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Protein

UDP-glucuronosyltransferase 2B7

Gene

UGT2B7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.1 Publication
Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro).1 Publication

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei398UDP-glucuronic acidCurated1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi373 – 379UDP-glucuronic acidCurated7

GO - Molecular functioni

  • glucuronosyltransferase activity Source: UniProtKB

GO - Biological processi

  • androgen metabolic process Source: UniProtKB
  • cellular glucuronidation Source: UniProtKB
  • lipid metabolic process Source: ProtInc

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processLipid metabolism, Steroid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:HS10272-MONOMER
BRENDAi2.4.1.17 2681
ReactomeiR-HSA-156588 Glucuronidation
SABIO-RKP16662
SIGNORiP16662

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Chemistry databases

SwissLipidsiSLP:000001695

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B7 (EC:2.4.1.17)
Short name:
UDPGT 2B7
Alternative name(s):
3,4-catechol estrogen-specific UDPGT
UDP-glucuronosyltransferase 2B9
Short name:
UDPGT 2B9
UDPGTh-2
Gene namesi
Name:UGT2B7
Synonyms:UGTB2B9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000171234.13
HGNCiHGNC:12554 UGT2B7
MIMi600068 gene
neXtProtiNX_P16662

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei493 – 509HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi15S → A: Almost abolishes enzyme activity. 1 Publication1
Mutagenesisi35H → A: Almost abolishes enzyme activity. 1 Publication1
Mutagenesisi151D → A: Almost abolishes enzyme activity. 1 Publication1
Mutagenesisi373T → V: Almost abolishes enzyme activity. 1 Publication1
Mutagenesisi374H → A: Almost abolishes enzyme activity. 1 Publication1
Mutagenesisi378N → A: Strongly reduced enzyme activity. 1 Publication1
Mutagenesisi379G → D: Almost abolishes enzyme activity. 1 Publication1
Mutagenesisi398D → A or N: Almost abolishes enzyme activity. 1 Publication1
Mutagenesisi399Q → A: Abolishes enzyme activity. 1 Publication1

Organism-specific databases

DisGeNETi7364
OpenTargetsiENSG00000171234
PharmGKBiPA361

Chemistry databases

ChEMBLiCHEMBL4370
DrugBankiDB06403 Ambrisentan
DB01076 Atorvastatin
DB00564 Carbamazepine
DB06777 Chenodeoxycholic acid
DB00318 Codeine
DB06695 Dabigatran etexilate
DB06292 Dapagliflozin
DB00586 Diclofenac
DB00445 Epirubicin
DB00749 Etodolac
DB00973 Ezetimibe
DB01544 Flunitrazepam
DB00712 Flurbiprofen
DB01095 Fluvastatin
DB01050 Ibuprofen
DB00328 Indomethacin
DB00678 Losartan
DB00227 Lovastatin
DB01252 Mitiglinide
DB00295 Morphine
DB00688 Mycophenolate mofetil
DB01024 Mycophenolic acid
DB00788 Naproxen
DB00842 Oxazepam
DB08860 Pitavastatin
DB06207 Silodosin
DB00641 Simvastatin
DB00870 Suprofen
DB06204 Tapentadol
DB00197 Troglitazone
DB00313 Valproic Acid
DB06737 Zaltoprofen
DB00495 Zidovudine

Polymorphism and mutation databases

BioMutaiUGT2B7
DMDMi136727

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000003603124 – 529UDP-glucuronosyltransferase 2B7Add BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi68N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP16662
PaxDbiP16662
PeptideAtlasiP16662
PRIDEiP16662

PTM databases

iPTMnetiP16662
PhosphoSitePlusiP16662

Expressioni

Gene expression databases

BgeeiENSG00000171234
CleanExiHS_UGT2B7
ExpressionAtlasiP16662 baseline and differential

Organism-specific databases

HPAiHPA045108

Interactioni

Protein-protein interaction databases

BioGridi113211, 2 interactors
IntActiP16662, 1 interactor
STRINGi9606.ENSP00000304811

Chemistry databases

BindingDBiP16662

Structurei

Secondary structure

1529
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi290 – 297Combined sources8
Turni298 – 302Combined sources5
Beta strandi304 – 308Combined sources5
Helixi318 – 328Combined sources11
Beta strandi331 – 338Combined sources8
Beta strandi351 – 356Combined sources6
Helixi359 – 363Combined sources5
Beta strandi368 – 373Combined sources6
Helixi377 – 386Combined sources10
Beta strandi390 – 392Combined sources3
Helixi399 – 407Combined sources9
Turni408 – 410Combined sources3
Beta strandi411 – 414Combined sources4
Turni417 – 419Combined sources3
Helixi422 – 434Combined sources13
Helixi436 – 445Combined sources10
Turni448 – 450Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O6LX-ray1.80A/B285-451[»]
ProteinModelPortaliP16662
SMRiP16662
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16662

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOGENOMiHOG000220831
HOVERGENiHBG004033
InParanoidiP16662
KOiK00699
OrthoDBiEOG091G06JC
PhylomeDBiP16662
TreeFamiTF315472

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16662-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVKWTSVIL LIQLSFCFSS GNCGKVLVWA AEYSHWMNIK TILDELIQRG
60 70 80 90 100
HEVTVLASSA SILFDPNNSS ALKIEIYPTS LTKTELENFI MQQIKRWSDL
110 120 130 140 150
PKDTFWLYFS QVQEIMSIFG DITRKFCKDV VSNKKFMKKV QESRFDVIFA
160 170 180 190 200
DAIFPCSELL AELFNIPFVY SLSFSPGYTF EKHSGGFIFP PSYVPVVMSE
210 220 230 240 250
LTDQMTFMER VKNMIYVLYF DFWFEIFDMK KWDQFYSEVL GRPTTLSETM
260 270 280 290 300
GKADVWLIRN SWNFQFPYPL LPNVDFVGGL HCKPAKPLPK EMEDFVQSSG
310 320 330 340 350
ENGVVVFSLG SMVSNMTEER ANVIASALAQ IPQKVLWRFD GNKPDTLGLN
360 370 380 390 400
TRLYKWIPQN DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGIPLFADQP
410 420 430 440 450
DNIAHMKARG AAVRVDFNTM SSTDLLNALK RVINDPSYKE NVMKLSRIQH
460 470 480 490 500
DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA HDLTWFQYHS LDVIGFLLVC
510 520
VATVIFIVTK CCLFCFWKFA RKAKKGKND
Length:529
Mass (Da):60,721
Last modified:April 25, 2018 - v2
Checksum:i94B8B31CE929C836
GO

Polymorphismi

2 alleles have been identified: UGT2B7*1 (His-268) and UGT2B7*2 (Tyr-268). The sequence shown is that of allele UGT2B7*2.2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05732771A → S. Corresponds to variant dbSNP:rs12233719Ensembl.1
Natural variantiVAR_012342268Y → H in allele UGT2B7*1. 2 PublicationsCorresponds to variant dbSNP:rs7439366Ensembl.1
Natural variantiVAR_057328378N → S. Corresponds to variant dbSNP:rs35590824Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05428 mRNA Translation: AAA36793.1
AK313190 mRNA Translation: BAG36007.1
AK223142 mRNA Translation: BAD96862.1
AC111000 Genomic DNA Translation: AAY41045.1
BC030974 mRNA Translation: AAH30974.1
CCDSiCCDS3526.1
PIRiA35366
RefSeqiNP_001065.2, NM_001074.3
NP_001317648.1, NM_001330719.1
UniGeneiHs.654424

Genome annotation databases

EnsembliENST00000305231; ENSP00000304811; ENSG00000171234
GeneIDi7364
KEGGihsa:7364
UCSCiuc003heg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUD2B7_HUMAN
AccessioniPrimary (citable) accession number: P16662
Secondary accession number(s): B2R810, Q6GTW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: April 25, 2018
Last modified: May 23, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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