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Protein

UDP-glucuronosyltransferase 2B7

Gene

UGT2B7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.1 Publication
Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro).1 Publication

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei398UDP-glucuronic acidCurated1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi373 – 379UDP-glucuronic acidCurated7

GO - Molecular functioni

  • glucuronosyltransferase activity Source: UniProtKB

GO - Biological processi

  • androgen metabolic process Source: UniProtKB
  • cellular glucuronidation Source: UniProtKB
  • flavonoid biosynthetic process Source: GO_Central
  • flavonoid glucuronidation Source: GO_Central
  • lipid metabolic process Source: ProtInc
  • steroid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid metabolism, Steroid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:HS10272-MONOMER.
ZFISH:HS10272-MONOMER.
BRENDAi2.4.1.17. 2681.
ReactomeiR-HSA-156588. Glucuronidation.
SABIO-RKP16662.
SIGNORiP16662.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B7 (EC:2.4.1.17)
Short name:
UDPGT 2B7
Alternative name(s):
3,4-catechol estrogen-specific UDPGT
UDP-glucuronosyltransferase 2B9
Short name:
UDPGT 2B9
UDPGTh-2
Gene namesi
Name:UGT2B7
Synonyms:UGTB2B9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:12554. UGT2B7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei493 – 509HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • intracellular membrane-bounded organelle Source: GO_Central
  • membrane Source: ProtInc
  • organelle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi15S → A: Almost abolishes enzyme activity. 1 Publication1
Mutagenesisi35H → A: Almost abolishes enzyme activity. 1 Publication1
Mutagenesisi151D → A: Almost abolishes enzyme activity. 1 Publication1
Mutagenesisi373T → V: Almost abolishes enzyme activity. 1 Publication1
Mutagenesisi374H → A: Almost abolishes enzyme activity. 1 Publication1
Mutagenesisi378N → A: Strongly reduced enzyme activity. 1 Publication1
Mutagenesisi379G → D: Almost abolishes enzyme activity. 1 Publication1
Mutagenesisi398D → A or N: Almost abolishes enzyme activity. 1 Publication1
Mutagenesisi399Q → A: Abolishes enzyme activity. 1 Publication1

Organism-specific databases

DisGeNETi7364.
PharmGKBiPA361.

Chemistry databases

ChEMBLiCHEMBL4370.
DrugBankiDB06403. Ambrisentan.
DB01076. Atorvastatin.
DB00564. Carbamazepine.
DB06777. Chenodeoxycholic acid.
DB00318. Codeine.
DB06695. Dabigatran etexilate.
DB06292. Dapagliflozin.
DB00586. Diclofenac.
DB00445. Epirubicin.
DB00749. Etodolac.
DB00973. Ezetimibe.
DB01544. Flunitrazepam.
DB00712. Flurbiprofen.
DB01095. Fluvastatin.
DB01050. Ibuprofen.
DB00328. Indomethacin.
DB00678. Losartan.
DB00227. Lovastatin.
DB01252. Mitiglinide.
DB00295. Morphine.
DB00688. Mycophenolate mofetil.
DB01024. Mycophenolic acid.
DB00788. Naproxen.
DB00842. Oxazepam.
DB08860. Pitavastatin.
DB06207. Silodosin.
DB00641. Simvastatin.
DB00870. Suprofen.
DB06204. Tapentadol.
DB00313. Valproic Acid.
DB00495. Zidovudine.

Polymorphism and mutation databases

BioMutaiUGT2B7.
DMDMi136727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000003603124 – 529UDP-glucuronosyltransferase 2B7Add BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi67N-linked (GlcNAc...)Sequence analysis1
Glycosylationi68N-linked (GlcNAc...)1 Publication1
Glycosylationi315N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP16662.
MaxQBiP16662.
PaxDbiP16662.
PeptideAtlasiP16662.
PRIDEiP16662.

PTM databases

iPTMnetiP16662.
PhosphoSitePlusiP16662.

Expressioni

Gene expression databases

BgeeiENSG00000171234.
CleanExiHS_UGT2B7.
ExpressionAtlasiP16662. baseline and differential.

Organism-specific databases

HPAiHPA045108.

Interactioni

Protein-protein interaction databases

BioGridi113211. 1 interactor.
IntActiP16662. 1 interactor.
STRINGi9606.ENSP00000304811.

Chemistry databases

BindingDBiP16662.

Structurei

Secondary structure

1529
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi290 – 297Combined sources8
Turni298 – 302Combined sources5
Beta strandi304 – 308Combined sources5
Helixi318 – 328Combined sources11
Beta strandi331 – 338Combined sources8
Beta strandi351 – 356Combined sources6
Helixi359 – 363Combined sources5
Beta strandi368 – 373Combined sources6
Helixi377 – 386Combined sources10
Beta strandi390 – 392Combined sources3
Helixi399 – 407Combined sources9
Turni408 – 410Combined sources3
Beta strandi411 – 414Combined sources4
Turni417 – 419Combined sources3
Helixi422 – 434Combined sources13
Helixi436 – 445Combined sources10
Turni448 – 450Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O6LX-ray1.80A/B285-451[»]
ProteinModelPortaliP16662.
SMRiP16662.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16662.

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP16662.
KOiK00699.
OrthoDBiEOG091G06JC.
PhylomeDBiP16662.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16662-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVKWTSVIL LIQLSFCFSS GNCGKVLVWA AEYSHWMNIK TILDELIQRG
60 70 80 90 100
HEVTVLASSA SILFDPNNSS ALKIEIYPTS LTKTELENFI MQQIKRWSDL
110 120 130 140 150
PKDTFWLYFS QVQEIMSIFG DITRKFCKDV VSNKKFMKKV QESRFDVIFA
160 170 180 190 200
DAIFPCSELL AELFNIPFVY SLSFSPGYTF EKHSGGFIFP PSYVPVVMSE
210 220 230 240 250
LTDQMTFMER VKNMIYVLYF DFWFEIFDMK KWDQFYSEVL GRPTTLSETM
260 270 280 290 300
GKADVWLIRN SWNFQFPHPL LPNVDFVGGL HCKPAKPLPK EMEDFVQSSG
310 320 330 340 350
ENGVVVFSLG SMVSNMTEER ANVIASALAQ IPQKVLWRFD GNKPDTLGLN
360 370 380 390 400
TRLYKWIPQN DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGIPLFADQP
410 420 430 440 450
DNIAHMKARG AAVRVDFNTM SSTDLLNALK RVINDPSYKE NVMKLSRIQH
460 470 480 490 500
DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA HDLTWFQYHS LDVIGFLLVC
510 520
VATVIFIVTK CCLFCFWKFA RKAKKGKND
Length:529
Mass (Da):60,695
Last modified:August 1, 1990 - v1
Checksum:i94B1CA6CE92F1446
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05732771A → S.Corresponds to variant rs12233719dbSNPEnsembl.1
Natural variantiVAR_012342268H → Y in allele UGT2B7*2. 5 PublicationsCorresponds to variant rs7439366dbSNPEnsembl.1
Natural variantiVAR_057328378N → S.Corresponds to variant rs35590824dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05428 mRNA. Translation: AAA36793.1.
AK313190 mRNA. Translation: BAG36007.1.
AK223142 mRNA. Translation: BAD96862.1.
AC111000 Genomic DNA. Translation: AAY41045.1.
BC030974 mRNA. Translation: AAH30974.1.
CCDSiCCDS3526.1.
PIRiA35366.
RefSeqiNP_001065.2. NM_001074.3.
NP_001317648.1. NM_001330719.1.
UniGeneiHs.654424.

Genome annotation databases

EnsembliENST00000305231; ENSP00000304811; ENSG00000171234.
GeneIDi7364.
KEGGihsa:7364.
UCSCiuc003heg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05428 mRNA. Translation: AAA36793.1.
AK313190 mRNA. Translation: BAG36007.1.
AK223142 mRNA. Translation: BAD96862.1.
AC111000 Genomic DNA. Translation: AAY41045.1.
BC030974 mRNA. Translation: AAH30974.1.
CCDSiCCDS3526.1.
PIRiA35366.
RefSeqiNP_001065.2. NM_001074.3.
NP_001317648.1. NM_001330719.1.
UniGeneiHs.654424.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O6LX-ray1.80A/B285-451[»]
ProteinModelPortaliP16662.
SMRiP16662.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113211. 1 interactor.
IntActiP16662. 1 interactor.
STRINGi9606.ENSP00000304811.

Chemistry databases

BindingDBiP16662.
ChEMBLiCHEMBL4370.
DrugBankiDB06403. Ambrisentan.
DB01076. Atorvastatin.
DB00564. Carbamazepine.
DB06777. Chenodeoxycholic acid.
DB00318. Codeine.
DB06695. Dabigatran etexilate.
DB06292. Dapagliflozin.
DB00586. Diclofenac.
DB00445. Epirubicin.
DB00749. Etodolac.
DB00973. Ezetimibe.
DB01544. Flunitrazepam.
DB00712. Flurbiprofen.
DB01095. Fluvastatin.
DB01050. Ibuprofen.
DB00328. Indomethacin.
DB00678. Losartan.
DB00227. Lovastatin.
DB01252. Mitiglinide.
DB00295. Morphine.
DB00688. Mycophenolate mofetil.
DB01024. Mycophenolic acid.
DB00788. Naproxen.
DB00842. Oxazepam.
DB08860. Pitavastatin.
DB06207. Silodosin.
DB00641. Simvastatin.
DB00870. Suprofen.
DB06204. Tapentadol.
DB00313. Valproic Acid.
DB00495. Zidovudine.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

iPTMnetiP16662.
PhosphoSitePlusiP16662.

Polymorphism and mutation databases

BioMutaiUGT2B7.
DMDMi136727.

Proteomic databases

EPDiP16662.
MaxQBiP16662.
PaxDbiP16662.
PeptideAtlasiP16662.
PRIDEiP16662.

Protocols and materials databases

DNASUi7364.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305231; ENSP00000304811; ENSG00000171234.
GeneIDi7364.
KEGGihsa:7364.
UCSCiuc003heg.4. human.

Organism-specific databases

CTDi7364.
DisGeNETi7364.
GeneCardsiUGT2B7.
HGNCiHGNC:12554. UGT2B7.
HPAiHPA045108.
MIMi600068. gene.
neXtProtiNX_P16662.
PharmGKBiPA361.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP16662.
KOiK00699.
OrthoDBiEOG091G06JC.
PhylomeDBiP16662.
TreeFamiTF315472.

Enzyme and pathway databases

BioCyciMetaCyc:HS10272-MONOMER.
ZFISH:HS10272-MONOMER.
BRENDAi2.4.1.17. 2681.
ReactomeiR-HSA-156588. Glucuronidation.
SABIO-RKP16662.
SIGNORiP16662.

Miscellaneous databases

ChiTaRSiUGT2B7. human.
EvolutionaryTraceiP16662.
GeneWikiiUGT2B7.
GenomeRNAii7364.
PROiP16662.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171234.
CleanExiHS_UGT2B7.
ExpressionAtlasiP16662. baseline and differential.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUD2B7_HUMAN
AccessioniPrimary (citable) accession number: P16662
Secondary accession number(s): B2R810, Q6GTW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 30, 2016
This is version 161 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.