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P16641

- KTRC_SCHMA

UniProt

P16641 - KTRC_SCHMA

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Protein
Taurocyamine kinase
Gene
Smp_194770
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

This family of enzymes reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate).1 Publication

Catalytic activityi

ATP + taurocyamine = ADP + N-phosphotaurocyamine.1 Publication

Cofactori

Magnesium.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei212 – 2121ATP By similarity
Binding sitei256 – 2561ATP By similarity
Active sitei298 – 2981 By similarity
Binding sitei575 – 5751ATP By similarity
Binding sitei619 – 6191ATP By similarity
Active sitei661 – 6611 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi149 – 1535ATP By similarity
Nucleotide bindingi307 – 3115ATP By similarity
Nucleotide bindingi335 – 3406ATP By similarity
Nucleotide bindingi512 – 5165ATP By similarity
Nucleotide bindingi670 – 6745ATP By similarity
Nucleotide bindingi699 – 7046ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. oxidoreductase activity Source: UniProtKB-KW
  4. taurocyamine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Oxidoreductase, Transferase

Keywords - Ligandi

ATP-binding, Flavoprotein, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Taurocyamine kinase (EC:2.7.3.4)
Alternative name(s):
ATP:guanidino kinase Smc74
ATP:guanidino phosphotransferase
Short name:
SmGK
Gene namesi
ORF Names:Smp_194770
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma
ProteomesiUP000008854: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 746746Taurocyamine kinase
PRO_0000212009Add
BLAST

Expressioni

Developmental stagei

Expressed at low levels in 37-day sporocysts, increases 25-fold in the infective cercarial and early schistosomular stages. Levels decrease dramatically in adults, adult males have approximately twice the expression level as in adult females.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati31 – 393363Approximate
Add
BLAST
Domaini35 – 11682Phosphagen kinase N-terminal 1
Add
BLAST
Domaini146 – 382237Phosphagen kinase C-terminal 1
Add
BLAST
Repeati394 – 705312Approximate
Add
BLAST
Domaini398 – 47982Phosphagen kinase N-terminal 2
Add
BLAST
Domaini509 – 746238Phosphagen kinase C-terminal 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000006584.

Family and domain databases

Gene3Di1.10.135.10. 2 hits.
3.30.590.10. 2 hits.
InterProiIPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PfamiPF00217. ATP-gua_Ptrans. 2 hits.
PF02807. ATP-gua_PtransN. 2 hits.
[Graphical view]
SUPFAMiSSF48034. SSF48034. 2 hits.
PROSITEiPS00112. PHOSPHAGEN_KINASE. 2 hits.
PS51510. PHOSPHAGEN_KINASE_C. 2 hits.
PS51509. PHOSPHAGEN_KINASE_N. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16641-1 [UniParc]FASTAAdd to Basket

« Hide

MTCTSAFIKV VRFIQVVIDT REIRSLCTIR MQVESLQNLQ AKIRNDERNH    50
SLTKKYLTDD IVKKYQATKT SLGGTLAQCV NTNAYNPGAL LPRSCDLNAY 100
ETFRDFFDAV IADYHKVPDG KIQHPKSNFG DLKSLSFTDL NTYGNLVVST 150
RVRLGRTVEG FGFGPTLTKE TRIELENKIS TALHNLSGEY EGTYYPLTGM 200
SEEDRIKLVN DHFLFRNDDN VLRDAGGYID WPTGRGIFIN KQKNFLVWIN 250
EEDHIRVISM QKGGDLIAVY KRLADAIQEL SKSLKFAFND RLGFITFCPS 300
NLGTTLRASV HAKIPMLASL PNFKEICEKH GIQPRGTHGE HTESVGGIYD 350
LSNKRRLGLT ELDAVTEMHS GVRALLELEV MLQEYNKGAP EGVMPVEPLT 400
YLAKLLEGAS IEKCYTRKYL TPEIIKKYDG KRTTHGATLA HMIRNGAYNN 450
RSICPRTGEA ECYSTFIDYL DPLICDYHGV KDSAFKHPAP TFGDLSKLPF 500
GDLDPTGKFI VSTRVRVGRS VEDFLFPTIM SKTDRIKLEQ VISGALKGLT 550
GEHAGTYYPL TDMKEEDRKQ LVEDHFLFKN DDPVLRDAGG YRDWPVGRGI 600
FHNNSKTFLV WVCEEDHMRI ISMQQGGNLA AVYKRLIEGI NAIGKSMKFA 650
HSDKYGYITC CPSNLGTSMR ASVLLKIPKL SSQPKKLDEI CAKYMLQARG 700
LYGEHTESPD GTYDISNKRR LGLTELQAAH EMAEGVAKMI EIEKGL 746
Length:746
Mass (Da):83,891
Last modified:June 13, 2012 - v3
Checksum:i03B55FFD75E979B1
GO

Sequence cautioni

The sequence AAA29927.1 differs from that shown. Reason: Frameshift at positions 416, 434 and 644.
The sequence CCD76533.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451N → S in ABU49846. 1 Publication
Sequence conflicti200 – 21112MSEED…KLVND → CQRGQNQTSKRH in AAA29927. 1 Publication
Add
BLAST
Sequence conflicti244 – 2441N → K in AAA29927. 1 Publication
Sequence conflicti264 – 2641G → R in AAA29927. 1 Publication
Sequence conflicti282 – 2821K → R in ABU49846. 1 Publication
Sequence conflicti523 – 5231D → G in AAA29927. 1 Publication
Sequence conflicti523 – 5231D → G no nucleotide entry 1 Publication
Sequence conflicti523 – 5231D → G in ABU49845. 1 Publication
Sequence conflicti632 – 6321V → A no nucleotide entry 1 Publication
Sequence conflicti681 – 74666SSQPK…IEKGL → VLNRKSWMKFVRSDMPSKLE VLLW in AAA29927. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05410 mRNA. Translation: AAA29927.1. Frameshift.
HE601624 Genomic DNA. Translation: CCD76533.1. Sequence problems.
EU042595 mRNA. Translation: ABU49845.1.
EU042596 mRNA. Translation: ABU49846.1.
L31768 Genomic DNA. Translation: AAA29912.1.
L31769 Genomic DNA. Translation: AAA29913.1.
PIRiA35743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05410 mRNA. Translation: AAA29927.1 . Frameshift.
HE601624 Genomic DNA. Translation: CCD76533.1 . Sequence problems.
EU042595 mRNA. Translation: ABU49845.1 .
EU042596 mRNA. Translation: ABU49846.1 .
L31768 Genomic DNA. Translation: AAA29912.1 .
L31769 Genomic DNA. Translation: AAA29913.1 .
PIRi A35743.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOGENOMi HOG000006584.

Family and domain databases

Gene3Di 1.10.135.10. 2 hits.
3.30.590.10. 2 hits.
InterProi IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view ]
Pfami PF00217. ATP-gua_Ptrans. 2 hits.
PF02807. ATP-gua_PtransN. 2 hits.
[Graphical view ]
SUPFAMi SSF48034. SSF48034. 2 hits.
PROSITEi PS00112. PHOSPHAGEN_KINASE. 2 hits.
PS51510. PHOSPHAGEN_KINASE_C. 2 hits.
PS51509. PHOSPHAGEN_KINASE_N. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A cloned ATP:guanidino kinase in the trematode Schistosoma mansoni has a novel duplicated structure."
    Stein L.D., Harn D.A., David J.R.
    J. Biol. Chem. 265:6582-6588(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Strain: Puerto Rican.
  2. "Crystallization and X-ray analysis of the Schistosoma mansoni guanidino kinase."
    Awama A.M., Paracuellos P., Laurent S., Dissous C., Marcillat O., Gouet P.
    Acta Crystallogr. F 64:854-857(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS), FUNCTION, CATALYTIC ACTIVITY, COFACTOR.
  3. "The genome of the blood fluke Schistosoma mansoni."
    Berriman M., Haas B.J., LoVerde P.T., Wilson R.A., Dillon G.P., Cerqueira G.C., Mashiyama S.T., Al-Lazikani B., Andrade L.F., Ashton P.D., Aslett M.A., Bartholomeu D.C., Blandin G., Caffrey C.R., Coghlan A., Coulson R., Day T.A., Delcher A.
    , DeMarco R., Djikeng A., Eyre T., Gamble J.A., Ghedin E., Gu Y., Hertz-Fowler C., Hirai H., Hirai Y., Houston R., Ivens A., Johnston D.A., Lacerda D., Macedo C.D., McVeigh P., Ning Z., Oliveira G., Overington J.P., Parkhill J., Pertea M., Pierce R.J., Protasio A.V., Quail M.A., Rajandream M.A., Rogers J., Sajid M., Salzberg S.L., Stanke M., Tivey A.R., White O., Williams D.L., Wortman J., Wu W., Zamanian M., Zerlotini A., Fraser-Liggett C.M., Barrell B.G., El-Sayed N.M.
    Nature 460:352-358(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Puerto Rican.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Puerto Rican.
  5. "Molecular determinants of compatibility polymorphism in the Biomphalaria glabrata/Schistosoma mansoni model: New candidates identified by a global comparative proteomics approach."
    Roger E., Mitta G., Mone Y., Bouchut A., Rognon A., Grunau C., Boissier J., Theron A., Gourbal B.E.
    Mol. Biochem. Parasitol. 157:205-216(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-683.
    Strain: C and IC.
  6. "The Schistosoma mansoni phosphagen kinase gene contains two closely apposed transcription initiation sites and arose from a fused gene duplication."
    Shoemaker C.B.
    Mol. Biochem. Parasitol. 68:319-322(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-52 AND 362-415.

Entry informationi

Entry nameiKTRC_SCHMA
AccessioniPrimary (citable) accession number: P16641
Secondary accession number(s): A7UAX4
, A7UAX5, C4QUJ5, G4VAV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: June 13, 2012
Last modified: October 16, 2013
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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