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Protein

Modification methylase Sau3AI

Gene

sau3AIM

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GATC, causes specific methylation on C-4 on both strands and protects the DNA from cleavage by the Sau3AI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi3494 M.Sau3AI

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase Sau3AI (EC:2.1.1.37)
Short name:
M.Sau3AI
Alternative name(s):
Cytosine-specific methyltransferase Sau3AI
Gene namesi
Name:sau3AIM
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000879071 – 412Modification methylase Sau3AIAdd BLAST412

Structurei

3D structure databases

ProteinModelPortaliP16668
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 402SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST399

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR031303 C5_meth_CS
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 2 hits
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00094 C5_MTASE_1, 1 hit
PS00095 C5_MTASE_2, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Complete.

P16668-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKIKVVELF AGVGGFRLGL ENTKNGIFDI TWANQWEPSR KIQHAFDCYS
60 70 80 90 100
KRFKNGIHSN KDIAQVSDEE MANTEADMIV GGFPCQDYSV ARSLNGELGI
110 120 130 140 150
QGKKGVLFWQ IIRYIQNTFP KYLLLENVDR LLKSPSSQRG RDFAVMLSTL
160 170 180 190 200
NELGYNVEWR VINAADYGNA QRRRRVFIFG YKQDLNYSKA MEESPLDKII
210 220 230 240 250
YHNGLFAEAF PIEDYANKNR VNRTHITHDI VDISDNFSFQ FYNSGIMKNG
260 270 280 290 300
EILTIDTIPK YEKSVTLGEI IESNVDDGFS LNQDQIDKFK YLRGPKKIKR
310 320 330 340 350
TTKDGHEYYF SEGGMSETDS LELPARTMLT SESSINRSTH FLNVDGVYRT
360 370 380 390 400
LTPIEAERLN GFPDNWTEGM PIKMRYFCMG NALVVPLITR IGNQIEKIDS
410
ITNDEFSQLR LF
Length:412
Mass (Da):47,295
Last modified:August 1, 1990 - v1
Checksum:iE6F008248749F085
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32470 Genomic DNA Translation: AAA26673.1
PIRiJQ0760
RefSeqiWP_001033636.1, NZ_PNPD01000030.1

Similar proteinsi

Entry informationi

Entry nameiMTS3_STAAU
AccessioniPrimary (citable) accession number: P16668
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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