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Protein

Platelet glycoprotein 4

Gene

CD36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellulare calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211).By similarity1 Publication7 Publications
(Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei463Critical for TLR4-TLR6 dimerization and signaling1 Publication1

GO - Molecular functioni

  • high-density lipoprotein particle binding Source: Ensembl
  • lipid binding Source: BHF-UCL
  • lipoprotein particle binding Source: UniProtKB
  • lipoteichoic acid receptor activity Source: Ensembl
  • low-density lipoprotein particle binding Source: BHF-UCL
  • low-density lipoprotein receptor activity Source: BHF-UCL
  • thrombospondin receptor activity Source: BHF-UCL
  • transforming growth factor beta binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135218-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-1236973. Cross-presentation of particulate exogenous antigens (phagosomes).
R-HSA-1236974. ER-Phagosome pathway.
R-HSA-166058. MyD88:Mal cascade initiated on plasma membrane.
R-HSA-168188. Toll Like Receptor TLR6:TLR2 Cascade.
R-HSA-1989781. PPARA activates gene expression.
R-HSA-3000471. Scavenging by Class B Receptors.
R-HSA-381340. Transcriptional regulation of white adipocyte differentiation.
R-HSA-5602498. MyD88 deficiency (TLR2/4).
R-HSA-5603041. IRAK4 deficiency (TLR2/4).
R-HSA-5686938. Regulation of TLR by endogenous ligand.
R-HSA-6798695. Neutrophil degranulation.

Protein family/group databases

TCDBi9.B.39.1.4. the long chain fatty acid translocase (lcfat) family.

Chemistry databases

SwissLipidsiSLP:000001098.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein 4
Alternative name(s):
Fatty acid translocase
Short name:
FAT
Glycoprotein IIIb
Short name:
GPIIIB
Leukocyte differentiation antigen CD36
PAS IV
PAS-4
Platelet collagen receptor
Platelet glycoprotein IV
Short name:
GPIV
Thrombospondin receptor
CD_antigen: CD36
Gene namesi
Name:CD36
Synonyms:GP3B, GP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:1663. CD36.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 7CytoplasmicSequence analysis6
Transmembranei8 – 29HelicalSequence analysisAdd BLAST22
Topological domaini30 – 439ExtracellularSequence analysisAdd BLAST410
Transmembranei440 – 461HelicalSequence analysisAdd BLAST22
Topological domaini462 – 472CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB-SubCell
  • brush border membrane Source: UniProtKB
  • cell surface Source: BHF-UCL
  • endocytic vesicle membrane Source: Reactome
  • external side of plasma membrane Source: Ensembl
  • extracellular space Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • integral component of plasma membrane Source: BHF-UCL
  • membrane Source: ProtInc
  • membrane raft Source: UniProtKB
  • phagocytic vesicle Source: Reactome
  • plasma membrane Source: UniProtKB
  • platelet alpha granule membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Platelet glycoprotein IV deficiency (PG4D)2 Publications
The disease is caused by mutations affecting the gene represented in this entry. Patients also have postprandial hypertriglyceridemia, insulin resistance and hypertension increasing atherosclerotic risk.1 Publication
Disease descriptionA disorder characterized by macrothrombocytopenia without notable hemostatic problems and bleeding tendency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.
See also OMIM:608404
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01791390P → S in PG4D; type I; degradation in the cytoplasm due to defects in maturation. 2 PublicationsCorresponds to variant rs3765187dbSNPEnsembl.1
Natural variantiVAR_017917254F → L in PG4D; type I. 1 PublicationCorresponds to variant rs142186404dbSNPEnsembl.1
Natural variantiVAR_017919413I → L in PG4D; type I. 1 PublicationCorresponds to variant rs121918035dbSNPEnsembl.1
Coronary heart disease 7 (CHDS7)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries.
See also OMIM:610938

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi462 – 472SYCACRSKTIK → AAAAAAAAAAA: No effect on cell surface location. Loss of oxLDL-induced NF-kappa-B activation. 1 PublicationAdd BLAST11
Mutagenesisi463Y → A: No effect on cell surface location. Loss of oxLDL-induced NF-kappa-B activation. Loss of complex formation with TLR4 and TLR6. 1 Publication1
Mutagenesisi464C → S: No effect on cell surface location, nor on oxLDL-induced NF-kappa-B activation. 1 Publication1
Mutagenesisi469 – 472KTIK → ATIA: Abolishes ubiquitination induced by lipids. Enhances fatty acid uptake. 2 Publications4

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi948.
MalaCardsiCD36.
MIMi248310. phenotype.
608404. phenotype.
610938. phenotype.
611162. phenotype.
OpenTargetsiENSG00000135218.
PharmGKBiPA26212.

Chemistry databases

ChEMBLiCHEMBL1744526.

Polymorphism and mutation databases

BioMutaiCD36.
DMDMi115982.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001441512 – 472Platelet glycoprotein 4Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi3S-palmitoyl cysteine1 Publication1
Lipidationi7S-palmitoyl cysteine1 Publication1
Glycosylationi79N-linked (GlcNAc...)Sequence analysis1
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Glycosylationi163N-linked (GlcNAc...)Sequence analysis1
Glycosylationi205N-linked (GlcNAc...)1 Publication1
Glycosylationi220N-linked (GlcNAc...)Sequence analysis1
Glycosylationi235N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi243 ↔ 311By similarity
Glycosylationi247N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi272 ↔ 333By similarity
Disulfide bondi313 ↔ 322By similarity
Glycosylationi321N-linked (GlcNAc...)1 Publication1
Glycosylationi417N-linked (GlcNAc...)2 Publications1
Lipidationi464S-palmitoyl cysteine1 Publication1
Lipidationi466S-palmitoyl cysteine1 Publication1
Cross-linki469Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Cross-linki472Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications

Post-translational modificationi

N-glycosylated and O-glycosylated with a ratio of 2:1.4 Publications
Ubiquitinated at Lys-469 and Lys-472. Ubiquitination is induced by fatty acids such as oleic acid and leads to degradation by the proteasome (PubMed:21610069, PubMed:18353783). Ubiquitination and degradation are inhibited by insulin which blocks the effect of fatty acids (PubMed:18353783).2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Lipoprotein, Palmitate, Ubl conjugation

Proteomic databases

MaxQBiP16671.
PaxDbiP16671.
PeptideAtlasiP16671.
PRIDEiP16671.

PTM databases

iPTMnetiP16671.
PhosphoSitePlusiP16671.
SwissPalmiP16671.

Expressioni

Gene expression databases

BgeeiENSG00000135218.
ExpressionAtlasiP16671. baseline and differential.
GenevisibleiP16671. HS.

Organism-specific databases

HPAiCAB025866.
HPA002018.

Interactioni

Subunit structurei

Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity (PubMed:1371676). Upon interaction with a ligand, such as oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, rapidly forms a complex with TLR4 and TLR6; the complex is internalized and triggers an inflammatory signal. Through its C-terminus, interacts with PTK2, PXN and LYN, but not with SRC. LYN kinase activity is required for facilitating TLR4:TLR6 heterodimerization and signal initiation (PubMed:1371676, PubMed:20037584). Upon interaction with ligands such as diacylated lipopeptides, interacts with the TLR2:TLR6 heterodimer (PubMed:16880211). Interacts with CD9, CD81, FCER1G, ITGB2 and/or ITGB2; forming a membrane heteromeric complex required for the internalization of CD36 and its ligands (By similarity).By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107386. 19 interactors.
IntActiP16671. 7 interactors.
STRINGi9606.ENSP00000308165.

Structurei

Secondary structure

1472
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi38 – 41Combined sources4
Beta strandi42 – 45Combined sources4
Helixi49 – 55Combined sources7
Beta strandi61 – 71Combined sources11
Helixi73 – 79Combined sources7
Beta strandi83 – 96Combined sources14
Beta strandi101 – 106Combined sources6
Turni107 – 110Combined sources4
Beta strandi111 – 117Combined sources7
Beta strandi120 – 122Combined sources3
Helixi124 – 126Combined sources3
Beta strandi127 – 129Combined sources3
Beta strandi134 – 138Combined sources5
Helixi140 – 148Combined sources9
Helixi152 – 164Combined sources13
Beta strandi169 – 174Combined sources6
Helixi175 – 180Combined sources6
Helixi187 – 189Combined sources3
Beta strandi208 – 215Combined sources8
Helixi221 – 223Combined sources3
Beta strandi227 – 230Combined sources4
Beta strandi233 – 235Combined sources3
Beta strandi237 – 240Combined sources4
Helixi241 – 244Combined sources4
Beta strandi251 – 253Combined sources3
Beta strandi263 – 268Combined sources6
Turni269 – 272Combined sources4
Beta strandi273 – 285Combined sources13
Beta strandi288 – 294Combined sources7
Helixi297 – 300Combined sources4
Turni303 – 305Combined sources3
Helixi307 – 312Combined sources6
Turni317 – 323Combined sources7
Beta strandi326 – 329Combined sources4
Helixi331 – 333Combined sources3
Turni334 – 336Combined sources3
Beta strandi339 – 342Combined sources4
Helixi344 – 346Combined sources3
Helixi351 – 354Combined sources4
Beta strandi357 – 359Combined sources3
Helixi364 – 367Combined sources4
Beta strandi370 – 373Combined sources4
Turni375 – 377Combined sources3
Beta strandi379 – 393Combined sources15
Helixi400 – 402Combined sources3
Beta strandi409 – 421Combined sources13
Helixi424 – 433Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LGDX-ray2.07A1-472[»]
ProteinModelPortaliP16671.
SMRiP16671.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni93 – 120Required for interaction with thrombospondins, THBS1 and THBS21 PublicationAdd BLAST28
Regioni460 – 472Interaction with PTK2, PXN and LYN1 PublicationAdd BLAST13

Sequence similaritiesi

Belongs to the CD36 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3776. Eukaryota.
ENOG410XS17. LUCA.
GeneTreeiENSGT00530000062927.
HOVERGENiHBG002754.
InParanoidiP16671.
KOiK06259.
OMAiNTVSFLQ.
OrthoDBiEOG091G0CH9.
PhylomeDBiP16671.
TreeFamiTF317925.

Family and domain databases

InterProiIPR005428. CD36/SCARB1/SNMP1.
IPR033076. CD36_chordates.
IPR002159. CD36_fam.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PTHR11923:SF12. PTHR11923:SF12. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P16671-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DLLIQKTIKK QVVLEEGTIA
60 70 80 90 100
FKNWVKTGTE VYRQFWIFDV QNPQEVMMNS SNIQVKQRGP YTYRVRFLAK
110 120 130 140 150
ENVTQDAEDN TVSFLQPNGA IFEPSLSVGT EADNFTVLNL AVAAASHIYQ
160 170 180 190 200
NQFVQMILNS LINKSKSSMF QVRTLRELLW GYRDPFLSLV PYPVTTTVGL
210 220 230 240 250
FYPYNNTADG VYKVFNGKDN ISKVAIIDTY KGKRNLSYWE SHCDMINGTD
260 270 280 290 300
AASFPPFVEK SQVLQFFSSD ICRSIYAVFE SDVNLKGIPV YRFVLPSKAF
310 320 330 340 350
ASPVENPDNY CFCTEKIISK NCTSYGVLDI SKCKEGRPVY ISLPHFLYAS
360 370 380 390 400
PDVSEPIDGL NPNEEEHRTY LDIEPITGFT LQFAKRLQVN LLVKPSEKIQ
410 420 430 440 450
VLKNLKRNYI VPILWLNETG TIGDEKANMF RSQVTGKINL LGLIEMILLS
460 470
VGVVMFVAFM ISYCACRSKT IK
Length:472
Mass (Da):53,053
Last modified:January 23, 2007 - v2
Checksum:i543E748259A094FA
GO
Isoform 2 (identifier: P16671-2) [UniParc]FASTAAdd to basket
Also known as: ex8-del

The sequence of this isoform differs from the canonical sequence as follows:
     274-288: SIYAVFESDVNLKGI → ETCVHFTSSFSVCKS
     289-472: Missing.

Show »
Length:288
Mass (Da):32,265
Checksum:iC82FFEF32AF7A690
GO
Isoform 3 (identifier: P16671-3) [UniParc]FASTAAdd to basket
Also known as: ex6-7-del

The sequence of this isoform differs from the canonical sequence as follows:
     234-272: Missing.

Show »
Length:433
Mass (Da):48,600
Checksum:i9D4A561C95F1ED4D
GO
Isoform 4 (identifier: P16671-4) [UniParc]FASTAAdd to basket
Also known as: ex4-del

The sequence of this isoform differs from the canonical sequence as follows:
     144-203: Missing.

Show »
Length:412
Mass (Da):46,090
Checksum:i33D8CA7991537066
GO

Sequence cautioni

The sequence AAM14636 differs from that shown. Reason: Frameshift at position 53.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44L → R in AAD13993 (PubMed:7505064).Curated1
Sequence conflicti238Y → D in AAD13993 (PubMed:7505064).Curated1
Sequence conflicti374E → Q in AAA16068 (PubMed:7693552).Curated1
Sequence conflicti374E → Q AA sequence (PubMed:15242332).Curated1

Polymorphismi

Genetic variations in CD36 are involved in susceptibility to malaria and influence the severity and outcome of malaria infection [MIMi:611162].

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01791390P → S in PG4D; type I; degradation in the cytoplasm due to defects in maturation. 2 PublicationsCorresponds to variant rs3765187dbSNPEnsembl.1
Natural variantiVAR_017914123E → K in individuals from a malaria endemic area in West Africa. 1 PublicationCorresponds to variant rs183461468dbSNPEnsembl.1
Natural variantiVAR_019049127S → L.1 PublicationCorresponds to variant rs201765331dbSNPEnsembl.1
Natural variantiVAR_013918154V → F.1 PublicationCorresponds to variant rs5957dbSNPEnsembl.1
Natural variantiVAR_017915174T → A in individuals from a malaria endemic area in West Africa. 1 PublicationCorresponds to variant rs756525492dbSNPEnsembl.1
Natural variantiVAR_017916232G → GN in individuals from a malaria endemic area in West Africa. 1 Publication1
Natural variantiVAR_017917254F → L in PG4D; type I. 1 PublicationCorresponds to variant rs142186404dbSNPEnsembl.1
Natural variantiVAR_017918271I → T in individuals from a malaria endemic area in West Africa. 1 PublicationCorresponds to variant rs370072057dbSNPEnsembl.1
Natural variantiVAR_071161386R → W.1 PublicationCorresponds to variant rs148910227dbSNPEnsembl.1
Natural variantiVAR_017919413I → L in PG4D; type I. 1 PublicationCorresponds to variant rs121918035dbSNPEnsembl.1
Natural variantiVAR_071162470T → I.1 PublicationCorresponds to variant rs200771788dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055976144 – 203Missing in isoform 4. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_055977234 – 272Missing in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_055978274 – 288SIYAV…NLKGI → ETCVHFTSSFSVCKS in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_055979289 – 472Missing in isoform 2. 1 PublicationAdd BLAST184

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24795 mRNA. Translation: AAA35534.1.
M98398 mRNA. Translation: AAA58412.1.
M98399 mRNA. Translation: AAA58413.1.
L06850 mRNA. Translation: AAA16068.1.
S67532 mRNA. Translation: AAD13993.1.
Z32770
, Z32754, Z32755, Z32756, Z32757, Z32758, Z32759, Z32760, Z32761, Z32762, Z32763, Z32764 Genomic DNA. Translation: CAA83662.1.
AY095373 Genomic DNA. Translation: AAM14636.2. Frameshift.
HM217023 mRNA. Translation: ADI80543.1.
HM217024 mRNA. Translation: ADI80544.1.
HM217025 mRNA. Translation: ADI80545.1.
HM217026 mRNA. Translation: ADI80546.1.
AC004862 Genomic DNA. No translation available.
AC073182 Genomic DNA. No translation available.
AC073850 Genomic DNA. No translation available.
AC092108 Genomic DNA. No translation available.
AC124834 Genomic DNA. No translation available.
BC008406 mRNA. Translation: AAH08406.1.
AF300626 Genomic DNA. Translation: AAG60625.1.
AF300627 Genomic DNA. Translation: AAG60626.1.
AF300628 Genomic DNA. Translation: AAG60627.1.
AF300633 Genomic DNA. Translation: AAG60632.1.
AF300634 Genomic DNA. Translation: AAG60633.1.
AF300635 Genomic DNA. Translation: AAG60634.1.
AF300639 Genomic DNA. Translation: AAG60638.1.
AF300640 Genomic DNA. Translation: AAG60639.1.
S67044 mRNA. Translation: AAB28992.1.
Z22924 Genomic DNA. Translation: CAA80504.1.
CCDSiCCDS34673.1. [P16671-1]
CCDS78249.1. [P16671-3]
CCDS78250.1. [P16671-4]
PIRiA54870.
RefSeqiNP_000063.2. NM_000072.3. [P16671-1]
NP_001001547.1. NM_001001547.2. [P16671-1]
NP_001001548.1. NM_001001548.2. [P16671-1]
NP_001120915.1. NM_001127443.1. [P16671-1]
NP_001120916.1. NM_001127444.1. [P16671-1]
NP_001276837.1. NM_001289908.1. [P16671-3]
NP_001276838.1. NM_001289909.1. [P16671-4]
NP_001276840.1. NM_001289911.1.
XP_005250770.1. XM_005250713.1. [P16671-1]
XP_005250771.1. XM_005250714.1. [P16671-1]
XP_005250772.1. XM_005250715.4. [P16671-1]
UniGeneiHs.120949.

Genome annotation databases

EnsembliENST00000309881; ENSP00000308165; ENSG00000135218. [P16671-1]
ENST00000394788; ENSP00000378268; ENSG00000135218. [P16671-1]
ENST00000432207; ENSP00000411411; ENSG00000135218. [P16671-1]
ENST00000433696; ENSP00000401863; ENSG00000135218. [P16671-3]
ENST00000435819; ENSP00000399421; ENSG00000135218. [P16671-1]
ENST00000447544; ENSP00000415743; ENSG00000135218. [P16671-1]
ENST00000538969; ENSP00000439543; ENSG00000135218. [P16671-4]
ENST00000544133; ENSP00000441956; ENSG00000135218. [P16671-2]
GeneIDi948.
KEGGihsa:948.
UCSCiuc003uhc.4. human. [P16671-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CD36 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24795 mRNA. Translation: AAA35534.1.
M98398 mRNA. Translation: AAA58412.1.
M98399 mRNA. Translation: AAA58413.1.
L06850 mRNA. Translation: AAA16068.1.
S67532 mRNA. Translation: AAD13993.1.
Z32770
, Z32754, Z32755, Z32756, Z32757, Z32758, Z32759, Z32760, Z32761, Z32762, Z32763, Z32764 Genomic DNA. Translation: CAA83662.1.
AY095373 Genomic DNA. Translation: AAM14636.2. Frameshift.
HM217023 mRNA. Translation: ADI80543.1.
HM217024 mRNA. Translation: ADI80544.1.
HM217025 mRNA. Translation: ADI80545.1.
HM217026 mRNA. Translation: ADI80546.1.
AC004862 Genomic DNA. No translation available.
AC073182 Genomic DNA. No translation available.
AC073850 Genomic DNA. No translation available.
AC092108 Genomic DNA. No translation available.
AC124834 Genomic DNA. No translation available.
BC008406 mRNA. Translation: AAH08406.1.
AF300626 Genomic DNA. Translation: AAG60625.1.
AF300627 Genomic DNA. Translation: AAG60626.1.
AF300628 Genomic DNA. Translation: AAG60627.1.
AF300633 Genomic DNA. Translation: AAG60632.1.
AF300634 Genomic DNA. Translation: AAG60633.1.
AF300635 Genomic DNA. Translation: AAG60634.1.
AF300639 Genomic DNA. Translation: AAG60638.1.
AF300640 Genomic DNA. Translation: AAG60639.1.
S67044 mRNA. Translation: AAB28992.1.
Z22924 Genomic DNA. Translation: CAA80504.1.
CCDSiCCDS34673.1. [P16671-1]
CCDS78249.1. [P16671-3]
CCDS78250.1. [P16671-4]
PIRiA54870.
RefSeqiNP_000063.2. NM_000072.3. [P16671-1]
NP_001001547.1. NM_001001547.2. [P16671-1]
NP_001001548.1. NM_001001548.2. [P16671-1]
NP_001120915.1. NM_001127443.1. [P16671-1]
NP_001120916.1. NM_001127444.1. [P16671-1]
NP_001276837.1. NM_001289908.1. [P16671-3]
NP_001276838.1. NM_001289909.1. [P16671-4]
NP_001276840.1. NM_001289911.1.
XP_005250770.1. XM_005250713.1. [P16671-1]
XP_005250771.1. XM_005250714.1. [P16671-1]
XP_005250772.1. XM_005250715.4. [P16671-1]
UniGeneiHs.120949.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LGDX-ray2.07A1-472[»]
ProteinModelPortaliP16671.
SMRiP16671.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107386. 19 interactors.
IntActiP16671. 7 interactors.
STRINGi9606.ENSP00000308165.

Chemistry databases

ChEMBLiCHEMBL1744526.
SwissLipidsiSLP:000001098.

Protein family/group databases

TCDBi9.B.39.1.4. the long chain fatty acid translocase (lcfat) family.

PTM databases

iPTMnetiP16671.
PhosphoSitePlusiP16671.
SwissPalmiP16671.

Polymorphism and mutation databases

BioMutaiCD36.
DMDMi115982.

Proteomic databases

MaxQBiP16671.
PaxDbiP16671.
PeptideAtlasiP16671.
PRIDEiP16671.

Protocols and materials databases

DNASUi948.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309881; ENSP00000308165; ENSG00000135218. [P16671-1]
ENST00000394788; ENSP00000378268; ENSG00000135218. [P16671-1]
ENST00000432207; ENSP00000411411; ENSG00000135218. [P16671-1]
ENST00000433696; ENSP00000401863; ENSG00000135218. [P16671-3]
ENST00000435819; ENSP00000399421; ENSG00000135218. [P16671-1]
ENST00000447544; ENSP00000415743; ENSG00000135218. [P16671-1]
ENST00000538969; ENSP00000439543; ENSG00000135218. [P16671-4]
ENST00000544133; ENSP00000441956; ENSG00000135218. [P16671-2]
GeneIDi948.
KEGGihsa:948.
UCSCiuc003uhc.4. human. [P16671-1]

Organism-specific databases

CTDi948.
DisGeNETi948.
GeneCardsiCD36.
HGNCiHGNC:1663. CD36.
HPAiCAB025866.
HPA002018.
MalaCardsiCD36.
MIMi173510. gene.
248310. phenotype.
608404. phenotype.
610938. phenotype.
611162. phenotype.
neXtProtiNX_P16671.
OpenTargetsiENSG00000135218.
PharmGKBiPA26212.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3776. Eukaryota.
ENOG410XS17. LUCA.
GeneTreeiENSGT00530000062927.
HOVERGENiHBG002754.
InParanoidiP16671.
KOiK06259.
OMAiNTVSFLQ.
OrthoDBiEOG091G0CH9.
PhylomeDBiP16671.
TreeFamiTF317925.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135218-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-1236973. Cross-presentation of particulate exogenous antigens (phagosomes).
R-HSA-1236974. ER-Phagosome pathway.
R-HSA-166058. MyD88:Mal cascade initiated on plasma membrane.
R-HSA-168188. Toll Like Receptor TLR6:TLR2 Cascade.
R-HSA-1989781. PPARA activates gene expression.
R-HSA-3000471. Scavenging by Class B Receptors.
R-HSA-381340. Transcriptional regulation of white adipocyte differentiation.
R-HSA-5602498. MyD88 deficiency (TLR2/4).
R-HSA-5603041. IRAK4 deficiency (TLR2/4).
R-HSA-5686938. Regulation of TLR by endogenous ligand.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiCD36. human.
GeneWikiiCD36.
GenomeRNAii948.
PROiP16671.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135218.
ExpressionAtlasiP16671. baseline and differential.
GenevisibleiP16671. HS.

Family and domain databases

InterProiIPR005428. CD36/SCARB1/SNMP1.
IPR033076. CD36_chordates.
IPR002159. CD36_fam.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PTHR11923:SF12. PTHR11923:SF12. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.
ProtoNetiSearch...

Entry informationi

Entry nameiCD36_HUMAN
AccessioniPrimary (citable) accession number: P16671
Secondary accession number(s): D9IX66
, D9IX67, D9IX68, D9IX69, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 185 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.