG00000135218.
    ENST00000432207; ENSP00000411411; ENSG00000135218.
    ENST00000433696; ENSP00000401863; ENSG00000135218.
    ENST00000435819; ENSP00000399421; ENSG00000135218.
    ENST00000447544; ENSP00000415743; ENSG00000135218.
    ENST00000538969; ENSP00000439543; ENSG00000135218.
    ENST00000544133; ENSP00000441956; ENSG00000135218.
    GeneIDi948.
    KEGGihsa:948.
    UCSCiuc003uhc.3. human.

    Polymorphism databases

    DMDMi115982.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CD36 entry

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24795 mRNA. Translation: AAA35534.1 .
    M98398 mRNA. Translation: AAA58412.1 .
    M98399 mRNA. Translation: AAA58413.1 .
    L06850 mRNA. Translation: AAA16068.1 .
    S67532 mRNA. Translation: AAD13993.1 .
    Z32770
    , Z32754 , Z32755 , Z32756 , Z32757 , Z32758 , Z32759 , Z32760 , Z32761 , Z32762 , Z32763 , Z32764 Genomic DNA. Translation: CAA83662.1 .
    AY095373 Genomic DNA. Translation: AAM14636.2 . Frameshift.
    HM217023 mRNA. Translation: ADI80543.1 .
    HM217024 mRNA. Translation: ADI80544.1 .
    HM217025 mRNA. Translation: ADI80545.1 .
    HM217026 mRNA. Translation: ADI80546.1 .
    AC004862 Genomic DNA. No translation available.
    AC073182 Genomic DNA. No translation available.
    AC073850 Genomic DNA. No translation available.
    AC092108 Genomic DNA. No translation available.
    AC124834 Genomic DNA. No translation available.
    BC008406 mRNA. Translation: AAH08406.1 .
    AF300626 Genomic DNA. Translation: AAG60625.1 .
    AF300627 Genomic DNA. Translation: AAG60626.1 .
    AF300628 Genomic DNA. Translation: AAG60627.1 .
    AF300633 Genomic DNA. Translation: AAG60632.1 .
    AF300634 Genomic DNA. Translation: AAG60633.1 .
    AF300635 Genomic DNA. Translation: AAG60634.1 .
    AF300639 Genomic DNA. Translation: AAG60638.1 .
    AF300640 Genomic DNA. Translation: AAG60639.1 .
    S67044 mRNA. Translation: AAB28992.1 .
    Z22924 Genomic DNA. Translation: CAA80504.1 .
    CCDSi CCDS34673.1.
    PIRi A54870.
    RefSeqi NP_000063.2. NM_000072.3.
    NP_001001547.1. NM_001001547.2.
    NP_001001548.1. NM_001001548.2.
    NP_001120915.1. NM_001127443.1.
    NP_001120916.1. NM_001127444.1.
    NP_001276837.1. NM_001289908.1.
    NP_001276838.1. NM_001289909.1.
    NP_001276840.1. NM_001289911.1.
    XP_005250770.1. XM_005250713.1.
    XP_005250771.1. XM_005250714.1.
    XP_005250772.1. XM_005250715.2.
    UniGenei Hs.120949.

    3D structure databases

    ProteinModelPortali P16671.
    SMRi P16671. Positions 38-434.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107386. 15 interactions.
    IntActi P16671. 7 interactions.

    Chemistry

    ChEMBLi CHEMBL1744526.

    Protein family/group databases

    TCDBi 9.B.39.1.4. the long chain fatty acid translocase (lcfat) family.

    PTM databases

    PhosphoSitei P16671.

    Polymorphism databases

    DMDMi 115982.

    Proteomic databases

    MaxQBi P16671.
    PaxDbi P16671.
    PRIDEi P16671.

    Protocols and materials databases

    DNASUi 948.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309881 ; ENSP00000308165 ; ENSG00000135218 .
    ENST00000394788 ; ENSP00000378268 ; ENSG00000135218 .
    ENST00000432207 ; ENSP00000411411 ; ENSG00000135218 .
    ENST00000433696 ; ENSP00000401863 ; ENSG00000135218 .
    ENST00000435819 ; ENSP00000399421 ; ENSG00000135218 .
    ENST00000447544 ; ENSP00000415743 ; ENSG00000135218 .
    ENST00000538969 ; ENSP00000439543 ; ENSG00000135218 .
    ENST00000544133 ; ENSP00000441956 ; ENSG00000135218 .
    GeneIDi 948.
    KEGGi hsa:948.
    UCSCi uc003uhc.3. human.

    Organism-specific databases

    CTDi 948.
    GeneCardsi GC07P080069.
    HGNCi HGNC:1663. CD36.
    HPAi CAB025866.
    HPA002018.
    MIMi 173510. gene.
    248310. phenotype.
    608404. phenotype.
    610938. phenotype.
    611162. phenotype.
    neXtProti NX_P16671.
    PharmGKBi PA26212.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG257244.
    HOVERGENi HBG002754.
    InParanoidi P16671.
    KOi K06259.
    OMAi KRNYIVP.
    OrthoDBi EOG79SDWX.
    PhylomeDBi P16671.
    TreeFami TF317925.

    Enzyme and pathway databases

    Reactomei REACT_111174. Cross-presentation of particulate exogenous antigens (phagosomes).
    REACT_116145. PPARA activates gene expression.
    REACT_163679. Scavenging by Class B Receptors.
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.
    REACT_6788. MyD88:Mal cascade initiated on plasma membrane.
    REACT_8006. Toll Like Receptor TLR6:TLR2 Cascade.

    Miscellaneous databases

    GeneWikii CD36.
    GenomeRNAii 948.
    NextBioi 3938.
    PROi P16671.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P16671.
    Bgeei P16671.
    Genevestigatori P16671.

    Family and domain databases

    InterProi IPR002159. CD36.
    IPR005428. CD36_antigen.
    [Graphical view ]
    PANTHERi PTHR11923. PTHR11923. 1 hit.
    Pfami PF01130. CD36. 1 hit.
    [Graphical view ]
    PRINTSi PR01610. CD36ANTIGEN.
    PR01609. CD36FAMILY.
    ProtoNeti Search...

    Publicationsi

    1. "CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes."
      Oquendo P., Hundt E., Lawler J., Seed B.
      Cell 58:95-101(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    2. Sugimoto Y., Tsuruo T.
      Submitted (AUG-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Characterization of two alternatively spliced 5'-untranslated exons of the human CD36 gene in different cell types."
      Taylor K.T., Tang Y., Sobieski D.A., Lipsky R.H.
      Gene 133:205-212(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Cloning of the cDNA encoding human platelet CD36: comparison to PCR amplified fragments of monocyte, endothelial and HEL cells."
      Wyler B., Daviet L., Bortkiewicz H., Bordet J.C., McGregor J.L.
      Thromb. Haemost. 70:500-505(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Platelet.
    5. "Structural organization of the gene for human CD36 glycoprotein."
      Armesilla A.L., Vega M.A.
      J. Biol. Chem. 269:18985-18991(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. SeattleSNPs variation discovery resource
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "Frequency of CD36 deficiency and identification of novel CD36 gene mutations in the Chinese population."
      Wu G.-G., Curtis B.R., He B.-R., Zhou Z.-L., Zhou Y., Yang Y.-L., Li H.-Y., Shen W.-D., Liu J.-L., Zhao T.-M.
      Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANTS TRP-386 AND ILE-470.
    8. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skeletal muscle.
    10. "Isolation and characterization of platelet glycoprotein IV (CD36)."
      Tandon N.N., Lipsky R.H., Burgess W.H., Jamieson G.A.
      J. Biol. Chem. 264:7570-7575(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-37, GLYCOSYLATION.
      Tissue: Platelet.
    11. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-203; 274-375 AND 419-472, VARIANTS LYS-123; ALA-174; ASN-232 INS AND THR-271.
    12. "Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2."
      Fernandez-Ruiz E., Armesilla A.L., Sanchez-Madrid F., Vega M.A.
      Genomics 17:759-761(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 144-203 (ISOFORM 1/2).
    13. "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
      Aboulaich N., Vainonen J.P., Stralfors P., Vener A.V.
      Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 261-273 AND 369-385.
      Tissue: Adipocyte.
    14. "Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding."
      Asch A.S., Silbiger S., Heimer E., Nachman R.L.
      Biochem. Biophys. Res. Commun. 182:1208-1217(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH THBS1 AND THBS2.
    15. "CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails."
      Tao N., Wagner S.J., Lublin D.M.
      J. Biol. Chem. 271:22315-22320(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION AT CYS-3; CYS-7; CYS-464 AND CYS-466.
    16. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
      Lewandrowski U., Moebius J., Walter U., Sickmann A.
      Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-417.
      Tissue: Platelet.
    17. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
      Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.
      Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-321.
      Tissue: Milk.
    18. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-205 AND ASN-417.
      Tissue: Liver.
    19. "Molecular basis of CD36 deficiency. Evidence that a 478C-->T substitution (proline90-->serine) in CD36 cDNA accounts for CD36 deficiency."
      Kashiwagi H., Tomiyama Y., Honda S., Kosugi S., Shiraga M., Nagao N., Sekiguchi S., Kanayama Y., Kurata Y., Matsuzawa Y.
      J. Clin. Invest. 95:1040-1046(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT PG4D SER-90.
    20. Cited for: VARIANT PHE-154.
    21. Cited for: ROLE IN MALARIA INFECTION.
    22. "Identification of cryptic splice site, exon skipping, and novel point mutations in type I CD36 deficiency."
      Hanawa H., Watanabe K., Nakamura T., Ogawa Y., Toba K., Fuse I., Kodama M., Kato K., Fuse K., Aizawa Y.
      J. Med. Genet. 39:286-291(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS PG4D SER-90; LEU-254 AND LEU-413.
    23. "CD36 polymorphism is associated with protection from cerebral malaria."
      Omi K., Ohashi J., Patarapotikul J., Hananantachai H., Naka I., Looareesuwan S., Tokunaga K.
      Am. J. Hum. Genet. 72:364-374(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LEU-127, ROLE IN MALARIA INFECTION.
    24. "A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians."
      Ma X., Bacci S., Mlynarski W., Gottardo L., Soccio T., Menzaghi C., Iori E., Lager R.A., Shroff A.R., Gervino E.V., Nesto R.W., Johnstone M.T., Abumrad N.A., Avogaro A., Trischitta V., Doria A.
      Hum. Mol. Genet. 13:2197-2205(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN CHDS7.

    Entry informationi

    Entry nameiCD36_HUMAN
    AccessioniPrimary (citable) accession number: P16671
    Secondary accession number(s): D9IX66
    , D9IX67, D9IX68, D9IX69, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 162 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3