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Protein

Antigen TpF1

Gene

tpf1

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play an important structural role in the outer membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-1093-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Antigen TpF1
Alternative name(s):
Antigen 4D
Antigen C1-5
Gene namesi
Name:tpf1
Ordered Locus Names:TP_1038
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000000811 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 177176Antigen TpF1PRO_0000201664Add
BLAST

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodecamer; either linked or stabilized by disulfide bonds.

Protein-protein interaction databases

IntActiP16665. 3 interactions.
STRINGi243276.TP1038.

Structurei

Secondary structure

1
177
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi29 – 5931Combined sources
Beta strandi60 – 623Combined sources
Helixi65 – 9228Combined sources
Helixi101 – 1077Combined sources
Beta strandi117 – 1193Combined sources
Helixi120 – 14728Combined sources
Helixi151 – 17525Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FJCX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P22-177[»]
ProteinModelPortaliP16665.
SMRiP16665. Positions 22-177.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16665.

Family & Domainsi

Sequence similaritiesi

Belongs to the Dps family.Curated

Phylogenomic databases

eggNOGiENOG4108RMU. Bacteria.
COG0783. LUCA.
KOiK04047.
OMAiPLHAYSD.
OrthoDBiEOG6Z9B6G.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR002177. DPS_DNA-bd.
IPR023188. DPS_DNA-bd_CS.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
PIRSFiPIRSF005900. Dps. 1 hit.
PRINTSiPR01346. HELNAPAPROT.
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00818. DPS_1. 1 hit.
PS00819. DPS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16665-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMCTDGKKY HSTATSAAVG ASAPGVPDAR AIAAICEQLR QHVADLGVLY
60 70 80 90 100
IKLHNYHWHI YGIEFKQVHE LLEEYYVSVT EAFDTIAERL LQLGAQAPAS
110 120 130 140 150
MAEYLALSGI AEETEKEITI VSALARVKRD FEYLSTRFSQ TQVLAAESGD
160 170
AVTDGIITDI LRTLGKAIWM LGATLKA
Length:177
Mass (Da):19,361
Last modified:January 23, 2007 - v2
Checksum:iA0E0855069566773
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32401 Genomic DNA. No translation available.
AE000520 Genomic DNA. Translation: AAC26592.1.
PIRiJS0097.
RefSeqiWP_010882482.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC26592; AAC26592; TP_1038.
GeneIDi2610937.
KEGGitpa:TP_1038.
PATRICi20532207. VBITrePal57110_1096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32401 Genomic DNA. No translation available.
AE000520 Genomic DNA. Translation: AAC26592.1.
PIRiJS0097.
RefSeqiWP_010882482.1. NC_021490.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FJCX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P22-177[»]
ProteinModelPortaliP16665.
SMRiP16665. Positions 22-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP16665. 3 interactions.
STRINGi243276.TP1038.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC26592; AAC26592; TP_1038.
GeneIDi2610937.
KEGGitpa:TP_1038.
PATRICi20532207. VBITrePal57110_1096.

Phylogenomic databases

eggNOGiENOG4108RMU. Bacteria.
COG0783. LUCA.
KOiK04047.
OMAiPLHAYSD.
OrthoDBiEOG6Z9B6G.

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-1093-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP16665.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR002177. DPS_DNA-bd.
IPR023188. DPS_DNA-bd_CS.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
PIRSFiPIRSF005900. Dps. 1 hit.
PRINTSiPR01346. HELNAPAPROT.
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00818. DPS_1. 1 hit.
PS00819. DPS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Treponema pallidum subspecies pallidum (Nichols) and Treponema pallidum subspecies pertenue (CDC 2575) differ in at least one nucleotide: comparison of two homologous antigens."
    Noordhoek G.T., Hermans P.W.M., Paul A.N., Schouls L.M., van der Sluis J.J., van Embden J.D.A.
    Microb. Pathog. 6:29-42(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-12.
    Strain: Nichols.
  2. "Primary structure of an oligomeric antigen of Treponema pallidum."
    Walfield A.M., Roche E.S., Zounes M.C., Kirkpatrick H., Wild M.A., Textor G., Tsai P.K., Richardson C.
    Infect. Immun. 57:633-635(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.
  4. "Role of disulfide bonds in the oligomeric structure and protease resistance of recombinant and native Treponema pallidum surface antigen 4D."
    Radolf J.D., Borenstein L.A., Kim J.Y., Fehniger T.E., Lovett M.A.
    J. Bacteriol. 169:1365-1371(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.
    Strain: Nichols.

Entry informationi

Entry nameiTPF1_TREPA
AccessioniPrimary (citable) accession number: P16665
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: December 9, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.